Prescription onlyLower-cost generic availableClass: Endocrine

Glyburide / MetforminAlternatives

Prescription onlyLower-cost generic availableClass: Endocrine
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Compare Glyburide / Metformin to alternatives

These medications are comparable to Glyburide / Metformin or used for similar purposes.

glyburide / metformin

Metaglip
(metformin / glipizide)

Byetta
(exenatide)

Januvia
(sitagliptin)

Nesina
(alogliptin)

Precose
(acarbose)

Glucotrol
(glipizide)

Actos
(pioglitazone)

Afrezza
(insulin)

Lowers blood sugar. Glyburide / Metformin is an effective combination medicine for lowering blood sugar, but it is likely to cause diarrhea in the first few weeks.Coming soon.Lowers blood sugar. Byetta (Exenatide) can lower your blood sugars in addition to metformin. It does not increase your appetite unlike some other anti-diabetics, but must be given by injection and usually causes upset stomach.Lowers your blood sugar. Januvia (sitagliptin) is a good add-on treatment if your blood sugars are not controlled and you don't want to use an injectable medicine.Lowers your blood sugar. alogliptin is a good add-on treatment if your blood sugar is still too high, but you don't want to use an injectable medicine.Lowers blood sugar. Precose (acarbose) helps lower your post-mealtime blood sugar levels, but it must be taken at the beginning of each main meal in order for it to be most effective.Lowers blood sugar. Glucotrol (glipizide) is an effective medicine for lowering blood sugar, but it can cause your blood sugar level to be too low so you must always carry some form of sugar with you that can be readily used.Lowers blood sugar. Actos (pioglitazone) can improve blood sugar control but is not a top choice since it has a lot of side effects.Controls mealtime blood sugar. Afrezza (insulin) is effective at controlling blood sugar, but you can't use it if you've had lung problems or smoke.
Reviews & ratings
Filter group. All currently selected
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Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Glyburide / Metformin?
Worth itNot sureNot worth it

Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Metaglip (metformin / glipizide)?
Worth itNot sureNot worth it

Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Byetta (exenatide)?
Worth itNot sureNot worth it
Reviews for Januvia
44%
-44% worse vs. Glucovance
34%
-34% worse vs. Glucovance
17%
+17% better vs. Glucovance
143 reviews
Have you used Januvia (sitagliptin)?
Worth itNot sureNot worth it

Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Nesina (alogliptin)?
Worth itNot sureNot worth it

Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Precose (acarbose)?
Worth itNot sureNot worth it
Reviews for Glucotrol
50%
-50% worse vs. Glucovance
32%
-32% worse vs. Glucovance
19%
+19% better vs. Glucovance
332 reviews
Have you used Glucotrol (glipizide)?
Worth itNot sureNot worth it
Reviews for Actos
42%
-42% worse vs. Glucovance
30%
-30% worse vs. Glucovance
21%
+21% better vs. Glucovance
175 reviews
Have you used Actos (pioglitazone)?
Worth itNot sureNot worth it

Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Afrezza (insulin)?
Worth itNot sureNot worth it
Side effects
GlucovanceMetaglipByettaJanuviaNesinaPrecoseGlucotrolActosAfrezza
  • Upper respiratory infection 3%
  • Diarrhea 11%
  • Nausea/vomiting 2%
  • Stomach pain 3%
  • Dizziness 2%
  • Gastrointestinal side effects (diarrhea, nausea/vomiting, and stomach pain) 8%
  • Low blood sugar 8%
More Glucovance side effects »

We haven’t found good data for Metaglip side effects.

FDA side effect reports for Metaglip »
  • Low blood sugar 11%
  • Nausea 33%
  • Diarrhea 10%
  • Vomiting 14%
  • Headache 10%
  • Constipation 8%
  • Indigestion 5%
  • Weakness 4%
  • Abdominal swelling 3%
  • Loss of appetite 3%
More Byetta side effects »
  • Common cold 2%
  • Diarrhea 1%
  • Upper respiratory infection 3%
  • Headache 1%
More Januvia side effects »

We haven’t found good data for Nesina side effects.

FDA side effect reports for Nesina »
  • Excessive gas 46%
  • Diarrhea 19%
  • Stomach pain 10%
More Precose side effects »
  • Dizziness 1%
  • Diarrhea 5%
  • Nervousness 1%
  • Tremor 4%
  • Passing gas 2%
  • Low blood sugar 3%
  • Constipation 3%
  • Nausea 3%
  • Headache 2%
More Glucotrol side effects »
  • Swelling 11%
  • Low blood sugar 8%
  • Colds and flu 4%
  • Headache 2%
  • Heart failure 2%
  • Sinus infection 1%
  • Back pain 1%
  • Muscle pain 2%
More Actos side effects »
  • Low blood sugar 37%
  • Dry cough 6%
  • Severe low blood sugar 3%
  • Diarrhea 2%
  • Wet cough 1%
  • Fatigue 1%
  • Nausea 2%
  • Cough 28%
More Afrezza side effects »
How it works
GlucovanceMetaglipByettaJanuviaNesinaPrecoseGlucotrolActosAfrezza
Glyburide / Metformin combines 2 prescription medicines (glyburide and metformin) into 1 pill to help treat diabetes. Glyburide stimulates your body to release insulin to lower blood sugar. Metformin helps your body use its own insulin more effectively as well as lowers the amount of sugar your body naturally makes and absorbs from food.Coming soon.Byetta (Exenatide) enhances the release of insulin in your gut and pancreas to lower your blood sugar.Januvia (sitagliptin) is an anti-diabetic drug that enhances your body's release of insulin.alogliptin is an anti-diabetic drug. It improves your body's ability to use insulin to lower your blood sugar.Precose (acarbose) stops an enzyme in your body from turning carbohydrates into sugar for energy. As a result, your body will absorb less sugar from the foods that you eat which will lead to lower blood sugar levels.Glucotrol (glipizide) stimulates your body to release insulin and lower blood sugar.Actos (pioglitazone) is a thiazolidinedione that improves your body's ability to use insulin to lower your blood sugar.Afrezza (insulin) is an insulin that controls your blood sugar by turning the sugars you eat into energy or storing it in your body for future use.
Type of medication
GlucovanceMetaglipByettaJanuviaNesinaPrecoseGlucotrolActosAfrezza
Prescription onlyPrescription onlyPrescription onlyPrescription onlyPrescription onlyPrescription onlyPrescription only
Available as
GlucovanceMetaglipByettaJanuviaNesinaPrecoseGlucotrolActosAfrezza
  • Pill
  • Pill
  • Injection
  • Pill
  • Pill
  • Pill
  • Pill
  • Extended release pill
  • Pill
  • Inhalation powder
Used for
GlucovanceMetaglipByettaJanuviaNesinaPrecoseGlucotrolActosAfrezza
  • Diabetes Mellitus Type 2
  • Diabetes Mellitus Type 2
Risk factors for serious side effects
GlucovanceMetaglipByettaJanuviaNesinaPrecoseGlucotrolActosAfrezza
  • History of kidney problems
  • History of liver problems
  • Those with congestive heart failure
  • Using contrast dye for procedures
  • Undergoing surgery
Detailed Glyburide / Metformin risks & warnings »
    Coming soon.
    • Severe renal impairment
    • End-stage renal disease
    • Severe gastrointestinal disease
    • Gastroparesis
    Detailed Byetta (exenatide) risks & warnings »
    • History of pancreatitis
    • High blood triglyceride levels
    • Gallstones (stones in gallbladder)
    • History of alchoholism
    • Kidney problems
    Detailed Januvia (sitagliptin) risks & warnings »
      Detailed Nesina (alogliptin) risks & warnings »
      • Using insulin or other medicines that stimulate insulin release
      • Those with kidney problems
      • Taking multiple medicines together
      Detailed Precose (acarbose) risks & warnings »
      • Skipping meals or having inconsistent meal times
      • Drinking alcohol
      • Using other blood sugar-lowering medicine
      • People age 60 or older
      • Those with kidney and/or liver problems
      Detailed Glucotrol (glipizide) risks & warnings »
      • Heart failure
      • Current liver problems
      • History of bladder cancer
      • Women
      Detailed Actos (pioglitazone) risks & warnings »
      • Changes in diet and exercise
      • Drinking alcohol
      • Taking other medications for diabetes
      • Over age 65
      • Liver or kidney problems
      Detailed Afrezza (insulin) risks & warnings »
      Pregnancy

      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

      Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

      Interactions
      GlucovanceMetaglipByettaJanuviaNesinaPrecoseGlucotrolActosAfrezza
      No interactions related info.No interactions related info.No interactions related info.No interactions related info.No interactions related info.
      • Has relatively few interactions with other medicines.
      No interactions related info.No interactions related info.No interactions related info.
      Alcohol
      GlucovanceMetaglipByettaJanuviaNesinaPrecoseGlucotrolActosAfrezza
      • Limit the amount of alcohol you drink while taking Glyburide / Metformin.
      • Drinking large amounts of or frequently using alcohol while taking Glyburide / Metformin can cause harm to your body.
      No alcohol related info.No alcohol related info.No alcohol related info.No alcohol related info.No alcohol related info.
      • Avoid drinking alcohol while taking Glucotrol (glipizide).
      No alcohol related info.
      • Avoid drinking alcohol or using over-the-counter medications that contain alcohol while on Afrezza (insulin).
      Food
      GlucovanceMetaglipByettaJanuviaNesinaPrecoseGlucotrolActosAfrezza
      No food related info.No food related info.No food related info.
      • Take once a day in the morning with or without food.
      No food related info.No food related info.
      • Eat regular and well-balanced meals to keep your blood sugar levels normal.
      • Take once a day with or without food.
      • You should inhale Afrezza (insulin) at the beginning of a meal.
      • Afrezza (insulin) is as effective as other mealtime insulin products.
      Kidneys and liver
      GlucovanceMetaglipByettaJanuviaNesinaPrecoseGlucotrolActosAfrezza
      • Not a good treatment option for those with kidney and/or liver problems.
      No kidneys and liver related info.
      • If you have severe kidney or liver problems, you should not take Byetta (Exenatide). Talk to your doctor about testing your kidneys before starting Byetta (Exenatide). People taking medications that are damaging to kidneys such as ACE inhibitors, NSAIDs or diuretics in addition to Byetta (Exenatide) may notice nausea, vomiting, or diarrhea.
      • Januvia (sitagliptin) can worsen kidney problems. Your doctor may check your kidney function before and during treatment. Your doctor may have to adjust the dose or stop this medicine based on changes in kidney function.
      No kidneys and liver related info.
      • Precose (acarbose) is not a recommended treatment option if you have bad kidney function or kidney problems. Your doctor will have you do a blood test to decide if this is the right medicine for you.
      No kidneys and liver related info.
      • If you've had liver problems or damage in the past, talk to your doctor before starting Actos (pioglitazone), since there's a small chance that it can hurt your liver. Tell your doctor about any stomach pain that don't go away, dark urine, or yellowing of eyes/skin. Your doctor will check your liver regularly.
      No kidneys and liver related info.
      Pain
      GlucovanceMetaglipByettaJanuviaNesinaPrecoseGlucotrolActosAfrezza
      No pain related info.No pain related info.
      • Using Byetta (Exenatide) has been associated with stomach pain, nausea, vomiting and diarrhea. If you have severe gastrointestinal disease such as Crohn’s Disease or Ulcerative Colitis, you should talk to your doctor about using a different medicine for diabetes. You should not use Byetta (Exenatide) if you have gastroparesis, a condition that causes slow or irregular digestion. Gastroparesis can be common for people that have had uncontrolled diabetes for a while.
      • Tell your doctor right away if you have severe stomach pain, nausea, and/or vomiting. These are symptoms of pancreatitis.
      No pain related info.
      • Causes side effects usually during the first few weeks of treatment including stomach pain, excessive gas, and diarrhea that will become less bothersome with time.
      No pain related info.No pain related info.No pain related info.
      Weight
      GlucovanceMetaglipByettaJanuviaNesinaPrecoseGlucotrolActosAfrezza
      • Can cause some weight gain.
      No weight related info.No weight related info.
      • It is less likely to cause weight gain and low blood sugar compared to other diabetes medicines.
      No weight related info.
      • Precose (acarbose) helps control meal-time blood sugar levels without causing weight gain.
      • Can cause mild weight gain of 2-3lb.
      • Can cause weight gain, headache, and swelling from fluid build-up.
      • Can cause weight gain.
      No weight related info.
      Upsides and benefits
      GlucovanceMetaglipByettaJanuviaNesinaPrecoseGlucotrolActosAfrezza
      • Glyburide / Metformin effectively lowers blood sugar levels more so than if each of the individual medicines it contains are taken alone.
      • Protects your organs and blood vessels from the harmful effects of high blood sugar levels.
      • Can potentially lower your "bad cholesterol" levels.
      • Glyburide / Metformin is available in a generic form and is cheaper than many other combination diabetes medicines.
      Coming soon
      • Can lower your A1c (average blood sugar over time) by 1%.
      • Not as likely to cause very low blood sugar as glyburine or insulin.
      • Does not increase your appetite like other anti-diabetic medicines.
      • Pen is dialed to a single dose for easy injections.
      • Oral blood sugar-lowering medicine.
      • Januvia (sitagliptin) is not linked to worsening heart failure like other medicines in its class.
      • Uses the hormones naturally produced by your body to affect how sugar is processed.
      • It is less likely to cause weight gain and low blood sugar compared to other diabetes medicines.
      • Oral blood sugar-lowering medicine.
      • Lowers A1c levels by around 1%. (Hemoglobin A1c measures your average blood sugar over time.)
      • Prevents the harmful effects of high sugar levels on your organs and blood vessels.
      • Rarely causes low blood sugar.
      • Patients taking alogliptin had less cold symptoms than patients taking Januvia.
      • Precose (acarbose) helps control meal-time blood sugar levels without causing weight gain.
      • When used alone it doesn't normally cause blood sugar levels to be too low unlike other anti-diabetes medicines.
      • Safe to be used in people age 65 or older.
      • Has relatively few interactions with other medicines.
      • Lowers A1c levels by 1-2%.
      • Glucotrol (glipizide) is an oral medicine so it might be a good alternative for those who don't like injections.
      • Protects your organs and blood vessels by preventing the harmful effects of high blood sugar levels.
      • Okay to use by people with kidney problems.
      • Available as a generic form and is relatively cheap.
      • Improves sugar control and lowers A1c levels by around 1%.
      • Easily taken by mouth as a once a day pill.
      • Prevents the harmful effects of high sugar levels on your organs.
      • Rarely causes low blood sugar.
      • Lower the risk of heart attack or stroke.
      • Afrezza (insulin) is as effective as other mealtime insulin products.
      • Starts working faster and stays in your body for a shorter time than other mealtime insulin products, so you're less likely to have severely low blood sugar.
      • If you don't like needles, Afrezza (insulin) is a good alternative since you inhale it.
      • Safe to use in people 65 or older.
      • Talk to your doctor or pharmacist about ways to lower your copay, such as coupons.
      Downsides and risks
      GlucovanceMetaglipByettaJanuviaNesinaPrecoseGlucotrolActosAfrezza
      • Has a higher risk than other diabetes medicine for causing blood sugar levels to be too low.
      • Glyburide / Metformin is likely to cause nausea, stomach upset, or diarrhea in the first few weeks.
      • Not a good treatment option for those with kidney and/or liver problems.
      • Drinking large amounts of or frequently using alcohol while taking Glyburide / Metformin can cause harm to your body.
      • Can cause some weight gain.
      Coming soon
      • Byetta (Exenatide) must be injected twice a day. Other medicines like it can be injected once daily or even weekly.
      • It commonly causes nausea, vomiting, diarrhea, constipation, or indigestion.
      • Can affect how well your antibiotics and birth control pills work. Take them no sooner than one hour after your injections.
      • Lowers A1c (average blood sugar over time) by less than 1%.
      • Available as brand version only.
      • Some people might get frequent cold-like symptoms.
      • Rare but serious side effects include pancreatitis and severe joint pain.
      • Not as strong as other diabetes medicines. Your doctor might add it to your blood sugar-lowering regimen if your sugar levels are still too high.
      • Likely expensive since there's no generic version available.
      • Some people might get frequent throat infections or nasal congestion.
      • Not a first choice medicine because it isn't as effective at lowering blood sugar compared to other treatment options.
      • Associated with bothersome side effects like excessive gas and diarrhea.
      • Relatively more expensive than other diabetes medicines.
      • Has to be taken three times a day with each meal.
      • Might cause episodes of low blood sugar when taken together with insulin or medicines that stimulate insulin release.
      • Has a higher risk than other diabetes medicine for causing blood sugar levels to be too low.
      • While taking Glucotrol (glipizide), your blood sugars should be checked 2 to 5 times a week, but less often once you are on a stable dose.
      • Can cause mild weight gain of 2-3lb.
      • Might lose its effectiveness over time.
      • Needs to be taken 30 minutes before a meal for it to be most effective.
      • May take several weeks to lower blood sugar.
      • Can cause weight gain.
      • People with heart failure or history of bladder cancer shouldn't use this medicine.
      • Some people might get fluid accumulation (edema), from minor ankle swelling to fluid in lungs that makes it hard to breathe.
      • Raises the risk of bone fractures, especially for people who already have a risk for fractures.
      • Not recommended if you're a smoker or if you've smoked in the last 6 months.
      • Afrezza (insulin) only comes in 3 different strengths, so it can be inconvenient if you need a lot of insulin.
      • Not recommended in children under 18.
      • If you're pregnant, you'll need to talk to your doctor before you start Afrezza (insulin).
      • There is no generic available, and may not be covered right away by Medicare or other insurances.
      Tips from our pharmacists for people taking the medication
      GlucovanceMetaglipByettaJanuviaNesinaPrecoseGlucotrolActosAfrezza
      • Check your blood sugar regularly.
      • Wear sunscreen and appropriate clothing to protect yourself from the sun.
      • Take the medicine with meals to prevent an upset stomach.
      • Tell your doctor right away if you experience rapid breathing, ongoing nausea, vomiting, or stomach pain.
      • Limit the amount of alcohol you drink while taking Glyburide / Metformin.
      Coming soon
      • Inject into your belly, thighs, or upper arms within an hour of your main meals.
      • Store unused pens in the refrigerator.
      • After first use, pens can be kept at room temperature for 30 days.
      • Change the needle and prime the pen every time you inject.
      • If you're also on insulin, don't inject into the same site.
      • Best to check your blood sugar once a day to make sure your medicine is working properly.
      • Take once a day in the morning with or without food.
      • Can cause headache and cold-like symptoms.
      • Tell your doctor right away if you have severe stomach pain, nausea, and/or vomiting. These are symptoms of pancreatitis.
      • Tell your doctor right away if you are experiencing severe joint pain.
      • Check your blood sugar regularly to check for low blood sugar.
      • Can cause headache and cold-like symptoms.
      • Tell your doctor about any mental confusion, persistent abdominal pain, dark urine, yellowing of eyes/skin, or easy bruising.
      • Can be expensive depending on insurance coverage.
      • Check your blood sugar regularly.
      • Take Precose (acarbose) with the first bite of each main meal.
      • Don't take the medicine for the times you have skipped a meal.
      • Causes side effects usually during the first few weeks of treatment including stomach pain, excessive gas, and diarrhea that will become less bothersome with time.
      • You should continue to maintain a healthy diet, exercise regularly, and monitor your blood sugar levels while taking Precose (acarbose).
      • Your doctor will work with you to increase your dose gradually.
      • Carry glucose tablets with you at all times so that you can take them when your blood sugar drops to dangerously low levels. This is more likely to happen if you are also using insulin or a medicine that stimulates insulin release.
      • Take the medicine 30 minutes before eating, usually before your first big meal of the day.
      • Avoid drinking alcohol while taking Glucotrol (glipizide).
      • Eat regular and well-balanced meals to keep your blood sugar levels normal.
      • Check your blood sugar regularly.
      • Glucotrol (glipizide) can cause dizziness so avoid activities that require coordination until you know how your body can handle the medicine.
      • Take once a day with or without food.
      • May need several weeks to see full effect on blood sugar control.
      • Can cause weight gain, headache, and swelling from fluid build-up.
      • Tell your doctor about any shortness of breath, heart troubles, or unusual swelling.
      • Not recommended for patients with a history of heart failure or bladder cancer.
      • Check your blood sugar regularly.
      • Take Afrezza (insulin) exactly as your doctor or pharmacist tells you, otherwise you might not get the full dose of the medicine.
      • Keep Afrezza (insulin) in the fridge until you're ready to use it. The Afrezza (insulin) cartridges and inhaler should be left at room temperature for 10 minutes before you use it.
      • You should inhale Afrezza (insulin) at the beginning of a meal.
      • Avoid drinking alcohol or using over-the-counter medications that contain alcohol while on Afrezza (insulin).
      • Avoid driving or operating heavy machinery until you know how Afrezza (insulin) can affect you.
      • If you're using a long-acting insulin, you need to keep using it with Afrezza (insulin).
      Learn more
      More about GlucovanceSide effectsAlternativesFDA package insert
      Have you used Glyburide / Metformin?
      Worth itNot sureNot worth it
      More about MetaglipSide effectsFDA package insert
      Have you used Metaglip (metformin / glipizide)?
      Worth itNot sureNot worth it
      More about ByettaSide effectsReviews & ratingsFDA package insert
      Have you used Byetta (exenatide)?
      Worth itNot sureNot worth it
      More about JanuviaSide effectsReviews & ratingsFDA package insert
      Have you used Januvia (sitagliptin)?
      Worth itNot sureNot worth it
      More about NesinaSide effectsReviews & ratingsFDA package insert
      Have you used Nesina (alogliptin)?
      Worth itNot sureNot worth it
      More about PrecoseSide effectsReviews & ratingsFDA package insert
      Have you used Precose (acarbose)?
      Worth itNot sureNot worth it
      More about GlucotrolSide effectsReviews & ratingsFDA package insert
      Have you used Glucotrol (glipizide)?
      Worth itNot sureNot worth it
      More about ActosSide effectsReviews & ratingsFDA package insert
      Have you used Actos (pioglitazone)?
      Worth itNot sureNot worth it
      More about AfrezzaSide effectsFDA package insert
      Have you used Afrezza (insulin)?
      Worth itNot sureNot worth it