Prescription onlyLower-cost generic available



  • Pill
  • Extended release
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Relaxes your muscles.

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Prescription onlyLower-cost generic available

Our pharmacists’ bottom line

Flexeril (Cyclobenzaprine) is widely used to treat muscle spasms and is available as a generic, but it shouldn't be used long-term.

Worth itNot sureNope
Worked WellSomewhatDidn't work
No hassleSomewhatHuge hassle
Worth it
Men: 66%
Women: 66%
Works well
Men: 36%
Women: 36%
It's a hassle
Men: 14%
Women: 14%
  • Can relieve pain associated with muscle spasms.
  • Available as a generic medication.
  • Can be used by pregnant women.
  • Can cause dizziness and sleepiness.
  • Not meant for long-term therapy.
  • Not recommended in elderly patients, people with glaucoma, or in people with recent heart issues (like rhythm problems, heart failure, or heart attack).

Save on your next Flexeril (Cyclobenzaprine) prescription. Be sure you’re getting the lowest price for your medication, even if you have insurance.

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Side effects for Flexeril (Cyclobenzaprine)

From clinical trials of Flexeril / Muscle spasms (Extended release - 15 mg) ( 255)

  • Dry mouthDry mouth6% for Cyclobenzaprine vs.2% for placebo
  • DizzinessDizziness3% for Cyclobenzaprine vs.2% for placebo
  • FatigueFatigue3% for Cyclobenzaprine vs.2% for placebo
  • NauseaNausea3% for Cyclobenzaprine vs.1% for placebo
  • ConstipationConstipation1% for Cyclobenzaprine vs.0% for placebo
  • DrowsinessDrowsiness1% for Cyclobenzaprine vs.0% for placebo

Manufacturers don’t say how common these side effects are

  • Indigestion

What to expect when you start + pharmacist tips

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  • Can cause dizziness, fatigue, and sleepiness.
  • Take the medication at the same time each day.
  • Not to be used for long-term treatment.
  • Don't drink alcohol while on this medication.
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Risks and Warnings for Flexeril (Cyclobenzaprine)

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    • Higher risk if:
    • Taking monoamine oxidase inhibitors (MAOI) 14 days before starting
    • Taking other medications for your mood

    Taking Flexeril (Cyclobenzaprine) along with other medications used for your mood, such as monoamine oxidase inhibitors and certain antidepressants, can make you more likely to have a serious condition called serotonin syndrome. Symptoms include sudden changes in your mental status (confusion and hallucinations), muscles (tremors and rigidity) and nausea, vomiting and diarrhea. Go to the emergency room or talk to your doctor immediately if you notice these symptoms. Talk to your doctor or pharmacist if you are unsure if your other medications will interact with Flexeril (Cyclobenzaprine).

Means that some groups have a high risk of experiencing this side effect

Tips from pharmacists and people taking Flexeril (Cyclobenzaprine)

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The FDA category for this medication is B. It is advised that you: Probably safe
  • Tips from our pharmacists
  • Don't drink alcohol while on this medication.
  • Risks from our pharmacists
  • Taking Flexeril (Cyclobenzaprine) may make you feel dizzy or sleepy for the first few days, especially if you drink a lot of alcohol or take recreational drugs. Your body should adjust to this, however, avoid driving or other activities requiring concentration until you know how your body responds to the medication. Talk to your doctor or pharmacist if these symptoms bother you.
  • It will make you sleepy pretty fast and sleep good
    Age: 69
    Gender: woman
    Taken for: Muscle spasm
Weight gain or loss
  • caused dry mouth and weight gain
    Age: 58
    Gender: woman