Prescription onlyLower-cost generic availableClass: Respiratory

Tussionex Pennkinetic 

(hydrocodone / chlorpheniramine)

Prescription onlyLower-cost generic availableClass: Respiratory
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Relieves cough.

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Our bottom line

Tussionex Pennkinetic (Hydrocodone / Chlorpheniramine) works well to relieve cough and allergy or cold symptoms, but since it's a schedule II (CII) drug, you’ll have to go back to the doctor if you need a refill.

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  • Tussionex Pennkinetic (Hydrocodone / Chlorpheniramine) is a combination opioid (hydrocodone) and antihistamine (chlorpheniramine) medicine that relieves cough and upper respiratory (nose, throat, and sinus) symptoms.
  • The long-acting forms (suspension and capsule) are best if you need all-day relief. The shorter acting solution is a good choice if you need it to work faster.
  • In addition to relieving your cough, it may help you fall asleep easier.
  • The antihistamine, chlorpheniramine, can help dry out your nose and prevent cough from post-nasal drip.


  • Tussionex Pennkinetic (Hydrocodone / Chlorpheniramine) is a controlled substance (CII) because it contains hydrocodone, a medicine with a high risk of abuse. You'll need to keep it in a safe place to avoid it being taken by others.
  • Constipation is very common, so you'll need to drink enough water and stool softeners while on it.
  • All opioid medicines have the risk of causing physical dependence and withdrawal when you stop using it.
  • None of the dosage forms of Tussionex Pennkinetic (Hydrocodone / Chlorpheniramine) are safe to give to children younger than 6 years. It can cause really slow breathing in children that can lead to death.
How it works

Tussionex Pennkinetic (Hydrocodone / Chlorpheniramine) is a combination medicine that treats cough, allergy, and cold symptoms. Hydrocodone is an opioid (similar to codeine) that relieves pain and works in the brain to control cough. Chlorpheniramine (an antihistamine) treats nasal allergy symptoms.

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Side effect rates for Tussionex Pennkinetic (hydrocodone / chlorpheniramine)

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These are side effects of Tussionex Pennkinetic (hydrocodone / chlorpheniramine) reported to the FDA by people taking it, and by doctors and pharmacists.
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Risks and Warnings for Tussionex Pennkinetic (hydrocodone / chlorpheniramine)

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    • Higher risk if:
    • Current use of medicine that affects liver enzyme CYP 3A4
    • Age 65 or greater
    • Higher doses
    • People with low thyroid hormones
    • History of lung problems

    Taking too much Tussionex Pennkinetic (Hydrocodone / Chlorpheniramine) can cause irregular or slow breathing that can put you in a coma and can cause death. TussiCaps should be swallowed whole, don't ever crush or chew. Don't take more than 2 doses Tussionex or TussiCaps in a 24 hour period. If your lips and fingers start turning blue from low oxygen, see a doctor immediately. In the hospital, doctors can give you a medicine that reverses the effects of Tussionex Pennkinetic (Hydrocodone / Chlorpheniramine). Don't take more than your doctor prescribes. Always check with your doctor before starting any new medicines or supplements.

Common concerns from people taking Tussionex Pennkinetic (hydrocodone / chlorpheniramine)

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  • In addition to relieving your cough, it may help you fall asleep easier.