Prescription onlyDrug class: Endocrine

Janumet

(Sitagliptin / Metformin)

Prescription onlyDrug class: Endocrine
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Lowers blood sugar.

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Our bottom line

Janumet is an expensive but very effective combination of oral blood sugar-lowering medicines.

Price and discounts

Upsides

  • 2-in-1 combination medicine. If you need more than one blood sugar medicine, this lowers the number of pills you have to take.
  • Lowers A1c levels by 1-2.5%. (Hemoglobin A1c measures your average blood sugar over time.)
  • Prevents the harmful effects of high sugar levels on your organs and blood vessels.
  • Doesn't cause weight gain or low blood sugar.
  • You don't have to check your blood sugar every day with this medicine.
People say this drug is:
79 reviews

Downsides

  • Likely expensive since there's no generic version available.
  • The metformin part of Janumet can cause nausea, indigestion, or diarrhea for most people in the first few weeks.
  • People with poor kidney function can't use it.
  • The sitagliptin part of Janumet can cause some people to have frequent throat infections or nasal congestion.
  • Might raise the risk of problems with your pancreas.
How it works

Janumet is an antidiabetic combination medicine. Metformin lowers the amount of sugar your body produces, and sitagliptin helps your body release more insulin.

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Side effect rates for Janumet (Sitagliptin / Metformin)

548 From clinical trials of Janumet / Type 2 diabetes
  • Diarrhea
  • Ear, nose, or throat infection
  • Headache
  • Nausea
  • Abdominal pain
  • Vomiting

Risks and Warnings for Janumet (Sitagliptin / Metformin)

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    • Higher risk if:
    • Kidney problems
    • Liver problems
    • Congestive heart failure
    • Contrast dye for procedure
    • Surgery
    • Alcohol use

    Janumet (Sitagliptin / Metformin) can cause this rare but life-threatening condition. Symptoms include deep and rapid breathing, nausea, vomiting, and stomach pain. This is a medical emergency and you should get help right away. Baseline blood work for kidney and liver function are helpful to see if you can use Janumet (Sitagliptin / Metformin). It may not be a good choice for people with kidney problems. Janumet (Sitagliptin / Metformin) should be stopped 48 hours before and/or after surgery or any imaging procedure needing contrast dye.

Common concerns from people taking Janumet (Sitagliptin / Metformin)

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Pregnancy
Food
  • Take it with food to avoid upset stomach with diarrhea, nausea, and vomiting.
  • Take with food to avoid an upset stomach. Drink lots of water.
Kidneys and liver
  • People with poor kidney function can't use it.
  • Janumet (Sitagliptin / Metformin) can cause this rare but life-threatening condition. Symptoms include deep and rapid breathing, nausea, vomiting, and stomach pain. This is a medical emergency and you should get help right away. Baseline blood work for kidney and liver function are helpful to see if you can use Janumet (Sitagliptin / Metformin). It may not be a good choice for people with kidney problems. Janumet (Sitagliptin / Metformin) should be stopped 48 hours before and/or after surgery or any imaging procedure needing contrast dye.
Weight
  • Doesn't cause weight gain or low blood sugar.
  • it's just very expensive! No side effects that I can tell. Lost quite a bit of weight too (obviously watching my diet and limiting carbs and sugars).