Prescription onlyNo lower cost generic available

Janumet

(Sitagliptin / Metformin)

  • Pill
  • Extended release
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Lowers blood sugar.

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Prescription onlyNo lower cost generic available

Our pharmacists’ bottom line

Janumet is an expensive but very effective combination of oral blood sugar-lowering medicines.

Worth it?Is it worth it?
Works well?Does it work?
Hassle?Is it a hassle?
  • 2-in-1 combination medicine. If you need more than one blood sugar medicine, this lowers the number of pills you have to take.
  • Lowers A1c levels by 1-2.5%. (Hemoglobin A1c measures your average blood sugar over time.)
  • Prevents the harmful effects of high sugar levels on your organs and blood vessels.
  • Doesn't cause weight gain or low blood sugar.
  • You don't have to check your blood sugar every day with this medicine.
  • Likely expensive since there's no generic version available.
  • The metformin part of Janumet can cause nausea, indigestion, or diarrhea for most people in the first few weeks.
  • People with poor kidney function can't use it.
  • The sitagliptin part of Janumet can cause some people to have frequent throat infections or nasal congestion.
  • Might raise the risk of problems with your pancreas.

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Side effects for Janumet (Sitagliptin / Metformin)

From clinical trials of Janumet / Type 2 diabetes ( 548)

  • DiarrheaDiarrhea8% for Janumet vs.4% for placebo
  • Ear, nose, or throat infectionEar, nose, or throat infection6% for Janumet vs.5% for placebo
  • HeadacheHeadache6% for Janumet vs.3% for placebo
  • NauseaNausea5% for Janumet vs.1% for placebo
  • Abdominal painAbdominal pain3% for Janumet vs.2% for placebo
  • VomitingVomiting2% for Janumet vs.0% for placebo

What to expect when you take Janumet (Sitagliptin / Metformin)

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Tips from our pharmacists
  • Take it with food to avoid upset stomach with diarrhea, nausea, and vomiting.
  • May cause headaches and cold-like symptoms.
  • Tell your doctor about any deep or rapid breathing, or persistent nausea, vomiting, and stomach pain.
  • Can be expensive depending on insurance coverage.
  • Check your blood sugar regularly.

Risks and Warnings for Janumet (Sitagliptin / Metformin)

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    • Higher risk if:
    • Kidney problems
    • Liver problems
    • Congestive heart failure
    • Contrast dye for procedure
    • Surgery
    • Alcohol use

    Janumet (Sitagliptin / Metformin) can cause this rare but life-threatening condition. Symptoms include deep and rapid breathing, nausea, vomiting, and stomach pain. This is a medical emergency and you should get help right away. Baseline blood work for kidney and liver function are helpful to see if you can use Janumet (Sitagliptin / Metformin). It may not be a good choice for people with kidney problems. Janumet (Sitagliptin / Metformin) should be stopped 48 hours before and/or after surgery or any imaging procedure needing contrast dye.

Means that some groups have a high risk of experiencing this side effect

Tips from pharmacists and people taking Janumet (Sitagliptin / Metformin)

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The FDA category for this medication is B. It is advised that you: Probably safe
Pregnancy
Food
  • Tips from our pharmacists
  • Take it with food to avoid upset stomach with diarrhea, nausea, and vomiting.
Kidneys & liver
  • Upsides and downsides from our pharmacists
  • People with poor kidney function can't use it.
  • Risks from our pharmacists
  • Janumet (Sitagliptin / Metformin) can cause this rare but life-threatening condition. Symptoms include deep and rapid breathing, nausea, vomiting, and stomach pain. This is a medical emergency and you should get help right away. Baseline blood work for kidney and liver function are helpful to see if you can use Janumet (Sitagliptin / Metformin). It may not be a good choice for people with kidney problems. Janumet (Sitagliptin / Metformin) should be stopped 48 hours before and/or after surgery or any imaging procedure needing contrast dye.
Weight gain or loss
  • Upsides and downsides from our pharmacists
  • Doesn't cause weight gain or low blood sugar.
  • Not designed for weight loss but following a type 2 diet along with janumet as prescribe has helped me lose 50 lbs after 1 year.
    Taken for: Type 2 diabetes
    Duration taken: Two years or more
  • it's just very expensive! No side effects that I can tell. Lost quite a bit of weight too (obviously watching my diet and limiting carbs and sugars).
    Age: 70
    Gender: Woman
    Taken for: Type 2 diabetes