Invokana Alternatives

(canagliflozin)

Alternatives

Compare Invokana (canagliflozin) to alternatives

These medications are comparable to Invokana (canagliflozin) or used for similar purposes.

Invokana
(canagliflozin)

Farxiga
(dapagliflozin)

Jardiance
(empagliflozin)

metformin

Glucotrol
(glipizide)

glyburide

Afrezza
(insulin)

Actos
(pioglitazone)

Lowers blood sugar. Invokana (canagliflozin) can be used together with other diabetes medicines to help lower your blood sugar, but it can be expensive because it's brand name.Lowers blood sugar. Farxiga (dapagliflozin) can be used together with other diabetes medicines to help lower your blood sugar, but it can be expensive because it's brand name.Lowers blood sugar. Jardiance (empagliflozin) lowers blood sugar for people with diabetes, but can increase the chance of a yeast infection.Lowers blood sugar. Glucophage (metformin) is the first choice medicine to control your blood sugar and lower the risk of death from diabetes, although a few people may not tolerate the stomach side effects.Lowers blood sugar. Glucotrol (glipizide) is an effective medicine for lowering blood sugar, but it can cause your blood sugar level to be too low so you must always carry some form of sugar with you that can be readily used.Lowers blood sugar. Diabeta (glyburide) is a good oral anti-diabetic medicine, but can cause hypoglycemia or low blood sugar.Controls mealtime blood sugar. Afrezza (insulin) is effective at controlling blood sugar, but you can't use it if you've had lung problems or smoke.Lowers blood sugar. Actos (pioglitazone) can improve blood sugar control but is not a top choice since it has a lot of side effects.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.52Invokana
Reviews for Invokana
67%
of people (All ages) say Invokana is worth it
56%
say it works well
19%
say it's a big hassle
Have you used Invokana (canagliflozin)?
Worth itNot sureNot worth it

Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Farxiga (dapagliflozin)?
Worth itNot sureNot worth it

Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Jardiance (empagliflozin)?
Worth itNot sureNot worth it
Reviews for metformin
65%
+2% better vs. Invokana
46%
+10% better vs. Invokana
16%
-3% worse vs. Invokana
938 reviews
Have you used Glucophage (metformin)?
Worth itNot sureNot worth it
Reviews for Glucotrol
50%
+17% better vs. Invokana
32%
+24% better vs. Invokana
19%
Same vs. Invokana
332 reviews
Have you used Glucotrol (glipizide)?
Worth itNot sureNot worth it
Reviews for glyburide
45%
+22% better vs. Invokana
34%
+22% better vs. Invokana
21%
+2% better vs. Invokana
110 reviews
Have you used Diabeta (glyburide)?
Worth itNot sureNot worth it

Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Afrezza (insulin)?
Worth itNot sureNot worth it
Reviews for Actos
42%
+25% better vs. Invokana
30%
+26% better vs. Invokana
21%
+2% better vs. Invokana
175 reviews
Have you used Actos (pioglitazone)?
Worth itNot sureNot worth it
Side effects
InvokanaFarxigaJardiancemetforminGlucotrolglyburideAfrezzaActos
  • Vaginal itching 2%
  • Constipation 1%
  • Abdominal pain 1%
  • Thirst 3%
  • Yeast infection in men 3%
  • Increased urination 4%
  • Urinary tract infections 2%
  • Yeast infection in women 8%
More Invokana side effects »
  • Discomfort with urination 1%
  • Pain in hands and feet 1%
  • Mild low blood sugar 2%
  • Increased urination 1%
  • Male yeast infection 3%
  • Nausea 1%
  • Flu 1%
More Farxiga side effects »
  • Nausea 1%
  • Low blood sugar 1%
  • Increased urination 2%
  • Yeast infection in men 3%
  • Elevated cholesterol levels 1%
  • Yeast infection in women 3%
  • Urinary tract infection 1%
More Jardiance side effects »
  • Stomach pain 1%
  • Headache 1%
  • Indigestion 3%
  • Weakness 3%
  • Gas 6%
  • Nausea/vomiting 18%
  • Diarrhea 41%
More metformin side effects »
  • Passing gas 2%
  • Low blood sugar 3%
  • Nervousness 1%
  • Tremor 4%
  • Diarrhea 5%
  • Dizziness 1%
  • Headache 2%
  • Constipation 3%
  • Nausea 3%
More Glucotrol side effects »
  • Nausea and heartburn 2%
  • Skin allergies 2%
More glyburide side effects »
  • Wet cough 1%
  • Fatigue 1%
  • Nausea 2%
  • Diarrhea 2%
  • Severe low blood sugar 3%
  • Dry cough 6%
  • Low blood sugar 37%
  • Urinary tract infection 2%
More Afrezza side effects »
  • Muscle pain 2%
  • Sore throat 4%
  • Sinus infection 1%
  • Back pain 1%
  • Heart failure 2%
  • Headache 2%
  • Colds and flu 4%
  • Low blood sugar 8%
More Actos side effects »
How it works
InvokanaFarxigaJardiancemetforminGlucotrolglyburideAfrezzaActos
Invokana (canagliflozin) is an anti-diabetes medication. It lowers blood sugar by causing your body to get rid of sugar in your urine.Farxiga (dapagliflozin) is an anti-diabetes medication. It lowers blood sugar by causing your body to get rid of sugar in your urine.Jardiance (empagliflozin) is an anti-diabetes medication. It passes the sugar from your blood through your urine.Glucophage (metformin) is an anti-diabetic drug. It lowers the amount of sugar your body makes or absorbs, and allows your body use the existing insulin better.Glucotrol (glipizide) stimulates your body to release insulin and lower blood sugar.Diabeta (glyburide) stimulates your body to release insulin and lower blood sugar.Afrezza (insulin) is an insulin that controls your blood sugar by turning the sugars you eat into energy or storing it in your body for future use.Actos (pioglitazone) is a thiazolidinedione that improves your body's ability to use insulin to lower your blood sugar.
Type of medication
InvokanaFarxigaJardiancemetforminGlucotrolglyburideAfrezzaActos
Prescription onlyNo lower cost generic availablePrescription onlyNo lower cost generic availablePrescription onlyNo lower cost generic availablePrescription onlyLower-cost generic availablePrescription onlyLower-cost generic availablePrescription onlyLower-cost generic availablePrescription onlyNo lower cost generic availablePrescription onlyLower-cost generic available
Available as
InvokanaFarxigaJardiancemetforminGlucotrolglyburideAfrezzaActos
  • Pill
  • Pill
  • Pill
  • Pill
  • Extended release pill
  • Liquid
  • Pill
  • Extended release pill
  • Pill
  • Inhalation powder
  • Pill
Used for
InvokanaFarxigaJardiancemetforminGlucotrolglyburideAfrezzaActos
Risk factors for serious side effects
InvokanaFarxigaJardiancemetforminGlucotrolglyburideAfrezzaActos
  • History of amputations 
  • Peripheral vascular disease (narrowed blood vessels)
  • Nerve problems
  • Diabetic foot ulcers 
  • History of kidney damage
Detailed Invokana (canagliflozin) risks & warnings »
  • Taking water pills for blood pressure
  • Over age 65
  • Kidney problems
  • Kidney damage
  • Taking water pills, ACE inhibitors or ARBs for blood pressure
Detailed Farxiga (dapagliflozin) risks & warnings »
  • Over age 65
  • Kidney disease
  • Taking blood pressure medications
  • Dehydration
  • Poor baseline kidney function
Detailed Jardiance (empagliflozin) risks & warnings »
  • Kidney problems
  • Liver problems
  • Congestive heart failure
  • Using contrast dye for procedures
  • Surgery
Detailed Glucophage (metformin) risks & warnings »
  • Skipping meals or having inconsistent meal times
  • Drinking alcohol
  • Using other blood sugar-lowering medicine
  • People age 60 or older
  • Those with kidney and/or liver problems
Detailed Glucotrol (glipizide) risks & warnings »
  • Over age 65
  • Kidney problems
  • Use of other blood sugar lowering medicines
  • Alcohol
  • Intense physical activity
Detailed Diabeta (glyburide) risks & warnings »
  • Changes in diet and exercise
  • Drinking alcohol
  • Taking other medications for diabetes
  • Over age 65
  • Liver or kidney problems
Detailed Afrezza (insulin) risks & warnings »
  • Heart failure
  • Current liver problems
  • History of bladder cancer
  • Women
Detailed Actos (pioglitazone) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Alcohol
InvokanaFarxigaJardiancemetforminGlucotrolglyburideAfrezzaActos
  • Avoid if you are a heavy drinker of alcohol.
  • Not a good choice if you drink a lot of alcohol.
No alcohol related info.
  • Limit or avoid alcohol when taking this medicine.
  • Excessive or chronic alcohol use can increase the risk of a dangerous side effect.
  • Avoid drinking alcohol while taking Glucotrol (glipizide).
  • Try to avoid drinking alcohol while on Diabeta (glyburide).
  • Avoid drinking alcohol or using over-the-counter medications that contain alcohol while on Afrezza (insulin).
No alcohol related info.
Food
InvokanaFarxigaJardiancemetforminGlucotrolglyburideAfrezzaActos
  • Take once daily before your first meal of the day.
  • You only have to take Invokana (canagliflozin) once a day before meals.
  • Take once in the morning with or without food.
  • Take once a day in the morning with or without food.
  • Always take it with food to lessen stomach upset.
  • Eat regular and well-balanced meals to keep your blood sugar levels normal.
  • Eat well-balanced meals to avoid low blood sugar.
  • You should inhale Afrezza (insulin) at the beginning of a meal.
  • Afrezza (insulin) is as effective as other mealtime insulin products.
  • Take once a day with or without food.
Kidneys and liver
InvokanaFarxigaJardiancemetforminGlucotrolglyburideAfrezzaActos
  • Not for people with severe kidney problems.
  • Farxiga (dapagliflozin) can cause or worsen kidney problems. If you already have severe kidney damage, you can't take Farxiga (dapagliflozin). You're more likely to have this happen if you're on certain medicines to lower your blood pressure or anti-inflammatory medicines (NSAIDs), have heart failure or mild kidney damage. Your doctor will have you do regular blood tests to make sure your kidneys are healthy.
  • Jardiance (empagliflozin) can cause or worsen kidney problems. Make sure to stay properly hydrated. Get blood test for kidney function before starting Jardiance (empagliflozin), a few weeks after starting, and regularly thereafter.
  • Glucophage (metformin) can cause this rare life-threatening condition. Your doctor will check your kidneys and liver before you start. Symptoms include deep and rapid breathing, nausea, vomiting, and stomach pain. This is a medical emergency and you should get help right away. You're more likely to get this if you already have kidney problems. Glucophage (metformin) should be stopped 48 hours before and after surgery or any imaging procedure needing contrast dye.
  • Usually not a good choice for people with kidney problems. Your doctor will tell you if Glucophage (metformin) is right for you to take.
No kidneys and liver related info.
  • Not ideal for elderly or those with poor kidney function.
No kidneys and liver related info.
  • If you've had liver problems or damage in the past, talk to your doctor before starting Actos (pioglitazone), since there's a small chance that it can hurt your liver. Tell your doctor about any stomach pain that don't go away, dark urine, or yellowing of eyes/skin. Your doctor will check your liver regularly.
Pain
InvokanaFarxigaJardiancemetforminGlucotrolglyburideAfrezzaActos
  • Rarely, Invokana (canagliflozin) can hurt the kidneys. This is more likely to happen if you already have kidney damage, heart failure, or take certain medicines for blood pressure or anti-inflammatories (NSAIDs). Invokana (canagliflozin) can also lower your blood pressure since it makes you urinate more. Your doctor will check your kidneys by blood tests regularly, and might ask you to change how you take Invokana (canagliflozin). Make sure to stay hydrated to prevent low blood pressure and kidney problems.
  • Tell your doctor right away if you have blood in urine, or pain when you urinate.
  • Let your doctor know of any constant dizziness, joint pain, cold-like symptoms, or unexplained nausea/vomiting.
No pain related info.No pain related info.No pain related info.No pain related info.No pain related info.
Weight
InvokanaFarxigaJardiancemetforminGlucotrolglyburideAfrezzaActos
No weight related info.
  • Can help you lose weight.
  • Can cause weight loss.
  • Doesn't cause weight gain.
  • Can cause mild weight gain of 2-3lb.
  • Can cause weight gain, dizziness, or stomach upset.
  • Can cause weight gain (about 2 to 3 pounds).
No weight related info.
  • Can cause weight gain, headache, and swelling from fluid build-up.
  • Can cause weight gain.
Upsides and benefits
InvokanaFarxigaJardiancemetforminGlucotrolglyburideAfrezzaActos
  • Lowers A1C (blood sugar) levels by 1%.
  • You only have to take Invokana (canagliflozin) once a day before meals.
  • Less likely to cause low blood sugar than other diabetes medicines.
  • Also available as a combination drug with metformin (Invokamet).
  • Can lower A1c by 1% (A1c measures your average blood sugar over time.)
  • Can help you lose weight.
  • Less chance of low blood sugar than other diabetes medicines.
  • Lowers A1c (average blood sugar over time) levels up to 1%.
  • Can prevent death from heart attack, stroke, or heart failure if you have pre-existing heart disease.
  • Can be easily taken orally as a pill.
  • Can cause weight loss.
  • Not likely to cause hypoglycemia or very low blood sugar.
  • Improves sugar control and lowers A1c levels as much as 2%.
  • One of the few diabetes medicines that lowers the risk of death from diabetes-related complications.
  • Doesn't cause weight gain.
  • Rarely causes low blood sugar.
  • Lowers A1c levels by 1-2%.
  • Glucotrol (glipizide) is an oral medicine so it might be a good alternative for those who don't like injections.
  • Protects your organs and blood vessels by preventing the harmful effects of high blood sugar levels.
  • Okay to use by people with kidney problems.
  • Available as a generic form and is relatively cheap.
  • Available as an oral tablet.
  • Lowers your A1c (average blood sugar over time) up to 2%.
  • Available in generic version.
  • Available in single pill combination with other anti-diabetic medicines.
  • Afrezza (insulin) is as effective as other mealtime insulin products.
  • Starts working faster and stays in your body for a shorter time than other mealtime insulin products, so you're less likely to have severely low blood sugar.
  • If you don't like needles, Afrezza (insulin) is a good alternative since you inhale it.
  • Safe to use in people 65 or older.
  • Talk to your doctor or pharmacist about ways to lower your copay, such as coupons.
  • Improves sugar control and lowers A1c levels by around 1%.
  • Easily taken by mouth as a once a day pill.
  • Prevents the harmful effects of high sugar levels on your organs.
  • Rarely causes low blood sugar.
  • Lower the risk of heart attack or stroke.
Downsides and risks
InvokanaFarxigaJardiancemetforminGlucotrolglyburideAfrezzaActos
  • You're more likely to have broken bones, yeast infections and urinary tract infections with Invokana (canagliflozin).
  • There's a rare but serious risk of leg and foot amputations with Invokana (canagliflozin). Talk to your doctor if you develop new pain or infections in your feet.
  • Not for people with severe kidney problems.
  • Can raise your cholesterol.
  • Avoid if you are a heavy drinker of alcohol.
  • Not a first choice medicine for diabetes because it doesn't lower blood sugar as much as other medicines.
  • Higher risk of genital yeast infections and urinary tract infections.
  • This is an expensive medication with no generic available at this time.
  • Not shown to improve cardiovascular outcomes like other similar medicines because it can increase cholesterol.
  • Not a good choice if you drink a lot of alcohol.
  • More expensive since it's available as brand name only.
  • Can cause dehydration.
  • Often causes stomach upset, like diarrhea, nausea, gas, or stomach cramping.
  • Usually not a good choice for people with kidney problems. Your doctor will tell you if Glucophage (metformin) is right for you to take.
  • Excessive or chronic alcohol use can increase the risk of a dangerous side effect.
  • Has a higher risk than other diabetes medicine for causing blood sugar levels to be too low.
  • While taking Glucotrol (glipizide), your blood sugars should be checked 2 to 5 times a week, but less often once you are on a stable dose.
  • Can cause mild weight gain of 2-3lb.
  • Might lose its effectiveness over time.
  • Needs to be taken 30 minutes before a meal for it to be most effective.
  • More likely to cause hypoglycemia or low blood sugar than other types of oral anti-diabetics.
  • You will have to check your blood sugar often when you first start taking it.
  • Can cause weight gain (about 2 to 3 pounds).
  • Not ideal for elderly or those with poor kidney function.
  • May not work as well for those with severe diabetes and when pancreas cannot produce insulin.
  • Not recommended if you're a smoker or if you've smoked in the last 6 months.
  • Afrezza (insulin) only comes in 3 different strengths, so it can be inconvenient if you need a lot of insulin.
  • Not recommended in children under 18.
  • If you're pregnant, you'll need to talk to your doctor before you start Afrezza (insulin).
  • There is no generic available, and may not be covered right away by Medicare or other insurances.
  • May take several weeks to lower blood sugar.
  • Can cause weight gain.
  • People with heart failure or history of bladder cancer shouldn't use this medicine.
  • Some people might get fluid accumulation (edema), from minor ankle swelling to fluid in lungs that makes it hard to breathe.
  • Raises the risk of bone fractures, especially for people who already have a risk for fractures.
Tips from our pharmacists for people taking the medication
InvokanaFarxigaJardiancemetforminGlucotrolglyburideAfrezzaActos
  • Take once daily before your first meal of the day.
  • Invokana (canagliflozin) can cause you to urinate more, so be sure to stay hydrated.
  • Can cause genital yeast infections in females and males.
  • Can cause urinary tract infections (UTI).
  • Can cause low blood sugar, so make sure to check your blood sugar if you don't feel well.
  • You should continue to exercise regularly, eat a healthy diet, and take your other diabetes medicines along with Invokana (canagliflozin).
  • Take once in the morning with or without food.
  • Farxiga (dapagliflozin) can cause you to urinate more, so be sure to stay hydrated.
  • Can cause genital yeast infections in females and males.
  • Can cause urinary tract infections (UTI).
  • Do not take if you have kidney problems or bladder cancer.
  • Tell your doctor right away if you have blood in urine, or pain when you urinate.
  • Take once a day in the morning with or without food.
  • You urinate more often so make sure to stay properly hydrated.
  • Can lower blood pressure.
  • Increases the chances of yeast or urinary tract infection, so practice good hygiene.
  • Check blood sugar and blood pressure regularly.
  • Let your doctor know of any constant dizziness, joint pain, cold-like symptoms, or unexplained nausea/vomiting.
  • Can cause upset stomach with nausea and especially diarrhea in the first couple of weeks.
  • Always take it with food to lessen stomach upset.
  • Stay hydrated.
  • Limit or avoid alcohol when taking this medicine.
  • Tell your doctor about any deep or rapid breathing, or persistent nausea, vomiting, and stomach pain.
  • Check your blood sugar regularly.
  • Take the medicine 30 minutes before eating, usually before your first big meal of the day.
  • Avoid drinking alcohol while taking Glucotrol (glipizide).
  • Eat regular and well-balanced meals to keep your blood sugar levels normal.
  • Check your blood sugar regularly.
  • Glucotrol (glipizide) can cause dizziness so avoid activities that require coordination until you know how your body can handle the medicine.
  • Check your blood sugar regularly.
  • Eat well-balanced meals to avoid low blood sugar.
  • Works best if you take it 30 minutes before first main meal of the day.
  • Can cause weight gain, dizziness, or stomach upset.
  • Try to avoid drinking alcohol while on Diabeta (glyburide).
  • Take Afrezza (insulin) exactly as your doctor or pharmacist tells you, otherwise you might not get the full dose of the medicine.
  • Keep Afrezza (insulin) in the fridge until you're ready to use it. The Afrezza (insulin) cartridges and inhaler should be left at room temperature for 10 minutes before you use it.
  • You should inhale Afrezza (insulin) at the beginning of a meal.
  • Avoid drinking alcohol or using over-the-counter medications that contain alcohol while on Afrezza (insulin).
  • Avoid driving or operating heavy machinery until you know how Afrezza (insulin) can affect you.
  • If you're using a long-acting insulin, you need to keep using it with Afrezza (insulin).
  • Take once a day with or without food.
  • May need several weeks to see full effect on blood sugar control.
  • Can cause weight gain, headache, and swelling from fluid build-up.
  • Tell your doctor about any shortness of breath, heart troubles, or unusual swelling.
  • Not recommended for patients with a history of heart failure or bladder cancer.
  • Check your blood sugar regularly.
Learn more
More about InvokanaSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Invokana (canagliflozin)?
Worth itNot sureNot worth it
More about FarxigaSide effectsFDA package insert
Have you used Farxiga (dapagliflozin)?
Worth itNot sureNot worth it
More about JardianceSide effectsFDA package insert
Have you used Jardiance (empagliflozin)?
Worth itNot sureNot worth it
More about metforminSide effectsReviews & ratingsFDA package insert
Have you used Glucophage (metformin)?
Worth itNot sureNot worth it
More about GlucotrolSide effectsReviews & ratingsFDA package insert
Have you used Glucotrol (glipizide)?
Worth itNot sureNot worth it
More about glyburideSide effectsReviews & ratingsFDA package insert
Have you used Diabeta (glyburide)?
Worth itNot sureNot worth it
More about AfrezzaSide effectsFDA package insert
Have you used Afrezza (insulin)?
Worth itNot sureNot worth it
More about ActosSide effectsReviews & ratingsFDA package insert
Have you used Actos (pioglitazone)?
Worth itNot sureNot worth it