Prescription onlyClass: Endocrine

Invokana 

(canagliflozin)

Prescription onlyClass: Endocrine
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Lowers blood sugar.

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Our bottom line

Invokana (canagliflozin) can be used together with other diabetes medicines to help lower your blood sugar, but it can be expensive because it's brand name.

Price and discounts
Best available price for 30 (300mg) tablets of invokana
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Upsides

  • Lowers A1C (blood sugar) levels by 1%.
  • You only have to take Invokana (canagliflozin) once a day before meals.
  • Less likely to cause low blood sugar than other diabetes medicines.
  • Also available as a combination drug with metformin (Invokamet).
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Downsides

  • You're more likely to have broken bones, yeast infections and urinary tract infections with Invokana (canagliflozin).
  • There's a rare but serious risk of leg and foot amputations with Invokana (canagliflozin). Talk to your doctor if you develop new pain or infections in your feet.
  • Not for people with severe kidney problems.
  • Can raise your cholesterol.
  • Avoid if you are a heavy drinker of alcohol.
How it works

Invokana (canagliflozin) is an anti-diabetes medication. It lowers blood sugar by causing your body to get rid of sugar in your urine.

What to expect when you take Invokana (canagliflozin) for Type 2 diabetes

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Side effect rates for Invokana (canagliflozin)

737 From clinical trials of Invokana / Type 2 diabetes (100 mg)
  • Yeast infection in women
  • Urinary tract infections
  • Increased urination
  • Yeast infection in men
  • Thirst
  • Vaginal itching
  • Constipation
  • Nausea
  • Abdominal pain

Risks and Warnings for Invokana (canagliflozin)

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    • Higher risk if:
    • History of amputations 
    • Peripheral vascular disease (narrowed blood vessels)
    • Nerve problems
    • Diabetic foot ulcers 

    Rarely, Invokana (canagliflozin) can increase your risk of getting foot or leg amputations. Let your doctor know if you experience any new pain, tenderness, sores, ulcers, or infections on your legs or feet.

Common concerns from people taking Invokana (canagliflozin)

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Pregnancy
Alcohol
  • Avoid if you are a heavy drinker of alcohol.
Food
  • You only have to take Invokana (canagliflozin) once a day before meals.
  • Take once daily before your first meal of the day.
Kidneys and liver
  • Not for people with severe kidney problems.
Pain
  • Rarely, Invokana (canagliflozin) can hurt the kidneys. This is more likely to happen if you already have kidney damage, heart failure, or take certain medicines for blood pressure or anti-inflammatories (NSAIDs). Invokana (canagliflozin) can also lower your blood pressure since it makes you urinate more. Your doctor will check your kidneys by blood tests regularly, and might ask you to change how you take Invokana (canagliflozin). Make sure to stay hydrated to prevent low blood pressure and kidney problems.
Weight
  • I actually gained weight with this,