Prescription onlyClass: Endocrine

Invokana Alternatives

(canagliflozin)

Prescription onlyClass: Endocrine
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Compare Invokana (canagliflozin) to alternatives

These medications are comparable to Invokana (canagliflozin) or used for similar purposes.

Invokana
(canagliflozin)

Farxiga
(dapagliflozin)

Glucophage
(metformin)

Glucotrol
(glipizide)

Diabeta
(glyburide)

Actos
(pioglitazone)

Lowers blood sugar. Invokana (canagliflozin) can be used together with other diabetes medicines to help lower your blood sugar, but it can be expensive because it's brand name.Lowers blood sugar. Farxiga (dapagliflozin) can be used together with other diabetes medicines to help lower your blood sugar, but it can be expensive because it's brand name.Lowers blood sugar. Glucophage (metformin) is the first choice medicine to control your blood sugar and lower the risk of death from diabetes, although a few people may not tolerate the stomach side effects.Lowers blood sugar. Glucotrol (Glipizide) is a very effective oral blood sugar-lowering medicine. It can cause low blood sugar, so make sure you know what the symptoms are and always have a source of sugar nearby.Lowers blood sugar. Diabeta (glyburide) is a good oral anti-diabetic medicine, but can cause hypoglycemia or low blood sugar.Lowers blood sugar. Actos (Pioglitazone) is a last-choice blood sugar-lowering medicine since it's only moderately effective but has a lot of undesirable side effects.
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Reviews & ratings
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5.52Invokana
Reviews for Invokana (canagliflozin)
67%
of people (All ages) say Invokana (canagliflozin) is worth it
56%
say it works well
19%
say it's a big hassle
Have you used Invokana (canagliflozin)?
Worth itNot sureNot worth it
Reviews for Farxiga (dapagliflozin)
Not enough review data. Review it!
-67% worse vs. Invokana (canagliflozin)
Not enough review data. Review it!
-56% worse vs. Invokana (canagliflozin)
Not enough review data. Review it!
+19% better vs. Invokana (canagliflozin)
Have you used Farxiga (dapagliflozin)?
Worth itNot sureNot worth it
Reviews for Glucophage (metformin)
65%
-2% worse vs. Invokana (canagliflozin)
46%
-10% worse vs. Invokana (canagliflozin)
16%
+3% better vs. Invokana (canagliflozin)
938 reviews
Have you used Glucophage (metformin)?
Worth itNot sureNot worth it
Reviews for Glucotrol (glipizide)
50%
-17% worse vs. Invokana (canagliflozin)
32%
-24% worse vs. Invokana (canagliflozin)
19%
Same vs. Invokana (canagliflozin)
332 reviews
Have you used Glucotrol (glipizide)?
Worth itNot sureNot worth it
Reviews for Diabeta (glyburide)
45%
-22% worse vs. Invokana (canagliflozin)
34%
-22% worse vs. Invokana (canagliflozin)
21%
-2% worse vs. Invokana (canagliflozin)
110 reviews
Have you used Diabeta (glyburide)?
Worth itNot sureNot worth it
Reviews for Actos (pioglitazone)
42%
-25% worse vs. Invokana (canagliflozin)
30%
-26% worse vs. Invokana (canagliflozin)
21%
-2% worse vs. Invokana (canagliflozin)
175 reviews
Have you used Actos (pioglitazone)?
Worth itNot sureNot worth it
Side effects
InvokanaFarxigametforminGlucotrolglyburideActos
  • Yeast infection in women 8%
  • Urinary tract infections 2%
  • Increased urination 4%
  • Yeast infection in men 3%
  • Thirst 3%
  • Vaginal itching 2%
  • Constipation 1%
  • Abdominal pain 1%
More Invokana side effects »
  • Female yeast infection 6%
  • Common cold symptoms 1%
  • Urinary tract infection 2%
  • Increased urination 1%
  • Male yeast infection 3%
  • Nausea 1%
  • Flu 1%
More Farxiga side effects »
  • Diarrhea 41%
  • Nausea/vomiting 18%
  • Gas 6%
  • Weakness 3%
  • Indigestion 3%
  • Stomach pain 1%
  • Headache 1%
More metformin side effects »
  • Dizziness 1%
  • Diarrhea 5%
  • Nervousness 1%
  • Tremor 4%
  • Passing gas 2%
  • Drowsiness 2%
More Glucotrol side effects »
  • Nausea and heartburn 2%
  • Skin allergies 2%
More glyburide side effects »
  • Swelling due to excess fluid 11%
  • Low blood sugar 8%
  • Ear, nose, or throat infection 4%
  • Headache 2%
  • Cardiac failure 2%
  • Back pain 1%
  • Sinus inflammation 1%
  • Muscle pain 2%
More Actos side effects »
How it works
InvokanaFarxigametforminGlucotrolglyburideActos
Invokana (canagliflozin) is an anti-diabetes medication. It lowers blood sugar by causing your body to get rid of sugar in your urine.Farxiga (dapagliflozin) is an anti-diabetes medication. It lowers blood sugar by causing your body to get rid of sugar in your urine.Glucophage (metformin) is an anti-diabetic drug. It lowers the amount of sugar your body makes or absorbs, and allows your body use the existing insulin better.Glucotrol (Glipizide) is an anti-diabetic drug. It stimulates your body to make more insulin to lower blood sugar.Diabeta (glyburide) stimulates your body to release insulin and lower blood sugar.Actos (Pioglitazone) is an anti-diabetic drug. It improves your body's ability to use insulin to lower your blood sugar.
Type of medication
InvokanaFarxigametforminGlucotrolglyburideActos
Prescription only
Prescription only
Prescription only
Prescription only
Prescription only
Prescription only
Available as
InvokanaFarxigametforminGlucotrolglyburideActos
  • Pill
  • Pill
  • Pill
  • Extended release pill
  • Liquid
  • Pill
  • Extended release
  • Pill
  • Pill
Used for
InvokanaFarxigametforminGlucotrolglyburideActos
Risk factors for serious side effects
InvokanaFarxigametforminGlucotrolglyburideActos
  • History of amputations 
  • Peripheral vascular disease (narrowed blood vessels)
  • Nerve problems
  • Diabetic foot ulcers 
  • History of kidney damage
Detailed Invokana (canagliflozin) risks & warnings »
  • Taking water pills for blood pressure
  • Over age 65
  • Kidney problems
  • Kidney damage
  • Taking water pills, ACE inhibitors or ARBs for blood pressure
Detailed Farxiga (dapagliflozin) risks & warnings »
  • Kidney problems
  • Liver problems
  • Congestive heart failure
  • Using contrast dye for procedures
  • Surgery
Detailed Glucophage (metformin) risks & warnings »
  • Use of other blood sugar lowering medicines
  • Alcohol
  • Intense physical activity
  • History of sulfa allergies
Detailed Glucotrol (glipizide) risks & warnings »
  • Over age 65
  • Kidney problems
  • Use of other blood sugar lowering medicines
  • Alcohol
  • Intense physical activity
Detailed Diabeta (glyburide) risks & warnings »
  • Heart failure diagnosis
  • Current liver problems
  • Female
Detailed Actos (pioglitazone) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Alcohol
InvokanaFarxigametforminGlucotrolglyburideActos
  • Avoid if you are a heavy drinker of alcohol.
  • Not a good choice if you drink a lot of alcohol.
  • Excessive or chronic alcohol use can increase the risk of a dangerous side effect.
  • Limit or avoid alcohol when taking this medicine.
  • Avoid drinking alcohol.
  • Try to avoid drinking alcohol while on Diabeta (glyburide).
No alcohol related info.
Food
InvokanaFarxigametforminGlucotrolglyburideActos
  • You only have to take Invokana (canagliflozin) once a day before meals.
  • Take once daily before your first meal of the day.
  • Take once in the morning with or without food.
  • Always take it with food to lessen stomach upset.
  • Food can cause unpredictable effects of the immediate-release version of Glipizide, so you have to take it at least 30 minutes before a meal.
  • Eat regular, balanced meals to avoid low blood sugar.
  • Eat well-balanced meals to avoid low blood sugar.
No food related info.
Kidneys and liver
InvokanaFarxigametforminGlucotrolglyburideActos
  • Not for people with severe kidney problems.
  • Farxiga (dapagliflozin) can cause or worsen kidney problems. If you already have severe kidney damage, you can't take Farxiga (dapagliflozin). You're more likely to have this happen if you're on certain medicines to lower your blood pressure or anti-inflammatory medicines (NSAIDs), have heart failure or mild kidney damage. Your doctor will have you do regular blood tests to make sure your kidneys are healthy.
  • Usually not a good choice for people with kidney problems. Your doctor will tell you if Glucophage (metformin) is right for you to take.
  • Glucophage (metformin) can cause this rare life-threatening condition. Your doctor will check your kidneys and liver before you start. Symptoms include deep and rapid breathing, nausea, vomiting, and stomach pain. This is a medical emergency and you should get help right away. You're more likely to get this if you already have kidney problems. Glucophage (metformin) should be stopped 48 hours before and after surgery or any imaging procedure needing contrast dye.
  • Might be a better choice for people with kidney problems compared to similar drugs because Glipizide isn't processed by the kidneys.
  • Not ideal for elderly or those with poor kidney function.
No kidneys and liver related info.
Pain
InvokanaFarxigametforminGlucotrolglyburideActos
  • Rarely, Invokana (canagliflozin) can hurt the kidneys. This is more likely to happen if you already have kidney damage, heart failure, or take certain medicines for blood pressure or anti-inflammatories (NSAIDs). Invokana (canagliflozin) can also lower your blood pressure since it makes you urinate more. Your doctor will check your kidneys by blood tests regularly, and might ask you to change how you take Invokana (canagliflozin). Make sure to stay hydrated to prevent low blood pressure and kidney problems.
  • Tell your doctor right away if you have blood in urine, or pain when you urinate.
No pain related info.No pain related info.No pain related info.No pain related info.
Weight
InvokanaFarxigametforminGlucotrolglyburideActos
No weight related info.
  • Can help you lose weight.
  • Doesn't cause weight gain.
  • Can cause mild weight gain (2 to 3 pounds).
  • Can cause weight gain, dizziness, or stomach upset.
  • Can cause weight gain (about 2 to 3 pounds).
  • Can cause weight gain, dizziness, or stomach upset.
  • More likely to cause weight gain (2 to 6 pounds or more) compared to other blood sugar-lowering medicines.
  • Can cause weight gain, headache, and fluid retention.
Upsides and benefits
InvokanaFarxigametforminGlucotrolglyburideActos
  • Lowers A1C (blood sugar) levels by 1%.
  • You only have to take Invokana (canagliflozin) once a day before meals.
  • Less likely to cause low blood sugar than other diabetes medicines.
  • Also available as a combination drug with metformin (Invokamet).
  • Can lower A1c by 1% (A1c measures your average blood sugar over time.)
  • Can help you lose weight.
  • Less chance of low blood sugar than other diabetes medicines.
  • Improves sugar control and lowers A1c levels as much as 2%.
  • One of the few diabetes medicines that lowers the risk of death from diabetes-related complications.
  • Doesn't cause weight gain.
  • Rarely causes low blood sugar.
  • Oral blood sugar-lowering medicine.
  • Lowers A1c levels by 1-2%. (Hemoglobin A1c measures your average blood sugar over time.)
  • Prevents the harmful effects of high sugar levels on your organs and blood vessels.
  • Might be a better choice for people with kidney problems compared to similar drugs because Glipizide isn't processed by the kidneys.
  • One of the least expensive diabetes medicines.
  • Available as an oral tablet.
  • Lowers your A1c (average blood sugar over time) up to 2%.
  • Available in generic version.
  • Available in single pill combination with other anti-diabetic medicines.
  • Oral blood sugar-lowering medicine.
  • Lowers A1c levels by around 1%. (Hemoglobin A1c measures your average blood sugar over time.)
  • Prevents the harmful effects of high sugar levels on your organs and blood vessels.
  • Rarely causes low blood sugar.
Downsides and risks
InvokanaFarxigametforminGlucotrolglyburideActos
  • You're more likely to have broken bones, yeast infections and urinary tract infections with Invokana (canagliflozin).
  • There's a rare but serious risk of leg and foot amputations with Invokana (canagliflozin). Talk to your doctor if you develop new pain or infections in your feet.
  • Not for people with severe kidney problems.
  • Can raise your cholesterol.
  • Avoid if you are a heavy drinker of alcohol.
  • Not a first choice medicine for diabetes because it doesn't lower blood sugar as much as other medicines.
  • Higher risk of genital yeast infections and urinary tract infections.
  • This is an expensive medication with no generic available at this time.
  • Not shown to improve cardiovascular outcomes like other similar medicines because it can increase cholesterol.
  • Not a good choice if you drink a lot of alcohol.
  • Often causes stomach upset, like diarrhea, nausea, gas, or stomach cramping.
  • Usually not a good choice for people with kidney problems. Your doctor will tell you if Glucophage (metformin) is right for you to take.
  • Excessive or chronic alcohol use can increase the risk of a dangerous side effect.
  • Higher risk of low blood sugar episodes than other kinds of oral diabetes medicines.
  • You have to check your blood sugar 2 to 5 times a week (less often once you are on a stable dose).
  • Can cause mild weight gain (2 to 3 pounds).
  • Loses effectiveness over time or as your body stops making insulin.
  • Food can cause unpredictable effects of the immediate-release version of Glipizide, so you have to take it at least 30 minutes before a meal.
  • More likely to cause hypoglycemia or low blood sugar than other types of oral anti-diabetics.
  • You will have to check your blood sugar often when you first start taking it.
  • Can cause weight gain (about 2 to 3 pounds).
  • Not ideal for elderly or those with poor kidney function.
  • May not work as well for those with severe diabetes and when pancreas cannot produce insulin.
  • May take several weeks to lower blood sugar.
  • You have to check your blood sugar regularly with this medicine.
  • Has more side effects than similar medicines, so it's usually not the first choice for new Type 2 diabetes patients.
  • More likely to cause weight gain (2 to 6 pounds or more) compared to other blood sugar-lowering medicines.
  • Up to 1 in 10 people might get fluid retention (edema), ranging from mild ankle swelling to severe swelling in the lungs that makes it hard to breathe. People with severe congestive heart failure shouldn't use Actos.
  • Raises the risk of bone fractures, especially for people who already have a risk for fractures.
  • Slightly raises the risk of bladder cancer.
Tips from our pharmacists for people taking the medication
InvokanaFarxigametforminGlucotrolglyburideActos
  • Take once daily before your first meal of the day.
  • Invokana (canagliflozin) can cause you to urinate more, so be sure to stay hydrated.
  • Can cause genital yeast infections in females and males.
  • Can cause urinary tract infections (UTI).
  • Can cause low blood sugar, so make sure to check your blood sugar if you don't feel well.
  • You should continue to exercise regularly, eat a healthy diet, and take your other diabetes medicines along with Invokana (canagliflozin).
  • Take once in the morning with or without food.
  • Farxiga (dapagliflozin) can cause you to urinate more, so be sure to stay hydrated.
  • Can cause genital yeast infections in females and males.
  • Can cause urinary tract infections (UTI).
  • Do not take if you have kidney problems or bladder cancer.
  • Tell your doctor right away if you have blood in urine, or pain when you urinate.
  • Can cause upset stomach with nausea and especially diarrhea in the first couple of weeks.
  • Always take it with food to lessen stomach upset.
  • Stay hydrated.
  • Limit or avoid alcohol when taking this medicine.
  • Tell your doctor about any deep or rapid breathing, or persistent nausea, vomiting, and stomach pain.
  • Check your blood sugar regularly.
  • Works best if you take it 30 minutes before a meal, usually your first big meal of the day.
  • Can cause weight gain, dizziness, or stomach upset.
  • Avoid drinking alcohol.
  • Eat regular, balanced meals to avoid low blood sugar.
  • Check your blood sugar regularly.
  • Check your blood sugar regularly.
  • Eat well-balanced meals to avoid low blood sugar.
  • Works best if you take it 30 minutes before first main meal of the day.
  • Can cause weight gain, dizziness, or stomach upset.
  • Try to avoid drinking alcohol while on Diabeta (glyburide).
  • Takes several weeks to see full effect on blood sugar control.
  • Can cause weight gain, headache, and fluid retention.
  • Tell your doctor about any mental confusion, persistent abdominal pain, dark urine, yellowing of eyes/skin, or easy bruising.
  • Not recommended for patients with certain heart problems.
  • Check your blood sugar regularly.
Learn more
More about InvokanaSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Invokana (canagliflozin)?
Worth itNot sureNot worth it
More about FarxigaSide effectsFDA package insert
Have you used Farxiga (dapagliflozin)?
Worth itNot sureNot worth it
More about metforminSide effectsReviews & ratingsFDA package insert
Have you used Glucophage (metformin)?
Worth itNot sureNot worth it
More about GlucotrolSide effectsReviews & ratingsFDA package insert
Have you used Glucotrol (glipizide)?
Worth itNot sureNot worth it
More about glyburideSide effectsReviews & ratingsFDA package insert
Have you used Diabeta (glyburide)?
Worth itNot sureNot worth it
More about ActosSide effectsReviews & ratingsFDA package insert
Have you used Actos (pioglitazone)?
Worth itNot sureNot worth it