Prescription onlyLower-cost generic available

Invega Alternatives

(Paliperidone)

  • Extended release
  • Injection
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Compare Invega (Paliperidone) to alternatives

These medications are comparable to Invega (Paliperidone) or used for similar purposes.

Invega
(Paliperidone)

Risperdal
(Risperidone)

Seroquel
(Quetiapine)

Abilify
(Aripiprazole)

Haldol
(Haloperidol)

Zyprexa
(Olanzapine)

Geodon
(Ziprasidone)

Helps control your thoughts and mood. Invega (Paliperidone) is good for treating psychosis and improving mood. It's more likely to cause hormone problems than other antipsychotics.Helps control your thoughts and mood. Risperdal (Risperidone) is good for treating psychosis, mania, and irritability. Among newer antipsychotic medicines, more likely to cause side effects, especially weight gain and hormone problems.Helps control your thoughts and mood. Seroquel (Quetiapine) is good for treating psychosis and mania. Fewer side effects than most antipsychotics, but might be less effective for people over age 40 with schizophrenia.Helps control your thoughts and mood. Abilify (Aripiprazole) is good for treating psychosis and mania, and can help with depression. Less likely to cause side effects than any other antipsychotic, but has a risk of suicidal thoughts for people age 24 and younger.Helps control your thoughts and calms agitation. Haldol (Haloperidol) is okay for treating psychosis and agitation. It's less likely to cause weight gain than other antipsychotics, but it's more likely to cause other bad side effects.Helps control your thoughts and mood. Zyprexa (Olanzapine) is good for treating psychosis, mania, and agitation. More likely to cause weight gain and sleepiness than other antipsychotics.Helps control your thoughts and mood. Geodon (Ziprasidone) treats bipolar disorder and schizophrenia, and causes fewer side effects than similar medicines. It’s not a good choice if you have heart problems.
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Reviews & ratings
Button Group. All currently active
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4.1Invega
Reviews for Invega (Paliperidone)
30%
of people say Invega (Paliperidone) is worth it
33%
say it works well
30%
say it's a big hassle
Reviews for Risperdal (Risperidone)
48%
+18% vs. Invega (Paliperidone)
41%
+8% vs. Invega (Paliperidone)
48%
18% vs. Invega (Paliperidone)
Reviews for Seroquel (Quetiapine)
52%
+22% vs. Invega (Paliperidone)
46%
+13% vs. Invega (Paliperidone)
28%
+2% vs. Invega (Paliperidone)
Reviews for Abilify (Aripiprazole)
42%
+12% vs. Invega (Paliperidone)
38%
+5% vs. Invega (Paliperidone)
35%
5% vs. Invega (Paliperidone)
Reviews for Haldol (Haloperidol)
37%
+7% vs. Invega (Paliperidone)
41%
+8% vs. Invega (Paliperidone)
35%
5% vs. Invega (Paliperidone)
Reviews for Zyprexa (Olanzapine)
45%
+15% vs. Invega (Paliperidone)
53%
+20% vs. Invega (Paliperidone)
47%
17% vs. Invega (Paliperidone)

Not enough reviews for this drug. Help someone out, leave a review!

Side effects
InvegaRisperdalSeroquelAbilifyHaldolZyprexaGeodon
  • Abnormally fast heart beat 7%
  • Anxiety 5%
  • Common cold 4%
  • Indigestion 4%
  • Constipation 3%
  • Positional low blood pressure 3%
  • Muscle weakness 3%
  • Headache 2%
  • Nausea 2%
  • Abdominal discomfort 2%
More Invega side effects »
  • Relaxation or sleepiness 48%
  • Increased appetite 29%
  • Fatigue 22%
  • Parkinsonism 17%
  • Constipation 11%
  • Dizziness 11%
  • Abdominal pain upper 11%
  • Common cold 10%
  • Nausea 9%
  • Indigestion 8%
More Risperdal side effects »
  • Drowsiness 42%
  • Dry mouth 31%
  • Dizziness 17%
  • Fatigue 10%
  • Increased appetite 9%
  • Headache 7%
  • Nausea 6%
  • Constipation 6%
  • Muscle weakness 6%
  • Positional low blood pressure 5%
More Seroquel side effects »
  • Drowsiness 20%
  • Extrapyramidal disorder 17%
  • Relaxation or sleepiness 17%
  • Fatigue 15%
  • Restlessness 9%
  • Fever 8%
  • Vomiting 7%
  • Decreased appetite 5%
  • Excessive saliva 5%
  • Sleep difficulty 5%
More Abilify side effects »

The Haldol FDA package insert doesn’t have numbers about how common side effects are.

More about Haldol side effects »
  • Relaxation or sleepiness 39%
  • Increased appetite 25%
  • Weight increase 22%
  • Drowsiness 22%
  • Dry mouth 15%
  • Dizziness 12%
  • Muscle weakness 9%
  • Fatigue 8%
  • Constipation 6%
  • Indigestion 6%
More Zyprexa side effects »
  • Drowsiness 19%
  • Extrapyramidal symptoms 19%
  • Dizziness 9%
  • Restlessness 5%
  • Respiratory tract infection 5%
  • Muscle weakness 4%
  • Adverse reaction 3%
  • Vomiting 3%
  • Abnormal vision 3%
  • Accidental injury 2%
More Geodon side effects »
How it works
InvegaRisperdalSeroquelAbilifyHaldolZyprexaGeodon
Invega (Paliperidone) is an atypical antipsychotic. Researchers don't know exactly how it works. It seems to change dopamine and serotonin activity in your brain, which affect your thoughts and mood.Risperdal (Risperidone) is an atypical antipsychotic. Researchers don't know exactly how it works. It seems to change dopamine and serotonin activity in your brain, which affects thoughts and mood.Seroquel (Quetiapine) is an atypical antipsychotic. Researchers don't know exactly how it works. It seems to change dopamine and serotonin activity in your brain, which affects thoughts and mood.Abilify (Aripiprazole) is an atypical antipsychotic. Researchers don't know exactly how it works. It seems to change dopamine and serotonin activity in your brain, which affects thoughts and mood.Haldol (Haloperidol) is a traditional antipsychotic. Researchers don't know exactly how it works, but it seems to change dopamine activity in your brain, which affects thoughts and mood.Zyprexa (Olanzapine) is an atypical antipsychotic. Researchers don't know exactly how it works. It seems to change dopamine and serotonin activity in your brain, which affects thoughts and mood.Geodon (Ziprasidone) is a second generation antipsychotic. It treats schizophrenia and bipolar disorder by adjusting the levels of dopamine and serotonin in your brain, which affects thoughts and mood.
Type of medication
InvegaRisperdalSeroquelAbilifyHaldolZyprexaGeodon
Antipsychotic
Atypical
Prescription only
Antipsychotic
Atypical
Prescription only
Antipsychotic
Atypical
Prescription only
Antipsychotic
Atypical
Prescription only
Antipsychotic
Typical
Prescription only
Antipsychotic
Atypical
Prescription only
Antipsychotic
2nd generation
Prescription only
Available as
InvegaRisperdalSeroquelAbilifyHaldolZyprexaGeodon
  • Extended release
  • Injection
  • Pill
  • Dissolving tablet
  • Liquid
  • Injection
  • Pill
  • Extended release
  • Pill
  • Dissolving tablet
  • Liquid
  • Injection
  • Pill
  • Liquid
  • Injection
  • Pill
  • Dissolving tablet
  • Injection
  • Pill
  • Injection
Used for (click to learn more)
InvegaRisperdalSeroquelAbilifyHaldolZyprexaGeodon
How well it works for depression
The free Iodine Start program helps people track how well they are improving, and find the right antidepressant faster.
The free Iodine Start program (personal reports and coaching) is currently only for antidepressants. For now, you can read our pharmacist info about this medication.Learn more about Invega (Paliperidone)The free Iodine Start program (personal reports and coaching) is currently only for antidepressants. For now, you can read our pharmacist info about this medication.Learn more about Risperdal (Risperidone)The free Iodine Start program (personal reports and coaching) is currently only for antidepressants. For now, you can read our pharmacist info about this medication.Learn more about Seroquel (Quetiapine)The free Iodine Start program (personal reports and coaching) is currently only for antidepressants. For now, you can read our pharmacist info about this medication.Learn more about Abilify (Aripiprazole)The free Iodine Start program (personal reports and coaching) is currently only for antidepressants. For now, you can read our pharmacist info about this medication.Learn more about Haldol (Haloperidol)The free Iodine Start program (personal reports and coaching) is currently only for antidepressants. For now, you can read our pharmacist info about this medication.Learn more about Zyprexa (Olanzapine)The free Iodine Start program (personal reports and coaching) is currently only for antidepressants. For now, you can read our pharmacist info about this medication.Learn more about Geodon (Ziprasidone)
Risk factors for serious side effects
InvegaRisperdalSeroquelAbilifyHaldolZyprexaGeodon
  • Elderly patients with dementia
      • History of heart problems
      • Drug interactions
        • People with diabetes
        • People with high cholesterol
        • People with diabetes
        • Alcohol
        • Taking other medicines that make you less alert
          Detailed Invega (Paliperidone) risks & warnings »
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          Pregnancy category
          InvegaRisperdalSeroquelAbilifyHaldolZyprexaGeodon
          CFDA pregnancy category (Weigh risks vs. benefits)

          Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

          See the FDA package insert
          CFDA pregnancy category (Weigh risks vs. benefits)

          Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

          See the FDA package insert
          CFDA pregnancy category (Weigh risks vs. benefits)

          Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

          See the FDA package insert
          CFDA pregnancy category (Weigh risks vs. benefits)

          Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

          See the FDA package insert
          CFDA pregnancy category (Weigh risks vs. benefits)

          Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

          See the FDA package insert
          CFDA pregnancy category (Weigh risks vs. benefits)

          Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

          See the FDA package insert
          CFDA pregnancy category (Weigh risks vs. benefits)

          Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

          See the FDA package insert
          Alcohol
          No specific alcohol-related info.No specific alcohol-related info.No specific alcohol-related info.No specific alcohol-related info.No specific alcohol-related info.No specific alcohol-related info.No specific alcohol-related info.
          Food
          • Invega (Paliperidone) can increase your blood sugar and cholesterol. Invega (Paliperidone) is moderately likely to raise your blood sugar and cholesterol compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
          • Invega (Paliperidone) can cause you to gain weight. Invega (Paliperidone) is moderately likely to cause weight gain compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
          No specific food-related info.No specific food-related info.No specific food-related info.No specific food-related info.No specific food-related info.
          • Take Geodon (Ziprasidone) twice a day, preferably with food.
          Kidneys and liver
          No specific kidneys and liver-related info.No specific kidneys and liver-related info.No specific kidneys and liver-related info.No specific kidneys and liver-related info.No specific kidneys and liver-related info.No specific kidneys and liver-related info.No specific kidneys and liver-related info.
          Sex
          No specific sex-related info.No specific sex-related info.No specific sex-related info.No specific sex-related info.No specific sex-related info.No specific sex-related info.No specific sex-related info.
          Sleep
          • Can cause dizziness and drowsiness, or worsen you cholesterol and blood sugar levels.
          • Can cause dizziness and drowsiness.
          • Can cause dizziness, drowsiness, and low blood pressure.
          • Makes you energized. Take in the morning to avoid difficulty sleeping.
          • It can cause dizziness, drowsiness, and can lower your blood pressure.
          • Can cause dizziness and drowsiness.
          • Can cause drowsiness when you first start taking it, so avoid activities that require you to be alert until you know how it affects you.
          Weight
          • Sometimes causes weight gain and low blood pressure.
          • Invega (Paliperidone) can cause you to gain weight. Invega (Paliperidone) is moderately likely to cause weight gain compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
          • Moderate risk of weight gain and problems with cholesterol or blood sugar compared to other antipsychotics.
          • May cause weight gain and worsen cholesterol or blood sugar.
          • Sometimes causes weight gain, sleepiness, and low blood pressure.
          • May cause weight gain and worsen cholesterol or blood sugar.
          • Least likely antipsychotic to cause weight gain.
          • Less likely to cause weight gain and problems with cholesterol and blood sugar than most other antipsychotics.
          • More likely to cause weight gain and problems with cholesterol or blood sugar compared to other antipsychotics.
          • May cause weight gain and worsen cholesterol or blood sugar.
          • It causes slightly less weight gain than similar medicines.
          • Compared to other antipsychotics, it has a lower risk of weight gain, hyperglycemia, and hyperlipidemia.
          Upsides and benefits
          InvegaRisperdalSeroquelAbilifyHaldolZyprexaGeodon
          • Effective at relieving psychotic symptoms and relapse rates for people with schizophrenia.
          • Also relieves psychotic symptoms and improves mood for people with schizoaffective disorder.
          • Less likely to cause heart or liver problems than some other antipsychotic medications.
          • Works just as well as other antipsychotic medicines.
          • Effective at relieving psychotic symptoms, manic episodes, irritability, and aggressive behavior.
          • Lowers relapse rates in people with schizophrenia and people with irritability associated with autism.
          • Antipsychotic medicines are all about equally effective.
          • Less likely to cause heart problems than some antipsychotics.
          • Effective at relieving psychotic symptoms and manic episodes.
          • Fewer side effects than most antipsychotic medicines.
          • Compared to other antipsychotics, the least likely to cause Extrapyramidal Symptoms (EPS): Movement disorders that include stiffness, tremor, restlessness, and slow, repetitive, or involuntary movements.
          • Antipsychotic medicines are all about equally effective.
          • Less likely to cause heart problems compared to some antipsychotics.
          • Effective at relieving psychotic symptoms and manic episodes. All antipsychotic medicines are about equally effective.
          • More energizing than other antipsychotics.
          • Fewer side effects than any other antipsychotics.
          • Least likely antipsychotic to cause weight gain.
          • Studies show that it can also be helpful for depression, especially in women, if your symptoms don't go away with an antidepressant alone.
          • Available as a generic, which is cheaper.
          • Less likely to cause heart problems compared to some antipsychotics.
          • Effective at relieving psychotic symptoms and agitation.
          • Less likely to cause weight gain and problems with cholesterol and blood sugar than most other antipsychotics.
          • Works just as well as other antipsychotic medicines.
          • Effective at relieving psychotic symptoms, manic episodes, and agitation in people with schizophrenia and bipolar disorder.
          • Lowers relapse rates for schizophrenia and bipolar disorder.
          • Antipsychotic medicines are all about equally effective.
          • Less likely to cause heart problems than some antipsychotics.
          • Geodon (Ziprasidone) can be used with lithium or valproate to better treat bipolar disorder.
          • Geodon (Ziprasidone) can treat agitation in people with schizophrenia by reducing symptoms of anxiety, nervousness, and distress.
          • Compared to other antipsychotics, it has a lower risk of weight gain, hyperglycemia, and hyperlipidemia.
          • The Geodon (Ziprasidone) capsule is available as a generic.
          • The injectable form can treat sudden agitation in schizophrenia when it's not possible to use the capsules.
          • It's available as a pill that you take by mouth daily for continuous treatment and as an injection used for short-term treatment of agitation.
          Downsides and risks
          InvegaRisperdalSeroquelAbilifyHaldolZyprexaGeodon
          • Invega (Paliperidone) has a high risk of causing hormone problems that cause nipples to leak fluid and male breasts to grow abnormally large.
          • Sometimes causes weight gain and low blood pressure.
          • Mild risk of causing extrapyramidal symptoms (EPS): movement disorders that include stiffness, tremor, restlessness, and slow, repetitive, or involuntary movements.
          • Not a good choice for elderly people who have dementia.
          • All antipsychotics have side effects that make them difficult to take. You might need to try a few different medicines until you find one that works best for you.
          • Mild to moderate risk of Extrapyramidal Symptoms (EPS): Movement disorders that include stiffness, tremor, restlessness, and slow, repetitive, or involuntary movements.
          • Moderate risk of weight gain and problems with cholesterol or blood sugar compared to other antipsychotics.
          • Compared to other antipsychotics, higher risk of hormone problems that cause nipples to leak and male breasts to grow abnormally large.
          • All antipsychotics come with side effects that make them difficult to take. You might need to try a few different medicines until you find one that works for you and that you can tolerate.
          • In studies, less effective for people over age 40 for schizophrenia.
          • Sometimes causes weight gain, sleepiness, and low blood pressure.
          • All antipsychotics come with side effects that make them difficult to take. You might need to try a few different medicines until you find one that works for you and that you can tolerate.
          • Can cause higher risk of suicidal thoughts and behavior for people age 24 and younger.
          • Mild risk of Extrapyramidal Symptoms (EPS): Movement disorders that include stiffness, tremor, restlessness, and slow, repetitive, or involuntary movements.
          • All antipsychotics come with side effects that make them difficult to take. You might need to try a few different medicines until you find one that works for you and that you can tolerate.
          • It's an older medicine and has a lot more side effects than newer antipsychotics.
          • Compared to other antipsychotics, it causes more hormone problems that can cause nipples to leak fluid, and sudden, dangerous abnormal heart rhythms.
          • Has a higher risk of extrapyramidal symptoms (EPS): movement disorders that include stiffness, tremor, restlessness, and slow, repetitive, or involuntary movements. One of these symptoms (called tardive dyskinesia) is permanent and more likely if you take this medicine for many years.
          • All antipsychotics have side effects that make them difficult to take. You might need to try a few different medicines until you find one that works best for you.
          • More likely to cause weight gain and problems with cholesterol or blood sugar compared to other antipsychotics.
          • Might make you more sleepy than some antipsychotics.
          • Mild risk of Extrapyramidal Symptoms (EPS): Movement disorders that include stiffness, tremor, restlessness, and slow, repetitive, or involuntary movements.
          • All antipsychotics come with side effects that make them difficult to take. You might need to try a few different medicines until you find one that works for you and that you can tolerate.
          • Elderly people with dementia shouldn’t take Geodon (Ziprasidone).
          • You shouldn’t take Geodon (Ziprasidone) if you have a history of heart problems (slow heart rate, recent heart attack, heart failure, or heart rhythm problems). It’s also not safe to take if you have low potassium or magnesium, or are taking medicines that increase the risk of this happening (diuretics).
          • You'll need to get blood tests before you start taking Geodon (Ziprasidone).
          • It causes slightly less weight gain than similar medicines.
          • Can't take Geodon (Ziprasidone) capsules and injections at the same time. Capsules should be used instead of the injection as soon as possible.
          Tips from our pharmacists for people taking the medication
          InvegaRisperdalSeroquelAbilifyHaldolZyprexaGeodon
          • It'll take 4 to 6 weeks to see the medication's full effects on thoughts and mood.
          • Can cause dizziness and drowsiness, or worsen you cholesterol and blood sugar levels.
          • Don't worry if you see tablet shells in your stool since the medication was already absorbed by your body.
          • Elderly people who have dementia shouldn't take Invega (Paliperidone).
          • For the first week, avoid activities like driving that require you to be alert.
          • Report any unusual thoughts, inability to control muscle movements, or fever and excess sweating to your doctor.
          • Takes 4 to 6 weeks to see full effects on thoughts and mood.
          • Can cause dizziness and drowsiness.
          • For the first week, avoid activities that require you to be alert.
          • May cause weight gain and worsen cholesterol or blood sugar.
          • Report any unusual thoughts, inability to control muscle movements, or fever and excess sweating to your doctor.
          • Elderly people with dementia shouldn't take it.
          • Can cause dizziness, drowsiness, and low blood pressure.
          • Takes 4 to 6 weeks to see full effects on thoughts and mood.
          • For the first week, avoid activities that require you to be alert.
          • May cause weight gain and worsen cholesterol or blood sugar.
          • Report any unusual thoughts, inability to control muscle movements, or fever and excess sweating to your doctor.
          • Elderly people with dementia shouldn't take it.
          • Makes you energized. Take in the morning to avoid difficulty sleeping.
          • May worsen cholesterol or blood sugar.
          • Takes 4 to 6 weeks to see full effects on thoughts and mood.
          • For the first week, avoid activities that require you to be alert.
          • Report any unusual thoughts, inability to control muscle movements, or fever and excess sweating to your doctor.
          • Elderly people with dementia shouldn't take it.
          • It'll take 4 to 6 weeks to see the medication's full effects on your thoughts.
          • It can cause dizziness, drowsiness, and can lower your blood pressure.
          • Immediately tell your doctor if you can't control your muscle movements or if you have a fever or excess sweating.
          • Don't use in elderly people who have dementia.
          • The oral liquid concentrate can be mixed with water or juice before taking it.
          • For the first week, avoid activities like driving that require you to be alert.
          • Takes 4 to 6 weeks to see full effects on thoughts and mood.
          • Can cause dizziness and drowsiness.
          • For the first week, avoid activities that require you to be alert.
          • May cause weight gain and worsen cholesterol or blood sugar.
          • Report any unusual thoughts, inability to control muscle movements, or fever and excess sweating to your doctor.
          • Elderly people with dementia shouldn't take it.
          • It usually takes 4 to 6 weeks to see the full effects, so hang in there and wait until it works to figure out the right dose for you.
          • Take Geodon (Ziprasidone) twice a day, preferably with food.
          • Can cause drowsiness when you first start taking it, so avoid activities that require you to be alert until you know how it affects you.
          • Geodon (Ziprasidone) can cause heart problems, so call your doctor right away if you faint or feel a change in your heartbeat.
          • Let your doctor know if you're taking a diuretic (water pill) or have a condition like chronic diarrhea that'll lower the amount of potassium or magnesium in your blood.
          Learn more
          More about InvegaSide effectsReviews & ratingsAlternativesFDA package insert
          More about RisperdalSide effectsReviews & ratingsFDA package insert
          More about SeroquelSide effectsReviews & ratingsFDA package insert
          More about AbilifySide effectsReviews & ratingsFDA package insert
          More about HaldolSide effectsReviews & ratingsFDA package insert
          More about ZyprexaSide effectsReviews & ratingsFDA package insert
          More about GeodonSide effectsReviews & ratingsFDA package insert