Prescription onlyLower-cost generic available

Invega

(Paliperidone)

  • Extended release
  • Injection
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Helps control your thoughts and mood.

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Prescription onlyLower-cost generic available

Our pharmacists’ bottom line

Invega (Paliperidone) is good for treating psychosis and improving mood. It's more likely to cause hormone problems than other antipsychotics.

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  • Effective at relieving psychotic symptoms and relapse rates for people with schizophrenia.
  • Also relieves psychotic symptoms and improves mood for people with schizoaffective disorder.
  • Works just as well as other antipsychotic medicines.
  • Less likely to cause heart or liver problems than some other antipsychotic medications.
  • Invega (Paliperidone) has a high risk of causing hormone problems that cause nipples to leak fluid and male breasts to grow abnormally large.
  • Sometimes causes weight gain and low blood pressure.
  • Mild risk of causing extrapyramidal symptoms (EPS): movement disorders that include stiffness, tremor, restlessness, and slow, repetitive, or involuntary movements.
  • You might need routine blood tests to check how the medicine is affecting your body.
  • Not a good choice for elderly people who have dementia.
  • All antipsychotics have side effects that make them difficult to take. You might need to try a few different medicines until you find one that works best for you.

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Side effects for Invega (Paliperidone)

From clinical trials of Invega / Adolescent schizophrenia (12 to 17 years old) (3 mg once daily) ( 67)

  • Extrapyramidal symptomsExtrapyramidal symptoms19% for Invega vs.0% for placebo
  • DrowsinessDrowsiness13% for Invega vs.0% for placebo
  • Abnormally fast heart beatAbnormally fast heart beat6% for Invega vs.0% for placebo
  • Excessive salivaExcessive saliva6% for Invega vs.0% for placebo
  • VomitingVomiting6% for Invega vs.10% for placebo
  • Weight increasedWeight increased6% for Invega vs.0% for placebo
  • RestlessnessRestlessness6% for Invega vs.0% for placebo
  • DizzinessDizziness6% for Invega vs.0% for placebo
  • HeadacheHeadache6% for Invega vs.4% for placebo
  • No periodsNo periods6% for Invega vs.0% for placebo

Manufacturers don’t say how common these side effects are

  • Abnormally large breasts in males
  • Anxiety
  • Common cold
  • Dry mouth
  • Fatigue
  • Lack of energy
  • Leaking fluid from nipples
  • Muscle weakness
  • Nosebleed
  • Swollen tongue
  • Tongue paralysis
  • Vision blurred

What to expect when you take Invega (Paliperidone)

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Tips from our pharmacists
  • It'll take 4 to 6 weeks to see the medication's full effects on thoughts and mood.
  • Can cause dizziness and drowsiness, or worsen you cholesterol and blood sugar levels.
  • For the first week, avoid activities like driving that require you to be alert.
  • Don't worry if you see tablet shells in your stool since the medication was already absorbed by your body.
  • Report any unusual thoughts, inability to control muscle movements, or fever and excess sweating to your doctor.
  • Elderly people who have dementia shouldn't take Invega (Paliperidone).

Risks and Warnings for Invega (Paliperidone)

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    • Higher risk if:
    • Elderly patients with dementia

    Older patients with dementia-related psychosis have a higher risk of death when treated with antipsychotic medications. Invega (Paliperidone) is not approved to treat dementia-related psychosis.

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Tips from pharmacists and people taking Invega (Paliperidone)

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The FDA category for this medication is C. It is advised that you: Weigh risks vs. benefits
Pregnancy
Food
  • Risks from our pharmacists
  • Invega (Paliperidone) can increase your blood sugar and cholesterol. Invega (Paliperidone) is moderately likely to raise your blood sugar and cholesterol compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
  • Invega (Paliperidone) can cause you to gain weight. Invega (Paliperidone) is moderately likely to cause weight gain compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
Sleep
  • Tips from our pharmacists
  • Can cause dizziness and drowsiness, or worsen you cholesterol and blood sugar levels.
Weight gain or loss
  • Upsides and downsides from our pharmacists
  • Sometimes causes weight gain and low blood pressure.
  • Risks from our pharmacists
  • Invega (Paliperidone) can cause you to gain weight. Invega (Paliperidone) is moderately likely to cause weight gain compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.