Prescription onlyLower-cost generic availableClass: Musculoskeletal



Prescription onlyLower-cost generic availableClass: Musculoskeletal
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Prevents bone loss.

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Our bottom line

Fosamax (alendronate) is a first-choice treatment for osteoporosis, but taking it can be a hassle.

Price and discounts
Prices and coupons for 1 (4 tablets of 70mg) dose pack of fosamax
What is GoodRx?


  • First choice to treat osteoporosis
  • Lowers your risk of fractures due to osteoporosis.
  • Available generic.
  • Available as daily, weekly, or twice weekly dosing.
  • Comes as a regular tablet, an oral solution, or effervescent tablet.
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  • Can harm your esophagus if you don't remain upright for 30 minutes after taking it.
  • Not recommended for people who can't sit or stand upright for at least 30 minutes.
  • Can increase the risk of atypical fractures.
  • Can cause bad heartburn or stomach problems.
How it works

Fosamax (alendronate) is a bisphosphonate, which inhibits bone breakdown.

What to expect when you take Fosamax (alendronate) for Paget's disease

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Side effect rates for Fosamax (alendronate)

6459 From clinical trials of Fosamax / Postmenopausal osteoporosis (5 mg daily)
  • Abdominal pain

Risks and Warnings for Fosamax (alendronate)

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    • Higher risk if:
    • Taking anti-inflammatory medicines like ibuprofen, and naproxen
    • History of ulcers or stomach or esophageal conditions
    • Difficulty swallowing
    • Problems sitting or standing for at least 30 minutes

    Fosamax (alendronate) can irritate the stomach and esophagus and cause ulcers. It is very important to remain standing or sitting upright for at least 30 minutes after you take the medicine to prevent this from happening. Take it first thing in the morning when you wake up with a full glass of plain water. Talk to your doctor if this will be a problem for you. Also, talk to your doctor if you notice new pain while swallowing, or pain around the middle of your chest or abdomen while taking this medication.

Common concerns from people taking Fosamax (alendronate)

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  • Fosamax (alendronate) can cause bone and muscle pain. However, this is very rare. Stop taking the medication and talk to your doctor if this happens to you.
  • Fosamax (alendronate) can cause fractures in the legs as a result of little or no force. This is rare. If you notice a new dull or aching pain in your hips or thighs, talk to your doctor right away.