Prescription onlyNo lower cost generic available

Janumet

(Sitagliptin / Metformin)

Prescription onlyNo lower cost generic available
  • Pill
  • Extended release
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Lowers blood sugar.

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Our bottom line

Janumet is an expensive but very effective combination of oral blood sugar-lowering medicines.

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Upsides

  • 2-in-1 combination medicine. If you need more than one blood sugar medicine, this lowers the number of pills you have to take.
  • Lowers A1c levels by 1-2.5%. (Hemoglobin A1c measures your average blood sugar over time.)
  • Prevents the harmful effects of high sugar levels on your organs and blood vessels.
  • Doesn't cause weight gain or low blood sugar.
  • You don't have to check your blood sugar every day with this medicine.
People say this drug is:
77 reviews

Downsides

  • Likely expensive since there's no generic version available.
  • The metformin part of Janumet can cause nausea, indigestion, or diarrhea for most people in the first few weeks.
  • People with poor kidney function can't use it.
  • The sitagliptin part of Janumet can cause some people to have frequent throat infections or nasal congestion.
  • Might raise the risk of problems with your pancreas.
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Side effect rates for Janumet (Sitagliptin / Metformin)

548 From clinical trials of Janumet / Type 2 diabetes
  • Diarrhea
  • Ear, nose, or throat infection
  • Headache
  • Nausea
  • Abdominal pain
  • Vomiting

Risks and Warnings for Janumet (Sitagliptin / Metformin)

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    • Higher risk if:
    • Kidney problems
    • Liver problems
    • Congestive heart failure
    • Contrast dye for procedure
    • Surgery
    • Alcohol use

    Janumet (Sitagliptin / Metformin) can cause this rare but life-threatening condition. Symptoms include deep and rapid breathing, nausea, vomiting, and stomach pain. This is a medical emergency and you should get help right away. Baseline blood work for kidney and liver function are helpful to see if you can use Janumet (Sitagliptin / Metformin). It may not be a good choice for people with kidney problems. Janumet (Sitagliptin / Metformin) should be stopped 48 hours before and/or after surgery or any imaging procedure needing contrast dye.

Common concerns from people taking Janumet (Sitagliptin / Metformin)

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Pregnancy
Food
  • Take it with food to avoid upset stomach with diarrhea, nausea, and vomiting.
  • Take with food to avoid an upset stomach. Drink lots of water.
Kidneys and liver
  • People with poor kidney function can't use it.
  • Janumet (Sitagliptin / Metformin) can cause this rare but life-threatening condition. Symptoms include deep and rapid breathing, nausea, vomiting, and stomach pain. This is a medical emergency and you should get help right away. Baseline blood work for kidney and liver function are helpful to see if you can use Janumet (Sitagliptin / Metformin). It may not be a good choice for people with kidney problems. Janumet (Sitagliptin / Metformin) should be stopped 48 hours before and/or after surgery or any imaging procedure needing contrast dye.
Weight
  • Doesn't cause weight gain or low blood sugar.
  • Not designed for weight loss but following a type 2 diet along with janumet as prescribe has helped me lose 50 lbs after 1 year.
  • it's just very expensive! No side effects that I can tell. Lost quite a bit of weight too (obviously watching my diet and limiting carbs and sugars).