Invirase

(saquinavir)

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Works with other medicines to treat HIV infection.

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Our bottom line

Invirase (saquinavir) is not a first choice medicine for HIV because other medicines similar to Invirase (saquinavir) work better with fewer side effects and with less pills to take every day.

Quick facts about Invirase
  • Drug class: Infection
  • Rx status: Prescription only
  • Generic status: No lower cost generic available
Prices and discounts
Lowest price for 30 200mg capsules
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$139.20

Upsides

  • If you have trouble swallowing capsules, they can be opened and mixed with syrup or jam.
  • People ages 16 and older can use this medicine.

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What to expect from Invirase, on one page

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Downsides

  • Have to take at least 4 pills to reach your daily dose, along with all the other medications you are taking for HIV treatment.
  • Invirase (saquinavir) interacts with many other medications. This interaction can be harmful.
  • Can raise your blood sugar and cholesterol levels.
  • If you have a history of heart problems, Invirase (saquinavir) can put you at risk for developing unusual heart rhythms.
  • Only use ritonavir to boost Invirase (saquinavir), not Tybost (cobicistat).

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Get our free fact sheet

What to expect from Invirase, on one page

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Prices and discounts
Lowest price for 30 200mg capsules
Determining your location...
$139.20
How it works

Invirase (saquinavir) is a protease inhibitor. It treats HIV by preventing the virus from fully forming in its last stages of development.

Quick facts about Invirase
  • Drug class: Infection
  • Rx status: Prescription only
  • Generic status: No lower cost generic available

Dosage forms

  • Pill
Tried Invirase? Write a review!

What to expect when you take Invirase (saquinavir) for HIV treatment

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Side effect rates for Invirase (saquinavir)

From 148 clinical trials of Invirase when taken for hiv treatment
  • Nausea
  • Diarrhea
  • Vomiting
  • Abdominal pain
  • Fatigue
  • Changes in fat distribution
  • Pneumonia
  • Diabetes or increased blood sugar
  • Fever
  • Bronchitis

Risks and Warnings for Invirase (saquinavir)

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    • Higher risk if:
    • Use with other QT or PR prolonging drugs
    • History of heart disease
    • Low potassium or magnesium levels

    Invirase (saquinavir) can increase the risk for having abnormal heart rhythms called QT or PR prolongation. If you already have problems with your heartbeat, Invirase (saquinavir) can make it worse. Your doctor will check your heart regularly to make sure you can safely take the medicine.

Common concerns from people taking Invirase (saquinavir)

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Interactions
  • Invirase (saquinavir) can interact with many other medications. Make sure your doctor and pharmacist know all of the medicines you're taking, including prescription, over-the-counter, and supplements. Your doctor might have to make changes to your medicines to avoid any harmful drug interactions.
  • Invirase (saquinavir) interacts with many other medications. This interaction can be harmful.
Kidneys and liver
  • Invirase (saquinavir) can damage your liver. If you already have liver damage or hepatitis, Invirase (saquinavir) can make it worse. Your doctor will do blood tests to check your liver regularly. If you notice yellowing of the eyes or skin, dark urine, or abdominal pain, talk to your doctor.