Prescription onlyLower-cost generic available

Hyzaar

(Losartan / Hydrochlorothiazide)

Prescription onlyLower-cost generic available
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Lowers blood pressure. Removes extra water from your body.

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Our bottom line

Hyzaar (Losartan / Hydrochlorothiazide) is a good combination blood pressure-lowering medicine to try if your blood pressure is very high.

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Upsides

  • Lowers the risk of heart attack and stroke.
  • A first-choice treatment for severe high blood pressure, combining the benefits of two blood pressure-lowering medicines with a single pill.
  • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
  • Helpful in getting rid of extra fluids if you have issues with fluid balance (like in congestive heart failure).
  • Most people have few side effects.

Downsides

  • Will make you urinate more often.
  • Requires a yearly blood test to see how the medicine is affecting your electrolytes and kidneys.
  • Not safe to use if you're pregnant.
  • Needs dose adjustment if you have liver problems.
  • Your skin will be more sensitive to the sun while taking this.
  • Won't work as well if you have severe kidney problems.
  • Shouldn't take if you have a sulfa allergy.
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Side effect rates for Hyzaar (Losartan / Hydrochlorothiazide)

1031 From clinical trials of Hyzaar / High blood pressure
  • Dizziness
  • Upper respiratory infection
  • Cough
  • Back pain

Risks and Warnings for Hyzaar (Losartan / Hydrochlorothiazide)

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    • Higher risk if:
    • Women of childbearing age

    Losartan in Hyzaar (Losartan / Hydrochlorothiazide) can cause birth defects or death to a fetus. If you are pregnant or considering having a baby, talk to your doctor about alternative medicines.

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Common concerns from people taking Hyzaar (Losartan / Hydrochlorothiazide)

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Pregnancy
Kidneys and liver
  • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
  • Requires a yearly blood test to see how the medicine is affecting your electrolytes and kidneys.
  • Needs dose adjustment if you have liver problems.
  • Get your blood pressure, potassium, and kidney function checked 1 week after starting the medicine, then routinely after.
  • Requires routine blood tests to check kidney function.
  • Hyzaar (Losartan / Hydrochlorothiazide) can affect the potassium level in your body. Too much potassium can cause heart problems and too little potassium can cause muscle problems. Baseline and routine lab tests are needed to measure your potassium and kidney function.