Prescription onlyLower-cost generic availableClass: Neuro/psych

Prolixin Decanoate 

(fluphenazine decanoate)

Prescription onlyLower-cost generic availableClass: Neuro/psych
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Treats schizophrenia or psychosis.

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Our bottom line

Prolixin Decanoate (fluphenazine decanoate) is long-acting medicine for stabilizing your mood that must be given by a trained healthcare professional.


  • Can be given less frequently than the oral, short-acting version.
  • Available in generic.


  • Can make you sensitive to the sun.
  • Can affect how your body regulates your temperature.
  • Can only be used if you're already stable on the short-acting version of this medicine.
How it works

Prolixin Decanoate (fluphenazine decanoate) is a derivative of phenothiazine. It regulates dopamine levels in your brain to control psychotic episodes or schizophrenia.

What to expect when you take Prolixin Decanoate (fluphenazine decanoate) for Schizophrenia

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Side effect rates for Prolixin Decanoate (fluphenazine decanoate)

Risks and Warnings for Prolixin Decanoate (fluphenazine decanoate)

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    • Higher risk if:
    • People over 65 with dementia and psychosis

    Older people with dementia and psychosis have a higher risk of death if they take antipsychotic medicines like Prolixin Decanoate (fluphenazine decanoate). They shouldn't be given this medicine.

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Common concerns from people taking Prolixin Decanoate (fluphenazine decanoate)

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  • Don't combine with alcohol or narcotics since it can stop your breathing.
  • Can make you very sleepy or dizzy. Don't drive or do anything that requires concentration until you know how it affects you.