Flexeril Alternatives

(cyclobenzaprine)

Alternatives

Compare Flexeril (cyclobenzaprine) to alternatives

These medications are comparable to Flexeril (cyclobenzaprine) or used for similar purposes.

Flexeril
(cyclobenzaprine)

Soma
(carisoprodol)

Robaxin
(Methocarbamol)

Valium
(Diazepam)

Skelaxin
(metaxalone)

Norflex
(Orphenadrine)

Zanaflex
(tizanidine)

Relaxes your muscles. Flexeril (cyclobenzaprine) is widely used to treat muscle spasms and is available as a generic, but it shouldn't be used long-term.Relaxes your muscles. Soma (carisoprodol) is used for muscle spasms and muscle pain but it's not considered a first-choice treatment and not meant for long-term therapy.Coming soon.Helps you relax. Valium (Diazepam) is okay for occasional or short-term use (up to 4 weeks) for anxiety and for pain and sleeplessness from muscle spasm. Less severe withdrawal symptoms compared to similar drugs.Relaxes your muscles. Skelaxin (metaxalone) is used for muscle spasms and musculoskeletal pain with mixed results.Coming soon.Relaxes your muscles. Zanaflex (tizanidine) isn't a first-choice treatment for muscle spasticity. Try other options before using this.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.69Flexeril
Reviews for Flexeril
66%
of people (All ages) say Flexeril is worth it
37%
say it works well
14%
say it's a big hassle
1064 reviews
Have you used Flexeril (cyclobenzaprine)?
Worth itNot sureNot worth it
Reviews for Soma
61%
+5% better vs. Flexeril
39%
-2% worse vs. Flexeril
9%
-5% worse vs. Flexeril
220 reviews
Have you used Soma (carisoprodol)?
Worth itNot sureNot worth it

Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Robaxin (Methocarbamol)?
Worth itNot sureNot worth it
Reviews for Valium
70%
-4% worse vs. Flexeril
53%
-16% worse vs. Flexeril
15%
+1% better vs. Flexeril
976 reviews
Have you used Valium (Diazepam)?
Worth itNot sureNot worth it

Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Skelaxin (metaxalone)?
Worth itNot sureNot worth it

Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Norflex (Orphenadrine)?
Worth itNot sureNot worth it
Reviews for Zanaflex
81%
-15% worse vs. Flexeril
73%
-36% worse vs. Flexeril
19%
+5% better vs. Flexeril
Have you used Zanaflex (tizanidine)?
Worth itNot sureNot worth it
Side effects
FlexerilSomaRobaxinValiumSkelaxinNorflexZanaflex
  • Dizziness 1%
  • Fatigue 1%
  • Nausea 2%
  • Dry mouth 4%
  • Sleepiness 2%
  • Constipation 3%
  • Blurry vision 3%
  • Indigestion 3%
  • Change in taste 6%
  • Rapid heartbeat 6%
More Flexeril side effects »
  • Headache 3%
  • Dizziness 6%
  • Drowsiness 7%
More Soma side effects »

We haven’t found good data for Robaxin side effects.

FDA side effect reports for Robaxin »

The Valium FDA package insert doesn’t have numbers about how common side effects are.

More about Valium side effects »

The Skelaxin FDA package insert doesn’t have numbers about how common side effects are.

More about Skelaxin side effects »

We haven’t found good data for Norflex side effects.

FDA side effect reports for Norflex »
  • Vomiting 3%
  • Speech disorder 3%
  • Blurred vision 2%
  • Urinary frequency 1%
  • Flu syndrome 1%
  • Involuntary muscle movement 3%
  • Nervousness 2%
  • Sore throat 2%
  • Hay fever 1%
  • Constipation 3%
More Zanaflex side effects »
How it works
FlexerilSomaRobaxinValiumSkelaxinNorflexZanaflex
Flexeril (cyclobenzaprine) is a muscle relaxer. It works in the brain to help calm down muscle spasms without interfering with normal muscle function.Soma (carisoprodol) is a muscle relaxant. It works in the brain to help calm down muscle spasms.Coming soon.Valium (Diazepam) is a fast-acting benzodiazepine. It affects neurotransmitters in the brain and calms the nervous system. This reduces anxiety and muscle spasms, and causes sleepiness.How Skelaxin (metaxalone) works is not exactly known. It is believed that it works on the brain to help relieve muscle pain and relax muscles.Coming soon.Zanaflex (tizanidine) is an alpha2-adrenergic agonist that works in the nervous system to calm down muscle spasticity.
Type of medication
FlexerilSomaRobaxinValiumSkelaxinNorflexZanaflex
Prescription onlyLower-cost generic availablePrescription onlyLower-cost generic availableLower-cost generic availablePrescription onlyLower-cost generic availableLower-cost generic availableLower-cost generic availablePrescription onlyLower-cost generic available
Available as
FlexerilSomaRobaxinValiumSkelaxinNorflexZanaflex
  • Pill
  • Liquid
  • Pill
  • Pill
  • Pill
  • Liquid
  • Rectal gel
  • Pill
  • Extended release
  • Pill
Used for
FlexerilSomaRobaxinValiumSkelaxinNorflexZanaflex
  • Musculoskeletal Pain Spasm Tetanus
  • Musculoskeletal Pain
  • Musculoskeletal Pain
Risk factors for serious side effects
FlexerilSomaRobaxinValiumSkelaxinNorflexZanaflex
  • Taking monoamine oxidase inhibitors (MAOI)
  • Taking other medications for your mood
  • Alcohol or drug use
  • Age over 65 years
  • Recent heart attack
Detailed Flexeril (cyclobenzaprine) risks & warnings »
  • Taking other medications that also cause sleepiness
  • Recreational drug use
  • Excessive alcohol use
  • Elderly
  • Prior history of drug abuse
Detailed Soma (carisoprodol) risks & warnings »
    Coming soon.
    • Taking more than the prescribed dose
    • Taking longer than 4 weeks
    • History of drug abuse
    • Long-term use
    • Alcohol
    Detailed Valium (Diazepam) risks & warnings »
    • Taking other medications that also cause sleepiness
    • Recreational drug use
    • Excessive alcohol use
    • Taking antidepressants
    • Higher than recommended doses of Skelaxin (metaxalone)
    Detailed Skelaxin (metaxalone) risks & warnings »
      Coming soon.
      • Taking maximum doses of Zanaflex (tizanidine)
      • Age 65 years or older
      • Currently on blood pressure control medications
      • Taking other medications that also cause sleepiness
      • Recreational drug use
      Detailed Zanaflex (tizanidine) risks & warnings »
      Pregnancy

      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      Alcohol
      FlexerilSomaRobaxinValiumSkelaxinNorflexZanaflex
      No alcohol related info.
      • Don't drink alcohol while on this medication.
      No alcohol related info.
      • Not safe to use with alcohol.
      • Can be habit-forming, so it's not typically used for long-term treatment, or for people who've had problems with drug or alcohol abuse.
      No alcohol related info.No alcohol related info.No alcohol related info.
      Food
      FlexerilSomaRobaxinValiumSkelaxinNorflexZanaflex
      No food related info.No food related info.No food related info.No food related info.
      • Can be taken with or without food. However, Skelaxin (metaxalone) may be stronger when taken with food, especially if you are older. Be on the lookout for more pronounced drowsiness or sleepiness.
      No food related info.
      • Can be taken with or without food, but you need to be consistent since food affects how the medication is absorbed and works.
      • Need to be consistent every day in taking this with or without food.
      Kidneys and liver
      FlexerilSomaRobaxinValiumSkelaxinNorflexZanaflex
      No kidneys and liver related info.No kidneys and liver related info.No kidneys and liver related info.
      • Processed by the liver, so might not be the best choice if you have liver problems.
      • People who have any liver or kidney problems should not use Skelaxin (metaxalone). Skelaxin (metaxalone) is broken down by the liver, and eliminated from the body via the kidneys. If either of those are not working at their best, you could have high levels of Skelaxin (metaxalone) in your body and more side effects.Your liver could also worsen. Talk to your doctor as you may need to get routine blood test for your liver and kidneys if you already have liver/kidney problems.
      No kidneys and liver related info.No kidneys and liver related info.
      Pain
      FlexerilSomaRobaxinValiumSkelaxinNorflexZanaflex
      • Can relieve pain associated with muscle spasms.
      No pain related info.No pain related info.No pain related info.No pain related info.No pain related info.No pain related info.
      Sleep
      FlexerilSomaRobaxinValiumSkelaxinNorflexZanaflex
      • Taking Flexeril (cyclobenzaprine) may make you feel dizzy or sleepy for the first few days. Avoid driving or other activities requiring concentration until you know how your body responds to the medication. Talk to your doctor or pharmacist if these symptoms bother you.
      • Flexeril (cyclobenzaprine) can make you feel very tired or sleepy. Don't drive or do anything that requires concentration until you know how it affects you.
      No sleep related info.No sleep related info.
      • Can cause temporary dizziness and drowsiness.
      • Can cause memory problems, drowsiness, dizziness, and confusion.
      • Taking Skelaxin (metaxalone) with alcohol or narcotics can worsen the drowsiness.
      • Can make you very drowsy or sleepy
      No sleep related info.
      • Taking Zanaflex (tizanidine) can make you feel sleepy and dizzy, especially if you're taking other medications that can also make you feel sleepy, or if you're taking recreational drugs or drinking too much alcohol. Avoid driving or doing other tasks that require concentration until you know how this medication affects you.
      • Can cause dizziness, fatigue, drowsiness, and dry mouth.
      Upsides and benefits
      FlexerilSomaRobaxinValiumSkelaxinNorflexZanaflex
      • Can relieve pain associated with muscle spasms.
      • Available as a generic medication.
      • Can be used by pregnant women, but talk to your doctor about it first.
      • Patients treated with Soma (carisoprodol) experienced improvement in function.
      • Available in generic.
      • Available in two different strengths.
      Coming soon
      • Effective at relieving short-term anxiety and sleeplessness.
      • Can be used together with antidepressants to manage anxiety disorders. Especially helpful for anxiety symptoms while you wait for an antidepressant to kick in (it can take several weeks).
      • Effective at relieving muscle spasms caused by a variety of conditions.
      • Less severe withdrawal symptoms compared to other benzodiazepines.
      • Can be used for muscle spasms and muscle pain if other medications have not worked.
      • Available as generic.
      • Slightly less sedation and side effects compared to other muscle relaxants.
      Coming soon
      • Relieves muscle spasticity.
      • Available as a generic.
      • Available in a tablet or capsule form. It also comes in a capsule that can be opened and sprinkled in applesauce for people that can't swallow pills.
      Downsides and risks
      FlexerilSomaRobaxinValiumSkelaxinNorflexZanaflex
      • Can cause dizziness and sleepiness.
      • Not meant for long-term therapy.
      • Not recommended in elderly patients, people with glaucoma, or in people with heart conditions (like rhythm problems, heart failure, or recent heart attack).
      • Can make you have dry mouth.
      • Not effective for muscle spasms caused by brain or spinal injuries.
      • Not first choice for treating muscle spasms or muscle pain, because it can cause dependence.
      • Can cause dizziness and sleepiness.
      • Not meant for long-term therapy, because it hasn't been shown to be effective after taking it for a short period.
      • Can cause withdrawal symptoms if you stop taking it suddenly.
      Coming soon
      • Processed by the liver, so might not be the best choice if you have liver problems.
      • Can cause memory problems, drowsiness, dizziness, and confusion.
      • Can be habit-forming, so it's not typically used for long-term treatment, or for people who've had problems with drug or alcohol abuse.
      • Most people find that it gets less effective over time.
      • Effects don't last that long. You need to take Skelaxin (metaxalone) up to 3-4 times daily.
      • Several studies showed mixed results when Skelaxin (metaxalone) was compared with a sugar pill for treatment of muscle spasms and musculoskeletal pain.
      • Can make you very drowsy or sleepy
      • Even though a generic is available, it is still fairly expensive.
      Coming soon
      • This isn't a first-choice muscle relaxing medication. Other drugs work better and have fewer side effects.
      • Takes over an hour to kick in and only lasts 3 to 6 hours.
      • Zanaflex (tizanidine) can lower blood pressure, so be careful if you are already on a blood pressure medication.
      • Need to be consistent every day in taking this with or without food.
      • Elderly individuals have more side effects when taking Zanaflex (tizanidine).
      Tips from our pharmacists for people taking the medication
      FlexerilSomaRobaxinValiumSkelaxinNorflexZanaflex
      • Flexeril (cyclobenzaprine) can make you feel very tired or sleepy. Don't drive or do anything that requires concentration until you know how it affects you.
      • Flexeril (cyclobenzaprine) is not meant to be used long-term. It should be used for only 2 to 3 weeks maximum.
      • Flexeril (cyclobenzaprine) can cause dry mouth.
      • Take it roughly at the same time every day.
      • If you are using the capsules, you may swallow it whole or sprinkle contents on a tablespoon of applesauce and swallow immediately without chewing.
      • Take the medication at the same time each day.
      • Soma (carisoprodol) is not meant to be used long-term. It should be used for only 2 to 3 weeks maximum.
      • Can cause dizziness, fatigue, and sleepiness.
      • Don't drink alcohol while on this medication.
      • Soma (carisoprodol) can cause stomach pain, nausea and vomiting.
      Coming soon
      • Good for short-term relief of anxiety symptoms.
      • Starts working in 30 minutes when swallowed.
      • Helpful with muscle spasms.
      • Can cause temporary dizziness and drowsiness.
      • Addictive. Long-term use can cause dependence or abuse.
      • Not safe to use with alcohol.
      • Can be taken with or without food. However, Skelaxin (metaxalone) may be stronger when taken with food, especially if you are older. Be on the lookout for more pronounced drowsiness or sleepiness.
      • Skelaxin (metaxalone) can make you feel very tired or sleepy. Don't drive or do anything that requires concentration until you know how it affects you.
      • Taking Skelaxin (metaxalone) with alcohol or narcotics can worsen the drowsiness.
      • Skelaxin (metaxalone) can also have a more pronounced effect on women.
      Coming soon
      • Can cause dizziness, fatigue, drowsiness, and dry mouth.
      • Avoid activities requiring mental alertness (like driving) until you know how it affects you.
      • Can be taken with or without food, but you need to be consistent since food affects how the medication is absorbed and works.
      • The tablets are not the same as the capsules. This could mean differences in how your body reacts to it, or how it works for you.
      • If you have been on Zanaflex (tizanidine) for a long period of time, you should not stop this abruptly. This can result in rebound high blood pressure, muscle spasticity or fast heart beat. Talk to your doctor about how to slowly lower your dose.
      Learn more
      More about FlexerilSide effectsReviews & ratingsAlternativesFDA package insert
      Have you used Flexeril (cyclobenzaprine)?
      Worth itNot sureNot worth it
      More about SomaSide effectsReviews & ratingsFDA package insert
      Have you used Soma (carisoprodol)?
      Worth itNot sureNot worth it
      More about RobaxinSide effectsReviews & ratingsFDA package insert
      Have you used Robaxin (Methocarbamol)?
      Worth itNot sureNot worth it
      More about ValiumSide effectsReviews & ratingsFDA package insert
      Have you used Valium (Diazepam)?
      Worth itNot sureNot worth it
      More about SkelaxinSide effectsReviews & ratingsFDA package insert
      Have you used Skelaxin (metaxalone)?
      Worth itNot sureNot worth it
      More about NorflexSide effectsReviews & ratingsFDA package insert
      Have you used Norflex (Orphenadrine)?
      Worth itNot sureNot worth it
      More about ZanaflexSide effectsReviews & ratingsFDA package insert
      Have you used Zanaflex (tizanidine)?
      Worth itNot sureNot worth it