Prescription onlyLower-cost generic availableClass: Cardiovascular

Microzide Alternatives

(Hydrochlorothiazide )

Prescription onlyLower-cost generic availableClass: Cardiovascular
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Compare Microzide (Hydrochlorothiazide (Hctz)) to alternatives

These medications are comparable to Microzide (Hydrochlorothiazide (Hctz)) or used for similar purposes.

Microzide
(Hydrochlorothiazide )

Lasix
(Furosemide)

Zestril
(Lisinopril)

Aldactone
(Spironolactone)

Edecrin
(Ethacrynic Acid)

Lanoxin
(Digoxin)

Lowers blood pressure. Removes extra water from your body. Microzide (Hydrochlorothiazide (Hctz)) is a well-tolerated water pill that's often the first-choice treatment for mild high blood pressure.Lowers blood pressure. Removes extra water from your body. Lasix (Furosemide) is a very effective water pill and it'll certainly make you go to the bathroom more often.Lowers blood pressure. Zestril (Lisinopril) is a good blood pressure-lowering medicine that protects kidney function.Removes extra water from your body. Aldactone (Spironolactone) should be used with other medicines to get rid of excess fluid in your body, especially if you have heart failure.Coming soon.Improves heart pumping. Digoxin is a good backup for treating heart failure symptoms, but it doesn't, by itself, lower your risk of death.
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Reviews & ratings
Filter group. All currently selected
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4.48Hydrochlorothiazide
Reviews for Microzide (Hydrochlorothiazide (Hctz))
47%
of people (All ages) say Microzide (Hydrochlorothiazide (Hctz)) is worth it
31%
say it works well
16%
say it's a big hassle
139 reviews
Have you used Microzide (Hydrochlorothiazide (Hctz))?
Worth itNot sureNot worth it
Reviews for Lasix (Furosemide)
67%
+20% better vs. Microzide (Hydrochlorothiazide (Hctz))
47%
+16% better vs. Microzide (Hydrochlorothiazide (Hctz))
16%
Same vs. Microzide (Hydrochlorothiazide (Hctz))
371 reviews
Have you used Lasix (Furosemide)?
Worth itNot sureNot worth it
Reviews for Zestril (Lisinopril)
61%
+14% better vs. Microzide (Hydrochlorothiazide (Hctz))
51%
+20% better vs. Microzide (Hydrochlorothiazide (Hctz))
14%
+2% better vs. Microzide (Hydrochlorothiazide (Hctz))
687 reviews
Have you used Zestril (Lisinopril)?
Worth itNot sureNot worth it

Not enough reviews for this drug. Help someone out, leave a review!

Have you used Aldactone (Spironolactone)?
Worth itNot sureNot worth it

Not enough reviews for this drug. Help someone out, leave a review!

Have you used Edecrin (Ethacrynic Acid)?
Worth itNot sureNot worth it
Reviews for Lanoxin (Digoxin)
64%
+17% better vs. Microzide (Hydrochlorothiazide (Hctz))
43%
+12% better vs. Microzide (Hydrochlorothiazide (Hctz))
31%
-15% worse vs. Microzide (Hydrochlorothiazide (Hctz))
Have you used Lanoxin (Digoxin)?
Worth itNot sureNot worth it
Side effects
HydrochlorothiazideLasixLisinoprilAldactoneEdecrinDigoxin

The Hydrochlorothiazide FDA package insert doesn’t have numbers about how common side effects are.

More about Hydrochlorothiazide side effects »

The Lasix FDA package insert doesn’t have numbers about how common side effects are.

More about Lasix side effects »
  • Headache 4%
  • Dizziness 3%
  • Cough 3%
  • Diarrhea 1%
  • Fatigue 2%
  • Infection 2%
  • Low blood pressure 4%
  • Chest pain 2%
More Lisinopril side effects »

The Aldactone FDA package insert doesn’t have numbers about how common side effects are.

More about Aldactone side effects »

We haven’t found good data for Edecrin side effects.

FDA side effect reports for Edecrin »
  • Any side effect 20%
  • Dizziness 1%
  • Mental disturbances 4%
  • Nausea 1%
  • Diarrhea 3%
  • Death 1%
  • Side effects requiring hospitalization 1%
  • Abnormally fast heart beat 2%
  • Vomiting 2%
More Digoxin side effects »
How it works
HydrochlorothiazideLasixLisinoprilAldactoneEdecrinDigoxin
Microzide (Hydrochlorothiazide (Hctz)) is a thiazide diuretic (water pill). It works in the kidneys to make you urinate more, which removes extra water and certain electrolytes. This lowers blood pressure and swelling.Lasix (Furosemide) is a loop diuretic (water pill). It works in the kidneys to make you urinate more, which removes extra water and certain electrolytes. This lowers blood pressure and swelling.Zestril (Lisinopril) is an angiotensin converting enzyme (ACE) inhibitor. It blocks a chemical that tightens blood vessels. This makes blood vessels relax, which lowers blood pressure and allows more blood and oxygen to get to your heart and other organs.Aldactone (Spironolactone) is a potassium-sparing diuretic that blocks aldosterone (a hormone) and helps the kidney get rid of excess fluids in your body.Coming soon.Digoxin helps your heart work more efficiently. It makes your heart pump slower and stronger, which helps it get more blood and oxygen out to your body and organs.
Type of medication
HydrochlorothiazideLasixLisinoprilAldactoneEdecrinDigoxin
Prescription only
Prescription only
Prescription only
Prescription only
Prescription only
Available as
HydrochlorothiazideLasixLisinoprilAldactoneEdecrinDigoxin
  • Pill
  • Pill
  • Liquid
  • Pill
  • Pill
  • Pill
  • Pill
  • Liquid
Used for
HydrochlorothiazideLasixLisinoprilAldactoneEdecrinDigoxin
  • Edema
Risk factors for serious side effects
HydrochlorothiazideLasixLisinoprilAldactoneEdecrinDigoxin
  • Current electrolyte imbalance
  • History of sulfa allergies
  • History of gout
  • Current kidney problems
    Detailed Microzide (Hydrochlorothiazide (Hctz)) risks & warnings »
    • Current electrolyte imbalance
    • History of sulfa allergies
    • Current kidney problems
    • Dose too high
    • Low blood protein
    • Other medicines that causes hearing problems
    Detailed Lasix (Furosemide) risks & warnings »
    • Women of childbearing age
      • African descent
      • Current kidney problems
      • Medicine that increase potassium
      • Use of salt substitute
      Detailed Zestril (Lisinopril) risks & warnings »
        • Taking with alcohol
        • Taking other medicines that lower your blood pressure
        • Current kidney problems
        • Taking other medicines that increase potassium
        • Use of salt substitutes
          Detailed Aldactone (Spironolactone) risks & warnings »
          Coming soon.
          • History of heart problems
          • Drug interactions
          • Wolff-Parkinson-White syndrome
          • Low body weight, advanced age, impaired renal function, electrolyte imbalances
          • Overactive or underactive thyroid
          • Aspirin allergy
          • Electrocardioversion
          Detailed Lanoxin (Digoxin) risks & warnings »
          Pregnancy

          Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

          Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

          Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

          Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

          Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

          Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

          Interactions
          HydrochlorothiazideLasixLisinoprilAldactoneEdecrinDigoxin
          No interactions related info.No interactions related info.No interactions related info.No interactions related info.No interactions related info.
          • Tell your doctor about other medicines you're taking to avoid drug interactions.
          Kidneys and liver
          HydrochlorothiazideLasixLisinoprilAldactoneEdecrinDigoxin
          • Requires routine blood tests to check kidney function.
          • Requires routine blood tests to check kidney function.
          • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
          • Requires routine blood tests to check kidney function.
          • You'll need to have blood tests done regularly since Aldactone (Spironolactone) can affect your potassium levels and kidneys.
          No kidneys and liver related info.No kidneys and liver related info.
          Pain
          HydrochlorothiazideLasixLisinoprilAldactoneEdecrinDigoxin
          No pain related info.No pain related info.No pain related info.
          • It can cause breast pain/swelling, irregular periods (women), or trouble with sexual performance.
          No pain related info.No pain related info.
          Upsides and benefits
          HydrochlorothiazideLasixLisinoprilAldactoneEdecrinDigoxin
          • Works well to get rid of extra fluids in your body through urination.
          • A first-choice blood pressure treatment for many people. Works especially well for African Americans.
          • Lowers the risk of heart attack and stroke.
          • Good option if you have both high blood pressure and heart failure.
          • Raises calcium levels in the body, so it can be good for people with osteoporosis to slow down bone loss and even help with new bone formation.
          • Most people have very few side effects.
          • A strong diuretic (water pill) that works well to get rid of extra fluids in your body through urination.
          • Lowers your blood pressure and your risk of heart attack and stroke.
          • Works better than thiazide diuretics (like Hydrochlorothiazide) at removing harmful levels of certain electrolytes, such as potassium.
          • Okay to take if you have kidney problems.
          • A first-choice blood pressure treatment for many people.
          • Lowers the risk of heart attack and stroke.
          • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
          • Recommended for anyone with heart failure since it lowers the risk of death and further damage to your heart.
          • Has a low risk of causing muscle problems from low potassium levels in your blood.
          • More useful when taken with another diuretic that'll also help your body get rid of extra fluids.
          • Can lower blood pressure.
          • Reduces the risk of death in people with heart failure.
          Coming soon
          • Used for some abnormal heart rhythms, and for heart failure that can't be controlled by other medications.
          • Relieves shortness of breath, and makes it easier to be active without having symptoms.
          • In studies, Digoxin lowered the risk of having to be admitted to the hospital for worsening heart failure.
          Downsides and risks
          HydrochlorothiazideLasixLisinoprilAldactoneEdecrinDigoxin
          • Makes you urinate more often.
          • Doesn't work well in people with severe kidney problems.
          • Makes you urinate very frequently.
          • Can cause low levels of important electrolytes, such as potassium.
          • Up to 1 in 10 people can get a dry cough with this medicine. It ranges from a mild tickle in the throat to a persistent hacking cough.
          • Requires a yearly blood test to see how the medicine is affecting your body.
          • Not safe to use if you're pregnant.
          • Aldactone (Spironolactone) doesn't work well on its own. It should be used with another drug to help get rid of excess fluids.
          • Has many possible side effects, especially when higher doses are used.
          • Can increase the risk of tumor growth.
          • You'll need to have blood tests done regularly since Aldactone (Spironolactone) can affect your potassium levels and kidneys.
          Coming soon
          • For heart failure, relieves symptoms, but does not lower the risk of death. That's why it's usually used together with other heart failure medicines that do lower the risk of death.
          • Requires blood tests, especially during the first few weeks of treatment.
          Tips from our pharmacists for people taking the medication
          HydrochlorothiazideLasixLisinoprilAldactoneEdecrinDigoxin
          • Starts working in about 2 hours.
          • Makes you urinate more often, so avoid taking it at bedtime.
          • Can cause dizziness in the first few days.
          • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
          • Tell your doctor about any dizziness, fatigue, or muscle weakness that doesn't go away.
          • Requires routine blood tests to check kidney function.
          • Starts working in 30 minutes.
          • Makes you urinate more often, so avoid taking it at bedtime.
          • Can cause dizziness in the first few days.
          • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
          • Tell your doctor about any dizziness, fatigue, or muscle weakness that doesn't go away.
          • Requires routine blood tests to check kidney function.
          • Can cause dizziness in the first few days.
          • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
          • Tell your doctor about any dizziness, fatigue, cough, or throat irritation that doesn't go away.
          • Requires routine blood tests to check kidney function.
          • Don't take it if you're pregnant.
          • Can make you dizzy or cause trouble concentrating, so be careful using it until you know how the medicine affects you.
          • Don't use supplements or salt substitutes that are high in potassium.
          • It can cause breast pain/swelling, irregular periods (women), or trouble with sexual performance.
          • Tell your doctor about any muscle weakness, skin changes, and red or black tarry stool.
          • You will urinate more often within 2 to 3 days, and will have lower blood pressure in 2 to 3 weeks.
          Coming soon
          • Take it at the same time every day.
          • Drink plenty of water while taking this medicine.
          • Requires routine blood tests to make sure you have the right amount of Digoxin in your body.
          • Tell your doctor about other medicines you're taking to avoid drug interactions.
          Learn more
          More about HydrochlorothiazideSide effectsReviews & ratingsAlternativesFDA package insert
          Have you used Microzide (Hydrochlorothiazide (Hctz))?
          Worth itNot sureNot worth it
          More about LasixSide effectsReviews & ratingsFDA package insert
          Have you used Lasix (Furosemide)?
          Worth itNot sureNot worth it
          More about LisinoprilSide effectsReviews & ratingsFDA package insert
          Have you used Zestril (Lisinopril)?
          Worth itNot sureNot worth it
          More about AldactoneSide effectsReviews & ratingsFDA package insert
          Have you used Aldactone (Spironolactone)?
          Worth itNot sureNot worth it
          More about EdecrinSide effectsFDA package insert
          Have you used Edecrin (Ethacrynic Acid)?
          Worth itNot sureNot worth it
          More about DigoxinSide effectsReviews & ratingsFDA package insert
          Have you used Lanoxin (Digoxin)?
          Worth itNot sureNot worth it