Prescription onlyLower-cost generic availableClass: Endocrine

Glucotrol Alternatives

(glipizide)

Prescription onlyLower-cost generic availableClass: Endocrine
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Compare Glucotrol (glipizide) to alternatives

These medications are comparable to Glucotrol (glipizide) or used for similar purposes.

Glucotrol
(glipizide)

Precose
(acarbose)

Humalog
(insulin lispro)

Glucophage
(metformin)

Novolog
(insulin aspart)

Levemir
(insulin detemir)

Januvia
(sitagliptin)

Byetta
(exenatide)

Actos
(pioglitazone)

Humulin
(human insulin)

Lantus
(insulin glargine)

Janumet
(sitagliptin / metformin)

Diabeta
(glyburide)

Lowers blood sugar. Glucotrol (Glipizide) is a very effective oral blood sugar-lowering medicine. It can cause low blood sugar, so make sure you know what the symptoms are and always have a source of sugar nearby.Coming soon.Lowers blood sugar. Humalog is a fast-acting insulin that provides meal-time sugar control. It can cause low blood sugar, so make sure you know what the symptoms are and always have a source of sugar nearby.Lowers blood sugar. Glucophage (metformin) is the first choice medicine to control your blood sugar and lower the risk of death from diabetes, although a few people may not tolerate the stomach side effects.Lowers blood sugar. Novolog is a fast-acting insulin that provides meal-time sugar control. It can cause low blood sugar, so make sure you know what the symptoms are and always have a source of sugar nearby.Lowers blood sugar. Levemir is a long-acting insulin that provides all-day sugar control. It can cause low blood sugar, so make sure you know what the symptoms are and always have a source of sugar nearby.Lowers your blood sugar. Januvia (sitagliptin) is a good add-on treatment if your blood sugars are not controlled and you don't want to use an injectable medicine.Lowers blood sugar. Byetta (Exenatide) can lower your blood sugars in addition to metformin. It does not increase your appetite unlike some other anti-diabetics, but must be given by injection and usually causes upset stomach.Lowers blood sugar. Actos (Pioglitazone) is a last-choice blood sugar-lowering medicine since it's only moderately effective but has a lot of undesirable side effects.Lowers blood sugar. This form of insulin is one of the few medications in its class that you can get without a prescription, but it's expensive.Lowers blood sugar. Lantus (Insulin Glargine) is a long-acting insulin that provides all-day sugar control. It can cause low blood sugar, so make sure you know what the symptoms are and always have a source of sugar nearby.Lowers your blood sugar. Janumet is a combination of two anti-diabetic medicines that work better together, but is available as brand only.Lowers blood sugar. Diabeta (glyburide) is a good oral anti-diabetic medicine, but can cause hypoglycemia or low blood sugar.
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Best available price for 60 (5mg) tablets of glipizide
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.29Glucotrol
Reviews for Glucotrol
50%
of people (All ages) say Glucotrol is worth it
32%
say it works well
19%
say it's a big hassle
332 reviews
Have you used Glucotrol (glipizide)?
Worth itNot sureNot worth it

Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Precose (acarbose)?
Worth itNot sureNot worth it
Reviews for Humalog
64%
-14% worse vs. Glucotrol
50%
-18% worse vs. Glucotrol
16%
-3% worse vs. Glucotrol
280 reviews
Have you used Humalog (insulin lispro)?
Worth itNot sureNot worth it
Reviews for metformin
65%
-15% worse vs. Glucotrol
46%
-14% worse vs. Glucotrol
16%
-3% worse vs. Glucotrol
938 reviews
Have you used Glucophage (metformin)?
Worth itNot sureNot worth it
Reviews for Novolog
58%
-8% worse vs. Glucotrol
46%
-14% worse vs. Glucotrol
19%
Same vs. Glucotrol
177 reviews
Have you used Novolog (insulin aspart)?
Worth itNot sureNot worth it
Reviews for Levemir
45%
+5% better vs. Glucotrol
35%
-3% worse vs. Glucotrol
22%
+3% better vs. Glucotrol
130 reviews
Have you used Levemir (insulin detemir)?
Worth itNot sureNot worth it
Reviews for Januvia
44%
+6% better vs. Glucotrol
34%
-2% worse vs. Glucotrol
17%
-2% worse vs. Glucotrol
143 reviews
Have you used Januvia (sitagliptin)?
Worth itNot sureNot worth it

Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Byetta (exenatide)?
Worth itNot sureNot worth it
Reviews for Actos
42%
+8% better vs. Glucotrol
30%
+2% better vs. Glucotrol
21%
+2% better vs. Glucotrol
175 reviews
Have you used Actos (pioglitazone)?
Worth itNot sureNot worth it
Reviews for Human Insulin
67%
-17% worse vs. Glucotrol
46%
-14% worse vs. Glucotrol
11%
-8% worse vs. Glucotrol
Have you used Humulin (human insulin)?
Worth itNot sureNot worth it
Reviews for Lantus
67%
-17% worse vs. Glucotrol
51%
-19% worse vs. Glucotrol
14%
-5% worse vs. Glucotrol
584 reviews
Have you used Lantus (insulin glargine)?
Worth itNot sureNot worth it
Reviews for Janumet
46%
+4% better vs. Glucotrol
38%
-6% worse vs. Glucotrol
15%
-4% worse vs. Glucotrol
Have you used Janumet (sitagliptin / metformin)?
Worth itNot sureNot worth it
Reviews for glyburide
45%
+5% better vs. Glucotrol
34%
-2% worse vs. Glucotrol
21%
+2% better vs. Glucotrol
110 reviews
Have you used Diabeta (glyburide)?
Worth itNot sureNot worth it
Side effects
GlucotrolPrecoseHumalogmetforminNovologLevemirJanuviaByettaActosHuman InsulinLantusJanumetglyburide
  • Dizziness 1%
  • Diarrhea 5%
  • Nervousness 1%
  • Tremor 4%
  • Passing gas 2%
  • Drowsiness 2%
More Glucotrol side effects »

We haven’t found good data for Precose side effects.

FDA side effect reports for Precose »
  • Flu syndrome 35%
  • Sore throat 33%
  • Headache 30%
  • Inflammation inside the nose 25%
  • Pain 20%
  • Cough increased 17%
  • Infection 14%
  • Accidental injury 9%
  • Diarrhea 9%
  • Muscle weakness 7%
More Humalog side effects »
  • Diarrhea 41%
  • Nausea/vomiting 18%
  • Gas 6%
  • Weakness 3%
  • Indigestion 3%
  • Stomach pain 1%
  • Headache 1%
More metformin side effects »
  • Decreased muscle reflexes 11%
  • Nail fungal infection 10%
  • Abnormal sense of touch 9%
  • Urinary tract infection 8%
  • Chest pain 5%
  • Headache 5%
  • Skin disorder 5%
  • Abdominal pain 5%
  • Sinus inflammation 5%
  • Injury accidental 11%
More Novolog side effects »
  • Ear, nose, or throat infection 26%
  • Headache 23%
  • Sore throat 10%
  • Influenza-like illness 8%
  • Abdominal pain 6%
  • "stomach flu" 17%
  • Fever 10%
  • Cough 8%
  • Viral infection 7%
  • Nausea 7%
More Levemir side effects »
  • Common cold 2%
  • Diarrhea 1%
  • Upper respiratory infection 3%
  • Headache 1%
More Januvia side effects »
  • Low blood sugar 11%
  • Nausea 33%
  • Diarrhea 10%
  • Vomiting 14%
  • Headache 10%
  • Constipation 8%
  • Indigestion 5%
  • Weakness 4%
  • Abdominal swelling 3%
  • Loss of appetite 3%
More Byetta side effects »
  • Swelling due to excess fluid 11%
  • Low blood sugar 8%
  • Ear, nose, or throat infection 4%
  • Headache 2%
  • Cardiac failure 2%
  • Back pain 1%
  • Sinus inflammation 1%
  • Muscle pain 2%
More Actos side effects »

The Human Insulin FDA package insert doesn’t have numbers about how common side effects are.

More about Human Insulin side effects »
  • Ear, nose, or throat infection 22%
  • Infection 9%
  • Accidental injury 6%
  • Headache 6%
  • Ankle and leg swelling 20%
  • High blood pressure 20%
  • Sinus inflammation 19%
  • Flu 19%
  • Clouded eye lens 18%
  • Bronchitis 15%
More Lantus side effects »
  • Low blood sugar 15%
  • Diarrhea 4%
  • Ear, nose, or throat infection 1%
  • Headache 3%
More Janumet side effects »
  • Nausea and heartburn 2%
  • Skin allergies 2%
More glyburide side effects »
How it works
GlucotrolPrecoseHumalogmetforminNovologLevemirJanuviaByettaActosHuman InsulinLantusJanumetglyburide
Glucotrol (Glipizide) is an anti-diabetic drug. It stimulates your body to make more insulin to lower blood sugar.Coming soon.Humalog is a short-acting insulin medicine for diabetes. It acts like the insulin that your body normally makes to process sugars and fats, and it keeps your blood sugar stable after meals.Glucophage (metformin) is an anti-diabetic drug. It lowers the amount of sugar your body makes or absorbs, and allows your body use the existing insulin better.Novolog is a short-acting insulin medicine for diabetes. It acts like the insulin that your body normally makes to process sugars and fats, and it keeps your blood sugar stable after meals.Levemir is a long-acting insulin medicine for diabetes. It acts like the insulin that your body normally makes to process sugars and fats, and it keeps your blood sugar stable throughout the day.Januvia (sitagliptin) is an anti-diabetic drug that enhances your body's release of insulin.Byetta (Exenatide) enhances the release of insulin in your gut and pancreas to lower your blood sugar.Actos (Pioglitazone) is an anti-diabetic drug. It improves your body's ability to use insulin to lower your blood sugar.Insulin is a hormone normally produced by your pancreas. It helps your body absorb and store sugar and fat from your bloodstream.Lantus (Insulin Glargine) is a long-acting insulin medicine for diabetes. It acts like the insulin that your body normally makes to process sugars and fats, and it keeps your blood sugar stable throughout the day.Janumet (sitagliptin / metformin) is a combination of two anti-diabetic medicines. Metformin lowers the amount of sugar your body produces, and sitagliptin enhances the release of insulin.Diabeta (glyburide) stimulates your body to release insulin and lower blood sugar.
Type of medication
GlucotrolPrecoseHumalogmetforminNovologLevemirJanuviaByettaActosHuman InsulinLantusJanumetglyburide
Prescription onlyPrescription onlyPrescription onlyPrescription onlyPrescription onlyPrescription onlyPrescription onlyPrescription onlyPrescription onlyPrescription onlyPrescription onlyPrescription only
Available as
GlucotrolPrecoseHumalogmetforminNovologLevemirJanuviaByettaActosHuman InsulinLantusJanumetglyburide
  • Pill
  • Extended release
  • Pill
  • Injection
  • Pill
  • Extended release pill
  • Liquid
  • Injection
  • Injection
  • Pill
  • Injection
  • Pill
  • Injection
  • Inhaler
  • Injection
  • Pill
  • Extended release
  • Pill
Used for
GlucotrolPrecoseHumalogmetforminNovologLevemirJanuviaByettaActosHuman InsulinLantusJanumetglyburide
  • Diabetes Mellitus Type 2
Risk factors for serious side effects
GlucotrolPrecoseHumalogmetforminNovologLevemirJanuviaByettaActosHuman InsulinLantusJanumetglyburide
  • Use of other blood sugar lowering medicines
  • Alcohol
  • Intense physical activity
  • History of sulfa allergies
Detailed Glucotrol (glipizide) risks & warnings »
    Coming soon.
    • Insulin dose too high
    • Use of other blood sugar lowering medicines
    • Poor injection techniques
    • Unstable kidney functions
    • Unstable liver functions
    Detailed Humalog (insulin lispro) risks & warnings »
    • Kidney problems
    • Liver problems
    • Congestive heart failure
    • Using contrast dye for procedures
    • Surgery
    Detailed Glucophage (metformin) risks & warnings »
    • Insulin dose too high
    • Use of other blood sugar lowering medicines
    • Poor injection techniques
    • Unstable kidney functions
    • Unstable liver functions
    Detailed Novolog (insulin aspart) risks & warnings »
    • Insulin dose too high
    • Use of other blood sugar lowering medicines
    • Poor injection techniques
    • Unstable kidney functions
    • Unstable liver functions
    Detailed Levemir (insulin detemir) risks & warnings »
    • History of pancreatitis
    • High blood triglyceride levels
    • Gallstones (stones in gallbladder)
    • History of alchoholism
    • Kidney problems
    Detailed Januvia (sitagliptin) risks & warnings »
    • Severe renal impairment
    • End-stage renal disease
    • Severe gastrointestinal disease
    • Gastroparesis
    Detailed Byetta (exenatide) risks & warnings »
    • Heart failure diagnosis
    • Current liver problems
    • Female
    Detailed Actos (pioglitazone) risks & warnings »
      Detailed Humulin (human insulin) risks & warnings »
      • Insulin dose too high
      • Use of other blood sugar lowering medicines
      • Poor injection techniques
      • Unstable kidney functions
      • Unstable liver functions
      Detailed Lantus (insulin glargine) risks & warnings »
      • Kidney problems
      • Liver problems
      • Congestive heart failure
      • Using contrast dye for procedures
      • Surgery
      Detailed Janumet (sitagliptin / metformin) risks & warnings »
      • Over age 65
      • Kidney problems
      • Use of other blood sugar lowering medicines
      • Alcohol
      • Intense physical activity
      Detailed Diabeta (glyburide) risks & warnings »
      Pregnancy

      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

      Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

      Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

      Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

      Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

      Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      Alcohol
      GlucotrolPrecoseHumalogmetforminNovologLevemirJanuviaByettaActosHuman InsulinLantusJanumetglyburide
      • Avoid drinking alcohol.
      No alcohol related info.No alcohol related info.
      • Excessive or chronic alcohol use can increase the risk of a dangerous side effect.
      • Limit or avoid alcohol when taking this medicine.
      No alcohol related info.No alcohol related info.No alcohol related info.No alcohol related info.No alcohol related info.No alcohol related info.No alcohol related info.No alcohol related info.
      • Try to avoid drinking alcohol while on Diabeta (glyburide).
      Food
      GlucotrolPrecoseHumalogmetforminNovologLevemirJanuviaByettaActosHuman InsulinLantusJanumetglyburide
      • Food can cause unpredictable effects of the immediate-release version of Glipizide, so you have to take it at least 30 minutes before a meal.
      • Eat regular, balanced meals to avoid low blood sugar.
      No food related info.
      • Short-acting insulin good for blood sugar control around meal times.
      • Always take it with food to lessen stomach upset.
      • Novolog is a fast-acting insulin that provides sugar control after meals.
      • Short-acting insulin good for blood sugar control around meal times.
      No food related info.
      • Take once a day in the morning with or without food.
      No food related info.No food related info.No food related info.No food related info.
      • Take with food to avoid upset stomach with diarrhea, nausea, and vomiting.
      • Eat well-balanced meals to avoid low blood sugar.
      Kidneys and liver
      GlucotrolPrecoseHumalogmetforminNovologLevemirJanuviaByettaActosHuman InsulinLantusJanumetglyburide
      • Might be a better choice for people with kidney problems compared to similar drugs because Glipizide isn't processed by the kidneys.
      No kidneys and liver related info.
      • Okay to use even if you have liver or kidney problems, unlike most other blood sugar-lowering medicines.
      • Usually not a good choice for people with kidney problems. Your doctor will tell you if Glucophage (metformin) is right for you to take.
      • Glucophage (metformin) can cause this rare life-threatening condition. Your doctor will check your kidneys and liver before you start. Symptoms include deep and rapid breathing, nausea, vomiting, and stomach pain. This is a medical emergency and you should get help right away. You're more likely to get this if you already have kidney problems. Glucophage (metformin) should be stopped 48 hours before and after surgery or any imaging procedure needing contrast dye.
      • Okay to use even if you have liver or kidney problems, unlike most other blood sugar-lowering medicines.
      • Okay to use even if you have liver or kidney problems, unlike most other blood sugar-lowering medicines.
      • Januvia (sitagliptin) can worsen kidney problems. Your doctor may check your kidney function before and during treatment. Your doctor may have to adjust the dose or stop this medicine based on changes in kidney function.
      • If you have severe kidney or liver problems, you should not take Byetta (Exenatide). Talk to your doctor about testing your kidneys before starting Byetta (Exenatide). People taking medications that are damaging to kidneys such as ACE inhibitors, NSAIDs or diuretics in addition to Byetta (Exenatide) may notice nausea, vomiting, or diarrhea.
      No kidneys and liver related info.No kidneys and liver related info.
      • Okay to use even if you have liver or kidney problems, unlike most other blood sugar-lowering medicines.
      • Not appropriate for those with poor kidney function.
      • Not ideal for elderly or those with poor kidney function.
      Pain
      GlucotrolPrecoseHumalogmetforminNovologLevemirJanuviaByettaActosHuman InsulinLantusJanumetglyburide
      No pain related info.No pain related info.No pain related info.No pain related info.No pain related info.No pain related info.
      • Tell your doctor right away if you have severe stomach pain, nausea, and/or vomiting. These are symptoms of pancreatitis.
      • Using Byetta (Exenatide) has been associated with stomach pain, nausea, vomiting and diarrhea. If you have severe gastrointestinal disease such as Crohn’s Disease or Ulcerative Colitis, you should talk to your doctor about using a different medicine for diabetes. You should not use Byetta (Exenatide) if you have gastroparesis, a condition that causes slow or irregular digestion. Gastroparesis can be common for people that have had uncontrolled diabetes for a while.
      No pain related info.No pain related info.No pain related info.No pain related info.No pain related info.
      Weight
      GlucotrolPrecoseHumalogmetforminNovologLevemirJanuviaByettaActosHuman InsulinLantusJanumetglyburide
      • Can cause mild weight gain (2 to 3 pounds).
      • Can cause weight gain, dizziness, or stomach upset.
      No weight related info.
      • Likely to cause moderate weight gain (around 4 to 6 pounds).
      • Can cause weight gain and low blood sugar.
      • Doesn't cause weight gain.
      • Likely to cause moderate weight gain (around 4 to 6 pounds).
      • Can cause weight gain and low blood sugar.
      • Likely to cause moderate weight gain (around 4 to 6 pounds).
      • Can cause weight gain and low blood sugar.
      • It is less likely to cause weight gain and low blood sugar compared to other diabetes medicines.
      No weight related info.
      • More likely to cause weight gain (2 to 6 pounds or more) compared to other blood sugar-lowering medicines.
      • Can cause weight gain, headache, and fluid retention.
      • People on Humulin (Human Insulin) can experience weight gain. Talk to your doctor or dietitian about changing your diet if this bothers you.
      • Likely to cause moderate weight gain (around 4 to 6 pounds).
      • Can cause weight gain and low blood sugar.
      No weight related info.
      • Can cause weight gain (about 2 to 3 pounds).
      • Can cause weight gain, dizziness, or stomach upset.
      Upsides and benefits
      GlucotrolPrecoseHumalogmetforminNovologLevemirJanuviaByettaActosHuman InsulinLantusJanumetglyburide
      • Oral blood sugar-lowering medicine.
      • Lowers A1c levels by 1-2%. (Hemoglobin A1c measures your average blood sugar over time.)
      • Prevents the harmful effects of high sugar levels on your organs and blood vessels.
      • Might be a better choice for people with kidney problems compared to similar drugs because Glipizide isn't processed by the kidneys.
      • One of the least expensive diabetes medicines.
      Coming soon
      • Insulin is the most effective blood sugar-lowering medicine. When used correctly, it'll lower blood sugar every time you use it and prevent the harmful effects of high sugar levels on your organs and blood vessels.
      • Humalog is a fast-acting insulin that provides sugar control after meals.
      • Dose can be easily adjusted to make a customized regimen that's tailored to your body.
      • Starting insulin early in the treatment of Type 2 diabetes can maintain your body's insulin-producing cells and slow down disease progression.
      • Okay to use even if you have liver or kidney problems, unlike most other blood sugar-lowering medicines.
      • Improves sugar control and lowers A1c levels as much as 2%.
      • One of the few diabetes medicines that lowers the risk of death from diabetes-related complications.
      • Doesn't cause weight gain.
      • Rarely causes low blood sugar.
      • Insulin is the most effective blood sugar-lowering medicine. When used correctly, it'll lower blood sugar every time you use it and prevent the harmful effects of high sugar levels on your organs and blood vessels.
      • Novolog is a fast-acting insulin that provides sugar control after meals.
      • Dose can be easily adjusted to make a customized regimen that's tailored to your body.
      • Starting insulin early in the treatment of Type 2 diabetes can maintain your body's insulin-producing cells and slow down disease progression.
      • Okay to use even if you have liver or kidney problems, unlike most other blood sugar-lowering medicines.
      • Insulin is the most effective blood sugar-lowering medicine. When used correctly, it'll lower blood sugar every time you use it and prevent the harmful effects of high sugar levels on your organs and blood vessels.
      • Levemir is a long-lasting insulin that provides consistent, all-day sugar control with less risk of low blood sugar.
      • Dose can be easily adjusted to make a customized regimen that's tailored to your body.
      • Starting insulin early in the treatment of Type 2 diabetes can maintain your body's insulin-producing cells and slow down disease progression.
      • Okay to use even if you have liver or kidney problems, unlike most other blood sugar-lowering medicines.
      • Oral blood sugar-lowering medicine.
      • Januvia (sitagliptin) is not linked to worsening heart failure like other medicines in its class.
      • Uses the hormones naturally produced by your body to affect how sugar is processed.
      • It is less likely to cause weight gain and low blood sugar compared to other diabetes medicines.
      • Can lower your A1c (average blood sugar over time) by 1%.
      • Not as likely to cause very low blood sugar as glyburine or insulin.
      • Does not increase your appetite like other anti-diabetic medicines.
      • Pen is dialed to a single dose for easy injections.
      • Oral blood sugar-lowering medicine.
      • Lowers A1c levels by around 1%. (Hemoglobin A1c measures your average blood sugar over time.)
      • Prevents the harmful effects of high sugar levels on your organs and blood vessels.
      • Rarely causes low blood sugar.
      • Some types of this medication are available without a prescription.
      • Available as a shot to be injected into the fatty part of the skin, and as a powder to be inhaled through your nose.
      • Available in different combinations so that you can do one shot or multiple shots a day.
      • Insulin is the most effective blood sugar-lowering medicine. When used correctly, it'll lower blood sugar every time you use it and prevent the harmful effects of high sugar levels on your organs and blood vessels.
      • Lantus is a long-lasting insulin that provides consistent, all-day sugar control with less risk of low blood sugar.
      • Dose can be easily adjusted to make a customized regimen that's tailored to your body.
      • Starting insulin early in the treatment of Type 2 diabetes can maintain your body's insulin-producing cells and slow down disease progression.
      • Okay to use even if you have liver or kidney problems, unlike most other blood sugar-lowering medicines.
      • This 2-in-1 combination can lower the number of pills you have to take daily.
      • Lowers A1c (average blood sugar over time) up to 2.5%.
      • Available in extended and immediate release forms to allow better control of your blood sugar.
      • Doesn't increase your appetite unlike other anti-diabetic medicines.
      • Does not cause hypoglycemia or very low blood sugar.
      • Available as an oral tablet.
      • Lowers your A1c (average blood sugar over time) up to 2%.
      • Available in generic version.
      • Available in single pill combination with other anti-diabetic medicines.
      Downsides and risks
      GlucotrolPrecoseHumalogmetforminNovologLevemirJanuviaByettaActosHuman InsulinLantusJanumetglyburide
      • Higher risk of low blood sugar episodes than other kinds of oral diabetes medicines.
      • You have to check your blood sugar 2 to 5 times a week (less often once you are on a stable dose).
      • Can cause mild weight gain (2 to 3 pounds).
      • Loses effectiveness over time or as your body stops making insulin.
      • Food can cause unpredictable effects of the immediate-release version of Glipizide, so you have to take it at least 30 minutes before a meal.
      Coming soon
      • You have to take insulin by injection.
      • You have to check your blood sugar multiple times every day, usually before each meal.
      • Likely to cause moderate weight gain (around 4 to 6 pounds).
      • Higher risk of low blood sugar episodes than other kinds of diabetes medicines.
      • Often causes stomach upset, like diarrhea, nausea, gas, or stomach cramping.
      • Usually not a good choice for people with kidney problems. Your doctor will tell you if Glucophage (metformin) is right for you to take.
      • Excessive or chronic alcohol use can increase the risk of a dangerous side effect.
      • You have to take insulin by injection.
      • You have to check your blood sugar multiple times every day, usually before each meal.
      • Likely to cause moderate weight gain (around 4 to 6 pounds).
      • Higher risk of low blood sugar episodes than other kinds of diabetes medicines.
      • You have to take insulin by injection.
      • You have to check your blood sugar every day.
      • Likely to cause moderate weight gain (around 4 to 6 pounds).
      • Higher risk of low blood sugar episodes than other kinds of diabetes medicines.
      • Lowers A1c (average blood sugar over time) by less than 1%.
      • Available as brand version only.
      • Some people might get frequent cold-like symptoms.
      • Rare but serious side effects include pancreatitis and severe joint pain.
      • Byetta (Exenatide) must be injected twice a day. Other medicines like it can be injected once daily or even weekly.
      • It commonly causes nausea, vomiting, diarrhea, constipation, or indigestion.
      • Can affect how well your antibiotics and birth control pills work. Take them no sooner than one hour after your injections.
      • May take several weeks to lower blood sugar.
      • You have to check your blood sugar regularly with this medicine.
      • Has more side effects than similar medicines, so it's usually not the first choice for new Type 2 diabetes patients.
      • More likely to cause weight gain (2 to 6 pounds or more) compared to other blood sugar-lowering medicines.
      • Up to 1 in 10 people might get fluid retention (edema), ranging from mild ankle swelling to severe swelling in the lungs that makes it hard to breathe. People with severe congestive heart failure shouldn't use Actos.
      • Raises the risk of bone fractures, especially for people who already have a risk for fractures.
      • Slightly raises the risk of bladder cancer.
      • Has to be taken exactly as directed or it can cause high or low blood sugar.
      • As with all insulins, you have to work with your doctor closely to make sure you're giving yourself the correct dose, or you can have low or high blood sugar.
      • You have to take insulin by injection.
      • You have to check your blood sugar every day.
      • Likely to cause moderate weight gain (around 4 to 6 pounds).
      • Higher risk of low blood sugar episodes than other kinds of diabetes medicines.
      • Available as brand name only and may be expensive.
      • Metformin component usually causes upset stomach.
      • Sitagliptin component may increase your risk for throat infections and inflammation of pancreas.
      • Not appropriate for those with poor kidney function.
      • More likely to cause hypoglycemia or low blood sugar than other types of oral anti-diabetics.
      • You will have to check your blood sugar often when you first start taking it.
      • Can cause weight gain (about 2 to 3 pounds).
      • Not ideal for elderly or those with poor kidney function.
      • May not work as well for those with severe diabetes and when pancreas cannot produce insulin.
      Tips from our pharmacists for people taking the medication
      GlucotrolPrecoseHumalogmetforminNovologLevemirJanuviaByettaActosHuman InsulinLantusJanumetglyburide
      • Works best if you take it 30 minutes before a meal, usually your first big meal of the day.
      • Can cause weight gain, dizziness, or stomach upset.
      • Avoid drinking alcohol.
      • Eat regular, balanced meals to avoid low blood sugar.
      • Check your blood sugar regularly.
      Coming soon
      • Short-acting insulin good for blood sugar control around meal times.
      • Take 5 to 10 minutes before a meal. Effects last for 2-4 hours.
      • Can cause weight gain and low blood sugar.
      • Make sure you and your family know the symptoms of low blood sugar: sweating, shakiness, weakness, fast heartbeat, nervousness, headache, blurry vision, trouble thinking clearly, or passing out.
      • Always have a good source of sugar nearby for low blood sugar episodes.
      • Make sure you understand how to give yourself the injections.
      • When mixing with another insulin (such as insulin NPH), draw this insulin into the syringe first.
      • Don't shake the vial. Store unopened vials in the refrigerator. Opened vials are good at room temperature for 28 days.
      • Check your blood sugar levels every day.
      • Can cause upset stomach with nausea and especially diarrhea in the first couple of weeks.
      • Always take it with food to lessen stomach upset.
      • Stay hydrated.
      • Limit or avoid alcohol when taking this medicine.
      • Tell your doctor about any deep or rapid breathing, or persistent nausea, vomiting, and stomach pain.
      • Check your blood sugar regularly.
      • Short-acting insulin good for blood sugar control around meal times.
      • Take 5 to 10 minutes before a meal. Effects last for 2-4 hours.
      • Can cause weight gain and low blood sugar.
      • Make sure you and your family know the symptoms of low blood sugar: sweating, shakiness, weakness, fast heartbeat, nervousness, headache, blurry vision, trouble thinking clearly, or passing out.
      • Always have a good source of sugar nearby for low blood sugar episodes.
      • Make sure you understand how to give yourself the injections.
      • When mixing with another insulin (such as insulin NPH), draw this insulin into the syringe first.
      • Don't shake the vial. Store unopened vials in the refrigerator. Opened vials are good at room temperature for 28 days.
      • Check your blood sugar levels every day.
      • Long-acting insulin good for baseline blood sugar control.
      • Works in 1 hour and lasts about 24 hours.
      • Can cause weight gain and low blood sugar.
      • Make sure you and your family know the symptoms of low blood sugar: sweating, shakiness, weakness, fast heartbeat, nervousness, headache, blurry vision, trouble thinking clearly, or passing out.
      • Always have a good source of sugar nearby for low blood sugar episodes.
      • Take it at the same time every day.
      • Make sure you understand how to give yourself the injections.
      • Don't shake the vial or mix with another insulin. Store unopened vials in the refrigerator. Opened vials are good at room temperature for 28 days.
      • Check your blood sugar levels every day.
      • Take once a day in the morning with or without food.
      • Can cause headache and cold-like symptoms.
      • Tell your doctor right away if you have severe stomach pain, nausea, and/or vomiting. These are symptoms of pancreatitis.
      • Tell your doctor right away if you are experiencing severe joint pain.
      • Check your blood sugar regularly to check for low blood sugar.
      • Inject into your belly, thighs, or upper arms within an hour of your main meals.
      • Store unused pens in the refrigerator.
      • After first use, pens can be kept at room temperature for 30 days.
      • Change the needle and prime the pen every time you inject.
      • If you're also on insulin, don't inject into the same site.
      • Best to check your blood sugar once a day to make sure your medicine is working properly.
      • Takes several weeks to see full effect on blood sugar control.
      • Can cause weight gain, headache, and fluid retention.
      • Tell your doctor about any mental confusion, persistent abdominal pain, dark urine, yellowing of eyes/skin, or easy bruising.
      • Not recommended for patients with certain heart problems.
      • Check your blood sugar regularly.
      • Change the location where you give yourself the shot every time.
      • Don't use if the liquid in the vial looks different than normal.
      • Store the unopened vials in the refrigerator. The used vials can be kept at room temperature for up to 28 days.
      • Take the medication exactly how your doctor tells you to.
      • Know the symptoms of low blood sugar.
      • Long-acting insulin good for baseline blood sugar control.
      • Works in 1 hour and lasts about 24 hours.
      • Can cause weight gain and low blood sugar.
      • Make sure you and your family know the symptoms of low blood sugar: sweating, shakiness, weakness, fast heartbeat, nervousness, headache, blurry vision, trouble thinking clearly, or passing out.
      • Always have a good source of sugar nearby for low blood sugar episodes.
      • Take it at the same time every day.
      • Make sure you understand how to give yourself the injections.
      • Don't shake the vial or mix with another insulin. Store unopened vials in the refrigerator. Opened vials are good at room temperature for 28 days.
      • Check your blood sugar levels every day.
      • Take with food to avoid upset stomach with diarrhea, nausea, and vomiting.
      • May cause headaches and cold-like symptoms.
      • Tell your doctor about any deep or rapid breathing, or persistent nausea, vomiting, and stomach pain.
      • Can be expensive depending on insurance coverage.
      • Check your blood sugar regularly.
      • Check your blood sugar regularly.
      • Eat well-balanced meals to avoid low blood sugar.
      • Works best if you take it 30 minutes before first main meal of the day.
      • Can cause weight gain, dizziness, or stomach upset.
      • Try to avoid drinking alcohol while on Diabeta (glyburide).
      Learn more
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