Prescription onlyNo lower cost generic available

Invokana

(Canagliflozin)

  • Pill
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Lowers your blood sugar.

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Prescription onlyNo lower cost generic available

Our pharmacists’ bottom line

Invokana (Canagliflozin) helps lower blood sugar for people with diabetes but it can increase the chance of a yeast infection and can be expensive.

  • Lowers A1c levels by 1% (A1c measures your average blood sugar over time.)
  • Prevents the harmful effects of high sugar levels on your organs.
  • Can be taken by mouth, only once a day, compared to other diabetes medications that require an injection.
  • Has a lower chance of causing low blood sugar than medications like glyburide or insulin.
  • Also available as a combination drug with metformin (Invokamet).
  • Only lowers A1c levels by 1%, which may not be enough to get your blood sugar in the safe range.
  • Not available as a generic.
  • Many other diabetes medications work as well and are cheaper.
  • Can cause increased urination, thirst, and increased likelihood to get yeast infections.
  • Not considered the best first choice drug to help lower blood sugar.

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Side effects for Invokana (Canagliflozin)

From clinical trials of Invokana / Type 2 diabetes (100 mg) ( 737)

  • Female genital mycotic infectionsFemale genital mycotic infections10% for Invokana vs.3% for placebo
  • Urinary tract infectionsUrinary tract infections6% for Invokana vs.4% for placebo
  • Increased urinationIncreased urination5% for Invokana vs.1% for placebo
  • Volume depletionVolume depletion5% for Invokana vs.0% for placebo
  • Volume depletionVolume depletion5% for Invokana vs.0% for placebo
  • Male genital mycotic infectionsMale genital mycotic infections4% for Invokana vs.1% for placebo
  • Hypersensitivity reactionHypersensitivity reaction4% for Invokana vs.0% for placebo
  • Low blood sugarLow blood sugar4% for Invokana vs.3% for placebo
  • ThirstThirst3% for Invokana vs.0% for placebo
  • Volume depletionVolume depletion3% for Invokana vs.0% for placebo

What to expect when you take Invokana (Canagliflozin)

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Tips from our pharmacists
  • Take Invokana (Canagliflozin) before your first meal of the day.
  • Drink plenty of fluids since Invokana (Canagliflozin) can make you thirsty.
  • Eat regular, balanced meals to avoid low blood sugar.
  • It's best to check your blood sugar at least once a day using a home blood sugar monitor to make sure the medication is working well. Some people may need to test more often.

Risks and Warnings for Invokana (Canagliflozin)

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    • Higher risk if:
    • Over age 65
    • Kidney disease
    • Taking blood pressure medications

    People on Invokana (Canagliflozin) have reported having low blood pressure. You are more likely to get this if you are over 65, have kidney disease, or taking blood pressure medications called ACE inhibitors or ARBs. Talk to your doctor since they might have to adjust your medications. Be very careful getting up from either sitting or lying down since you can feel dizzy the first few days you take Invokana (Canagliflozin).

Means that some groups have a high risk of experiencing this side effect

Tips from pharmacists and people taking Invokana (Canagliflozin)

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The FDA category for this medication is C. It is advised that you: Weigh risks vs. benefits
Pregnancy
Food
  • Tips from our pharmacists
  • Take Invokana (Canagliflozin) before your first meal of the day.
  • Eat regular, balanced meals to avoid low blood sugar.
  • Risks from our pharmacists
  • If you're taking Invokana (Canagliflozin) and you're on insulin or other drugs that increase the amount of insulin in your body, you can be at risk for having low blood sugar. Your doctor might have to adjust your dose of these other medications. Always have glucose tablets or another blood sugar rescue food with you in case you get low blood sugar. Good blood sugar rescue foods are 1/2 cup of orange juice, regular (not diet) soda, and 3 teaspoons of table sugar (or 3 sugar packets).
Kidneys & liver
  • Risks from our pharmacists
  • People on Invokana (Canagliflozin) have reported having low blood pressure. You are more likely to get this if you are over 65, have kidney disease, or taking blood pressure medications called ACE inhibitors or ARBs. Talk to your doctor since they might have to adjust your medications. Be very careful getting up from either sitting or lying down since you can feel dizzy the first few days you take Invokana (Canagliflozin).
  • People on Invokana (Canagliflozin) can get high potassium levels in the blood, especially if you have kidney disease or taking blood pressure medications that keep your potassium levels high. Your doctor can monitor your blood for potassium. Talk to your doctor if you suddenly feel weakness in your muscles, numbness or tingling, or if your heart starts beating irregularly.
Weight gain or loss
  • I actually gained weight with this,
    Age: 60
    Gender: Woman
    Taken for: Type 2 diabetes