Prescription onlyLower-cost generic availableClass: Cardiovascular

Hyzaar Alternatives

(losartan / hydrochlorothiazide)

Prescription onlyLower-cost generic availableClass: Cardiovascular
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Compare Hyzaar (losartan / hydrochlorothiazide) to alternatives

These medications are comparable to Hyzaar (losartan / hydrochlorothiazide) or used for similar purposes.

Hyzaar
(losartan / hydrochlorothiazide)

Cozaar
(losartan)

Microzide
(hydrochlorothiazide )

Lotensin Hct
(benazepril / hydrochlorothiazide)

Diovan Hct
(valsartan / hydrochlorothiazide)

Lowers blood pressure. Removes extra water from your body. Hyzaar (Losartan / Hydrochlorothiazide) is a good combination blood pressure-lowering medicine to try if your blood pressure is very high.Lowers blood pressure. Cozaar (Losartan) is a good blood pressure-lowering medicine that protects kidney function like an ACE inhibitor, but with fewer side effects.Removes water from the body, which lowers blood pressure. Microzide (hydrochlorothiazide (HCTZ)) is a well-tolerated water pill that's often the first-choice treatment for mild high blood pressure.Coming soon.Lowers blood pressure. Diovan Hct (Valsartan / Hydrochlorothiazide) is a good 2-in-1 blood pressure-lowering medicine that protects kidney function like an ACE inhibitor, but with fewer side effects.
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Reviews & ratings
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Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Hyzaar (losartan / hydrochlorothiazide)?
Worth itNot sureNot worth it
Reviews for Losartan
57%
-32% worse vs. Hyzaar
48%
+2% better vs. Hyzaar
16%
-9% worse vs. Hyzaar
535 reviews
Have you used Cozaar (losartan)?
Worth itNot sureNot worth it
Reviews for hydrochlorothiazide
47%
-22% worse vs. Hyzaar
31%
+19% better vs. Hyzaar
16%
-9% worse vs. Hyzaar
139 reviews
Have you used Microzide (hydrochlorothiazide )?
Worth itNot sureNot worth it

Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Lotensin Hct (benazepril / hydrochlorothiazide)?
Worth itNot sureNot worth it
Reviews for Diovan HCT
63%
-38% worse vs. Hyzaar
52%
-2% worse vs. Hyzaar
19%
-6% worse vs. Hyzaar
412 reviews
Have you used Diovan Hct (valsartan / hydrochlorothiazide)?
Worth itNot sureNot worth it
Side effects
HyzaarLosartanhydrochlorothiazideLotensin HCTDiovan HCT
  • Dizziness 3%
  • Upper respiratory infection 1%
  • Cough 1%
  • Back pain 1%
More Hyzaar side effects »
  • Upper respiratory infection 1%
  • Dizziness 1%
  • Back pain 1%
  • Nasal congestion 1%
  • Urinary tract infection 6%
  • Diarrhea 5%
  • Muscle weakness/fatiguea/fatigue 4%
  • Low red blood cells 3%
  • Low blood sugar 4%
  • Back pain 2%
More Losartan side effects »

The hydrochlorothiazide FDA package insert doesn’t have numbers about how common side effects are.

More about hydrochlorothiazide side effects »

We haven’t found good data for Lotensin HCT side effects.

FDA side effect reports for Lotensin HCT »
  • Dizziness 4%
More Diovan HCT side effects »
How it works
HyzaarLosartanhydrochlorothiazideLotensin HCTDiovan HCT
Hyzaar (Losartan / Hydrochlorothiazide) is a combination medicine that lowers your blood pressure. Hydrochlorothiazide is a diuretic that removes extra water from your body. Losartan is an angiotensin receptor blocker (ARB) that relaxes your blood vessels to lower you blood pressure and allow more blood and oxygen to get to your heart and other organs.Cozaar (Losartan) is an angiotensin receptor blocker (ARB). It blocks a chemical that tightens blood vessels. This makes blood vessels relax, which lowers blood pressure and allows more blood and oxygen to get to your heart and other organs.Microzide (hydrochlorothiazide (HCTZ)) is a thiazide diuretic (water pill) that makes you urinate more. It works in the kidneys to remove extra water and certain electrolytes, while lowering blood pressure and reducing swelling.Coming soon.Diovan Hct (Valsartan / Hydrochlorothiazide) is a combination medicine. Valsartan (an angiotensin receptor blocker) lowers blood pressure by making blood vessels relax. Hydrochlorothiazide (a diuretic or water pill) lowers blood pressure and swelling by removing extra fluid from your body.
Type of medication
HyzaarLosartanhydrochlorothiazideLotensin HCTDiovan HCT
Prescription onlyPrescription onlyPrescription onlyPrescription only
Available as
HyzaarLosartanhydrochlorothiazideLotensin HCTDiovan HCT
  • Pill
  • Pill
  • Pill
  • Pill
  • Pill
Used for
HyzaarLosartanhydrochlorothiazideLotensin HCTDiovan HCT
  • Hypertension
Risk factors for serious side effects
HyzaarLosartanhydrochlorothiazideLotensin HCTDiovan HCT
  • Women of childbearing age
  • History of kidney problems
  • African descent
  • Current kidney problems
  • Medicine that affects potassium
Detailed Hyzaar (losartan / hydrochlorothiazide) risks & warnings »
  • Women of childbearing age
  • Concurrent liver disease
  • Current kidney problems
  • Medicine that increase potassium
  • Use of salt substitute
Detailed Cozaar (losartan) risks & warnings »
  • Current electrolyte imbalance
  • Lower kidney function
  • Dehydration
  • History of sulfa allergies
  • History of gout
Detailed Microzide (hydrochlorothiazide ) risks & warnings »
    Coming soon.
    • Women of childbearing age
    • African descent
    • History of kidney disease
    • History of lupus
    • Taking lithium
    Detailed Diovan Hct (valsartan / hydrochlorothiazide) risks & warnings »
    Pregnancy

    Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

    Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Kidneys and liver
    HyzaarLosartanhydrochlorothiazideLotensin HCTDiovan HCT
    • Hyzaar (Losartan / Hydrochlorothiazide) can affect the potassium level in your body. Too much potassium can cause heart problems and too little potassium can cause muscle problems. Baseline and routine lab tests are needed to measure your potassium and kidney function.
    • Get your blood pressure, potassium, and kidney function checked 1 week after starting the medicine, then routinely after.
    • Requires routine blood tests to check kidney function.
    • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
    • Requires a yearly blood test to see how the medicine is affecting your electrolytes and kidneys.
    • Needs dose adjustment if you have liver problems.
    • Requires routine blood tests to check kidney function.
    • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
    • Requires routine blood tests to check kidney function.
    No kidneys and liver related info.
    • Diovan Hct (Valsartan / Hydrochlorothiazide) can cause kidney damage, especially if you already have a history of kidney disease. Talk to your doctor to discuss possible alternatives if this is a concern.
    • Requires routine blood tests to check kidney function.
    • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
    Upsides and benefits
    HyzaarLosartanhydrochlorothiazideLotensin HCTDiovan HCT
    • Lowers the risk of heart attack and stroke.
    • A first-choice treatment for severe high blood pressure, combining the benefits of two blood pressure-lowering medicines with a single pill.
    • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
    • Helpful in getting rid of extra fluids if you have issues with fluid balance (like in congestive heart failure).
    • Most people have few side effects.
    • A first-choice blood pressure treatment for many people.
    • Lowers the risk of heart attack and stroke.
    • Similar to ACE inhibitors (like Lisinopril), with fewer side effects like cough and swelling.
    • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
    • Recommended for anyone with heart failure since it lowers the risk of death and further damage to your heart.
    • Does a good job getting rid of extra fluids in your body by making you urinate more.
    • A first-choice blood pressure treatment. Works especially well for people of African descent.
    • Lowers the risk of heart attack and stroke.
    • Good option if you have high blood pressure and heart failure.
    • Most people have very few side effects from Microzide (hydrochlorothiazide (HCTZ)).
    • Can be good for patients with osteoporosis since it raises the body's level of calcium.
    Coming soon
    • Combination medicine for people with high blood pressure. Doctors might prescribe it when you need more than one medicine to control your blood pressure.
    • The two drugs in Diovan HCT work together to lower blood pressure and remove extra water from your body.
    • Lowers the risk of heart attack and stroke.
    • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
    • Recommended for anyone with heart failure since it lowers the risk of death and further damage to your heart.
    Downsides and risks
    HyzaarLosartanhydrochlorothiazideLotensin HCTDiovan HCT
    • Will make you urinate more often.
    • Requires a yearly blood test to see how the medicine is affecting your electrolytes and kidneys.
    • Not safe to use if you're pregnant.
    • Needs dose adjustment if you have liver problems.
    • Your skin will be more sensitive to the sun while taking this.
    • Won't work as well if you have severe kidney problems.
    • Shouldn't take if you have a sulfa allergy.
    • Requires a yearly blood test to see how the medicine is affecting your body.
    • Not safe to use if you're pregnant.
    • Makes you urinate more often.
    • Microzide (hydrochlorothiazide (HCTZ)) doesn't work well in people with severe kidney problems.
    • It can increase the risk of gout attacks in people with poor kidney function or a history of gout.
    • People with a sulfa allergy may be allergic to Microzide (hydrochlorothiazide (HCTZ)).
    Coming soon
    • Comes in fixed dosage strengths, so it's harder for your doctor to adjust your dose.
    • Makes you urinate more often.
    • Doesn't work as well in people with severe kidney problems.
    • Requires a yearly blood test to see how the medicine is affecting your body.
    • Not safe to use if you're pregnant.
    Tips from our pharmacists for people taking the medication
    HyzaarLosartanhydrochlorothiazideLotensin HCTDiovan HCT
    • Can cause dizziness in the first few days.
    • Get your blood pressure, potassium, and kidney function checked 1 week after starting the medicine, then routinely after.
    • Tell your doctor about any dizziness or muscle weakness that doesn't go away.
    • Get immediate medical help if you notice any swelling, especially around your head and neck.
    • Requires routine blood tests to check kidney function.
    • Don't take it if you're pregnant.
    • Can cause dizziness in the first few days.
    • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
    • Tell your doctor about any dizziness, fatigue, cough, or throat irritation that doesn't go away.
    • Requires routine blood tests to check kidney function.
    • Don't take it if you're pregnant.
    • Microzide (hydrochlorothiazide (HCTZ)) starts working in about 2 hours.
    • It makes you urinate more often, so don't take it at bedtime.
    • Can cause dizziness in the first few days.
    • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
    • Tell your doctor about any tiredness or muscle weakness that doesn't go away.
    • Requires routine blood tests to check kidney function.
    Coming soon
    • Makes you urinate more often, so avoid taking it at bedtime.
    • Can cause dizziness in the first few days.
    • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
    • Tell your doctor about any dizziness, fatigue, cough, or throat irritation that doesn't go away.
    • Requires routine blood tests to check kidney function.
    • Don't take it if you're pregnant.
    Learn more
    More about HyzaarSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Hyzaar (losartan / hydrochlorothiazide)?
    Worth itNot sureNot worth it
    More about LosartanSide effectsReviews & ratingsFDA package insert
    Have you used Cozaar (losartan)?
    Worth itNot sureNot worth it
    More about hydrochlorothiazideSide effectsReviews & ratingsFDA package insert
    Have you used Microzide (hydrochlorothiazide )?
    Worth itNot sureNot worth it
    More about Lotensin HCTSide effectsFDA package insert
    Have you used Lotensin Hct (benazepril / hydrochlorothiazide)?
    Worth itNot sureNot worth it
    More about Diovan HCTSide effectsReviews & ratingsFDA package insert
    Have you used Diovan Hct (valsartan / hydrochlorothiazide)?
    Worth itNot sureNot worth it