Prescription onlyLower-cost generic availableClass: Cardiovascular


(propranolol / hydrochlorothiazide)

Prescription onlyLower-cost generic availableClass: Cardiovascular
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Lowers blood pressure. Removes extra water from your body.

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Our bottom line

Inderide (Propranolol / Hydrochlorothiazide) is a good combination blood pressure-lowering medicine to try if your blood pressure is very high.

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  • Lowers the risk of heart attack and stroke.
  • Combines the benefits of two blood pressure lowering medicines with a single pill.
  • For people with problems of fluid balance (like in congestive heart failure), it's helpful for taking off extra fluids.


  • Can make you urinate more often and feel out of breath during physical activities.
  • Can make you sensitive to sunlight.
  • Can hide symptoms of low blood sugar if you have diabetes.
  • Forgetting to take the medicine or stopping it suddenly can cause serious heart problems.
  • May not work as well if you have severe kidney problems.
  • Shouldn't take it if you have a sulfa allergy.
How it works

Inderide (Propranolol / Hydrochlorothiazide) is a combination medicine that lowers your blood pressure with a diuretic (hydrochlorothiazide) and a beta blocker (propranolol). Hydrochlorothiazide removes extra water from your body and propranolol lowers your heart rate.

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Side effect rates for Inderide (propranolol / hydrochlorothiazide)

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These are side effects of Inderide (propranolol / hydrochlorothiazide) reported to the FDA by people taking it, and by doctors and pharmacists.
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Risks and Warnings for Inderide (propranolol / hydrochlorothiazide)

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    • Higher risk if:
    • Sudden discontinuation of medicine

    Stopping Inderide (Propranolol / Hydrochlorothiazide) suddenly can cause irregular fast heartbeat, high blood pressure, poor blood circulation to your heart and increase your risk of chest pain or heart attack. Work with your doctor to gradually reduce your dose if you would like to stop taking Inderide (Propranolol / Hydrochlorothiazide).

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Common concerns from people taking Inderide (propranolol / hydrochlorothiazide)

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Kidneys and liver
  • Get your blood pressure, potassium, and kidney function checked 1 week after starting the medicine, then routinely after.