Prescription onlyLower-cost generic availableClass: Cardiovascular

Inspra 

(eplerenone)

Prescription onlyLower-cost generic availableClass: Cardiovascular
Back to: Full Site NavigationSkip to: side effects sectionSkip to: What to expect sectionSkip to: Risks and warnings sectionSkip to: Common concerns from users and pharmacists

Helps lower blood pressure and protect the heart in people with heart failure.

Skip Upsides & Downsides section. Skip to side effects section.

Our bottom line

Inspra (eplerenone) lowers blood pressure and can help remove fluid when it's used with other drugs. It reduces the risk of death in people with heart failure and is usually used when people can't take spironolactone.

Price and discounts
What is GoodRx?

Upsides

  • Lowers your blood pressure.
  • It can help remove fluid from your body when it's used with other drugs.
  • Reduces the risk of death in people with heart failure.
  • It can have fewer side effects than spironolactone.

Downsides

  • Inspra (eplerenone) isn't a first choice medicine for lowering blood pressure or getting rid of fluid in the body. It's usually used in combination with other medicines.
  • It can make you feel dizzy for the first few days. Be careful driving until you know how it affects you.
  • You'll need to have blood tests done regularly since Inspra (eplerenone) can affect your potassium levels and kidney function.
  • It can be very expensive compared to spironolactone.
How it works

Inspra (eplerenone) is an aldosterone antagonist. It blocks aldosterone (a hormone) and helps your kidneys get rid of excess fluid in your body, which helps lower blood pressure.

What to expect when you take Inspra (eplerenone) for High blood pressure

Skip what to expect section. Skip to Risks & Warnings section.
Skip side effects section. Skip to What to Expect and Pharmacists Tips section.

Side effect rates for Inspra (eplerenone)

6608 From clinical trials of Inspra / Heart failure
  • High potassium
  • Abnormal renal function

Risks and Warnings for Inspra (eplerenone)

Skip risks section. Skip to common concerns section.
    • Higher risk if:
    • Taking with alcohol
    • Taking other medicines that lower your blood pressure

    Inspra (eplerenone) lowers your blood pressure and can make you feel lightheaded or dizzy. This should go away after a few days, but talk to your doctor if it doesn't. They may change your dose or put you on a different medication.

Common concerns from people taking Inspra (eplerenone)

Final section. Do you want to return to drug navigation?
Pregnancy
Kidneys and liver
  • You'll need to have blood tests done regularly since Inspra (eplerenone) can affect your potassium levels and kidney function.
  • Shouldn't be used by people with kidney or liver damage.
  • Inspra (eplerenone) shouldn't be used by people with bad kidneys since it can hurt your kidneys or cause worse side effects, such as high potassium levels. Your doctor will do frequent blood tests to monitor your kidney function and electrolytes while you're on this drug.