Prescription onlyLower-cost generic available

Tussionex Pennkinetic

(Hydrocodone / Chlorpheniramine)

  • Extended release
  • Liquid
  • Liquid extended release
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Relieves cough.

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Prescription onlyLower-cost generic available

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Tussionex Pennkinetic (Hydrocodone / Chlorpheniramine) works well to relieve cough and allergy or cold symptoms, but since it's a schedule II (CII) drug, you’ll have to go back to the doctor if you need a refill.


  • Tussionex Pennkinetic (Hydrocodone / Chlorpheniramine) is a combination opioid (hydrocodone) and antihistamine (chlorpheniramine) medicine that relieves cough and upper respiratory (nose, throat, and sinus) symptoms.
  • The long-acting forms (suspension and capsule) are best if you need all-day relief. The shorter acting solution is a good choice if you need it to work faster.
  • In addition to relieving your cough, it may help you fall asleep easier.
  • The antihistamine, chlorpheniramine, can help dry out your nose and prevent cough from post-nasal drip.


  • Tussionex Pennkinetic (Hydrocodone / Chlorpheniramine) is a controlled substance (CII) because it contains hydrocodone, a medicine with a high risk of abuse. You'll need to keep it in a safe place to avoid it being taken by others.
  • Constipation is very common, so you'll need to drink enough water and stool softeners while on it.
  • All opioid medicines have the risk of causing physical dependence and withdrawal when you stop using it.
  • None of the dosage forms of Tussionex Pennkinetic (Hydrocodone / Chlorpheniramine) are safe to give to children younger than 6 years. It can cause really slow breathing in children that can lead to death.

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What to expect when you take Tussionex Pennkinetic (Hydrocodone / Chlorpheniramine)

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Tips from our pharmacists
  • It’s available in different dosage forms. Tussionex suspension and TussiCaps capsules are long-acting and dosed every 12 hours, while Vituz is short-acting and dosed every 4 to 6 hours as needed.
  • Can make you dizzy or drowsy, so avoid activities where you need to be fully alert until you know how it affects you.
  • To prevent taking too much, use the oral syringe that comes with the solution and don’t use a household teaspoon or tablespoon.
  • Constipation is common, so drink lots of water and use stool softeners if necessary.
  • Use it for the shortest time possible, since it can cause dependence.
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Side effects for Tussionex Pennkinetic (Hydrocodone / Chlorpheniramine)

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These are side effects of Tussionex Pennkinetic (Hydrocodone / Chlorpheniramine) reported to the FDA by people taking it, and by doctors and pharmacists.

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Risks and Warnings for Tussionex Pennkinetic (Hydrocodone / Chlorpheniramine)

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    • Higher risk if:
    • Current use of medicine that affects liver enzyme CYP 3A4
    • Age 65 or greater
    • Higher doses
    • People with low thyroid hormones
    • History of lung problems

    Taking too much Tussionex Pennkinetic (Hydrocodone / Chlorpheniramine) can cause irregular or slow breathing that can put you in a coma and can cause death. TussiCaps should be swallowed whole, don't ever crush or chew. Don't take more than 2 doses Tussionex or TussiCaps in a 24 hour period. If your lips and fingers start turning blue from low oxygen, see a doctor immediately. In the hospital, doctors can give you a medicine that reverses the effects of Tussionex Pennkinetic (Hydrocodone / Chlorpheniramine). Don't take more than your doctor prescribes. Always check with your doctor before starting any new medicines or supplements.

Means that some groups have a high risk of experiencing this side effect

Tips from pharmacists and people taking Tussionex Pennkinetic (Hydrocodone / Chlorpheniramine)

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The FDA category for this medication is C. It is advised that you: Weigh risks vs. benefits
  • Tips from our pharmacists
  • Can make you dizzy or drowsy, so avoid activities where you need to be fully alert until you know how it affects you.
  • You have to take the dosage exactly. I have found this is the only product that will work for me when I have a cough. It allows me to sleep through the night where no other cough medicine has helped.
  • Risks from our pharmacists
  • Tussionex Pennkinetic (Hydrocodone / Chlorpheniramine) passes into breast milk. Women with a history of long-term opioid use increase the risk of neonatal withdrawal syndrome. Symptoms in the newborn include irritability, vomiting, diarrhea, tremor, and lack of weight gain. Opioid withdrawal in infants is a life-threatening emergency and needs immediate medical care.