Prescription onlyLower-cost generic available

Flexeril Alternatives

(Cyclobenzaprine)

  • Pill
  • Extended release
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Compare Flexeril (Cyclobenzaprine) to alternatives

These medications are comparable to Flexeril (Cyclobenzaprine) or used for similar purposes.

Flexeril
(Cyclobenzaprine)

Soma
(Carisoprodol)

Robaxin
(Methocarbamol)

Valium
(Diazepam)

Skelaxin
(Metaxalone)

Norflex
(Orphenadrine)

Zanaflex
(Tizanidine)

Relaxes your muscles. Flexeril (Cyclobenzaprine) is widely used to treat muscle spasms and is available as a generic, but it shouldn't be used long-term.Relaxes your muscles. Soma (Carisoprodol) is widely used to treat muscle spasms and is available as a generic, but it's not considered a first-choice treatment for muscle spasms. It's also not meant for long-term therapy.Coming soon.Helps you relax. Valium (Diazepam) is okay for occasional or short-term use (up to 4 weeks) for anxiety and for pain and sleeplessness from muscle spasm. Less severe withdrawal symptoms compared to similar drugs.Coming soon.Coming soon.Relaxes your muscles. Zanaflex (Tizanidine) isn't a first-choice treatment for muscle spasms. Try other options before using this.
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Reviews & ratings
Button Group. All currently active
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4.682646212847555Flexeril
Reviews for Flexeril (Cyclobenzaprine)
66%
of people say Flexeril (Cyclobenzaprine) is worth it
37%
say it works well
14%
say it's a big hassle
Reviews for Soma (Carisoprodol)
59%
7% vs. Flexeril (Cyclobenzaprine)
36%
1% vs. Flexeril (Cyclobenzaprine)
10%
+4% vs. Flexeril (Cyclobenzaprine)

Not enough reviews for this drug. Help someone out, leave a review!

Reviews for Valium (Diazepam)
69%
+3% vs. Flexeril (Cyclobenzaprine)
52%
+15% vs. Flexeril (Cyclobenzaprine)
16%
2% vs. Flexeril (Cyclobenzaprine)

Not enough reviews for this drug. Help someone out, leave a review!

Not enough reviews for this drug. Help someone out, leave a review!

Not enough reviews for this drug. Help someone out, leave a review!

Side effects
FlexerilSomaRobaxinValiumSkelaxinNorflexZanaflex
  • Indigestion 3%
  • Fatigue 1%
More Flexeril side effects »
  • Drowsiness 11%
  • Dizziness 6%
  • Hedache 3%
  • Any side effect 2%
More Soma side effects »

We haven’t found good data for Robaxin side effects.

FDA side effect reports for Robaxin »

The Valium FDA package insert doesn’t have numbers about how common side effects are.

More about Valium side effects »

We haven’t found good data for Skelaxin side effects.

FDA side effect reports for Skelaxin »

We haven’t found good data for Norflex side effects.

FDA side effect reports for Norflex »

We haven’t found good data for Zanaflex side effects.

FDA side effect reports for Zanaflex »
How it works
FlexerilSomaRobaxinValiumSkelaxinNorflexZanaflex
Flexeril (Cyclobenzaprine) is a muscle relaxer. It works in the brain to help calm down muscle spasms without interfering with normal muscle function.Soma (Carisoprodol) is a muscle relaxant. It works in the brain to help calm down muscle spasms.Coming soon.Valium (Diazepam) is a fast-acting benzodiazepine. It affects neurotransmitters in the brain and calms the nervous system. This reduces anxiety and muscle spasms, and causes sleepiness.Coming soon.Coming soon.Zanaflex (Tizanidine) is a muscle relaxer. It works in the nervous system to calm down muscle spasms without interfering with normal muscle function.
Type of medication
FlexerilSomaRobaxinValiumSkelaxinNorflexZanaflex
Muscle relaxerPrescription only
Muscle relaxerPrescription only
Coming soon.
Anti-anxiety
Benzodiazepine
Prescription only
Coming soon.
Coming soon.
Muscle relaxer
Centrally-acting alpha agonist
Prescription only
Available as
FlexerilSomaRobaxinValiumSkelaxinNorflexZanaflex
  • Pill
  • Extended release
  • Pill
  • Pill
  • Pill
  • Liquid
  • Rectal gel
  • Pill
  • Extended release
  • Pill
Used for (click to learn more)
FlexerilSomaRobaxinValiumSkelaxinNorflexZanaflex
  • Musculoskeletal pain Spasm - Tetanus
  • Musculoskeletal pain
  • Musculoskeletal pain
Risk factors for serious side effects
FlexerilSomaRobaxinValiumSkelaxinNorflexZanaflex
  • Taking monoamine oxidase inhibitors (MAOI) 14 days before starting
  • Taking other medications for your mood
  • Alcohol or drug use
  • Age over 65
  • Taking tramadol
Detailed Flexeril (Cyclobenzaprine) risks & warnings »
Coming soon.Coming soon.Coming soon.Coming soon.Coming soon.Coming soon.
Pregnancy category
FlexerilSomaRobaxinValiumSkelaxinNorflexZanaflex
BFDA pregnancy category (Probably safe)

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

See the FDA package insert
CFDA pregnancy category (Weigh risks vs. benefits)

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

See the FDA package insert
CFDA pregnancy category (Weigh risks vs. benefits)

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

See the FDA package insert
DFDA pregnancy category (Weigh risks vs. benefits)

Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

See the FDA package insert
NFDA pregnancy category (Unknown)

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

See the FDA package insert
CFDA pregnancy category (Weigh risks vs. benefits)

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

See the FDA package insert
CFDA pregnancy category (Weigh risks vs. benefits)

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

See the FDA package insert
Alcohol
  • Don't drink alcohol while on this medication.
  • Taking Flexeril (Cyclobenzaprine) may make you feel dizzy or sleepy for the first few days, especially if you drink a lot of alcohol or take recreational drugs. Your body should adjust to this, however, avoid driving or other activities requiring concentration until you know how your body responds to the medication. Talk to your doctor or pharmacist if these symptoms bother you.
  • Don't drink alcohol while on this medication.
No specific alcohol-related info.
  • Can be habit-forming, so it's not typically used for long-term treatment, or for people who've had problems with drug or alcohol abuse.
  • Not safe to use with alcohol.
No specific alcohol-related info.No specific alcohol-related info.
  • Don't drink alcohol while using this.
Food
No specific food-related info.No specific food-related info.No specific food-related info.No specific food-related info.No specific food-related info.No specific food-related info.
  • Need to be consistent every day in taking this with or without food.
  • Can be taken with or without food, but you need to be consistent in how you take it every day.
  • Can be taken with or without food, but you need to be consistent since food affects how the medication is absorbed and works.
Kidneys and liver
No specific kidneys and liver-related info.No specific kidneys and liver-related info.No specific kidneys and liver-related info.No specific kidneys and liver-related info.No specific kidneys and liver-related info.No specific kidneys and liver-related info.No specific kidneys and liver-related info.
Sex
No specific sex-related info.No specific sex-related info.No specific sex-related info.No specific sex-related info.No specific sex-related info.No specific sex-related info.No specific sex-related info.
Sleep
No specific sleep-related info.No specific sleep-related info.No specific sleep-related info.
  • Can cause memory problems, drowsiness, dizziness, and confusion.
  • Can cause temporary dizziness and drowsiness.
No specific sleep-related info.No specific sleep-related info.
  • Can cause dizziness, fatigue, drowsiness, and dry mouth.
  • Can cause extreme drowsiness or dizziness if you are taking meds for high blood pressure.
Weight
No specific weight-related info.No specific weight-related info.No specific weight-related info.No specific weight-related info.No specific weight-related info.No specific weight-related info.No specific weight-related info.
Upsides and benefits
FlexerilSomaRobaxinValiumSkelaxinNorflexZanaflex
  • Can relieve pain associated with muscle spasms.
  • Available as a generic medication.
  • Can be used by pregnant women.
  • Available in generic.
  • Available in two different strengths, although the smaller strength is only available as brand name and thus more expensive.
Coming soon.
  • Effective at relieving short-term anxiety and sleeplessness.
  • Can be used together with antidepressants to manage anxiety disorders. Especially helpful for anxiety symptoms while you wait for an antidepressant to kick in (it can take several weeks).
  • Effective at relieving muscle spasms caused by a variety of conditions.
  • Less severe withdrawal symptoms compared to other benzodiazepines.
Coming soon.Coming soon.
  • Relieves muscle spasms well.
  • Can be taken with or without food, but you need to be consistent in how you take it every day.
  • Available as a generic.
  • Available in a tablet or capsule form. It also comes in a capsule that can be opened and sprinkled in applesauce for people that can't swallow pills.
Downsides and risks
FlexerilSomaRobaxinValiumSkelaxinNorflexZanaflex
  • Not meant for long-term therapy.
  • Not recommended in elderly patients, people with glaucoma, or in people with recent heart issues (like rhythm problems, heart failure, or heart attack).
  • Can cause dizziness and sleepiness.
  • Not first line for treating muscle spasms.
  • Not meant for long term therapy.
  • Can cause dependence and withdrawal symptoms if you stop taking it suddenly.
  • Can cause dizziness and sleepiness.
Coming soon.
  • Processed by the liver, so might not be the best choice if you have liver problems.
  • Can cause memory problems, drowsiness, dizziness, and confusion.
  • Can be habit-forming, so it's not typically used for long-term treatment, or for people who've had problems with drug or alcohol abuse.
  • Most people find that it gets less effective over time.
Coming soon.Coming soon.
  • This isn't a first-choice muscle relaxing medication. Other drugs work better and have fewer side effects.
  • Zanaflex (Tizanidine) can lower blood pressure, so be careful if you are already on a blood pressure medication.
  • Need to be consistent every day in taking this with or without food.
  • Elderly individuals have more side effects when taking Zanaflex (Tizanidine).
  • Can't stop taking this abruptly if you use it regularly.
Tips from our pharmacists for people taking the medication
FlexerilSomaRobaxinValiumSkelaxinNorflexZanaflex
  • Not to be used for long-term treatment.
  • Can cause dizziness, fatigue, and sleepiness.
  • Take the medication at the same time each day.
  • Don't drink alcohol while on this medication.
  • Not to be used for long-term treatment (2 to 3 weeks maximum)
  • Can cause stomach pain, nausea and vomiting.
  • Can cause dizziness, fatigue, and sleepiness.
  • Take the medication at the same time each day.
  • Don't drink alcohol while on this medication.
Coming soon.
  • Good for short-term relief of anxiety symptoms.
  • Starts working in 30 minutes when swallowed.
  • Helpful with muscle spasms.
  • Can cause temporary dizziness and drowsiness.
  • Addictive. Long-term use can cause dependence or abuse.
  • Not safe to use with alcohol.
Coming soon.Coming soon.
  • Can cause dizziness, fatigue, drowsiness, and dry mouth.
  • Avoid activities requiring mental alertness (like driving) until you know how it affects you.
  • Can cause extreme drowsiness or dizziness if you are taking meds for high blood pressure.
  • Side effects are more prevalent in the elderly.
  • Don't drink alcohol while using this.
  • Can be taken with or without food, but you need to be consistent since food affects how the medication is absorbed and works.
Learn more
More about FlexerilSide effectsReviews & ratingsAlternativesFDA package insert
More about SomaSide effectsReviews & ratingsFDA package insert
More about RobaxinSide effectsReviews & ratingsFDA package insert
More about ValiumSide effectsReviews & ratingsFDA package insert
More about SkelaxinSide effectsReviews & ratingsFDA package insert
More about NorflexSide effectsReviews & ratingsFDA package insert
More about ZanaflexSide effectsReviews & ratingsFDA package insert