Over-the-counterLower-cost generic availableClass: Dermatologic

Anusol Hc Alternatives

(Hydrocortisone)

Over-the-counterLower-cost generic availableClass: Dermatologic
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Compare Anusol Hc (Hydrocortisone) to alternatives

These medications are comparable to Anusol Hc (Hydrocortisone) or used for similar purposes.

Anusol Hc
(Hydrocortisone)

Cortisone

Benadryl
(Diphenhydramine)

Atarax
(Hydroxyzine Hydrochloride)

Treats itchy or irritated skin. Anusol Hc (Hydrocortisone) is a good topical steroid to try for treating minor rashes or skin irritation.Coming soon.Treats allergy symptoms and helps you sleep. Benadryl (Diphenhydramine) is great for allergies, but curl up on the couch after taking it and get ready for a nap.Relieves anxiety and itching caused by allergic reactions. Atarax (Hydroxyzine Hydrochloride) is an effective treatment for the itching caused by an allergic reaction. It can also help treat mild anxiety.
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Reviews & ratings
Filter group. All currently selected
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Not enough reviews for this drug. Help someone out, leave a review!

Have you used Anusol Hc (Hydrocortisone)?
Worth itNot sureNot worth it

Not enough reviews for this drug. Help someone out, leave a review!

Have you used Cortisone?
Worth itNot sureNot worth it
Reviews for Benadryl (Diphenhydramine)
86%
+36% better vs. Anusol Hc (Hydrocortisone)
59%
+9% better vs. Anusol Hc (Hydrocortisone)
8%
-8% worse vs. Anusol Hc (Hydrocortisone)
294 reviews
Have you used Benadryl (Diphenhydramine)?
Worth itNot sureNot worth it
Reviews for Atarax (Hydroxyzine Hydrochloride)
79%
+29% better vs. Anusol Hc (Hydrocortisone)
68%
+18% better vs. Anusol Hc (Hydrocortisone)
9%
-9% worse vs. Anusol Hc (Hydrocortisone)
Have you used Atarax (Hydroxyzine Hydrochloride)?
Worth itNot sureNot worth it
Side effects
HydrocortisoneCortisoneBenadrylAtarax

We haven’t found good data for Hydrocortisone side effects.

FDA side effect reports for Hydrocortisone »

We haven’t found good data for Cortisone side effects.

FDA side effect reports for Cortisone »

We haven’t found good data for Benadryl side effects.

FDA side effect reports for Benadryl »

We haven’t found good data for Atarax side effects.

FDA side effect reports for Atarax »
How it works
HydrocortisoneCortisoneBenadrylAtarax
Anusol Hc (Hydrocortisone) is a topical steroid that works by decreasing skin itching, swelling, and redness.Coming soon.Benadryl (Diphenhydramine) is an antihistamine. It blocks histamine, a chemical that causes congestion, itching, and other allergic reactions. It also makes you sleepy.Atarax (Hydroxyzine Hydrochloride) is an antihistamine. It treats allergy symptoms by stopping the effects of histamine in the body. It's also used to control anxiety before surgery.
Type of medication
HydrocortisoneCortisoneBenadrylAtarax
Over-the-counter
Prescription or OTC
Prescription only
Available as
HydrocortisoneCortisoneBenadrylAtarax
  • Cream, gel, or ointment
  • Lotion
  • Topical solution
  • Pill
  • Pill
  • Oral solution
  • Cream, gel, or ointment
  • Pill
  • Liquid
Used for
HydrocortisoneCortisoneBenadrylAtarax
  • Skin Inflammation
  • Acute Lymphoid Leukemia Adrenal Insufficiency Allergic Disorder Chronic Lymphoid Leukemia Collagen Disease Disorder Of Endocrine System Disorder Of Eye Disorder Of Gastrointestinal Tract Disorder Of Hematopoietic Structure Disorder Of Respiratory System Disorder Of Skin Hodgkins Disease Hypercalcemia Of Malignancy Inflammatory Disorder Of Musculoskeletal System Mycosis Fungoides Neoplastic Disease Nephrotic Syndrome Non Hodgkins Lymphoma Trichinosis Tuberculosis Of Meninges Adjunct
Risk factors for serious side effects
HydrocortisoneCortisoneBenadrylAtarax
  • Long-term treatment
  • Not vaccinated against viral diseases
  • Contact with people who have viral illness
  • History of bacterial or viral conditions
  • Long-term treatment
  • Dose of Anusol Hc (Hydrocortisone)
  • Duration of treatment
Detailed Anusol Hc (Hydrocortisone) risks & warnings »
Coming soon.
  • Using other drugs with the same ingredients
  • Age 65 years or older
  • Taking with alcohol
  • Taking other medicines that make you less alert
  • Children age 6 years and younger
  • Enlarged prostate
  • History of bladder problems
  • Glaucoma
  • Nursing mothers
Detailed Benadryl (Diphenhydramine) risks & warnings »
  • Taking with alcohol
  • Taking other medicines that make you less alert and sleepy
  • Women of childbearing age
  • Breastfeeding
  • People 65 years or older
  • Reduced kidney function
  • Glaucoma
  • Urinary problems or enlarged prostate
Detailed Atarax (Hydroxyzine Hydrochloride) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

Alcohol
HydrocortisoneCortisoneBenadrylAtarax
No alcohol related info.No alcohol related info.
  • Don't take it with alcohol or other drugs that make you sleepy.
No alcohol related info.
Food
HydrocortisoneCortisoneBenadrylAtarax
No food related info.No food related info.No food related info.
  • It can be taken with or without food.
Kidneys and liver
HydrocortisoneCortisoneBenadrylAtarax
No kidneys and liver related info.No kidneys and liver related info.No kidneys and liver related info.
  • The dose of Atarax (Hydroxyzine Hydrochloride) should be reduced for people who are older or who have reduced liver or kidney function.
Pain
HydrocortisoneCortisoneBenadrylAtarax
No pain related info.No pain related info.No pain related info.
  • Can cause drowsiness or dizziness. Atarax (Hydroxyzine Hydrochloride) shouldn't be mixed with other medicines that cause drowsiness like other antihistamines, pain or sleep medications or alcohol.
Sleep
HydrocortisoneCortisoneBenadrylAtarax
No sleep related info.No sleep related info.
  • Benadryl (Diphenhydramine) makes you more tired than Claritin, Allegra, or Zyrtec.
  • Benadryl (Diphenhydramine) makes you tired, so take it before you go to sleep.
  • Shouldn't take other medicines that cause drowsiness or dizziness.
  • Can cause drowsiness or dizziness. Atarax (Hydroxyzine Hydrochloride) shouldn't be mixed with other medicines that cause drowsiness like other antihistamines, pain or sleep medications or alcohol.
Upsides and benefits
HydrocortisoneCortisoneBenadrylAtarax
  • Relieves itchy and irritated skin.
  • Doesn't cause the same types of side effects that oral forms of steroids do.
  • It's available over the counter in the drugstore.
  • Most people have very few side effects.
Coming soon
  • Benadryl (Diphenhydramine) is often better than other antihistamines at treating allergy symptoms and hives.
  • It can provide quick relief of allergy symptoms for both kids and adults.
  • It makes you sleepy, so it'll help if your allergies are bothering you at night.
  • The effects wear off in 4 to 6 hours, so side effects don't last that long.
  • It comes as a tablet, capsule, liquid, and quick dissolving tablet.
  • Atarax (Hydroxyzine Hydrochloride) can be used to treat mild cases of anxiety, and for alcohol withdrawal.
  • Can be a better option for some people to treat anxiety than more addicting medications like benzodiazepines.
  • Atarax (Hydroxyzine Hydrochloride) is available as a liquid or as tablets.
  • It can be taken with or without food.
Downsides and risks
HydrocortisoneCortisoneBenadrylAtarax
  • It's not a strong steroid, so it doesn't work for everyone.
  • When used longer than a week, it can cause skin-thinning and make it harder for broken skin to heal.
Coming soon
  • Benadryl (Diphenhydramine) makes you more tired than Claritin, Allegra, or Zyrtec.
  • You shouldn't drive after taking Benadryl (Diphenhydramine) until you know how it affects you.
  • Talk to a pediatrician before giving Benadryl (Diphenhydramine) to a child.
  • It can increase the risk of falls, so elderly people shouldn't use Benadryl (Diphenhydramine).
  • Don't use Benadryl (Diphenhydramine) if you are breastfeeding.
  • The dose of Atarax (Hydroxyzine Hydrochloride) should be reduced for people who are older or who have reduced liver or kidney function.
  • Atarax (Hydroxyzine Hydrochloride) can cause confusion, dry mouth, constipation, and urinary side effects. These symptoms are worse in older people.
  • As with some medicines, the tablets contain lactose. If you’re lactose intolerant, you could be sensitive to this.
  • Not recommended if you’re pregnant or breastfeeding.
  • Shouldn't take other medicines that cause drowsiness or dizziness.
Tips from our pharmacists for people taking the medication
HydrocortisoneCortisoneBenadrylAtarax
  • Rub a thin layer of Anusol Hc (Hydrocortisone) into the area of skin that is affected.
  • Don't rub it into broken areas of skin and leave the area uncovered.
  • Wash your hands after applying it each time.
  • Don't use Anusol Hc (Hydrocortisone) more often than your doctor or the package label recommends.
  • Wait at least 30 minutes between applying moisturizing lotions and this medication.
  • Talk to your doctor if your skin gets worse or hasn't improved in seven days.
Coming soon
  • Take it as needed every 4 to 6 hours.
  • Benadryl (Diphenhydramine) can make you dehydrated, so avoid this side effect by drinking plenty of fluids.
  • Benadryl (Diphenhydramine) makes you tired, so take it before you go to sleep.
  • Don't take it with alcohol or other drugs that make you sleepy.
  • If you need to use it for more than a few weeks, talk with your doctor. A different medication might work better for you long-term.
  • If you only have itchy or watery eyes, try using just an antihistamine eye drop.
  • Atarax (Hydroxyzine Hydrochloride) shouldn't be taken if you're taking other medications that slow down the nervous system, like narcotics and barbiturates.
  • Can cause drowsiness or dizziness. Atarax (Hydroxyzine Hydrochloride) shouldn't be mixed with other medicines that cause drowsiness like other antihistamines, pain or sleep medications or alcohol.
  • Side effects are more likely in older adults and young children.
  • Takes about 2 hours for full antihistamine effect if you’re taking it for itching or rash.
Learn more
More about HydrocortisoneSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Anusol Hc (Hydrocortisone)?
Worth itNot sureNot worth it
More about CortisoneSide effectsReviews & ratingsFDA package insert
Have you used Cortisone?
Worth itNot sureNot worth it
More about BenadrylSide effectsReviews & ratingsFDA package insert
Have you used Benadryl (Diphenhydramine)?
Worth itNot sureNot worth it
More about AtaraxSide effectsReviews & ratingsFDA package insert
Have you used Atarax (Hydroxyzine Hydrochloride)?
Worth itNot sureNot worth it