Prescription onlyLower-cost generic available

Glucotrol

(Glipizide)

  • Pill
  • Extended release
Back to: Full Site NavigationSkip to: side effects sectionSkip to: What to expect sectionSkip to: Risks and warnings sectionSkip to: Tips from users and pharmacists

Lowers blood sugar.

Skip Upsides & Downsides section. Skip to side effects section.
Prescription onlyLower-cost generic available

Our pharmacists’ bottom line

Glucotrol (Glipizide) is a very effective oral blood sugar-lowering medicine. It can cause low blood sugar, so make sure you know what the symptoms are and always have a source of sugar nearby.

Worth it?Is it worth it?
Works well?Does it work?
Hassle?Is it a hassle?
  • Oral blood sugar-lowering medicine.
  • Lowers A1c levels by 1-2%. (Hemoglobin A1c measures your average blood sugar over time.)
  • Prevents the harmful effects of high sugar levels on your organs and blood vessels.
  • Might be a better choice for people with kidney problems compared to similar drugs because Glipizide isn't processed by the kidneys.
  • One of the least expensive diabetes medicines.
  • Higher risk of low blood sugar episodes than other kinds of oral diabetes medicines.
  • You have to check your blood sugar 2 to 5 times a week (less often once you are on a stable dose).
  • Can cause mild weight gain (2 to 3 pounds).
  • Loses effectiveness over time or as your body stops making insulin.
  • Food can cause unpredictable effects of the immediate-release version of Glipizide, so you have to take it at least 30 minutes before a meal.

Save on your next Glucotrol (Glipizide) prescription

Be sure you’re getting the lowest price for your medication, even if you have insurance.

Skip side effects sections. Skip to What to Expect and Pharmacists Tips section.

Side effects for Glucotrol (Glipizide)

From clinical trials of Glucotrol / Type 2 diabetes (XL) ( 347)

  • Muscle weaknessMuscle weakness10% for Glipizide vs.13% for placebo
  • HeadacheHeadache9% for Glipizide vs.9% for placebo
  • DizzinessDizziness7% for Glipizide vs.6% for placebo
  • DiarrheaDiarrhea5% for Glipizide vs.0% for placebo
  • NervousnessNervousness4% for Glipizide vs.3% for placebo
  • TremorTremor4% for Glipizide vs.0% for placebo
  • Passing gasPassing gas3% for Glipizide vs.1% for placebo

What to expect when you take Glucotrol (Glipizide) for Improves blood sugar levels

Skip what to expect section. Skip to Risks & Warnings section.
Tips from our pharmacists
  • Works best if you take it 30 minutes before a meal, usually your first big meal of the day.
  • Can cause weight gain, dizziness, or stomach upset.
  • Avoid drinking alcohol.
  • Eat regular, balanced meals to avoid low blood sugar.
  • Check your blood sugar regularly.

Risks and Warnings for Glucotrol (Glipizide)

Skip Risks and Warnings section. Skip to Tips section.
  • Oral blood sugar lowering medicines in the sulfonylurea class, like Glucotrol (Glipizide), may increase the risk of death from heart problems when compared to controlling blood sugar with diet or diet and insulin. Talk to your doctor about the benefits, risks, and if Glucotrol (Glipizide) is right for you.

Means that some groups have a high risk of experiencing this side effect

Tips from pharmacists and people taking Glucotrol (Glipizide)

Final section. Do you want to return to drug navigation?
The FDA category for this medication is C. It is advised that you: Weigh risks vs. benefits
Pregnancy
Alcohol
  • Tips from our pharmacists
  • Avoid drinking alcohol.
Food
  • Upsides and downsides from our pharmacists
  • Food can cause unpredictable effects of the immediate-release version of Glipizide, so you have to take it at least 30 minutes before a meal.
  • Tips from our pharmacists
  • Works best if you take it 30 minutes before a meal, usually your first big meal of the day.
  • Eat regular, balanced meals to avoid low blood sugar.
  • If not taken half an hour before a meal with enough carbs, this med causes dangerously low blood levels in the 40's. Follow food recommendations exactly.
    Age: 67
    Gender: Man
    Taken for: Type 2 diabetes
Kidneys & liver
  • Upsides and downsides from our pharmacists
  • Might be a better choice for people with kidney problems compared to similar drugs because Glipizide isn't processed by the kidneys.
Weight gain or loss
  • Upsides and downsides from our pharmacists
  • Can cause mild weight gain (2 to 3 pounds).
  • Tips from our pharmacists
  • Can cause weight gain, dizziness, or stomach upset.