Prescription onlyClass: Endocrine


(sitagliptin / metformin)

Prescription onlyClass: Endocrine
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Lowers your blood sugar.

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Our bottom line

Janumet is a combination of two anti-diabetic medicines that work better together, but is available as brand only.

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  • This 2-in-1 combination can lower the number of pills you have to take daily.
  • Lowers A1c (average blood sugar over time) up to 2.5%.
  • Available in extended and immediate release forms to allow better control of your blood sugar.
  • Doesn't increase your appetite unlike other anti-diabetic medicines.
  • Does not cause hypoglycemia or very low blood sugar.
People say this drug is:
79 reviews


  • Available as brand name only and may be expensive.
  • Metformin component usually causes upset stomach.
  • Sitagliptin component may increase your risk for throat infections and inflammation of pancreas.
  • Not appropriate for those with poor kidney function.
How it works

Janumet (sitagliptin / metformin) is a combination of two anti-diabetic medicines. Metformin lowers the amount of sugar your body produces, and sitagliptin enhances the release of insulin.

What to expect when you take Janumet (sitagliptin / metformin) for Type 2 diabetes

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Side effect rates for Janumet (sitagliptin / metformin)

Risks and Warnings for Janumet (sitagliptin / metformin)

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    • Higher risk if:
    • Kidney problems
    • Liver problems
    • Congestive heart failure
    • Using contrast dye for procedures
    • Surgery
    • Alcohol use

    Janumet (sitagliptin / metformin) can cause excess acid to build up in your blood. This is a rare life-threatening condition. You're more likely to get this if you already have kidney problems, are having surgery or any imaging that needs contrast dye. Your doctor will check your kidneys and liver functions before you start. Symptoms include deep and rapid breathing, nausea, vomiting, and stomach pain.

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Common concerns from people taking Janumet (sitagliptin / metformin)

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  • Take with food to avoid upset stomach with diarrhea, nausea, and vomiting.
  • Take with food to avoid an upset stomach. Drink lots of water.
Kidneys and liver
  • Not appropriate for those with poor kidney function.
  • it's just very expensive! No side effects that I can tell. Lost quite a bit of weight too (obviously watching my diet and limiting carbs and sugars).