Prescription onlyClass: Endocrine

Invokana Alternatives

(Canagliflozin)

Prescription onlyClass: Endocrine
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Compare Invokana (Canagliflozin) to alternatives

These medications are comparable to Invokana (Canagliflozin) or used for similar purposes.

Invokana
(Canagliflozin)

Glucophage
(Metformin)

Diabeta
(Glyburide)

Glucotrol
(Glipizide)

Actos
(Pioglitazone)

Lowers your blood sugar. Invokana (Canagliflozin) helps lower blood sugar for people with diabetes but it can increase the chance of a yeast infection and can be expensive.Lowers blood sugar. Glucophage (Metformin) is a very effective medicine to lower blood sugar and the risk of complications and death from diabetes, but it's likely to cause diarrhea for the first few weeks.Lowers blood sugar. Glyburide is a very effective oral blood sugar-lowering medicine, but has more side effects and restrictions compared to other medicines in this class (sulfonylureas).Lowers blood sugar. Glucotrol (Glipizide) is a very effective oral blood sugar-lowering medicine. It can cause low blood sugar, so make sure you know what the symptoms are and always have a source of sugar nearby.Lowers blood sugar. Actos (Pioglitazone) is a last-choice blood sugar-lowering medicine since it's only moderately effective but has a lot of undesirable side effects.
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Reviews & ratings
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Have you used Invokana (Canagliflozin)?
Worth itNot sureNot worth it
Reviews for Glucophage (Metformin)
65%
-2% worse vs. Invokana (Canagliflozin)
46%
-10% worse vs. Invokana (Canagliflozin)
16%
+3% better vs. Invokana (Canagliflozin)
938 reviews
Have you used Glucophage (Metformin)?
Worth itNot sureNot worth it
Reviews for Diabeta (Glyburide)
45%
-22% worse vs. Invokana (Canagliflozin)
34%
-22% worse vs. Invokana (Canagliflozin)
21%
-2% worse vs. Invokana (Canagliflozin)
110 reviews
Have you used Diabeta (Glyburide)?
Worth itNot sureNot worth it
Reviews for Glucotrol (Glipizide)
50%
-17% worse vs. Invokana (Canagliflozin)
32%
-24% worse vs. Invokana (Canagliflozin)
19%
Same vs. Invokana (Canagliflozin)
332 reviews
Have you used Glucotrol (Glipizide)?
Worth itNot sureNot worth it
Reviews for Actos (Pioglitazone)
42%
-25% worse vs. Invokana (Canagliflozin)
30%
-26% worse vs. Invokana (Canagliflozin)
21%
-2% worse vs. Invokana (Canagliflozin)
175 reviews
Have you used Actos (Pioglitazone)?
Worth itNot sureNot worth it
Side effects
InvokanaMetforminGlyburideGlucotrolActos
  • Female genital mycotic infections 7%
  • Urinary tract infections 2%
  • Increased urination 4%
  • Volume depletion 5%
  • Male genital mycotic infections 3%
  • Hypersensitivity reaction 4%
  • Low blood sugar 1%
  • Thirst 3%
  • Vulvovaginal pruritus 3%
More Invokana side effects »
  • Diarrhea 41%
  • Nausea/vomiting 18%
  • Passing gas 6%
  • Muscle weakness 3%
  • Indigestion 3%
  • Abdominal discomfort 1%
  • Headache 1%
More Metformin side effects »
  • Gastrointestinal disturbances 2%
  • Allergic skin reactions 2%
More Glyburide side effects »
  • Dizziness 1%
  • Diarrhea 5%
  • Nervousness 1%
  • Tremor 4%
  • Passing gas 2%
  • Drowsiness 2%
More Glucotrol side effects »
  • Swelling due to excess fluid 11%
  • Low blood sugar 8%
  • Ear, nose, or throat infection 4%
  • Headache 2%
  • Cardiac failure 2%
  • Back pain 1%
  • Sinus inflammation 1%
  • Muscle pain 2%
More Actos side effects »
How it works
InvokanaMetforminGlyburideGlucotrolActos
Invokana (Canagliflozin) is an anti-diabetes medication. It lowers blood sugar by causing your body to get rid of sugar in your urine.Glucophage (Metformin) is an anti-diabetic drug. It lowers sugar production in your body, decreases sugar absorption in your intestines, and makes your body more sensitive to insulin.Glyburide is an anti-diabetic drug. It stimulates your body to make more insulin to lower blood sugar.Glucotrol (Glipizide) is an anti-diabetic drug. It stimulates your body to make more insulin to lower blood sugar.Actos (Pioglitazone) is an anti-diabetic drug. It improves your body's ability to use insulin to lower your blood sugar.
Type of medication
InvokanaMetforminGlyburideGlucotrolActos
Prescription only
Prescription only
Prescription only
Prescription only
Prescription only
Available as
InvokanaMetforminGlyburideGlucotrolActos
  • Pill
  • Pill
  • Extended release
  • Liquid
  • Pill
  • Pill
  • Extended release
  • Pill
Used for
InvokanaMetforminGlyburideGlucotrolActos
Risk factors for serious side effects
InvokanaMetforminGlyburideGlucotrolActos
  • Over age 65
  • Kidney disease
  • Taking blood pressure medications
  • Kidney disease
  • Taking blood pressure medications
  • Using insulin
  • Using medications that increase the amount of insulin in your body (glipizide, glyburide or glimepiride)
  • Women
  • Uncircumcised men
      Detailed Invokana (Canagliflozin) risks & warnings »
      • Kidney problems
      • Liver problems
      • Congestive heart failure
      • Using contrast dye for procedures
      • Surgery
      • Alcohol use
        Detailed Glucophage (Metformin) risks & warnings »
          • Elderly
          • Use of other blood sugar lowering medicines
          • Alcohol
          • Intense physical activity
          • History of sulfa allergies
          Detailed Diabeta (Glyburide) risks & warnings »
            • Use of other blood sugar lowering medicines
            • Alcohol
            • Intense physical activity
            • History of sulfa allergies
            Detailed Glucotrol (Glipizide) risks & warnings »
            • Heart failure diagnosis
              • Current liver problems
                • Female
                Detailed Actos (Pioglitazone) risks & warnings »
                Pregnancy

                Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

                Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

                Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

                Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

                Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

                Alcohol
                InvokanaMetforminGlyburideGlucotrolActos
                No alcohol related info.No alcohol related info.
                • Avoid drinking alcohol.
                • Avoid drinking alcohol.
                No alcohol related info.
                Food
                InvokanaMetforminGlyburideGlucotrolActos
                • Take Invokana (Canagliflozin) before your first meal of the day.
                • Eat regular, balanced meals to avoid low blood sugar.
                • Always take it with food or switch to the extended release version to avoid upset stomach.
                • Eat regular, balanced meals to avoid low blood sugar.
                • Food can cause unpredictable effects of the immediate-release version of Glipizide, so you have to take it at least 30 minutes before a meal.
                • Eat regular, balanced meals to avoid low blood sugar.
                No food related info.
                Kidneys and liver
                InvokanaMetforminGlyburideGlucotrolActos
                No kidneys and liver related info.
                • People with poor kidney function can't use it.
                • Glucophage (Metformin) can cause this rare but life-threatening condition. Symptoms include deep and rapid breathing, nausea, vomiting, and stomach pain. This is a medical emergency and you should get help right away. Baseline blood work for kidney and liver function are helpful to see if you can use Glucophage (Metformin). It may not be a good choice for people with kidney problems. Glucophage (Metformin) should be stopped 48 hours before and/or after surgery or any imaging procedure needing contrast dye.
                • Not a good choice for people with kidney problems because it's processed by the kidneys.
                • Might be a better choice for people with kidney problems compared to similar drugs because Glipizide isn't processed by the kidneys.
                No kidneys and liver related info.
                Weight
                InvokanaMetforminGlyburideGlucotrolActos
                No weight related info.
                • Unlike some diabetes medicines, doesn't cause weight gain or low blood sugar.
                • Can cause mild weight gain (2 to 3 pounds).
                • Can cause weight gain, dizziness, or stomach upset.
                • Can cause mild weight gain (2 to 3 pounds).
                • Can cause weight gain, dizziness, or stomach upset.
                • More likely to cause weight gain (2 to 6 pounds or more) compared to other blood sugar-lowering medicines.
                • Can cause weight gain, headache, and fluid retention.
                Upsides and benefits
                InvokanaMetforminGlyburideGlucotrolActos
                • Lowers A1c levels by 1% (A1c measures your average blood sugar over time.)
                • Prevents the harmful effects of high sugar levels on your organs.
                • Can be taken by mouth, only once a day, compared to other diabetes medications that require an injection.
                • Has a lower chance of causing low blood sugar than medications like glyburide or insulin.
                • Also available as a combination drug with metformin (Invokamet).
                • Oral blood sugar-lowering medicine.
                • A common first treatment for people with newly-diagnosed Type 2 diabetes.
                • The only oral diabetes medicine that lowers complications and deaths from conditions related to diabetes.
                • Lowers A1c levels by 1-2%. (Hemoglobin A1c measures your average blood sugar over time.)
                • Prevents the harmful effects of high sugar levels on your organs and blood vessels.
                • Also lowers certain lipid (fat and cholesterol) levels.
                • Unlike some diabetes medicines, doesn't cause weight gain or low blood sugar.
                • You don't have to check your blood sugar every day with this medicine.
                • One of the least expensive diabetes medicines.
                • Oral blood sugar-lowering medicine.
                • Lowers A1c levels by 1-2%. (Hemoglobin A1c measures your average blood sugar over time.)
                • Prevents the harmful effects of high sugar levels on your organs and blood vessels.
                • One of the least expensive diabetes medicines.
                • Oral blood sugar-lowering medicine.
                • Lowers A1c levels by 1-2%. (Hemoglobin A1c measures your average blood sugar over time.)
                • Prevents the harmful effects of high sugar levels on your organs and blood vessels.
                • Might be a better choice for people with kidney problems compared to similar drugs because Glipizide isn't processed by the kidneys.
                • One of the least expensive diabetes medicines.
                • Oral blood sugar-lowering medicine.
                • Lowers A1c levels by around 1%. (Hemoglobin A1c measures your average blood sugar over time.)
                • Prevents the harmful effects of high sugar levels on your organs and blood vessels.
                • Rarely causes low blood sugar.
                Downsides and risks
                InvokanaMetforminGlyburideGlucotrolActos
                • Only lowers A1c levels by 1%, which may not be enough to get your blood sugar in the safe range.
                • Not available as a generic.
                • Many other diabetes medications work as well and are cheaper.
                • Can cause increased urination, thirst, and increased likelihood to get yeast infections.
                • Not considered the best first choice drug to help lower blood sugar.
                • Most people will have nausea, indigestion, or diarrhea in the first few weeks. You can minimize this if you take it on a full stomach.
                • People with poor kidney function can't use it.
                • Only works if your body can still make your own insulin, a hormone that tells your body what to do with sugar, protein, and fat.
                • Higher risk of low blood sugar episodes than other kinds of oral diabetes medicines.
                • You have to check your blood sugar 2 to 5 times a week (less often once you are on a stable dose).
                • Can cause mild weight gain (2 to 3 pounds).
                • Not preferred for people 65 years or older since it can cause prolonged low blood sugar (more than 12 hours).
                • Not a good choice for people with kidney problems because it's processed by the kidneys.
                • Loses effectiveness over time or as your body stops making insulin.
                • Higher risk of low blood sugar episodes than other kinds of oral diabetes medicines.
                • You have to check your blood sugar 2 to 5 times a week (less often once you are on a stable dose).
                • Can cause mild weight gain (2 to 3 pounds).
                • Loses effectiveness over time or as your body stops making insulin.
                • Food can cause unpredictable effects of the immediate-release version of Glipizide, so you have to take it at least 30 minutes before a meal.
                • May take several weeks to lower blood sugar.
                • You have to check your blood sugar regularly with this medicine.
                • Has more side effects than similar medicines, so it's usually not the first choice for new Type 2 diabetes patients.
                • More likely to cause weight gain (2 to 6 pounds or more) compared to other blood sugar-lowering medicines.
                • Up to 1 in 10 people might get fluid retention (edema), ranging from mild ankle swelling to severe swelling in the lungs that makes it hard to breathe. People with severe congestive heart failure shouldn't use Actos.
                • Raises the risk of bone fractures, especially for people who already have a risk for fractures.
                • Slightly raises the risk of bladder cancer.
                Tips from our pharmacists for people taking the medication
                InvokanaMetforminGlyburideGlucotrolActos
                • Take Invokana (Canagliflozin) before your first meal of the day.
                • Drink plenty of fluids since Invokana (Canagliflozin) can make you thirsty.
                • Eat regular, balanced meals to avoid low blood sugar.
                • It's best to check your blood sugar at least once a day using a home blood sugar monitor to make sure the medication is working well. Some people may need to test more often.
                • Can cause upset stomach with nausea and especially diarrhea in the first couple of weeks.
                • Always take it with food or switch to the extended release version to avoid upset stomach.
                • Tell your doctor about any deep or rapid breathing, or persistent nausea, vomiting, and stomach pain.
                • Check your blood sugar regularly.
                • Works best if you take it 30 minutes before a meal, usually your first big meal of the day.
                • Can cause weight gain, dizziness, or stomach upset.
                • Avoid drinking alcohol.
                • Eat regular, balanced meals to avoid low blood sugar.
                • Check your blood sugar regularly.
                • Works best if you take it 30 minutes before a meal, usually your first big meal of the day.
                • Can cause weight gain, dizziness, or stomach upset.
                • Avoid drinking alcohol.
                • Eat regular, balanced meals to avoid low blood sugar.
                • Check your blood sugar regularly.
                • Takes several weeks to see full effect on blood sugar control.
                • Can cause weight gain, headache, and fluid retention.
                • Tell your doctor about any mental confusion, persistent abdominal pain, dark urine, yellowing of eyes/skin, or easy bruising.
                • Not recommended for patients with certain heart problems.
                • Check your blood sugar regularly.
                Learn more
                More about InvokanaSide effectsReviews & ratingsAlternativesFDA package insert
                Have you used Invokana (Canagliflozin)?
                Worth itNot sureNot worth it
                More about MetforminSide effectsReviews & ratingsFDA package insert
                Have you used Glucophage (Metformin)?
                Worth itNot sureNot worth it
                More about GlyburideSide effectsReviews & ratingsFDA package insert
                Have you used Diabeta (Glyburide)?
                Worth itNot sureNot worth it
                More about GlucotrolSide effectsReviews & ratingsFDA package insert
                Have you used Glucotrol (Glipizide)?
                Worth itNot sureNot worth it
                More about ActosSide effectsReviews & ratingsFDA package insert
                Have you used Actos (Pioglitazone)?
                Worth itNot sureNot worth it