Over-the-counterLower-cost generic available

Imodium Alternatives

(Loperamide)

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Compare Imodium (Loperamide) to alternatives

These medications are comparable to Imodium (Loperamide) or used for similar purposes.

Imodium
(Loperamide)

Questran
(Cholestyramine)

Pepto Bismol
(Bismuth Subsalicylate)

Pepto Bismol
(Bismuth Subsalicylate)

Treats diarrhea. One day is too many days to have diarrhea. Having Imodium (Loperamide) on hand to relieve your symptoms can be a life-saver.Coming soon.Relieves heartburn, upset tummy and diarrhea. Pepto Bismol (Bismuth Subsalicylate) does it all, from upset stomach to crampy diarrhea.Relieves heartburn, upset tummy and diarrhea. Pepto Bismol (Bismuth Subsalicylate) does it all, from upset stomach to crampy diarrhea.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
5.738181818181818Imodium
Reviews for Imodium (Loperamide)
89%
of people say Imodium (Loperamide) is worth it
64%
say it works well
6%
say it's a big hassle

Not enough reviews for this drug. Help someone out, leave a review!

Reviews for Pepto Bismol (Bismuth Subsalicylate)
84%
5% vs. Imodium (Loperamide)
48%
16% vs. Imodium (Loperamide)
6%
Same vs. Imodium (Loperamide)
Reviews for Pepto Bismol (Bismuth Subsalicylate)
84%
5% vs. Imodium (Loperamide)
48%
16% vs. Imodium (Loperamide)
6%
Same vs. Imodium (Loperamide)
Side effects
ImodiumQuestranPepto BismolPepto Bismol

The Imodium FDA package insert doesn’t have numbers about how common side effects are.

More about Imodium side effects »

We haven’t found good data for Questran side effects.

FDA side effect reports for Questran »

We haven’t found good data for Pepto Bismol side effects.

FDA side effect reports for Pepto Bismol »

We haven’t found good data for Pepto Bismol side effects.

FDA side effect reports for Pepto Bismol »
How it works
ImodiumQuestranPepto BismolPepto Bismol
Imodium (Loperamide) is an antidiarrheal medicine. It's actually an opioid related to morphine, though it doesn't affect the brain like opioid pain medicines do. Instead, it works directly on muscles in your large intestine to stop contractions and increase the time it takes for stool to move through. The result is less diarrhea and more formed stool.Coming soon.Pepto Bismol (Bismuth Subsalicylate) is a stomach and intestine medicine with multiple effects. It relieves diarrhea by helping your intestines absorb water and electrolytes, and by lowering intestine inflammation and movement. It also has antibacterial and antacid effects.Pepto Bismol (Bismuth Subsalicylate) is a stomach and intestine medicine with multiple effects. It relieves diarrhea by helping your intestines absorb water and electrolytes, and by lowering intestine inflammation and movement. It also has antibacterial and antacid effects.
Type of medication
ImodiumQuestranPepto BismolPepto Bismol
Antidiarrheal
Antimotility
Over-the-counter
Coming soon.
Antidiarrheal
Antisecretory
Over-the-counter
Antidiarrheal
Antisecretory
Over-the-counter
Available as
ImodiumQuestranPepto BismolPepto Bismol
  • Pill
  • Chewable tablet
  • Liquid
  • Liquid
  • Chewable tablet
  • Liquid
  • Chewable tablet
  • Liquid
Used for (click to learn more)
ImodiumQuestranPepto BismolPepto Bismol
  • Hypercholesterolemia; Adjunct Pruritus of skin
Risk factors for serious side effects
ImodiumQuestranPepto BismolPepto Bismol
  • Allergy to loperamide
  • Taking with alcohol
  • Taking other medicines that make you less alert
  • Current liver problems
  • Taking HIV medicines
  • Active infectious colitis
  • Women of childbearing age
Detailed Imodium (Loperamide) risks & warnings »
Coming soon.Coming soon.Coming soon.
Pregnancy category
ImodiumQuestranPepto BismolPepto Bismol
CFDA pregnancy category (Weigh risks vs. benefits)

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

See the FDA package insert
CFDA pregnancy category (Weigh risks vs. benefits)

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

See the FDA package insert
NFDA pregnancy category (Unknown)

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

See the FDA package insert
NFDA pregnancy category (Unknown)

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

See the FDA package insert
Alcohol
No specific alcohol-related info.No specific alcohol-related info.No specific alcohol-related info.No specific alcohol-related info.
Food
No specific food-related info.No specific food-related info.No specific food-related info.No specific food-related info.
Kidneys and liver
No specific kidneys and liver-related info.No specific kidneys and liver-related info.No specific kidneys and liver-related info.No specific kidneys and liver-related info.
Sex
No specific sex-related info.No specific sex-related info.No specific sex-related info.No specific sex-related info.
Sleep
No specific sleep-related info.No specific sleep-related info.No specific sleep-related info.No specific sleep-related info.
Weight
  • The correct dose of Imodium may be different depending on age. Use the dosing chart to find the right amount of medicine based on age and weight.
No specific weight-related info.No specific weight-related info.No specific weight-related info.
Upsides and benefits
ImodiumQuestranPepto BismolPepto Bismol
  • Non-habit forming and available over-the-counter.
  • Imodium is used for short-term, chronic and traveler's diarrhea. It's also used for people who have diarrhea caused by cancer or certain medicines that treat cancer.
  • Most people who take Imodium feel there's no hassle and it's definitely worth it!
  • It comes in caplets, liquid, and chewable tablets so you can use it anywhere you need it.
Coming soon.
  • Most people who take Pepto Bismol feel there's no hassle and it's definitely worth it!
  • It's can also be used as part of treatment plan for H. Pylori., a stomach infection. H. Pylori is thought to be one of the reasons some people get ulcers.
  • It comes in caplets, liquid, and chewable tablets so you can use it anywhere you need it.
  • Most people who take Pepto Bismol feel there's no hassle and it's definitely worth it!
  • It's can also be used as part of treatment plan for H. Pylori., a stomach infection. H. Pylori is thought to be one of the reasons some people get ulcers.
  • It comes in caplets, liquid, and chewable tablets so you can use it anywhere you need it.
Downsides and risks
ImodiumQuestranPepto BismolPepto Bismol
  • Imodium only treats your diarrhea symptoms. Diarrhea may be caused by a number of conditions and will need specific treatment that deals with the underlying issue.
  • Studies in people taking Imodium for chronic diarrhea showed if the maximum number of doses didn't relieve symptoms in 10 days, then it probably won't work for that condition. You can talk to your doctor about other treatment options.
Coming soon.
  • You might be surprised that Pepto Bismol can cause temporary darkening of your tongue, but it's harmless.
  • Doesn't treat every intestinal infection so make sure you let your doctor know if your diarrhea and symptoms last more than 2 days or your symptoms get worse. You may need a stronger medicine.
  • You might be surprised that Pepto Bismol can cause temporary darkening of your tongue, but it's harmless.
  • Doesn't treat every intestinal infection so make sure you let your doctor know if your diarrhea and symptoms last more than 2 days or your symptoms get worse. You may need a stronger medicine.
Tips from our pharmacists for people taking the medication
ImodiumQuestranPepto BismolPepto Bismol
  • Try to drink plenty of clear liquids. Having diarrhea can make you dehydrated.
  • The correct dose of Imodium may be different depending on age. Use the dosing chart to find the right amount of medicine based on age and weight.
  • Shake Imodium liquid well before using. Use dosing cup that comes with bottle to get the best dose.
  • Imodium lowers your ability to focus, think, and react. Avoid activities that require you to be alert, such as driving a car or operating machinery, until you know how this medication affects you.
  • Check with your baby doctor before using if you're breastfeeding.
  • Ask your doctor before taking Imodium if you have a fever, liver problems, mucus in your stool or are taking antibiotics.
  • Don't use if you have blood in your stool or it's dark or black in color.
  • Stop using Imodium and call your doctor if you have pain, swelling or bulging in your belly or your symptoms get worse after 2 days. This could be serious.
Coming soon.
  • Chew or dissolve chewable tablets in mouth.
  • Shake Pepto Bismol liquid well before using. Use dosing cup that comes with bottle to get the best dose.
  • You can take a dose every 1/2 to 1 hour but don't take more than 8 doses in 24 hours.
  • Chewable tablets and liquid are not for children under 12 years.
  • Use until diarrhea stops but not more than 2 days. Let your doctor know if your symptoms don't go away after 2 days.
  • Don't take Pepto Bismol if you have an allergy to aspirin or nonsteroidal anti-inflammatory drugs (NSAIDs).
  • Don't give Pepto Bismol to children or teenagers who have or are getting better from chickenpox, the flu or other viral sickness because of the risk of getting Reye's Syndrome. Reye's syndrome causes brain and liver damage.
  • Can temporarily make your tongue and stools darker.
  • Stop taking Pepto Bismol and tell your doctor if you notice ringing in your ears, unusual bleeding, or nausea and vomiting.
  • Not a good choice if you have stomach bleeding, bleeding problems, diabetes, gout or are taking medicines to thin your blood.
  • Chew or dissolve chewable tablets in mouth.
  • Shake Pepto Bismol liquid well before using. Use dosing cup that comes with bottle to get the best dose.
  • You can take a dose every 1/2 to 1 hour but don't take more than 8 doses in 24 hours.
  • Chewable tablets and liquid are not for children under 12 years.
  • Use until diarrhea stops but not more than 2 days. Let your doctor know if your symptoms don't go away after 2 days.
  • Don't take Pepto Bismol if you have an allergy to aspirin or nonsteroidal anti-inflammatory drugs (NSAIDs).
  • Don't give Pepto Bismol to children or teenagers who have or are getting better from chickenpox, the flu or other viral sickness because of the risk of getting Reye's Syndrome. Reye's syndrome causes brain and liver damage.
  • Can temporarily make your tongue and stools darker.
  • Stop taking Pepto Bismol and tell your doctor if you notice ringing in your ears, unusual bleeding, or nausea and vomiting.
  • Not a good choice if you have stomach bleeding, bleeding problems, diabetes, gout or are taking medicines to thin your blood.
Learn more
More about ImodiumSide effectsReviews & ratingsAlternativesFDA package insert
More about QuestranSide effectsReviews & ratingsFDA package insert
More about Pepto BismolSide effectsReviews & ratingsFDA package insert
More about Pepto BismolSide effectsReviews & ratingsFDA package insert