Over-the-counterLower-cost generic availableClass: Gastrointestinal

Imodium Alternatives

(loperamide)

Over-the-counterLower-cost generic availableClass: Gastrointestinal
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Compare Imodium (loperamide) to alternatives

These medications are comparable to Imodium (loperamide) or used for similar purposes.

Imodium
(loperamide)

Questran
(cholestyramine)

Pepto-Bismol
(bismuth subsalicylate)

Treats diarrhea. One day is too many days to have diarrhea. Having Imodium (Loperamide) on hand to relieve your symptoms can be a life-saver.Coming soon.Relieves heartburn, upset stomach, and diarrhea. Pepto-Bismol (bismuth subsalicylate) can help for many stomach and intestinal problems, but may take longer to work compared to some other anti-diarrheal medicines.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.75Imodium
Reviews for Imodium
89%
of people (All ages) say Imodium is worth it
65%
say it works well
6%
say it's a big hassle
285 reviews
Have you used Imodium (loperamide)?
Worth itNot sureNot worth it

Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Questran (cholestyramine)?
Worth itNot sureNot worth it
Reviews for Pepto-Bismol
84%
+5% better vs. Imodium
48%
+17% better vs. Imodium
6%
Same vs. Imodium
1376 reviews
Have you used Pepto-Bismol (bismuth subsalicylate)?
Worth itNot sureNot worth it
Side effects
ImodiumQuestranPepto-Bismol
  • Constipation 3%
  • Nausea 3%
  • Abdominal cramp 3%
More Imodium side effects »

We haven’t found good data for Questran side effects.

FDA side effect reports for Questran »

The Pepto-Bismol FDA package insert doesn’t have numbers about how common side effects are.

More about Pepto-Bismol side effects »
How it works
ImodiumQuestranPepto-Bismol
Imodium (Loperamide) is an antidiarrheal medicine. It's actually an opioid related to morphine, though it doesn't affect the brain like opioid pain medicines do. Instead, it works directly on muscles in your large intestine to stop contractions and increase the time it takes for stool to move through. The result is less diarrhea and more formed stool.Coming soon.Pepto-Bismol (bismuth subsalicylate) reduces inflammation and irritation in the stomach by reducing the amount of water that goes into the stool. It also has antibacterial and antacid properties.
Type of medication
ImodiumQuestranPepto-Bismol
Over-the-counterOver-the-counter
Available as
ImodiumQuestranPepto-Bismol
  • Pill
  • Chewable tablet
  • Liquid
  • Liquid
  • Chewable tablet
  • Liquid
  • Pill
Used for
ImodiumQuestranPepto-Bismol
  • Hypercholesterolemia Adjunct Pruritus Of Skin
Risk factors for serious side effects
ImodiumQuestranPepto-Bismol
  • Allergy to loperamide
  • Taking with alcohol
  • Taking other medicines that make you less alert
  • Current liver problems
  • Taking HIV medicines
Detailed Imodium (loperamide) risks & warnings »
    Coming soon.
    • Children or teenagers that have or are recovering from flu/flu-like symptoms or chickenpox
    • Aspirin allergy
    • NSAID allergy
    • Age 60 or older
    • Anticoagulants
    Detailed Pepto-Bismol (bismuth subsalicylate) risks & warnings »
    Pregnancy

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Kidneys and liver
    ImodiumQuestranPepto-Bismol
    • Ask your doctor before taking Imodium if you have a fever, liver problems, mucus in your stool or are taking antibiotics.
    No kidneys and liver related info.No kidneys and liver related info.
    Pain
    ImodiumQuestranPepto-Bismol
    • Do not use if you have diarrhea with a high fever, blood in your stool, pain, swelling or bulging in your belly. People taking HIV medicine together with Imodium (Loperamide) can have a serious intestinal problem called toxic megacolon. Call your doctor or get medical care right away if you develop these symptoms or your diarrhea gets worse after 2 days.
    No pain related info.No pain related info.
    Weight
    ImodiumQuestranPepto-Bismol
    • The correct dose of Imodium may be different depending on age. Use the dosing chart to find the right amount of medicine based on age and weight.
    No weight related info.No weight related info.
    Upsides and benefits
    ImodiumQuestranPepto-Bismol
    • Most people who take Imodium feel there's no hassle and it's definitely worth it!
    • Non-habit forming and available over-the-counter.
    • It comes in caplets, liquid, and chewable tablets so you can use it anywhere you need it.
    • Imodium is used for short-term, chronic and traveler's diarrhea. It's also used for people who have diarrhea caused by cancer or certain medicines that treat cancer.
    Coming soon
    • Pepto-Bismol (bismuth subsalicylate) works well to alleviate stomach and intestinal problems and doesn't have many side effects.
    • Comes in easy to take chewable pills or liquid, if you do not like swallowing pills.
    • Is inexpensive and available over the counter.
    • Coupons are available. Speak to your doctor or pharmacist.
    Downsides and risks
    ImodiumQuestranPepto-Bismol
    • Imodium only treats your diarrhea symptoms. Diarrhea may be caused by a number of conditions and will need specific treatment that deals with the underlying issue.
    • Studies in people taking Imodium for chronic diarrhea showed if the maximum number of doses didn't relieve symptoms in 10 days, then it probably won't work for that condition. You can talk to your doctor about other treatment options.
    Coming soon
    • May not be as strong as other anti-diarrheal or antacid medications.
    • Should not be used for more than 2 days if your diarrhea does not go away or if you have a fever.
    • For symptoms other than diarrhea, should not be used for more than 7 days without your doctor's approval. Speak to your doctor if symptoms persist.
    Tips from our pharmacists for people taking the medication
    ImodiumQuestranPepto-Bismol
    • Try to drink plenty of clear liquids. Having diarrhea can make you dehydrated.
    • The correct dose of Imodium may be different depending on age. Use the dosing chart to find the right amount of medicine based on age and weight.
    • Shake Imodium liquid well before using. Use dosing cup that comes with bottle to get the best dose.
    • Imodium lowers your ability to focus, think, and react. Avoid activities that require you to be alert, such as driving a car or operating machinery, until you know how this medication affects you.
    • Check with your baby doctor before using if you're breastfeeding.
    • Ask your doctor before taking Imodium if you have a fever, liver problems, mucus in your stool or are taking antibiotics.
    • Don't use if you have blood in your stool or it's dark or black in color.
    • Stop using Imodium and call your doctor if you have pain, swelling or bulging in your belly or your symptoms get worse after 2 days. This could be serious.
    Coming soon
    • If you have the liquid product, make sure to shake well before use.
    • Non-chewable pills should be taken with a full glass of water.
    • Pepto-Bismol (bismuth subsalicylate) may cause your tongue and stool to become dark, this is normal. However, contact your doctor right away if you notice bloody stools, or if you are vomiting blood or a substance that looks like coffee grounds.
    • Diarrhea can cause you to be dehyrated and lose electrolytes. Make sure to stay hydated. Rehydration solutions are available over-the-counter. Speak to your doctor or pharmacist.
    • Eating smaller meals and avoiding eating 3 hours before bedtime can help prevent heartburn.
    Learn more
    More about ImodiumSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Imodium (loperamide)?
    Worth itNot sureNot worth it
    More about QuestranSide effectsReviews & ratingsFDA package insert
    Have you used Questran (cholestyramine)?
    Worth itNot sureNot worth it
    More about Pepto-BismolSide effectsReviews & ratingsFDA package insert
    Have you used Pepto-Bismol (bismuth subsalicylate)?
    Worth itNot sureNot worth it