Prescription onlyLower-cost generic available

Diabeta

(Glyburide)

  • Pill
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Lowers blood sugar.

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Prescription onlyLower-cost generic available

Our pharmacists’ bottom line

Glyburide is a very effective oral blood sugar-lowering medicine, but has more side effects and restrictions compared to other medicines in this class (sulfonylureas).

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  • Oral blood sugar-lowering medicine.
  • Lowers A1c levels by 1-2%. (Hemoglobin A1c measures your average blood sugar over time.)
  • Prevents the harmful effects of high sugar levels on your organs and blood vessels.
  • One of the least expensive diabetes medicines.
  • Higher risk of low blood sugar episodes than other kinds of oral diabetes medicines.
  • You have to check your blood sugar 2 to 5 times a week (less often once you are on a stable dose).
  • Can cause mild weight gain (2 to 3 pounds).
  • Not preferred for people 65 years or older since it can cause prolonged low blood sugar (more than 12 hours).
  • Not a good choice for people with kidney problems because it's processed by the kidneys.
  • Loses effectiveness over time or as your body stops making insulin.

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Side effects for Diabeta (Glyburide)

From clinical trials of Glyburide / Type 2 diabetes 

  • Gastrointestinal disturbancesGastrointestinal disturbances2% for Glyburide vs.0% for placebo
  • Allergic skin reactionsAllergic skin reactions2% for Glyburide vs.0% for placebo

Manufacturers don’t say how common these side effects are

  • Agranuocytosis
  • Aplastic anemia
  • Destruction of red blood cells
  • Low blood cell count
  • Low white blood cells
  • Thrombocytopenia

What to expect when you take Diabeta (Glyburide)

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Tips from our pharmacists
  • Works best if you take it 30 minutes before a meal, usually your first big meal of the day.
  • Can cause weight gain, dizziness, or stomach upset.
  • Avoid drinking alcohol.
  • Eat regular, balanced meals to avoid low blood sugar.
  • Check your blood sugar regularly.

Risks and Warnings for Diabeta (Glyburide)

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  • Oral blood sugar lowering medicines in the sulfonylurea class, like Diabeta (Glyburide), may increase the risk of death from heart problems when compared to controlling blood sugar with diet or diet and insulin. Talk to your doctor about the benefits, risks, and if Diabeta (Glyburide) is right for you.

Means that some groups have a high risk of experiencing this side effect

Tips from pharmacists and people taking Diabeta (Glyburide)

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The FDA category for this medication is C. It is advised that you: Weigh risks vs. benefits
Pregnancy
Alcohol
  • Tips from our pharmacists
  • Avoid drinking alcohol.
Food
  • Tips from our pharmacists
  • Works best if you take it 30 minutes before a meal, usually your first big meal of the day.
  • Eat regular, balanced meals to avoid low blood sugar.
Kidneys & liver
  • Upsides and downsides from our pharmacists
  • Not a good choice for people with kidney problems because it's processed by the kidneys.
Weight gain or loss
  • Upsides and downsides from our pharmacists
  • Can cause mild weight gain (2 to 3 pounds).
  • Tips from our pharmacists
  • Can cause weight gain, dizziness, or stomach upset.