Prescription onlyLower-cost generic availableClass: Autoimmune


Prescription onlyLower-cost generic availableClass: Autoimmune
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Treats electrolyte imbalance.

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Our bottom line

Fludrocortisone is one of the first choices used in Addison's disease to help maintain your electrolytes, but there are side effects.


  • Fludrocortisone is effective in correcting electrolyte imbalances associated with Addison's disease.
  • Generic is available.
  • Only need to take it once daily.
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  • Fludrocortisone can cause reactivation of old infections such as Hepatits B, C, or tuberculosis.
  • Fludrocortisone can make it easier for you to get sick.
  • Fludrocortisone can interact with other drugs and vaccines.
  • While on Fludrocortisone, you may need to have blood tests done for monitoring.
How it works

Fludrocortisone is a corticosteroid that is similar to what your body naturally makes. It is primarily used to maintain the sodium, potassium, and water balance in your body.

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Used for
Dosage forms
  • Pill

What to expect when you take Fludrocortisone for Addison's disease

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Side effect rates for Fludrocortisone

Risks and Warnings for Fludrocortisone

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    • Higher risk if:
    • Lowering dose or stopping too quickly especially after long-term treatment
    • Stress such as trauma, surgery or infection

    If you've been taking corticosteroids like Fludrocortisone for a long time, lowering your dose or stopping it too quickly can be really dangerous since your body can't respond to stress. Symptoms include joint or muscle pain, extreme low energy and depression. Changes in your Fludrocortisone dose need to be done slowly over time. Talk to your doctor before you make any changes or stop it.

Common concerns from people taking Fludrocortisone

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  • Fludrocortisone can interact with other drugs and vaccines.
  • Taking Fludrocortisone increases the risk of injury to the lining of your stomach and intestine including irritation and tears. You should avoid alcohol/alcoholic beverages because it can worsen stomach irritation. Tell your doctor and get medical care right away if you have stomach pain or bloody/dark stools when you go to the bathroom.