Prescription onlyLower-cost generic availableClass: Endocrine

Diabeta Alternatives

(Glyburide)

Prescription onlyLower-cost generic availableClass: Endocrine
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Compare Diabeta (Glyburide) to alternatives

These medications are comparable to Diabeta (Glyburide) or used for similar purposes.

Diabeta
(Glyburide)

Precose
(Acarbose)

Humalog
(Insulin Lispro)

Glucophage
(Metformin)

Novolog
(Insulin Aspart)

Levemir
(Insulin Detemir)

Januvia
(Sitagliptin)

Byetta
(Exenatide)

Actos
(Pioglitazone)

Humulin
(Human Insulin)

Glucotrol
(Glipizide)

Lantus
(Insulin Glargine)

Janumet
(Sitagliptin / Metformin)

Lowers blood sugar. Glyburide is a very effective oral blood sugar-lowering medicine, but has more side effects and restrictions compared to other medicines in this class (sulfonylureas).Coming soon.Lowers blood sugar. Humalog is a fast-acting insulin that provides meal-time sugar control. It can cause low blood sugar, so make sure you know what the symptoms are and always have a source of sugar nearby.Lowers blood sugar. Glucophage (Metformin) is a very effective medicine to lower blood sugar and the risk of complications and death from diabetes, but it's likely to cause diarrhea for the first few weeks.Lowers blood sugar. Novolog is a fast-acting insulin that provides meal-time sugar control. It can cause low blood sugar, so make sure you know what the symptoms are and always have a source of sugar nearby.Lowers blood sugar. Levemir is a long-acting insulin that provides all-day sugar control. It can cause low blood sugar, so make sure you know what the symptoms are and always have a source of sugar nearby.Lowers blood sugar. Januvia (Sitagliptin) is a good add-on treatment if your blood sugar is still too high, but you don't want to use an injectable medicine.Lowers your blood sugar. Byetta (Exenatide) helps lower blood sugar for people with diabetes and causes weight loss, but it has to be given by injection and many people have upset stomach.Lowers blood sugar. Actos (Pioglitazone) is a last-choice blood sugar-lowering medicine since it's only moderately effective but has a lot of undesirable side effects.Lowers blood sugar. This form of insulin is one of the few medications in its class that you can get without a prescription, but it's expensive.Lowers blood sugar. Glucotrol (Glipizide) is a very effective oral blood sugar-lowering medicine. It can cause low blood sugar, so make sure you know what the symptoms are and always have a source of sugar nearby.Lowers blood sugar. Lantus (Insulin Glargine) is a long-acting insulin that provides all-day sugar control. It can cause low blood sugar, so make sure you know what the symptoms are and always have a source of sugar nearby.Lowers blood sugar. Janumet is an expensive but very effective combination of oral blood sugar-lowering medicines.
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Reviews & ratings
Filter group. All currently selected
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4.42Glyburide
Reviews for Diabeta (Glyburide)
45%
of people (All ages) say Diabeta (Glyburide) is worth it
34%
say it works well
21%
say it's a big hassle
110 reviews
Have you used Diabeta (Glyburide)?
Worth itNot sureNot worth it

Not enough reviews for this drug. Help someone out, leave a review!

Have you used Precose (Acarbose)?
Worth itNot sureNot worth it
Reviews for Humalog (Insulin Lispro)
64%
+19% better vs. Diabeta (Glyburide)
50%
+16% better vs. Diabeta (Glyburide)
16%
+5% better vs. Diabeta (Glyburide)
280 reviews
Have you used Humalog (Insulin Lispro)?
Worth itNot sureNot worth it
Reviews for Glucophage (Metformin)
65%
+20% better vs. Diabeta (Glyburide)
46%
+12% better vs. Diabeta (Glyburide)
16%
+5% better vs. Diabeta (Glyburide)
938 reviews
Have you used Glucophage (Metformin)?
Worth itNot sureNot worth it
Reviews for Novolog (Insulin Aspart)
58%
+13% better vs. Diabeta (Glyburide)
46%
+12% better vs. Diabeta (Glyburide)
19%
+2% better vs. Diabeta (Glyburide)
177 reviews
Have you used Novolog (Insulin Aspart)?
Worth itNot sureNot worth it
Reviews for Levemir (Insulin Detemir)
45%
Same vs. Diabeta (Glyburide)
35%
+1% better vs. Diabeta (Glyburide)
22%
-1% worse vs. Diabeta (Glyburide)
130 reviews
Have you used Levemir (Insulin Detemir)?
Worth itNot sureNot worth it
Reviews for Januvia (Sitagliptin)
44%
-1% worse vs. Diabeta (Glyburide)
34%
Same vs. Diabeta (Glyburide)
17%
+4% better vs. Diabeta (Glyburide)
143 reviews
Have you used Januvia (Sitagliptin)?
Worth itNot sureNot worth it

Not enough reviews for this drug. Help someone out, leave a review!

Have you used Byetta (Exenatide)?
Worth itNot sureNot worth it
Reviews for Actos (Pioglitazone)
42%
-3% worse vs. Diabeta (Glyburide)
30%
-4% worse vs. Diabeta (Glyburide)
21%
Same vs. Diabeta (Glyburide)
175 reviews
Have you used Actos (Pioglitazone)?
Worth itNot sureNot worth it
Reviews for Humulin (Human Insulin)
67%
+22% better vs. Diabeta (Glyburide)
46%
+12% better vs. Diabeta (Glyburide)
11%
+10% better vs. Diabeta (Glyburide)
Have you used Humulin (Human Insulin)?
Worth itNot sureNot worth it
Reviews for Glucotrol (Glipizide)
50%
+5% better vs. Diabeta (Glyburide)
32%
-2% worse vs. Diabeta (Glyburide)
19%
+2% better vs. Diabeta (Glyburide)
332 reviews
Have you used Glucotrol (Glipizide)?
Worth itNot sureNot worth it
Reviews for Lantus (Insulin Glargine)
67%
+22% better vs. Diabeta (Glyburide)
51%
+17% better vs. Diabeta (Glyburide)
14%
+7% better vs. Diabeta (Glyburide)
584 reviews
Have you used Lantus (Insulin Glargine)?
Worth itNot sureNot worth it
Reviews for Janumet (Sitagliptin / Metformin)
46%
+1% better vs. Diabeta (Glyburide)
38%
+4% better vs. Diabeta (Glyburide)
15%
+6% better vs. Diabeta (Glyburide)
Have you used Janumet (Sitagliptin / Metformin)?
Worth itNot sureNot worth it
Side effects
GlyburidePrecoseHumalogMetforminNovologLevemirJanuviaByettaActosHuman InsulinGlucotrolLantusJanumet
  • Gastrointestinal disturbances 2%
  • Allergic skin reactions 2%
More Glyburide side effects »

We haven’t found good data for Precose side effects.

FDA side effect reports for Precose »
  • Flu syndrome 35%
  • Sore throat 33%
  • Headache 30%
  • Inflammation inside the nose 25%
  • Pain 20%
  • Cough increased 17%
  • Infection 14%
  • Accidental injury 9%
  • Diarrhea 9%
  • Muscle weakness 7%
More Humalog side effects »
  • Diarrhea 41%
  • Nausea/vomiting 18%
  • Passing gas 6%
  • Muscle weakness 3%
  • Indigestion 3%
  • Abdominal discomfort 1%
  • Headache 1%
More Metformin side effects »
  • Decreased muscle reflexes 11%
  • Nail fungal infection 10%
  • Abnormal sense of touch 9%
  • Urinary tract infection 8%
  • Chest pain 5%
  • Headache 5%
  • Skin disorder 5%
  • Abdominal pain 5%
  • Sinus inflammation 5%
  • Injury accidental 11%
More Novolog side effects »
  • Ear, nose, or throat infection 26%
  • Headache 23%
  • Sore throat 10%
  • Influenza-like illness 8%
  • Abdominal pain 6%
  • "stomach flu" 17%
  • Fever 10%
  • Cough 8%
  • Viral infection 7%
  • Nausea 7%
More Levemir side effects »
  • Common cold 2%
  • Diarrhea 1%
More Januvia side effects »
  • Low blood sugar 6%
  • Nausea 26%
  • Vomiting 14%
  • Diarrhea 10%
  • Headache 10%
  • Constipation 8%
  • Dizziness 3%
More Byetta side effects »
  • Swelling due to excess fluid 11%
  • Low blood sugar 8%
  • Ear, nose, or throat infection 4%
  • Headache 2%
  • Cardiac failure 2%
  • Back pain 1%
  • Sinus inflammation 1%
  • Muscle pain 2%
More Actos side effects »

The Human Insulin FDA package insert doesn’t have numbers about how common side effects are.

More about Human Insulin side effects »
  • Dizziness 1%
  • Diarrhea 5%
  • Nervousness 1%
  • Tremor 4%
  • Passing gas 2%
  • Drowsiness 2%
More Glucotrol side effects »
  • Ear, nose, or throat infection 22%
  • Infection 9%
  • Accidental injury 6%
  • Headache 6%
  • Ankle and leg swelling 20%
  • High blood pressure 20%
  • Sinus inflammation 19%
  • Flu 19%
  • Clouded eye lens 18%
  • Bronchitis 15%
More Lantus side effects »
  • Diarrhea 4%
  • Ear, nose, or throat infection 1%
  • Headache 3%
  • Nausea 4%
  • Abdominal pain 1%
  • Vomiting 2%
More Janumet side effects »
How it works
GlyburidePrecoseHumalogMetforminNovologLevemirJanuviaByettaActosHuman InsulinGlucotrolLantusJanumet
Glyburide is an anti-diabetic drug. It stimulates your body to make more insulin to lower blood sugar.Coming soon.Humalog is a short-acting insulin medicine for diabetes. It acts like the insulin that your body normally makes to process sugars and fats, and it keeps your blood sugar stable after meals.Glucophage (Metformin) is an anti-diabetic drug. It lowers sugar production in your body, decreases sugar absorption in your intestines, and makes your body more sensitive to insulin.Novolog is a short-acting insulin medicine for diabetes. It acts like the insulin that your body normally makes to process sugars and fats, and it keeps your blood sugar stable after meals.Levemir is a long-acting insulin medicine for diabetes. It acts like the insulin that your body normally makes to process sugars and fats, and it keeps your blood sugar stable throughout the day.Januvia (Sitagliptin) is an anti-diabetic drug. It helps your body release more insulin in order to lower blood sugar.Byetta (Exenatide) is a medication for diabetes. It stimulates your body to produce and release more insulin, lower the sugar hormone (glucagon), and slow down digestion.Actos (Pioglitazone) is an anti-diabetic drug. It improves your body's ability to use insulin to lower your blood sugar.Insulin is a hormone normally produced by your pancreas. It helps your body absorb and store sugar and fat from your bloodstream.Glucotrol (Glipizide) is an anti-diabetic drug. It stimulates your body to make more insulin to lower blood sugar.Lantus (Insulin Glargine) is a long-acting insulin medicine for diabetes. It acts like the insulin that your body normally makes to process sugars and fats, and it keeps your blood sugar stable throughout the day.Janumet is an antidiabetic combination medicine. Metformin lowers the amount of sugar your body produces, and sitagliptin helps your body release more insulin.
Type of medication
GlyburidePrecoseHumalogMetforminNovologLevemirJanuviaByettaActosHuman InsulinGlucotrolLantusJanumet
Prescription only
Prescription only
Prescription only
Prescription only
Prescription only
Prescription only
Prescription only
Prescription only
Prescription only
Prescription only
Prescription only
Prescription only
Available as
GlyburidePrecoseHumalogMetforminNovologLevemirJanuviaByettaActosHuman InsulinGlucotrolLantusJanumet
  • Pill
  • Pill
  • Injection
  • Pill
  • Extended release
  • Liquid
  • Injection
  • Injection
  • Pill
  • Injection
  • Pill
  • Injection
  • Inhaler
  • Pill
  • Extended release
  • Injection
  • Pill
  • Extended release
Used for
GlyburidePrecoseHumalogMetforminNovologLevemirJanuviaByettaActosHuman InsulinGlucotrolLantusJanumet
  • Diabetes Mellitus Type 2
Risk factors for serious side effects
GlyburidePrecoseHumalogMetforminNovologLevemirJanuviaByettaActosHuman InsulinGlucotrolLantusJanumet
    • Elderly
    • Use of other blood sugar lowering medicines
    • Alcohol
    • Intense physical activity
    • History of sulfa allergies
    Detailed Diabeta (Glyburide) risks & warnings »
    Coming soon.
    • Insulin dose too high
    • Use of other blood sugar lowering medicines
    • Poor injection techniques
    • Unstable kidney functions
    • Unstable liver functions
    • Use of other medicine that lowers potassium
    • Current electrolyte imbalance
      Detailed Humalog (Insulin Lispro) risks & warnings »
      • Kidney problems
      • Liver problems
      • Congestive heart failure
      • Using contrast dye for procedures
      • Surgery
      • Alcohol use
        Detailed Glucophage (Metformin) risks & warnings »
        • Insulin dose too high
        • Use of other blood sugar lowering medicines
        • Poor injection techniques
        • Unstable kidney functions
        • Unstable liver functions
        • Use of other medicine that lowers potassium
        • Current electrolyte imbalance
          Detailed Novolog (Insulin Aspart) risks & warnings »
          • Insulin dose too high
          • Use of other blood sugar lowering medicines
          • Poor injection techniques
          • Unstable kidney functions
          • Unstable liver functions
          • Use of other medicine that lowers potassium
          • Current electrolyte imbalance
            Detailed Levemir (Insulin Detemir) risks & warnings »
                Detailed Januvia (Sitagliptin) risks & warnings »
                      • Severe renal impairment
                      • End-stage renal disease
                      • Severe gastrointestinal disease
                      • Gastroparesis
                        Detailed Byetta (Exenatide) risks & warnings »
                        • Heart failure diagnosis
                          • Current liver problems
                            • Female
                            Detailed Actos (Pioglitazone) risks & warnings »
                                  Detailed Humulin (Human Insulin) risks & warnings »
                                    • Use of other blood sugar lowering medicines
                                    • Alcohol
                                    • Intense physical activity
                                    • History of sulfa allergies
                                    Detailed Glucotrol (Glipizide) risks & warnings »
                                    • Insulin dose too high
                                    • Use of other blood sugar lowering medicines
                                    • Poor injection techniques
                                    • Unstable kidney functions
                                    • Unstable liver functions
                                    • Use of other medicine that lowers potassium
                                    • Current electrolyte imbalance
                                      Detailed Lantus (Insulin Glargine) risks & warnings »
                                      • Kidney problems
                                      • Liver problems
                                      • Congestive heart failure
                                      • Contrast dye for procedure
                                      • Surgery
                                      • Alcohol use
                                            Detailed Janumet (Sitagliptin / Metformin) risks & warnings »
                                            Pregnancy

                                            Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

                                            Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

                                            Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

                                            Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

                                            Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

                                            Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

                                            Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

                                            Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

                                            Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

                                            Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

                                            Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

                                            Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

                                            Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

                                            Interactions
                                            GlyburidePrecoseHumalogMetforminNovologLevemirJanuviaByettaActosHuman InsulinGlucotrolLantusJanumet
                                            No interactions related info.No interactions related info.No interactions related info.No interactions related info.No interactions related info.No interactions related info.No interactions related info.
                                            • Because Byetta (Exenatide) can interact with antibiotics and birth control pills, you can't take it until one hour after these medications.
                                            No interactions related info.No interactions related info.No interactions related info.No interactions related info.No interactions related info.
                                            Alcohol
                                            GlyburidePrecoseHumalogMetforminNovologLevemirJanuviaByettaActosHuman InsulinGlucotrolLantusJanumet
                                            • Avoid drinking alcohol.
                                            No alcohol related info.No alcohol related info.No alcohol related info.No alcohol related info.No alcohol related info.No alcohol related info.No alcohol related info.No alcohol related info.No alcohol related info.
                                            • Avoid drinking alcohol.
                                            No alcohol related info.No alcohol related info.
                                            Food
                                            GlyburidePrecoseHumalogMetforminNovologLevemirJanuviaByettaActosHuman InsulinGlucotrolLantusJanumet
                                            • Eat regular, balanced meals to avoid low blood sugar.
                                            No food related info.
                                            • Short-acting insulin good for blood sugar control around meal times.
                                            • Always take it with food or switch to the extended release version to avoid upset stomach.
                                            • Novolog is a fast-acting insulin that provides sugar control after meals.
                                            • Short-acting insulin good for blood sugar control around meal times.
                                            No food related info.No food related info.
                                            • Eat regular, balanced meals to avoid low blood sugar.
                                            No food related info.No food related info.
                                            • Food can cause unpredictable effects of the immediate-release version of Glipizide, so you have to take it at least 30 minutes before a meal.
                                            • Eat regular, balanced meals to avoid low blood sugar.
                                            No food related info.
                                            • Take it with food to avoid upset stomach with diarrhea, nausea, and vomiting.
                                            Kidneys and liver
                                            GlyburidePrecoseHumalogMetforminNovologLevemirJanuviaByettaActosHuman InsulinGlucotrolLantusJanumet
                                            • Not a good choice for people with kidney problems because it's processed by the kidneys.
                                            No kidneys and liver related info.
                                            • Okay to use even if you have liver or kidney problems, unlike most other blood sugar-lowering medicines.
                                            • People with poor kidney function can't use it.
                                            • Glucophage (Metformin) can cause this rare but life-threatening condition. Symptoms include deep and rapid breathing, nausea, vomiting, and stomach pain. This is a medical emergency and you should get help right away. Baseline blood work for kidney and liver function are helpful to see if you can use Glucophage (Metformin). It may not be a good choice for people with kidney problems. Glucophage (Metformin) should be stopped 48 hours before and/or after surgery or any imaging procedure needing contrast dye.
                                            • Okay to use even if you have liver or kidney problems, unlike most other blood sugar-lowering medicines.
                                            • Okay to use even if you have liver or kidney problems, unlike most other blood sugar-lowering medicines.
                                            No kidneys and liver related info.
                                            • If you have severe kidney or liver problems, you should not take Byetta (Exenatide). Talk to your doctor about testing your kidneys before starting Byetta (Exenatide). People taking medications that are damaging to kidneys such as ACE inhibitors, NSAIDs or diuretics in addition to Byetta (Exenatide) may notice nausea, vomiting, or diarrhea.
                                            No kidneys and liver related info.No kidneys and liver related info.
                                            • Might be a better choice for people with kidney problems compared to similar drugs because Glipizide isn't processed by the kidneys.
                                            • Okay to use even if you have liver or kidney problems, unlike most other blood sugar-lowering medicines.
                                            • People with poor kidney function can't use it.
                                            • Janumet (Sitagliptin / Metformin) can cause this rare but life-threatening condition. Symptoms include deep and rapid breathing, nausea, vomiting, and stomach pain. This is a medical emergency and you should get help right away. Baseline blood work for kidney and liver function are helpful to see if you can use Janumet (Sitagliptin / Metformin). It may not be a good choice for people with kidney problems. Janumet (Sitagliptin / Metformin) should be stopped 48 hours before and/or after surgery or any imaging procedure needing contrast dye.
                                            Pain
                                            GlyburidePrecoseHumalogMetforminNovologLevemirJanuviaByettaActosHuman InsulinGlucotrolLantusJanumet
                                            No pain related info.No pain related info.No pain related info.No pain related info.No pain related info.No pain related info.No pain related info.
                                            • Using Byetta (Exenatide) has been associated with stomach pain, nausea, vomiting and diarrhea. If you have severe gastrointestinal disease such as Crohn’s Disease or Ulcerative Colitis, you should talk to your doctor about using a different medication for diabetes. You should not use Byetta (Exenatide) if you have gastroparesis, a condition that causes slow or irregular digestion. Gastroparesis can be common for people that have had uncontrolled diabetes for a while.
                                            No pain related info.No pain related info.No pain related info.No pain related info.No pain related info.
                                            Weight
                                            GlyburidePrecoseHumalogMetforminNovologLevemirJanuviaByettaActosHuman InsulinGlucotrolLantusJanumet
                                            • Can cause mild weight gain (2 to 3 pounds).
                                            • Can cause weight gain, dizziness, or stomach upset.
                                            No weight related info.
                                            • Likely to cause moderate weight gain (around 4 to 6 pounds).
                                            • Can cause weight gain and low blood sugar.
                                            • Unlike some diabetes medicines, doesn't cause weight gain or low blood sugar.
                                            • Likely to cause moderate weight gain (around 4 to 6 pounds).
                                            • Can cause weight gain and low blood sugar.
                                            • Likely to cause moderate weight gain (around 4 to 6 pounds).
                                            • Can cause weight gain and low blood sugar.
                                            • Unlike some diabetes medicines, it's unlikely to cause weight gain and low blood sugar.
                                            No weight related info.
                                            • More likely to cause weight gain (2 to 6 pounds or more) compared to other blood sugar-lowering medicines.
                                            • Can cause weight gain, headache, and fluid retention.
                                            • People on Humulin (Human Insulin) can experience weight gain. Talk to your doctor or dietitian about changing your diet if this bothers you.
                                            • Can cause mild weight gain (2 to 3 pounds).
                                            • Can cause weight gain, dizziness, or stomach upset.
                                            • Likely to cause moderate weight gain (around 4 to 6 pounds).
                                            • Can cause weight gain and low blood sugar.
                                            • Doesn't cause weight gain or low blood sugar.
                                            Upsides and benefits
                                            GlyburidePrecoseHumalogMetforminNovologLevemirJanuviaByettaActosHuman InsulinGlucotrolLantusJanumet
                                            • Oral blood sugar-lowering medicine.
                                            • Lowers A1c levels by 1-2%. (Hemoglobin A1c measures your average blood sugar over time.)
                                            • Prevents the harmful effects of high sugar levels on your organs and blood vessels.
                                            • One of the least expensive diabetes medicines.
                                            Coming soon
                                            • Insulin is the most effective blood sugar-lowering medicine. When used correctly, it'll lower blood sugar every time you use it and prevent the harmful effects of high sugar levels on your organs and blood vessels.
                                            • Humalog is a fast-acting insulin that provides sugar control after meals.
                                            • Dose can be easily adjusted to make a customized regimen that's tailored to your body.
                                            • Starting insulin early in the treatment of Type 2 diabetes can maintain your body's insulin-producing cells and slow down disease progression.
                                            • Okay to use even if you have liver or kidney problems, unlike most other blood sugar-lowering medicines.
                                            • Oral blood sugar-lowering medicine.
                                            • A common first treatment for people with newly-diagnosed Type 2 diabetes.
                                            • The only oral diabetes medicine that lowers complications and deaths from conditions related to diabetes.
                                            • Lowers A1c levels by 1-2%. (Hemoglobin A1c measures your average blood sugar over time.)
                                            • Prevents the harmful effects of high sugar levels on your organs and blood vessels.
                                            • Also lowers certain lipid (fat and cholesterol) levels.
                                            • Unlike some diabetes medicines, doesn't cause weight gain or low blood sugar.
                                            • You don't have to check your blood sugar every day with this medicine.
                                            • One of the least expensive diabetes medicines.
                                            • Insulin is the most effective blood sugar-lowering medicine. When used correctly, it'll lower blood sugar every time you use it and prevent the harmful effects of high sugar levels on your organs and blood vessels.
                                            • Novolog is a fast-acting insulin that provides sugar control after meals.
                                            • Dose can be easily adjusted to make a customized regimen that's tailored to your body.
                                            • Starting insulin early in the treatment of Type 2 diabetes can maintain your body's insulin-producing cells and slow down disease progression.
                                            • Okay to use even if you have liver or kidney problems, unlike most other blood sugar-lowering medicines.
                                            • Insulin is the most effective blood sugar-lowering medicine. When used correctly, it'll lower blood sugar every time you use it and prevent the harmful effects of high sugar levels on your organs and blood vessels.
                                            • Levemir is a long-lasting insulin that provides consistent, all-day sugar control with less risk of low blood sugar.
                                            • Dose can be easily adjusted to make a customized regimen that's tailored to your body.
                                            • Starting insulin early in the treatment of Type 2 diabetes can maintain your body's insulin-producing cells and slow down disease progression.
                                            • Okay to use even if you have liver or kidney problems, unlike most other blood sugar-lowering medicines.
                                            • Oral blood sugar-lowering medicine.
                                            • Lowers A1c levels by 0.5-0.8%. (Hemoglobin A1c measures your average blood sugar over time.)
                                            • Prevents the harmful effects of high sugar levels on your organs and blood vessels.
                                            • Uses the hormones naturally produced by your body to affect how sugar is processed.
                                            • Unlike some diabetes medicines, it's unlikely to cause weight gain and low blood sugar.
                                            • You don't have to check your blood sugar every day with this medicine.
                                            • Lowers A1c levels by 1% (A1c measures your average blood sugar over time.)
                                            • Prevents the harmful effects of high sugar levels on your organs.
                                            • Has a lower chance of causing low blood sugar than medications like glyburide or insulin.
                                            • Can lower your appetite by making you feel full. Some people also lose weight when taking Byetta (Exenatide).
                                            • Byetta (Exenatide) is not a replacement for diabetes pills, but you may be able to use it alone without the need for pills.
                                            • The injectable “pen” has easy to use doses which you may find more convenient than other types of injections.
                                            • Oral blood sugar-lowering medicine.
                                            • Lowers A1c levels by around 1%. (Hemoglobin A1c measures your average blood sugar over time.)
                                            • Prevents the harmful effects of high sugar levels on your organs and blood vessels.
                                            • Rarely causes low blood sugar.
                                            • Some types of this medication are available without a prescription.
                                            • Available as a shot to be injected into the fatty part of the skin, and as a powder to be inhaled through your nose.
                                            • Available in different combinations so that you can do one shot or multiple shots a day.
                                            • Oral blood sugar-lowering medicine.
                                            • Lowers A1c levels by 1-2%. (Hemoglobin A1c measures your average blood sugar over time.)
                                            • Prevents the harmful effects of high sugar levels on your organs and blood vessels.
                                            • Might be a better choice for people with kidney problems compared to similar drugs because Glipizide isn't processed by the kidneys.
                                            • One of the least expensive diabetes medicines.
                                            • Insulin is the most effective blood sugar-lowering medicine. When used correctly, it'll lower blood sugar every time you use it and prevent the harmful effects of high sugar levels on your organs and blood vessels.
                                            • Lantus is a long-lasting insulin that provides consistent, all-day sugar control with less risk of low blood sugar.
                                            • Dose can be easily adjusted to make a customized regimen that's tailored to your body.
                                            • Starting insulin early in the treatment of Type 2 diabetes can maintain your body's insulin-producing cells and slow down disease progression.
                                            • Okay to use even if you have liver or kidney problems, unlike most other blood sugar-lowering medicines.
                                            • 2-in-1 combination medicine. If you need more than one blood sugar medicine, this lowers the number of pills you have to take.
                                            • Lowers A1c levels by 1-2.5%. (Hemoglobin A1c measures your average blood sugar over time.)
                                            • Prevents the harmful effects of high sugar levels on your organs and blood vessels.
                                            • Doesn't cause weight gain or low blood sugar.
                                            • You don't have to check your blood sugar every day with this medicine.
                                            Downsides and risks
                                            GlyburidePrecoseHumalogMetforminNovologLevemirJanuviaByettaActosHuman InsulinGlucotrolLantusJanumet
                                            • Higher risk of low blood sugar episodes than other kinds of oral diabetes medicines.
                                            • You have to check your blood sugar 2 to 5 times a week (less often once you are on a stable dose).
                                            • Can cause mild weight gain (2 to 3 pounds).
                                            • Not preferred for people 65 years or older since it can cause prolonged low blood sugar (more than 12 hours).
                                            • Not a good choice for people with kidney problems because it's processed by the kidneys.
                                            • Loses effectiveness over time or as your body stops making insulin.
                                            Coming soon
                                            • You have to take insulin by injection.
                                            • You have to check your blood sugar multiple times every day, usually before each meal.
                                            • Likely to cause moderate weight gain (around 4 to 6 pounds).
                                            • Higher risk of low blood sugar episodes than other kinds of diabetes medicines.
                                            • Most people will have nausea, indigestion, or diarrhea in the first few weeks. You can minimize this if you take it on a full stomach.
                                            • People with poor kidney function can't use it.
                                            • Only works if your body can still make your own insulin, a hormone that tells your body what to do with sugar, protein, and fat.
                                            • You have to take insulin by injection.
                                            • You have to check your blood sugar multiple times every day, usually before each meal.
                                            • Likely to cause moderate weight gain (around 4 to 6 pounds).
                                            • Higher risk of low blood sugar episodes than other kinds of diabetes medicines.
                                            • You have to take insulin by injection.
                                            • You have to check your blood sugar every day.
                                            • Likely to cause moderate weight gain (around 4 to 6 pounds).
                                            • Higher risk of low blood sugar episodes than other kinds of diabetes medicines.
                                            • Not as strong as other diabetes medicines. Your doctor might add it to your blood sugar-lowering regimen if your sugar levels are still too high.
                                            • Likely expensive since there's no generic version available.
                                            • Some people might get frequent throat infections or nasal congestion.
                                            • Only lowers A1c levels by 1%, which may not be enough to get your blood sugar in the safe range.
                                            • Byetta (Exenatide) must be injected twice a day.
                                            • Up to 40% of people taking Byetta (Exenatide) have upset stomach and side effects like nausea, vomiting, diarrhea, constipation, or indigestion.
                                            • Because Byetta (Exenatide) can interact with antibiotics and birth control pills, you can't take it until one hour after these medications.
                                            • Other diabetes medications work as well and are cheaper.
                                            • May take several weeks to lower blood sugar.
                                            • You have to check your blood sugar regularly with this medicine.
                                            • Has more side effects than similar medicines, so it's usually not the first choice for new Type 2 diabetes patients.
                                            • More likely to cause weight gain (2 to 6 pounds or more) compared to other blood sugar-lowering medicines.
                                            • Up to 1 in 10 people might get fluid retention (edema), ranging from mild ankle swelling to severe swelling in the lungs that makes it hard to breathe. People with severe congestive heart failure shouldn't use Actos.
                                            • Raises the risk of bone fractures, especially for people who already have a risk for fractures.
                                            • Slightly raises the risk of bladder cancer.
                                            • Has to be taken exactly as directed or it can cause high or low blood sugar.
                                            • As with all insulins, you have to work with your doctor closely to make sure you're giving yourself the correct dose, or you can have low or high blood sugar.
                                            • Higher risk of low blood sugar episodes than other kinds of oral diabetes medicines.
                                            • You have to check your blood sugar 2 to 5 times a week (less often once you are on a stable dose).
                                            • Can cause mild weight gain (2 to 3 pounds).
                                            • Loses effectiveness over time or as your body stops making insulin.
                                            • Food can cause unpredictable effects of the immediate-release version of Glipizide, so you have to take it at least 30 minutes before a meal.
                                            • You have to take insulin by injection.
                                            • You have to check your blood sugar every day.
                                            • Likely to cause moderate weight gain (around 4 to 6 pounds).
                                            • Higher risk of low blood sugar episodes than other kinds of diabetes medicines.
                                            • Likely expensive since there's no generic version available.
                                            • The metformin part of Janumet can cause nausea, indigestion, or diarrhea for most people in the first few weeks.
                                            • People with poor kidney function can't use it.
                                            • The sitagliptin part of Janumet can cause some people to have frequent throat infections or nasal congestion.
                                            • Might raise the risk of problems with your pancreas.
                                            Tips from our pharmacists for people taking the medication
                                            GlyburidePrecoseHumalogMetforminNovologLevemirJanuviaByettaActosHuman InsulinGlucotrolLantusJanumet
                                            • Works best if you take it 30 minutes before a meal, usually your first big meal of the day.
                                            • Can cause weight gain, dizziness, or stomach upset.
                                            • Avoid drinking alcohol.
                                            • Eat regular, balanced meals to avoid low blood sugar.
                                            • Check your blood sugar regularly.
                                            Coming soon
                                            • Short-acting insulin good for blood sugar control around meal times.
                                            • Take 5 to 10 minutes before a meal. Effects last for 2-4 hours.
                                            • Can cause weight gain and low blood sugar.
                                            • Make sure you and your family know the symptoms of low blood sugar: sweating, shakiness, weakness, fast heartbeat, nervousness, headache, blurry vision, trouble thinking clearly, or passing out.
                                            • Always have a good source of sugar nearby for low blood sugar episodes.
                                            • Make sure you understand how to give yourself the injections.
                                            • When mixing with another insulin (such as insulin NPH), draw this insulin into the syringe first.
                                            • Don't shake the vial. Store unopened vials in the refrigerator. Opened vials are good at room temperature for 28 days.
                                            • Check your blood sugar levels every day.
                                            • Can cause upset stomach with nausea and especially diarrhea in the first couple of weeks.
                                            • Always take it with food or switch to the extended release version to avoid upset stomach.
                                            • Tell your doctor about any deep or rapid breathing, or persistent nausea, vomiting, and stomach pain.
                                            • Check your blood sugar regularly.
                                            • Short-acting insulin good for blood sugar control around meal times.
                                            • Take 5 to 10 minutes before a meal. Effects last for 2-4 hours.
                                            • Can cause weight gain and low blood sugar.
                                            • Make sure you and your family know the symptoms of low blood sugar: sweating, shakiness, weakness, fast heartbeat, nervousness, headache, blurry vision, trouble thinking clearly, or passing out.
                                            • Always have a good source of sugar nearby for low blood sugar episodes.
                                            • Make sure you understand how to give yourself the injections.
                                            • When mixing with another insulin (such as insulin NPH), draw this insulin into the syringe first.
                                            • Don't shake the vial. Store unopened vials in the refrigerator. Opened vials are good at room temperature for 28 days.
                                            • Check your blood sugar levels every day.
                                            • Long-acting insulin good for baseline blood sugar control.
                                            • Works in 1 hour and lasts about 24 hours.
                                            • Can cause weight gain and low blood sugar.
                                            • Make sure you and your family know the symptoms of low blood sugar: sweating, shakiness, weakness, fast heartbeat, nervousness, headache, blurry vision, trouble thinking clearly, or passing out.
                                            • Always have a good source of sugar nearby for low blood sugar episodes.
                                            • Take it at the same time every day.
                                            • Make sure you understand how to give yourself the injections.
                                            • Don't shake the vial or mix with another insulin. Store unopened vials in the refrigerator. Opened vials are good at room temperature for 28 days.
                                            • Check your blood sugar levels every day.
                                            • Can cause headache and cold-like symptoms.
                                            • Tell your doctor about persistent stomach pain, nausea, vomiting, or loss of appetite.
                                            • Can be expensive depending on insurance coverage.
                                            • Check your blood sugar regularly.
                                            • Store in the refrigerator until opening. Do not freeze.
                                            • Give injections in your belly, thighs, or upper arm within an hour of your two main meals of the day (separate doses by 6 or more hours).
                                            • Change the needle and prime the pen every time you inject.
                                            • It’s not safe to share this medication with other people, even if you change the needle.
                                            • Don’t mix with insulin; give separate injections. Can be given at the same time as insulin, but in different injection areas.
                                            • Eat regular, balanced meals to avoid low blood sugar.
                                            • It's best to check your blood sugar at least once a day using a home blood sugar monitor to make sure your medication is working and is safe. Some people may need to test more often, ask your doctor.
                                            • Takes several weeks to see full effect on blood sugar control.
                                            • Can cause weight gain, headache, and fluid retention.
                                            • Tell your doctor about any mental confusion, persistent abdominal pain, dark urine, yellowing of eyes/skin, or easy bruising.
                                            • Not recommended for patients with certain heart problems.
                                            • Check your blood sugar regularly.
                                            • Change the location where you give yourself the shot every time.
                                            • Don't use if the liquid in the vial looks different than normal.
                                            • Store the unopened vials in the refrigerator. The used vials can be kept at room temperature for up to 28 days.
                                            • Take the medication exactly how your doctor tells you to.
                                            • Know the symptoms of low blood sugar.
                                            • Works best if you take it 30 minutes before a meal, usually your first big meal of the day.
                                            • Can cause weight gain, dizziness, or stomach upset.
                                            • Avoid drinking alcohol.
                                            • Eat regular, balanced meals to avoid low blood sugar.
                                            • Check your blood sugar regularly.
                                            • Long-acting insulin good for baseline blood sugar control.
                                            • Works in 1 hour and lasts about 24 hours.
                                            • Can cause weight gain and low blood sugar.
                                            • Make sure you and your family know the symptoms of low blood sugar: sweating, shakiness, weakness, fast heartbeat, nervousness, headache, blurry vision, trouble thinking clearly, or passing out.
                                            • Always have a good source of sugar nearby for low blood sugar episodes.
                                            • Take it at the same time every day.
                                            • Make sure you understand how to give yourself the injections.
                                            • Don't shake the vial or mix with another insulin. Store unopened vials in the refrigerator. Opened vials are good at room temperature for 28 days.
                                            • Check your blood sugar levels every day.
                                            • Take it with food to avoid upset stomach with diarrhea, nausea, and vomiting.
                                            • May cause headaches and cold-like symptoms.
                                            • Tell your doctor about any deep or rapid breathing, or persistent nausea, vomiting, and stomach pain.
                                            • Can be expensive depending on insurance coverage.
                                            • Check your blood sugar regularly.
                                            Learn more
                                            More about GlyburideSide effectsReviews & ratingsAlternativesFDA package insert
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