Over-the-counterLower-cost generic available

Anusol Hc Alternatives

(Hydrocortisone)

  • Cream, gel, or ointment
  • Lotion
  • Topical solution
  • Skin inflammation
  • Itching
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Compare Anusol Hc (Hydrocortisone) to alternatives

These medications are comparable to Anusol Hc (Hydrocortisone) or used for similar purposes.

Anusol Hc
(Hydrocortisone)

Cortisone

Benadryl
(Diphenhydramine)

Atarax
(Hydroxyzine Hydrochloride)

Treats itchy or irritated skin. Anusol Hc (Hydrocortisone) is a good topical steroid to try for treating minor rashes or skin irritation.Coming soon.Treats allergy symptoms and helps you sleep. Benadryl (Diphenhydramine) is great for allergies, but curl up on the couch after taking it and get ready for a nap.Relieves anxiety and itching caused by allergic reactions. Atarax (Hydroxyzine Hydrochloride) is an effective treatment for the itching caused by an allergic reaction. It can also help treat mild anxiety.
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Reviews & ratings
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Reviews for Benadryl (Diphenhydramine)
85%
+35% vs. Anusol Hc (Hydrocortisone)
57%
+7% vs. Anusol Hc (Hydrocortisone)
8%
8% vs. Anusol Hc (Hydrocortisone)
Reviews for Atarax (Hydroxyzine Hydrochloride)
77%
+27% vs. Anusol Hc (Hydrocortisone)
73%
+23% vs. Anusol Hc (Hydrocortisone)
9%
9% vs. Anusol Hc (Hydrocortisone)
Side effects
HydrocortisonecortisoneBenadrylAtarax

We haven’t found good data for Hydrocortisone side effects.

FDA side effect reports for Hydrocortisone »

We haven’t found good data for cortisone side effects.

FDA side effect reports for cortisone »

We haven’t found good data for Benadryl side effects.

FDA side effect reports for Benadryl »

We haven’t found good data for Atarax side effects.

FDA side effect reports for Atarax »
How it works
HydrocortisonecortisoneBenadrylAtarax
Anusol Hc (Hydrocortisone) is a topical steroid that works by decreasing skin itching, swelling, and redness.Coming soon.Benadryl (Diphenhydramine) is an antihistamine. It blocks histamine, a chemical that causes congestion, itching, and other allergic reactions. It also makes you sleepy.Atarax (Hydroxyzine Hydrochloride) is an antihistamine. It treats allergy symptoms by stopping the effects of histamine in the body. It's also used to control anxiety before surgery.
Type of medication
HydrocortisonecortisoneBenadrylAtarax
CorticosteroidOver-the-counter
Coming soon.
Antihistamine
1st generation
Prescription or OTC
Antihistamine
1st generation
Prescription only
Available as
HydrocortisonecortisoneBenadrylAtarax
  • Cream, gel, or ointment
  • Lotion
  • Topical solution
  • Pill
  • Pill
  • Oral solution
  • Cream, gel, or ointment
  • Pill
  • Liquid
Used for (click to learn more)
HydrocortisonecortisoneBenadrylAtarax
  • Skin inflammation
  • Acute lymphoid leukemia Adrenal insufficiency Allergic disorder Chronic lymphoid leukemia Collagen disease Disorder of endocrine system Disorder of eye Disorder of gastrointestinal tract Disorder of hematopoietic structure Disorder of respiratory system Disorder of skin Hodgkin's disease Hypercalcemia of malignancy Inflammatory disorder of musculoskeletal system Mycosis fungoides Neoplastic disease Nephrotic syndrome Non-Hodgkin's lymphoma Trichinosis Tuberculosis of meninges; Adjunct
Risk factors for serious side effects
HydrocortisonecortisoneBenadrylAtarax
  • Long-term treatment
  • Not vaccinated against viral diseases
  • Contact with people who have viral illness
  • History of bacterial or viral conditions
  • Long-term treatment
  • Dose of Anusol Hc (Hydrocortisone)
  • Duration of treatment
Detailed Anusol Hc (Hydrocortisone) risks & warnings »
Coming soon.Coming soon.Coming soon.
Pregnancy category
HydrocortisonecortisoneBenadrylAtarax
CFDA pregnancy category (Weigh risks vs. benefits)

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

See the FDA package insert
DFDA pregnancy category (Weigh risks vs. benefits)

Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

See the FDA package insert
BFDA pregnancy category (Probably safe)

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

See the FDA package insert
NFDA pregnancy category (Unknown)

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

See the FDA package insert
Alcohol
No specific alcohol-related info.No specific alcohol-related info.
  • Don't take it with alcohol or other drugs that make you sleepy.
  • Atarax (Hydroxyzine Hydrochloride) can be used to treat mild cases of anxiety, and for alcohol withdrawal.
  • Can cause drowsiness or dizziness. Atarax (Hydroxyzine Hydrochloride) shouldn't be mixed with other medicines that cause drowsiness like other antihistamines, pain or sleep medications or alcohol.
Food
No specific food-related info.No specific food-related info.No specific food-related info.
  • It can be taken with or without food.
Kidneys and liver
No specific kidneys and liver-related info.No specific kidneys and liver-related info.No specific kidneys and liver-related info.
  • The dose of Atarax (Hydroxyzine Hydrochloride) should be reduced for people who are older or who have reduced liver or kidney function.
Sex
No specific sex-related info.No specific sex-related info.No specific sex-related info.No specific sex-related info.
Sleep
No specific sleep-related info.No specific sleep-related info.
  • Benadryl (Diphenhydramine) makes you tired, so take it before you go to sleep.
  • Shouldn't take other medicines that cause drowsiness or dizziness.
  • Can cause drowsiness or dizziness. Atarax (Hydroxyzine Hydrochloride) shouldn't be mixed with other medicines that cause drowsiness like other antihistamines, pain or sleep medications or alcohol.
Weight
No specific weight-related info.No specific weight-related info.No specific weight-related info.No specific weight-related info.
Upsides and benefits
HydrocortisonecortisoneBenadrylAtarax
  • Relieves itchy and irritated skin.
  • Doesn't cause the same types of side effects that oral forms of steroids do.
  • It's available over the counter in the drugstore.
  • Most people have very few side effects.
Coming soon.
  • Benadryl (Diphenhydramine) is often better than other antihistamines at treating allergy symptoms and hives.
  • It can provide quick relief of allergy symptoms for both kids and adults.
  • It makes you sleepy, so it'll help if your allergies are bothering you at night.
  • The effects wear off in 4 to 6 hours, so side effects don't last that long.
  • It comes as a tablet, capsule, liquid, and quick dissolving tablet.
  • Atarax (Hydroxyzine Hydrochloride) can be used to treat mild cases of anxiety, and for alcohol withdrawal.
  • Can be a better option for some people to treat anxiety than more addicting medications like benzodiazepines.
  • Atarax (Hydroxyzine Hydrochloride) is available as a liquid or as tablets.
  • It can be taken with or without food.
Downsides and risks
HydrocortisonecortisoneBenadrylAtarax
  • It's not a strong steroid, so it doesn't work for everyone.
  • When used longer than a week, it can cause skin-thinning and make it harder for broken skin to heal.
Coming soon.
  • Benadryl (Diphenhydramine) makes you more tired than Claritin, Allegra, or Zyrtec.
  • You shouldn't drive after taking Benadryl (Diphenhydramine) until you know how it affects you.
  • Talk to a pediatrician before giving Benadryl (Diphenhydramine) to a child.
  • It can increase the risk of falls, so elderly people shouldn't use Benadryl (Diphenhydramine).
  • Don't use Benadryl (Diphenhydramine) if you are breastfeeding.
  • The dose of Atarax (Hydroxyzine Hydrochloride) should be reduced for people who are older or who have reduced liver or kidney function.
  • Atarax (Hydroxyzine Hydrochloride) can cause confusion, dry mouth, constipation, and urinary side effects. These symptoms are worse in older people.
  • As with some medicines, the tablets contain lactose. If you’re lactose intolerant, you could be sensitive to this.
  • Not recommended if you’re pregnant or breastfeeding.
  • Shouldn't take other medicines that cause drowsiness or dizziness.
Tips from our pharmacists for people taking the medication
HydrocortisonecortisoneBenadrylAtarax
  • Rub a thin layer of Anusol Hc (Hydrocortisone) into the area of skin that is affected.
  • Don't rub it into broken areas of skin and leave the area uncovered.
  • Wash your hands after applying it each time.
  • Don't use Anusol Hc (Hydrocortisone) more often than your doctor or the package label recommends.
  • Wait at least 30 minutes between applying moisturizing lotions and this medication.
  • Talk to your doctor if your skin gets worse or hasn't improved in seven days.
Coming soon.
  • Take it as needed every 4 to 6 hours.
  • Benadryl (Diphenhydramine) can make you dehydrated, so avoid this side effect by drinking plenty of fluids.
  • Benadryl (Diphenhydramine) makes you tired, so take it before you go to sleep.
  • Don't take it with alcohol or other drugs that make you sleepy.
  • If you need to use it for more than a few weeks, talk with your doctor. A different medication might work better for you long-term.
  • If you only have itchy or watery eyes, try using just an antihistamine eye drop.
  • Atarax (Hydroxyzine Hydrochloride) shouldn't be taken if you're taking other medications that slow down the nervous system, like narcotics and barbiturates.
  • Can cause drowsiness or dizziness. Atarax (Hydroxyzine Hydrochloride) shouldn't be mixed with other medicines that cause drowsiness like other antihistamines, pain or sleep medications or alcohol.
  • Side effects are more likely in older adults and young children.
  • Takes about 2 hours for full antihistamine effect if you’re taking it for itching or rash.
Learn more
More about HydrocortisoneSide effectsReviews & ratingsAlternativesFDA package insert
More about cortisoneSide effectsReviews & ratingsFDA package insert
More about BenadrylSide effectsReviews & ratingsFDA package insert
More about AtaraxSide effectsReviews & ratingsFDA package insert