Prescription onlyLower-cost generic available

Glucovance

(Metformin / Glyburide)

  • Pill
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Lowers blood sugar.

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Prescription onlyLower-cost generic available

Our pharmacists’ bottom line

Glucovance (Metformin / Glyburide) is a very effective combo medication to lower blood sugar when taking one medication alone isn't enough. It's likely to cause diarrhea for the first few weeks, and you can’t drink much alcohol.

  • A combination medication that lowers your blood sugar in multiple ways. It's used by people who need tighter control of their blood sugar.
  • Can greatly lower A1c levels. The Hemoglobin A1c test measures your average blood sugar levels over the last few months.
  • Prevents harmful effects of high blood sugar levels on your organs and blood vessels.
  • Also lowers certain lipid (fat and cholesterol) levels.
  • There's a higher risk of low blood sugar episodes than with other kinds of oral diabetes medications.
  • Most people will have nausea, stomach upset, or diarrhea in the first few weeks. You can lower these symptoms if you take it on a full stomach.
  • People with poor kidney function can't use Glucovance (Metformin / Glyburide).
  • Can't drink excessive amounts of alcohol or “binge drink” while taking this.
  • Can cause some weight gain.
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Side effects for Glucovance (Metformin / Glyburide)

From clinical trials of Glucovance / Type 2 diabetes ( 803)

  • Upper respiratory infectionUpper respiratory infection17% for Metformin/Glyburide vs.14% for placebo
  • DiarrheaDiarrhea17% for Metformin/Glyburide vs.6% for placebo
  • HeadacheHeadache9% for Metformin/Glyburide vs.11% for placebo
  • Nausea/vomitingNausea/vomiting8% for Metformin/Glyburide vs.6% for placebo
  • Abdominal painAbdominal pain7% for Metformin/Glyburide vs.4% for placebo
  • DizzinessDizziness6% for Metformin/Glyburide vs.4% for placebo

What to expect when you take Glucovance (Metformin / Glyburide) for Improves blood sugar levels

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Tips from our pharmacists
  • Can cause upset stomach, nausea, and diarrhea in the first couple of weeks.
  • Works best if you take it 30 minutes before a meal, usually your first big meal of the day.
  • Tell your doctor about any deep or rapid breathing, persistent nausea, vomiting, or stomach pain.
  • Try limiting the amount of alcohol you drink while taking this medication.
  • Check your blood sugar regularly.

Risks and Warnings for Glucovance (Metformin / Glyburide)

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    • Higher risk if:
    • Kidney problems
    • Liver problems
    • Congestive heart failure
    • Using contrast dye for procedures
    • Surgery
    • Alcohol use

    Glucovance (Metformin / Glyburide) can cause lactic acidosis, a rare but life-threatening condition. Symptoms include deep and rapid breathing, nausea, vomiting, and stomach pain. This is a medical emergency and you should get help right away. Baseline blood work for kidney and liver function are helpful to see if you can use Glucovance (Metformin / Glyburide). It may not be a good choice for people with kidney problems. Glucovance (Metformin / Glyburide) should be stopped 48 hours before and/or after surgery or procedure that'll use contrast dye.

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Tips from pharmacists and people taking Glucovance (Metformin / Glyburide)

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The FDA category for this medication is B. It is advised that you: Probably safe
Pregnancy
Alcohol
  • Upsides and downsides from our pharmacists
  • Can't drink excessive amounts of alcohol or “binge drink” while taking this.
  • Tips from our pharmacists
  • Try limiting the amount of alcohol you drink while taking this medication.
Food
  • Tips from our pharmacists
  • Works best if you take it 30 minutes before a meal, usually your first big meal of the day.
Kidneys & liver
  • Upsides and downsides from our pharmacists
  • People with poor kidney function can't use Glucovance (Metformin / Glyburide).
  • Risks from our pharmacists
  • Glucovance (Metformin / Glyburide) can cause lactic acidosis, a rare but life-threatening condition. Symptoms include deep and rapid breathing, nausea, vomiting, and stomach pain. This is a medical emergency and you should get help right away. Baseline blood work for kidney and liver function are helpful to see if you can use Glucovance (Metformin / Glyburide). It may not be a good choice for people with kidney problems. Glucovance (Metformin / Glyburide) should be stopped 48 hours before and/or after surgery or procedure that'll use contrast dye.
Weight gain or loss
  • Upsides and downsides from our pharmacists
  • Can cause some weight gain.