Prescription onlyLower-cost generic availableDrug class: Pain

Indocin

(Indomethacin)

Prescription onlyLower-cost generic availableDrug class: Pain
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Treats pain and swelling.

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Our bottom line

Indocin (Indomethacin) works well for mild to moderate pain and swelling, but it shouldn't be used long-term since it has some serious side effects.

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Upsides

  • Effective option to relieve mild to moderate pain and swelling.
  • Treats inflammation problems, such as rheumatoid arthritis, osteoarthritis, and acute gout attacks.
  • In studies, Indocin (Indomethacin) was more effective than Tylenol for treating osteoarthritis pain.
  • It works as well as Celebrex for treating an acute gout attacks.
  • Available in capsules, long-acting capsules, suppositories, and as a suspension. All forms, except the suspension, are available as generic medications.

Downsides

  • Indocin (Indomethacin) can cause serious heart and stomach problems. The risk goes up the longer you take it, but problems can happen at any time. Don't take Indocin (Indomethacin) any longer than your doctor recommends.
  • Indocin (Indomethacin) raises your risk of bleeding, especially when taken with other blood-thinning medicines.
  • There are similar medicines that you don't have to take as often and can work just as well.
  • Not a good choice if you have kidney, liver, or stomach problems.
How it works

Indocin (Indomethacin) is a non-steroidal anti-inflammatory drug (NSAID). It blocks the inflammation process in your body, which relieves swelling and pain.

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Side effect rates for Indocin (Indomethacin)

371 From clinical trials of Indocin / Mild to moderate acute pain (20 mg)
  • Nausea
  • Post procedural edema
  • Vomiting
  • Headache
  • Dizziness
  • Constipation
  • Post procedural hemorrhage
  • Itching
  • Diarrhea
  • Rash

Risks and Warnings for Indocin (Indomethacin)

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    • Higher risk if:
    • History of cardiovascular disease
    • High blood pressure
    • Smoking

    Indocin (Indomethacin) can increase your chance of having blood clots, heart attack, or stroke. The risk can increase the longer you take it. Talk to your doctor about taking the lowest dose that works for you for the shortest time possible.

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Common concerns from people taking Indocin (Indomethacin)

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Pregnancy
Food
  • Take with food or milk to help prevent upset stomach.
  • always take with food
  • Make sure you take with food. I made the mistake of not and could not function at work.
  • take with food
Kidneys and liver
  • Not a good choice if you have kidney, liver, or stomach problems.
  • Indocin (Indomethacin) is processed by the kidney and liver. If you have kidney or liver problems, talk to your doctor because you may need a different dose. (No dose adjustments are specified on the manufacturer's label.)
Pain
  • In studies, Indocin (Indomethacin) was more effective than Tylenol for treating osteoarthritis pain.
  • Works rather quickly for gout. Pain while walking started reducing within about 8 hours of 1st dose. (75mg)
  • I've taken Indometacin for over 3 years as needed for gout and gouty aches and pains, usually one or two a day when the symptoms start, up to 3 if severe. Works fast and effectively. I've not had any side effects.