Prescription onlyLower-cost generic available



  • Pill
  • Extended release
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Relaxes your muscles.

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Prescription onlyLower-cost generic available

Our pharmacists’ bottom line

Flexeril (Cyclobenzaprine) is widely used to treat muscle spasms and is available as a generic, but it shouldn't be used long-term.

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  • Can relieve pain associated with muscle spasms.
  • Available as a generic medication.
  • Can be used by pregnant women.
  • Can cause dizziness and sleepiness.
  • Not meant for long-term therapy.
  • Not recommended in elderly patients, people with glaucoma, or in people with recent heart issues (like rhythm problems, heart failure, or heart attack).

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Side effects for Flexeril (Cyclobenzaprine)

From clinical trials of Flexeril / Muscle spasms (Extended release - 15 mg)  ( 255)

  • Dry mouthDry mouth6% for Cyclobenzaprine vs.2% for placebo
  • DizzinessDizziness3% for Cyclobenzaprine vs.2% for placebo
  • FatigueFatigue3% for Cyclobenzaprine vs.2% for placebo
  • NauseaNausea3% for Cyclobenzaprine vs.1% for placebo
  • ConstipationConstipation1% for Cyclobenzaprine vs.0% for placebo
  • DrowsinessDrowsiness1% for Cyclobenzaprine vs.0% for placebo

Manufacturers don’t say how common these side effects are

  • Indigestion

What to expect when you take Flexeril (Cyclobenzaprine) for Muscle relaxant

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Tips from our pharmacists
  • Can cause dizziness, fatigue, and sleepiness.
  • Take the medication at the same time each day.
  • Not to be used for long-term treatment.
  • Don't drink alcohol while on this medication.

Risks and Warnings for Flexeril (Cyclobenzaprine)

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    • Higher risk if:
    • Taking monoamine oxidase inhibitors (MAOI) 14 days before starting
    • Taking other medications for your mood

    Taking Flexeril (Cyclobenzaprine) along with other medications used for your mood, such as monoamine oxidase inhibitors and certain antidepressants, can make you more likely to have a serious condition called serotonin syndrome. Symptoms include sudden changes in your mental status (confusion and hallucinations), muscles (tremors and rigidity) and nausea, vomiting and diarrhea. Go to the emergency room or talk to your doctor immediately if you notice these symptoms. Talk to your doctor or pharmacist if you are unsure if your other medications will interact with Flexeril (Cyclobenzaprine).

Means that some groups have a high risk of experiencing this side effect

Tips from pharmacists and people taking Flexeril (Cyclobenzaprine)

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The FDA category for this medication is B. It is advised that you: Probably safe
  • Tips from our pharmacists
  • Don't drink alcohol while on this medication.
  • Risks from our pharmacists
  • Taking Flexeril (Cyclobenzaprine) may make you feel dizzy or sleepy for the first few days, especially if you drink a lot of alcohol or take recreational drugs. Your body should adjust to this, however, avoid driving or other activities requiring concentration until you know how your body responds to the medication. Talk to your doctor or pharmacist if these symptoms bother you.
  • I was only able to take it at night, since it made me drowsy. I wouldn't drive for sure.
    Age: 32
    Gender: Woman
    Taken for: Muscle spasm
  • Awful! I may have had a bad reaction to this medication . I took one 5mg and went to sleep. Woke up an hr later having hallucinations. Scary
    Age: 36
    Gender: Woman
    Taken for: Muscle spasm
  • Prescribed mainly for sleep with my sciatica. Helps with that quite well. Not so much for the actual pain.
    Age: 22
    Gender: Man
    Taken for: Muscle spasm
  • caused dry mouth and weight gain
    Age: 58
    Gender: Woman