Prescription onlyClass: Pain

Horizant Alternatives

(Gabapentin Enacarbil)

Prescription onlyClass: Pain
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Compare Horizant (Gabapentin Enacarbil) to alternatives

These medications are comparable to Horizant (Gabapentin Enacarbil) or used for similar purposes.

Horizant
(Gabapentin Enacarbil)

Neurontin
(Gabapentin)

Neurontin
(Gabapentin)

Lyrica
(Pregabalin)

Pamelor
(Nortriptyline)

Lidoderm
(Lidocaine)

Calms leg movements and nerve pain. Horizant (Gabapentin Enacarbil) is a good way to treat pain since it can be used with other pain medications and it's not addictive. You'll need to stop drinking alcohol and it can be somewhat expensive.Treats tingling and burning nerve pain. Neurontin (Gabapentin) is an old seizure disorder medicine that's now used to treat nerve-related pain caused by different conditions.Treats tingling and burning nerve pain. Neurontin (Gabapentin) is an old seizure disorder medicine that's now used to treat nerve-related pain caused by different conditions.Treats nerve pain and prevents seizures. Lyrica (Pregabalin) works well as an add-on medicine for seizures and fibromyalgia, but it's especially effective for nerve-related pain after shingles. Not available as a generic, so it might be expensive.Improves your mood. Pamelor (Nortriptyline) is a good option for treating depression, especially for people who also have problems with persistent nerve pain.Treats nerve pain. Lidoderm (Lidocaine) patches work well by releasing a local anesthetic into the skin and relieving pain by targeting damaged nerves.
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Reviews & ratings
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Have you used Horizant (Gabapentin Enacarbil)?
Worth itNot sureNot worth it
Reviews for Neurontin (Gabapentin)
57%
-43% worse vs. Horizant (Gabapentin Enacarbil)
40%
-52% worse vs. Horizant (Gabapentin Enacarbil)
19%
-19% worse vs. Horizant (Gabapentin Enacarbil)
620 reviews
Have you used Neurontin (Gabapentin)?
Worth itNot sureNot worth it
Reviews for Lyrica (Pregabalin)
47%
-53% worse vs. Horizant (Gabapentin Enacarbil)
42%
-50% worse vs. Horizant (Gabapentin Enacarbil)
32%
-32% worse vs. Horizant (Gabapentin Enacarbil)
Have you used Lyrica (Pregabalin)?
Worth itNot sureNot worth it

Not enough reviews for this drug. Help someone out, leave a review!

Have you used Pamelor (Nortriptyline)?
Worth itNot sureNot worth it

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Have you used Lidoderm (Lidocaine)?
Worth itNot sureNot worth it
Side effects
HorizantNeurontinNeurontinLyricaPamelorLidocaine
  • Somnolence/sedation 14%
  • Dizziness 9%
  • Headache 1%
  • Nausea 1%
  • Fatigue 2%
  • Irritability 3%
  • Dry mouth 1%
  • Passing gas 3%
  • Increased appetite 2%
More Horizant side effects »
  • Dizziness 21%
  • Drowsiness 16%
  • Leg or ankle swelling 6%
  • Muscle weakness 1%
  • Diarrhea 2%
  • Infection 2%
  • Dry mouth 3%
  • Constipation 2%
  • Accidental injury 2%
  • Vomiting 2%
More Neurontin side effects »
  • Dizziness 21%
  • Drowsiness 16%
  • Leg or ankle swelling 6%
  • Muscle weakness 1%
  • Diarrhea 2%
  • Infection 2%
  • Dry mouth 3%
  • Constipation 2%
  • Accidental injury 2%
  • Vomiting 2%
More Neurontin side effects »
  • Nerve damage 6%
  • Dizziness 3%
  • Lack of muscle coordination 5%
  • Accidental injury 2%
  • Chest pain 3%
  • Leg or ankle swelling 2%
  • Muscle weakness 2%
  • Drowsiness 1%
  • Passing gas 2%
  • Dry mouth 2%
More Lyrica side effects »

We haven’t found good data for Pamelor side effects.

FDA side effect reports for Pamelor »

The Lidocaine FDA package insert doesn’t have numbers about how common side effects are.

More about Lidocaine side effects »
How it works
HorizantNeurontinNeurontinLyricaPamelorLidocaine
Horizant (Gabapentin Enacarbil) treats restless leg syndrome and pain caused by shingles by lowering your body's response to pain. It's used for long-lasting (chronic) pain and doesn't work for sudden (acute) pain.Neurontin (Gabapentin) is an antiepileptic and nerve pain reliever. Researchers don't know exactly how it works, but it has a similar structure to GABA, a neurotransmitter that calms nerves in the brain and spinal cord.Neurontin (Gabapentin) is an antiepileptic and nerve pain reliever. Researchers don't know exactly how it works, but it has a similar structure to GABA, a neurotransmitter that calms nerves in the brain and spinal cord.Lyrica (Pregabalin) is a nerve pain reliever. Researchers don't know exactly how it works, but it has a similar structure to GABA, a neurotransmitter that calms nerves in the brain and spinal cord.Pamelor (Nortriptyline) is a tricyclic antidepressant (TCA). It helps improve your mood by altering the levels of serotonin, norepinephrine, and other similar chemicals in your brain.Lidoderm (Lidocaine) is a local anesthetic. It absorbs into your skin where it targets damaged nerves and relieves burning pain.
Type of medication
HorizantNeurontinNeurontinLyricaPamelorLidocaine
Prescription only
Prescription only
Prescription only
Prescription only
Prescription only
Prescription only
Available as
HorizantNeurontinNeurontinLyricaPamelorLidocaine
  • Pill
  • Pill
  • Oral solution
  • Pill
  • Liquid
  • Pill
  • Liquid
  • Cream, gel, or ointment
  • Jelly
  • Spray
  • Topical solution
  • Patch
Used for
HorizantNeurontinNeurontinLyricaPamelorLidocaine
Risk factors for serious side effects
HorizantNeurontinNeurontinLyricaPamelorLidocaine
          • Stopping Horizant (Gabapentin Enacarbil) suddenly
          Detailed Horizant (Gabapentin Enacarbil) risks & warnings »
            • Children ages 3 to 12
              • Taking with alcohol or drugs
              • Stopping Neurontin (Gabapentin) suddenly
              Detailed Neurontin (Gabapentin) risks & warnings »
                • Children ages 3 to 12
                  • Taking with alcohol or drugs
                  • Stopping Neurontin (Gabapentin) suddenly
                  Detailed Neurontin (Gabapentin) risks & warnings »
                    • Taking with alcohol
                    • Taking other medicines that make you less alert
                    • History of unusual swelling (angioedema)
                    • Taking other medications that can angioedema
                    • History of cardiovascular disease
                    • Taking with certain diabetes medications
                    • Stopping Lyrica (Pregabalin) suddenly
                      • Both male and females taking Lyrica (Pregabalin)
                      Detailed Lyrica (Pregabalin) risks & warnings »
                      • Age 24 years or younger
                      • Age 65 years or older
                      • Stopping Pamelor (Nortriptyline) suddenly
                      • Using other medications that affect serotonin
                      • History of heart disease
                      • Older age
                      • Electrolyte imbalance
                      Detailed Pamelor (Nortriptyline) risks & warnings »
                      • Use of heating pad on skin
                      • Applying patch to red, irritated or broken skin
                      • Leaving patch on for more than 12 hours
                      • Using patch on a very large area
                      • Older age and lower body weight
                      • Liver disease
                      • Allergy to numbing medications (local anesthetics)
                      • Not disposing of Lidoderm (Lidocaine) correctly
                      • Children and pets can reach medication
                      • Not washing hands after touching or applying Lidoderm (Lidocaine)
                      • Applying Lidoderm (Lidocaine) to warm skin
                      • Covering patch with wrap or heating pad
                      • History of heart problems
                      • Using Lidoderm (Lidocaine) with drugs to treat irregular heartbeat
                      Detailed Lidoderm (Lidocaine) risks & warnings »
                      Pregnancy

                      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

                      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

                      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

                      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

                      The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

                      Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

                      Alcohol
                      HorizantNeurontinLyricaPamelorLidocaine
                      • Need to avoid alcohol while on Horizant (Gabapentin Enacarbil).
                      No alcohol related info.
                      • It's not safe to take this medication with alcohol or other drugs that make you drowsy.
                      No alcohol related info.No alcohol related info.
                      Food
                      HorizantNeurontinLyricaPamelorLidocaine
                      • Has to be taken with food.
                      • Swallow the pills whole and take with food.
                      • Take the extended-release tablet with food.
                      No food related info.
                      • Take it with food and/or at bedtime to decrease the potential side effects.
                      No food related info.
                      Pain
                      HorizantNeurontinLyricaPamelorLidocaine
                      • Can be used with other pain medications.
                      • Studies show it's most effective for nerve pain from diabetes, shingles, and fibromyalgia (a painful muscle condition).
                      • Has a higher risk than other pain medicines of affecting your heart rate or rhythm, so it might not be the best choice if you have cardiovascular disease (previous heart attack, stroke, fast/uncontrolled heart rate, or irregular heartbeat).
                      No pain related info.
                      • Lidoderm (Lidocaine) can treat pain better for people who can't take oral pain medications due to allergies or bad side effects.
                      • Has been shown to relieve nerve pain due to shingles for up to 12 hours at a time.
                      Sleep
                      HorizantNeurontinLyricaPamelorLidocaine
                      • Horizant (Gabapentin Enacarbil) can make you feel dizzy or sleepy for the first few days or weeks that you take it. Until your body has adjusted to the medication, be very careful getting up from sitting or lying down, and don't drive or use machinery.
                      • Neurontin (Gabapentin) is likely to cause some side effects, including memory problems, drowsiness, dizziness, or confusion.
                      • Lyrica (Pregabalin) is likely to cause some side effects, including memory problems, drowsiness, dizziness, and confusion.
                      • Can make you drowsy or dizzy.
                      No sleep related info.No sleep related info.
                      Upsides and benefits
                      HorizantNeurontinNeurontinLyricaPamelorLidocaine
                      • Not habit-forming or addictive.
                      • Can be used with other pain medications.
                      • Only has to be taken once or twice a day.
                      • Originally used to treat epilepsy (partial seizures), but now it primarily treats neuropathic pain that's caused by nerve stimulation or damage.
                      • Studies show it's most effective for nerve pain from diabetes, shingles, and fibromyalgia (a painful muscle condition).
                      • It's available as a generic, so it's less expensive than similar medications.
                      • Originally used to treat epilepsy (partial seizures), but now it primarily treats neuropathic pain that's caused by nerve stimulation or damage.
                      • Studies show it's most effective for nerve pain from diabetes, shingles, and fibromyalgia (a painful muscle condition).
                      • It's available as a generic, so it's less expensive than similar medications.
                      • Relieves nerve-related (neuropathic) pain caused by different conditions including diabetes, shingles (herpes zoster), fibromyalgia, and spinal cord damage.
                      • Studies show that lower doses of Lyrica (Pregabalin) cause fewer side effects and still relieve pain just as well as higher doses.
                      • Also used in combination with other medications to treat epilepsy (partial seizures).
                      • Helpful with treating certain types of pain, like migraines or nerve-related pain.
                      • Generally well tolerated and has fewer side effects than other medicines in the same class of drugs.
                      • Lidoderm (Lidocaine) can treat pain better for people who can't take oral pain medications due to allergies or bad side effects.
                      • Has been shown to relieve nerve pain due to shingles for up to 12 hours at a time.
                      • Patches can be cut into smaller pieces to best fit the areas of skin they need to be used on.
                      Downsides and risks
                      HorizantNeurontinNeurontinLyricaPamelorLidocaine
                      • Need to avoid alcohol while on Horizant (Gabapentin Enacarbil).
                      • Has to be taken with food.
                      • If you want to stop taking this medication, you need to talk to your doctor first since stopping it cold turkey can cause seizures.
                      • Not available as a generic.
                      • Neurontin (Gabapentin) is likely to cause some side effects, including memory problems, drowsiness, dizziness, or confusion.
                      • You can't skip or miss doses since suddenly stopping Neurontin (Gabapentin) can cause seizures. This is even more likely if you drink alcohol, so it might not be the best medication for heavy drinkers.
                      • Neurontin (Gabapentin) is likely to cause some side effects, including memory problems, drowsiness, dizziness, or confusion.
                      • You can't skip or miss doses since suddenly stopping Neurontin (Gabapentin) can cause seizures. This is even more likely if you drink alcohol, so it might not be the best medication for heavy drinkers.
                      • Not available as a generic, so it can be pricey.
                      • You can't skip or miss doses since suddenly stopping Lyrica (Pregabalin) can cause seizures.
                      • Lyrica (Pregabalin) is likely to cause some side effects, including memory problems, drowsiness, dizziness, and confusion.
                      • Has a higher risk than other pain medicines of affecting your heart rate or rhythm, so it might not be the best choice if you have cardiovascular disease (previous heart attack, stroke, fast/uncontrolled heart rate, or irregular heartbeat).
                      • Side effects are usually manageable, but can be annoying.
                      • Increases the risk of falls, especially when used in the elderly.
                      • There's an increased chance of it causing heart problems, especially in people with a history of heart problems.
                      • Can cause skin irritation after using it the first time, but for most people it's mild and goes away in a few minutes or hours.
                      • Used patches contain enough medicine to be dangerous to children and pets, so store and dispose of the patches in a safe place out of their reach.
                      • Might not be the best choice if you've had allergic reactions to numbing medications (local anesthetics) in the past.
                      • Even though only small amounts of Lidoderm (Lidocaine) are absorbed into the body through the skin, if you're taking medications that treat arrhythmias, Lidoderm (Lidocaine) can affect how they work.
                      • Patches shouldn't be left on for more than 12 hours, used on very large areas of skin, or covered with a heating pad.
                      Tips from our pharmacists for people taking the medication
                      HorizantNeurontinNeurontinLyricaPamelorLidocaine
                      • Don't stop taking Horizant (Gabapentin Enacarbil) suddenly without telling your doctor.
                      • Can make you feel dizzy or drowsy the first few days or weeks that you're taking it.
                      • Swallow the pills whole and take with food.
                      • Horizant (Gabapentin Enacarbil) is different from other forms of gabapentin (like Neurontin), so these two medications can't be switched or substituted for each other.
                      • Side effects are common, but usually manageable.
                      • Don't drive while taking Neurontin (Gabapentin) until you know how the medication affects you.
                      • Neurontin and generic forms of Gabapentin have the same ingredients as Gralise and Horizant, but are dosed differently. Make sure you know which form you're taking since they are used for different purposes.
                      • Take the extended-release tablet with food.
                      • Stop taking Neurontin (Gabapentin) slowly over at least one week to avoid getting withdrawal symptoms.
                      • Side effects are common, but usually manageable.
                      • Don't drive while taking Neurontin (Gabapentin) until you know how the medication affects you.
                      • Neurontin and generic forms of Gabapentin have the same ingredients as Gralise and Horizant, but are dosed differently. Make sure you know which form you're taking since they are used for different purposes.
                      • Take the extended-release tablet with food.
                      • Stop taking Neurontin (Gabapentin) slowly over at least one week to avoid getting withdrawal symptoms.
                      • Some people feel relief from pain in a week.
                      • Can make you drowsy or dizzy.
                      • Don't stop taking it suddenly without talking to your doctor. You'll need to slowly lower your dose over at least a week to avoid withdrawal symptoms.
                      • Tell your doctor if you have unexplained confusion or changes in your thoughts or behavior.
                      • It's not safe to take this medication with alcohol or other drugs that make you drowsy.
                      • Needs to be taken every day for 1 to 2 weeks to start feeling better, and for 6 to 8 weeks to see the full effect of the medication.
                      • It's important to keep taking Pamelor (Nortriptyline) even when you feel your symptoms are getting better.
                      • Take it with food and/or at bedtime to decrease the potential side effects.
                      • Tell your doctor if you notice sudden mood changes or unusual thoughts.
                      • If you decide to stop taking Pamelor (Nortriptyline), work with your doctor to slowly get off this medicine to avoid getting withdrawal symptoms.
                      • Starts working with the first dose, but full effects can take longer.
                      • Remove the protective lining on the patch before applying the patch to unbroken skin.
                      • Leave the patch on for up to 12 hours during a 24 hour period.
                      • You can cut the patches to create a custom fit for the area of skin you need to apply it to.
                      • Don't place any tight wraps or heating pads over the patch while it's on.
                      • Make sure not to touch your eyes after touching the patch. Always wash your hands after putting it on or taking it off.
                      Learn more
                      More about HorizantSide effectsReviews & ratingsAlternativesFDA package insert
                      Have you used Horizant (Gabapentin Enacarbil)?
                      Worth itNot sureNot worth it
                      More about NeurontinSide effectsReviews & ratingsFDA package insert
                      Have you used Neurontin (Gabapentin)?
                      Worth itNot sureNot worth it
                      More about NeurontinSide effectsReviews & ratingsFDA package insert
                      Have you used Neurontin (Gabapentin)?
                      Worth itNot sureNot worth it
                      More about LyricaSide effectsReviews & ratingsFDA package insert
                      Have you used Lyrica (Pregabalin)?
                      Worth itNot sureNot worth it
                      More about PamelorSide effectsReviews & ratingsFDA package insert
                      Have you used Pamelor (Nortriptyline)?
                      Worth itNot sureNot worth it
                      More about LidocaineSide effectsReviews & ratingsFDA package insert
                      Have you used Lidoderm (Lidocaine)?
                      Worth itNot sureNot worth it