Prescription onlyLower-cost generic available

Hyzaar

(Losartan / Hydrochlorothiazide)

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Lowers blood pressure. Removes extra water from your body.

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Prescription onlyLower-cost generic available

Our pharmacists’ bottom line

Hyzaar (Losartan / Hydrochlorothiazide) is a good combination blood pressure-lowering medicine to try if your blood pressure is very high.

  • Lowers the risk of heart attack and stroke.
  • A first-choice treatment for severe high blood pressure, combining the benefits of two blood pressure-lowering medicines with a single pill.
  • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
  • Helpful in getting rid of extra fluids if you have issues with fluid balance (like in congestive heart failure).
  • Most people have few side effects.
  • Will make you urinate more often.
  • Requires a yearly blood test to see how the medicine is affecting your electrolytes and kidneys.
  • Not safe to use if you're pregnant.
  • Needs dose adjustment if you have liver problems.
  • Your skin will be more sensitive to the sun while taking this.
  • Won't work as well if you have severe kidney problems.
  • Shouldn't take if you have a sulfa allergy.

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Side effects for Hyzaar (Losartan / Hydrochlorothiazide)

From clinical trials of Hyzaar / High blood pressure ( 1031)

  • DizzinessDizziness6% for Hyzaar vs.3% for placebo
  • Upper respiratory infectionUpper respiratory infection6% for Hyzaar vs.5% for placebo
  • CoughCough3% for Hyzaar vs.2% for placebo
  • Back painBack pain2% for Hyzaar vs.1% for placebo
  • Abdominal painAbdominal pain1% for Hyzaar vs.1% for placebo
  • Edema/swellingEdema/swelling1% for Hyzaar vs.1% for placebo
  • Heart pounding or racing sensationHeart pounding or racing sensation1% for Hyzaar vs.0% for placebo
  • Sinus inflammationsSinus inflammations1% for Hyzaar vs.1% for placebo
  • RashRash1% for Hyzaar vs.0% for placebo

What to expect when you take Hyzaar (Losartan / Hydrochlorothiazide)

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Tips from our pharmacists
  • Can cause dizziness in the first few days.
  • Get your blood pressure, potassium, and kidney function checked 1 week after starting the medicine, then routinely after.
  • Tell your doctor about any dizziness or muscle weakness that doesn't go away.
  • Get immediate medical help if you notice any swelling, especially around your head and neck.
  • Requires routine blood tests to check kidney function.
  • Don't take it if you're pregnant.

Risks and Warnings for Hyzaar (Losartan / Hydrochlorothiazide)

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    • Higher risk if:
    • Women of childbearing age

    Losartan in Hyzaar (Losartan / Hydrochlorothiazide) can cause birth defects or death to a fetus. If you are pregnant or considering having a baby, talk to your doctor about alternative medicines.

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Tips from pharmacists and people taking Hyzaar (Losartan / Hydrochlorothiazide)

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The FDA category for this medication is D. It is advised that you: Weigh risks vs. benefits
Pregnancy
Kidneys & liver
  • Upsides and downsides from our pharmacists
  • Requires a yearly blood test to see how the medicine is affecting your electrolytes and kidneys.
  • Won't work as well if you have severe kidney problems.
  • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
  • Tips from our pharmacists
  • Get your blood pressure, potassium, and kidney function checked 1 week after starting the medicine, then routinely after.
  • Requires routine blood tests to check kidney function.
  • Risks from our pharmacists
  • Hyzaar (Losartan / Hydrochlorothiazide) has a risk of making your kidneys not work as well. It is important to get blood work done to check your kidney function before starting Hyzaar (Losartan / Hydrochlorothiazide) and at least annually after.
  • Hyzaar (Losartan / Hydrochlorothiazide) can affect the potassium level in your body. Too much potassium can cause heart problems and too little potassium can cause muscle problems. Baseline and routine lab tests are needed to measure your potassium and kidney function.