Prescription onlyLower-cost generic availableClass: Musculoskeletal

Flexeril Alternatives

(cyclobenzaprine)

Prescription onlyLower-cost generic availableClass: Musculoskeletal
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Compare Flexeril (cyclobenzaprine) to alternatives

These medications are comparable to Flexeril (cyclobenzaprine) or used for similar purposes.

Flexeril
(cyclobenzaprine)

Soma
(carisoprodol)

Robaxin
(methocarbamol)

Valium
(diazepam)

Skelaxin
(metaxalone)

Norflex
(orphenadrine)

Zanaflex
(tizanidine)

Relaxes your muscles. Flexeril (Cyclobenzaprine) is widely used to treat muscle spasms and is available as a generic, but it shouldn't be used long-term.Relaxes your muscles. Soma (Carisoprodol) is widely used to treat muscle spasms and is available as a generic, but it's not considered a first-choice treatment for muscle spasms. It's also not meant for long-term therapy.Coming soon.Helps you relax. Valium (Diazepam) is okay for occasional or short-term use (up to 4 weeks) for anxiety and for pain and sleeplessness from muscle spasm. Less severe withdrawal symptoms compared to similar drugs.Coming soon.Coming soon.Relaxes your muscles. Zanaflex (Tizanidine) isn't a first-choice treatment for muscle spasms. Try other options before using this.
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Prices and coupon for 90 (10mg) tablets of cyclobenzaprine
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Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.69Flexeril
Reviews for Flexeril (cyclobenzaprine)
66%
of people (All ages) say Flexeril (cyclobenzaprine) is worth it
37%
say it works well
14%
say it's a big hassle
1064 reviews
Have you used Flexeril (cyclobenzaprine)?
Worth itNot sureNot worth it
Reviews for Soma (carisoprodol)
61%
-5% worse vs. Flexeril (cyclobenzaprine)
39%
+2% better vs. Flexeril (cyclobenzaprine)
9%
+5% better vs. Flexeril (cyclobenzaprine)
220 reviews
Have you used Soma (carisoprodol)?
Worth itNot sureNot worth it
Reviews for Robaxin (methocarbamol)
Not enough review data. Review it!
+1% better vs. Flexeril (cyclobenzaprine)
Not enough review data. Review it!
-26% worse vs. Flexeril (cyclobenzaprine)
Not enough review data. Review it!
+14% better vs. Flexeril (cyclobenzaprine)
Have you used Robaxin (methocarbamol)?
Worth itNot sureNot worth it
Reviews for Valium (diazepam)
70%
+4% better vs. Flexeril (cyclobenzaprine)
53%
+16% better vs. Flexeril (cyclobenzaprine)
15%
-1% worse vs. Flexeril (cyclobenzaprine)
976 reviews
Have you used Valium (diazepam)?
Worth itNot sureNot worth it
Reviews for Skelaxin (metaxalone)
Not enough review data. Review it!
+34% better vs. Flexeril (cyclobenzaprine)
Not enough review data. Review it!
+13% better vs. Flexeril (cyclobenzaprine)
Not enough review data. Review it!
+14% better vs. Flexeril (cyclobenzaprine)
Have you used Skelaxin (metaxalone)?
Worth itNot sureNot worth it
Reviews for Norflex (orphenadrine)
Not enough review data. Review it!
-26% worse vs. Flexeril (cyclobenzaprine)
Not enough review data. Review it!
-17% worse vs. Flexeril (cyclobenzaprine)
Not enough review data. Review it!
-6% worse vs. Flexeril (cyclobenzaprine)
Have you used Norflex (orphenadrine)?
Worth itNot sureNot worth it
Reviews for Zanaflex (tizanidine)
81%
+15% better vs. Flexeril (cyclobenzaprine)
73%
+36% better vs. Flexeril (cyclobenzaprine)
19%
-5% worse vs. Flexeril (cyclobenzaprine)
Have you used Zanaflex (tizanidine)?
Worth itNot sureNot worth it
Side effects
FlexerilSomaRobaxinValiumSkelaxinNorflexZanaflex
  • Dry mouth 4%
  • Dizziness 1%
  • Fatigue 1%
  • Nausea 2%
  • Drowsiness 100%
  • Headache nos 17%
  • Dry throat 8%
  • Acne nos 6%
  • Disturbance in attention 6%
More Flexeril side effects »
  • Drowsiness 7%
  • Dizziness 6%
  • Hedache 3%
  • Central nervous system reactions 2%
More Soma side effects »

We haven’t found good data for Robaxin side effects.

FDA side effect reports for Robaxin »

The Valium FDA package insert doesn’t have numbers about how common side effects are.

More about Valium side effects »

We haven’t found good data for Skelaxin side effects.

FDA side effect reports for Skelaxin »

We haven’t found good data for Norflex side effects.

FDA side effect reports for Norflex »

We haven’t found good data for Zanaflex side effects.

FDA side effect reports for Zanaflex »
How it works
FlexerilSomaRobaxinValiumSkelaxinNorflexZanaflex
Flexeril (Cyclobenzaprine) is a muscle relaxer. It works in the brain to help calm down muscle spasms without interfering with normal muscle function.Soma (Carisoprodol) is a muscle relaxant. It works in the brain to help calm down muscle spasms.Coming soon.Valium (Diazepam) is a fast-acting benzodiazepine. It affects neurotransmitters in the brain and calms the nervous system. This reduces anxiety and muscle spasms, and causes sleepiness.Coming soon.Coming soon.Zanaflex (Tizanidine) is a muscle relaxer. It works in the nervous system to calm down muscle spasms without interfering with normal muscle function.
Type of medication
FlexerilSomaRobaxinValiumSkelaxinNorflexZanaflex
Prescription only
Prescription only
Prescription only
Prescription only
Available as
FlexerilSomaRobaxinValiumSkelaxinNorflexZanaflex
  • Pill
  • Extended release
  • Pill
  • Pill
  • Pill
  • Liquid
  • Rectal gel
  • Pill
  • Extended release
  • Pill
Used for
FlexerilSomaRobaxinValiumSkelaxinNorflexZanaflex
  • Musculoskeletal Pain Spasm Tetanus
  • Musculoskeletal Pain
  • Musculoskeletal Pain
Risk factors for serious side effects
FlexerilSomaRobaxinValiumSkelaxinNorflexZanaflex
  • Taking monoamine oxidase inhibitors (MAOI) 14 days before starting
  • Taking other medications for your mood
  • Alcohol or drug use
  • Age over 65
  • Taking tramadol
Detailed Flexeril (cyclobenzaprine) risks & warnings »
  • Taking other medications that also cause sleepiness
  • Recreational drug use
  • Excessive alcohol use
  • Prior history of drug abuse
  • Prior history of overdoses of drugs of abuse, recreational drugs or alcohol
Detailed Soma (carisoprodol) risks & warnings »
    Coming soon.
    • Taking more than the prescribed dose
    • Taking longer than 4 weeks
    • History of drug abuse
    • Long-term use
    • Alcohol
    Detailed Valium (diazepam) risks & warnings »
      Coming soon.
        Coming soon.
        • Age 65 years or older
        • Taking with alcohol
        • Taking other medicines that make you less alert
        • Age 65 or greater
        Detailed Zanaflex (tizanidine) risks & warnings »
        Pregnancy

        Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

        Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

        Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

        Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

        The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

        Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

        Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

        Alcohol
        FlexerilSomaRobaxinValiumSkelaxinNorflexZanaflex
        • Don't drink alcohol while on this medication.
        • Don't drink alcohol while on this medication.
        No alcohol related info.
        • Can be habit-forming, so it's not typically used for long-term treatment, or for people who've had problems with drug or alcohol abuse.
        • Not safe to use with alcohol.
        No alcohol related info.No alcohol related info.
        • Don't drink alcohol while using this.
        Food
        FlexerilSomaRobaxinValiumSkelaxinNorflexZanaflex
        No food related info.No food related info.No food related info.No food related info.No food related info.No food related info.
        • Can be taken with or without food, but you need to be consistent in how you take it every day.
        • Need to be consistent every day in taking this with or without food.
        • Can be taken with or without food, but you need to be consistent since food affects how the medication is absorbed and works.
        Kidneys and liver
        FlexerilSomaRobaxinValiumSkelaxinNorflexZanaflex
        No kidneys and liver related info.No kidneys and liver related info.No kidneys and liver related info.
        • Processed by the liver, so might not be the best choice if you have liver problems.
        No kidneys and liver related info.No kidneys and liver related info.No kidneys and liver related info.
        Pain
        FlexerilSomaRobaxinValiumSkelaxinNorflexZanaflex
        • Can relieve pain associated with muscle spasms.
        • Can cause stomach pain, nausea and vomiting.
        No pain related info.No pain related info.No pain related info.No pain related info.No pain related info.
        Sleep
        FlexerilSomaRobaxinValiumSkelaxinNorflexZanaflex
        • Taking Flexeril (Cyclobenzaprine) may make you feel dizzy or sleepy for the first few days, especially if you drink a lot of alcohol or take recreational drugs. Your body should adjust to this, however, avoid driving or other activities requiring concentration until you know how your body responds to the medication. Talk to your doctor or pharmacist if these symptoms bother you.
        No sleep related info.No sleep related info.
        • Can cause memory problems, drowsiness, dizziness, and confusion.
        • Can cause temporary dizziness and drowsiness.
        No sleep related info.No sleep related info.
        • Can cause dizziness, fatigue, drowsiness, and dry mouth.
        • Can cause extreme drowsiness or dizziness if you are taking meds for high blood pressure.
        Upsides and benefits
        FlexerilSomaRobaxinValiumSkelaxinNorflexZanaflex
        • Can relieve pain associated with muscle spasms.
        • Available as a generic medication.
        • Can be used by pregnant women.
        • Available in generic.
        • Available in two different strengths, although the smaller strength is only available as brand name and thus more expensive.
        Coming soon
        • Effective at relieving short-term anxiety and sleeplessness.
        • Can be used together with antidepressants to manage anxiety disorders. Especially helpful for anxiety symptoms while you wait for an antidepressant to kick in (it can take several weeks).
        • Effective at relieving muscle spasms caused by a variety of conditions.
        • Less severe withdrawal symptoms compared to other benzodiazepines.
        Coming soonComing soon
        • Relieves muscle spasms well.
        • Can be taken with or without food, but you need to be consistent in how you take it every day.
        • Available as a generic.
        • Available in a tablet or capsule form. It also comes in a capsule that can be opened and sprinkled in applesauce for people that can't swallow pills.
        Downsides and risks
        FlexerilSomaRobaxinValiumSkelaxinNorflexZanaflex
        • Can cause dizziness and sleepiness.
        • Not meant for long-term therapy.
        • Not recommended in elderly patients, people with glaucoma, or in people with recent heart issues (like rhythm problems, heart failure, or heart attack).
        • Not first line for treating muscle spasms.
        • Can cause dizziness and sleepiness.
        • Not meant for long term therapy.
        • Can cause dependence and withdrawal symptoms if you stop taking it suddenly.
        Coming soon
        • Processed by the liver, so might not be the best choice if you have liver problems.
        • Can cause memory problems, drowsiness, dizziness, and confusion.
        • Can be habit-forming, so it's not typically used for long-term treatment, or for people who've had problems with drug or alcohol abuse.
        • Most people find that it gets less effective over time.
        Coming soonComing soon
        • This isn't a first-choice muscle relaxing medication. Other drugs work better and have fewer side effects.
        • Zanaflex (Tizanidine) can lower blood pressure, so be careful if you are already on a blood pressure medication.
        • Need to be consistent every day in taking this with or without food.
        • Elderly individuals have more side effects when taking Zanaflex (Tizanidine).
        • Can't stop taking this abruptly if you use it regularly.
        Tips from our pharmacists for people taking the medication
        FlexerilSomaRobaxinValiumSkelaxinNorflexZanaflex
        • Can cause dizziness, fatigue, and sleepiness.
        • Take the medication at the same time each day.
        • Not to be used for long-term treatment.
        • Don't drink alcohol while on this medication.
        • Can cause dizziness, fatigue, and sleepiness.
        • Take the medication at the same time each day.
        • Not to be used for long-term treatment (2 to 3 weeks maximum)
        • Don't drink alcohol while on this medication.
        • Can cause stomach pain, nausea and vomiting.
        Coming soon
        • Good for short-term relief of anxiety symptoms.
        • Starts working in 30 minutes when swallowed.
        • Helpful with muscle spasms.
        • Can cause temporary dizziness and drowsiness.
        • Addictive. Long-term use can cause dependence or abuse.
        • Not safe to use with alcohol.
        Coming soonComing soon
        • Can cause dizziness, fatigue, drowsiness, and dry mouth.
        • Avoid activities requiring mental alertness (like driving) until you know how it affects you.
        • Can cause extreme drowsiness or dizziness if you are taking meds for high blood pressure.
        • Side effects are more prevalent in the elderly.
        • Don't drink alcohol while using this.
        • Can be taken with or without food, but you need to be consistent since food affects how the medication is absorbed and works.
        Learn more
        More about FlexerilSide effectsReviews & ratingsAlternativesFDA package insert
        Have you used Flexeril (cyclobenzaprine)?
        Worth itNot sureNot worth it
        More about SomaSide effectsReviews & ratingsFDA package insert
        Have you used Soma (carisoprodol)?
        Worth itNot sureNot worth it
        More about RobaxinSide effectsReviews & ratingsFDA package insert
        Have you used Robaxin (methocarbamol)?
        Worth itNot sureNot worth it
        More about ValiumSide effectsReviews & ratingsFDA package insert
        Have you used Valium (diazepam)?
        Worth itNot sureNot worth it
        More about SkelaxinSide effectsReviews & ratingsFDA package insert
        Have you used Skelaxin (metaxalone)?
        Worth itNot sureNot worth it
        More about NorflexSide effectsReviews & ratingsFDA package insert
        Have you used Norflex (orphenadrine)?
        Worth itNot sureNot worth it
        More about ZanaflexSide effectsReviews & ratingsFDA package insert
        Have you used Zanaflex (tizanidine)?
        Worth itNot sureNot worth it