Prescription onlyClass: Endocrine

Janumet Alternatives

(sitagliptin / metformin)

Prescription onlyClass: Endocrine
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Compare Janumet (sitagliptin / metformin) to alternatives

These medications are comparable to Janumet (sitagliptin / metformin) or used for similar purposes.

Janumet
(sitagliptin / metformin)

Precose
(acarbose)

Humalog
(insulin lispro)

Glucophage
(metformin)

glyburide / metformin

Novolog
(insulin aspart)

Levemir
(insulin detemir)

Januvia
(sitagliptin)

Metaglip
(metformin / glipizide)

Byetta
(exenatide)

Actos
(pioglitazone)

Humulin
(human insulin)

Glucotrol
(glipizide)

Lantus
(insulin glargine)

Diabeta
(glyburide)

Lowers your blood sugar. Janumet is a combination of two anti-diabetic medicines that work better together, but is available as brand only.Lowers blood sugar. Precose (acarbose) helps lower your post-mealtime blood sugar levels, but it must be taken at the beginning of each main meal in order for it to be most effective.Lowers blood sugar. Humalog is a fast-acting insulin that provides meal-time sugar control. It can cause low blood sugar, so make sure you know what the symptoms are and always have a source of sugar nearby.Lowers blood sugar. Glucophage (metformin) is the first choice medicine to control your blood sugar and lower the risk of death from diabetes, although a few people may not tolerate the stomach side effects.Lowers blood sugar. Glyburide / Metformin is an effective combination medicine for lowering blood sugar, but it is likely to cause diarrhea in the first few weeks.Lowers blood sugar. Novolog is a fast-acting insulin that provides meal-time sugar control. It can cause low blood sugar, so make sure you know what the symptoms are and always have a source of sugar nearby.Lowers blood sugar. Levemir is a long-acting insulin that provides all-day sugar control. It can cause low blood sugar, so make sure you know what the symptoms are and always have a source of sugar nearby.Lowers your blood sugar. Januvia (sitagliptin) is a good add-on treatment if your blood sugars are not controlled and you don't want to use an injectable medicine.Coming soon.Lowers blood sugar. Byetta (Exenatide) can lower your blood sugars in addition to metformin. It does not increase your appetite unlike some other anti-diabetics, but must be given by injection and usually causes upset stomach.Lowers blood sugar. Actos (pioglitazone) can improve blood sugar control but is not a top choice since it has a lot of side effects.Lowers blood sugar. This form of insulin is one of the few medications in its class that you can get without a prescription, but it's expensive.Lowers blood sugar. Glucotrol (glipizide) is an effective medicine for lowering blood sugar, but it can cause your blood sugar level to be too low so you must always carry some form of sugar with you that can be readily used.Lowers blood sugar. Lantus (Insulin Glargine) is a long-acting insulin that provides all-day sugar control. It can cause low blood sugar, so make sure you know what the symptoms are and always have a source of sugar nearby.Lowers blood sugar. Diabeta (glyburide) is a good oral anti-diabetic medicine, but can cause hypoglycemia or low blood sugar.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.53Janumet
Reviews for Janumet
46%
of people (All ages) say Janumet is worth it
38%
say it works well
15%
say it's a big hassle
Have you used Janumet (sitagliptin / metformin)?
Worth itNot sureNot worth it

Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Precose (acarbose)?
Worth itNot sureNot worth it
Reviews for Humalog
64%
-18% worse vs. Janumet
50%
-12% worse vs. Janumet
16%
+1% better vs. Janumet
280 reviews
Have you used Humalog (insulin lispro)?
Worth itNot sureNot worth it
Reviews for metformin
65%
-19% worse vs. Janumet
46%
-8% worse vs. Janumet
16%
+1% better vs. Janumet
938 reviews
Have you used Glucophage (metformin)?
Worth itNot sureNot worth it

Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Glyburide / Metformin?
Worth itNot sureNot worth it
Reviews for Novolog
58%
-12% worse vs. Janumet
46%
-8% worse vs. Janumet
19%
+4% better vs. Janumet
177 reviews
Have you used Novolog (insulin aspart)?
Worth itNot sureNot worth it
Reviews for Levemir
45%
+1% better vs. Janumet
35%
+3% better vs. Janumet
22%
+7% better vs. Janumet
130 reviews
Have you used Levemir (insulin detemir)?
Worth itNot sureNot worth it
Reviews for Januvia
44%
+2% better vs. Janumet
34%
+4% better vs. Janumet
17%
+2% better vs. Janumet
143 reviews
Have you used Januvia (sitagliptin)?
Worth itNot sureNot worth it

Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Metaglip (metformin / glipizide)?
Worth itNot sureNot worth it

Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Byetta (exenatide)?
Worth itNot sureNot worth it
Reviews for Actos
42%
+4% better vs. Janumet
30%
+8% better vs. Janumet
21%
+6% better vs. Janumet
175 reviews
Have you used Actos (pioglitazone)?
Worth itNot sureNot worth it
Reviews for Human Insulin
67%
-21% worse vs. Janumet
46%
-8% worse vs. Janumet
11%
-4% worse vs. Janumet
Have you used Humulin (human insulin)?
Worth itNot sureNot worth it
Reviews for Glucotrol
50%
-4% worse vs. Janumet
32%
+6% better vs. Janumet
19%
+4% better vs. Janumet
332 reviews
Have you used Glucotrol (glipizide)?
Worth itNot sureNot worth it
Reviews for Lantus
67%
-21% worse vs. Janumet
51%
-13% worse vs. Janumet
14%
-1% worse vs. Janumet
584 reviews
Have you used Lantus (insulin glargine)?
Worth itNot sureNot worth it
Reviews for glyburide
45%
+1% better vs. Janumet
34%
+4% better vs. Janumet
21%
+6% better vs. Janumet
110 reviews
Have you used Diabeta (glyburide)?
Worth itNot sureNot worth it
Side effects
JanumetPrecoseHumalogmetforminGlucovanceNovologLevemirJanuviaMetaglipByettaActosHuman InsulinGlucotrolLantusglyburide
  • Low blood sugar 15%
  • Diarrhea 4%
  • Upper respiratory tract infection 1%
  • Headache 3%
More Janumet side effects »
  • Excessive gas 46%
  • Diarrhea 19%
  • Stomach pain 10%
More Precose side effects »
  • Flu syndrome 35%
  • Pharyngitis 33%
  • Headache 30%
  • Rhinitis 25%
  • Pain 20%
  • Cough increased 17%
  • Infection 14%
  • Accidental injury 9%
  • Diarrhea 9%
  • Asthenia 7%
More Humalog side effects »
  • Diarrhea 41%
  • Nausea/vomiting 18%
  • Gas 6%
  • Weakness 3%
  • Indigestion 3%
  • Stomach pain 1%
  • Headache 1%
More metformin side effects »
  • Upper respiratory infection 3%
  • Diarrhea 11%
  • Nausea/vomiting 2%
  • Stomach pain 3%
  • Dizziness 2%
  • Gastrointestinal side effects (diarrhea, nausea/vomiting, and stomach pain) 8%
  • Low blood sugar 8%
More Glucovance side effects »
  • Hyporeflexia 11%
  • Onychomycosis 10%
  • Sensory disturbance 9%
  • Urinary tract infection 8%
  • Chest pain 5%
  • Headache 5%
  • Skin disorder 5%
  • Abdominal pain 5%
  • Sinusitis 5%
  • Injury accidental 11%
More Novolog side effects »
  • Upper respiratory tract infection 26%
  • Headache 23%
  • Pharyngitis 10%
  • Influenza-like illness 8%
  • Abdominal Pain 6%
  • Gastroenteritis 17%
  • Abdominal pain 13%
  • Pyrexia 10%
  • Cough 8%
  • Viral infection 7%
More Levemir side effects »
  • Common cold 2%
  • Diarrhea 1%
  • Upper respiratory infection 3%
  • Headache 1%
More Januvia side effects »

We haven’t found good data for Metaglip side effects.

FDA side effect reports for Metaglip »
  • Low blood sugar 11%
  • Nausea 33%
  • Diarrhea 10%
  • Vomiting 14%
  • Headache 10%
  • Constipation 8%
  • Indigestion 5%
  • Weakness 4%
  • Abdominal swelling 3%
  • Loss of appetite 3%
More Byetta side effects »
  • Swelling 11%
  • Low blood sugar 8%
  • Colds and flu 4%
  • Headache 2%
  • Heart failure 2%
  • Sinus infection 1%
  • Back pain 1%
  • Muscle pain 2%
More Actos side effects »

The Human Insulin FDA package insert doesn’t have numbers about how common side effects are.

More about Human Insulin side effects »
  • Dizziness 1%
  • Diarrhea 5%
  • Nervousness 1%
  • Tremor 4%
  • Passing gas 2%
  • Low blood sugar 3%
  • Constipation 3%
  • Nausea 3%
  • Headache 2%
More Glucotrol side effects »
  • Upper respiratory tract infection 22%
  • Infection 9%
  • Accidental injury 6%
  • Headache 6%
  • Edema peripheral 20%
  • Hypertension 20%
  • Sinusitis 19%
  • Influenza 19%
  • Cataract 18%
  • Bronchitis 15%
More Lantus side effects »
  • Nausea and heartburn 2%
  • Skin allergies 2%
More glyburide side effects »
How it works
JanumetPrecoseHumalogmetforminGlucovanceNovologLevemirJanuviaMetaglipByettaActosHuman InsulinGlucotrolLantusglyburide
Janumet (sitagliptin / metformin) is a combination of two anti-diabetic medicines. Metformin lowers the amount of sugar your body produces, and sitagliptin enhances the release of insulin.Precose (acarbose) stops an enzyme in your body from turning carbohydrates into sugar for energy. As a result, your body will absorb less sugar from the foods that you eat which will lead to lower blood sugar levels.Humalog is a short-acting insulin medicine for diabetes. It acts like the insulin that your body normally makes to process sugars and fats, and it keeps your blood sugar stable after meals.Glucophage (metformin) is an anti-diabetic drug. It lowers the amount of sugar your body makes or absorbs, and allows your body use the existing insulin better.Glyburide / Metformin combines 2 prescription medicines (glyburide and metformin) into 1 pill to help treat diabetes. Glyburide stimulates your body to release insulin to lower blood sugar. Metformin helps your body use its own insulin more effectively as well as lowers the amount of sugar your body naturally makes and absorbs from food.Novolog is a short-acting insulin medicine for diabetes. It acts like the insulin that your body normally makes to process sugars and fats, and it keeps your blood sugar stable after meals.Levemir is a long-acting insulin medicine for diabetes. It acts like the insulin that your body normally makes to process sugars and fats, and it keeps your blood sugar stable throughout the day.Januvia (sitagliptin) is an anti-diabetic drug that enhances your body's release of insulin.Coming soon.Byetta (Exenatide) enhances the release of insulin in your gut and pancreas to lower your blood sugar.Actos (pioglitazone) is a thiazolidinedione that improves your body's ability to use insulin to lower your blood sugar.Insulin is a hormone normally produced by your pancreas. It helps your body absorb and store sugar and fat from your bloodstream.Glucotrol (glipizide) stimulates your body to release insulin and lower blood sugar.Lantus (Insulin Glargine) is a long-acting insulin medicine for diabetes. It acts like the insulin that your body normally makes to process sugars and fats, and it keeps your blood sugar stable throughout the day.Diabeta (glyburide) stimulates your body to release insulin and lower blood sugar.
Type of medication
JanumetPrecoseHumalogmetforminGlucovanceNovologLevemirJanuviaMetaglipByettaActosHuman InsulinGlucotrolLantusglyburide
Prescription onlyPrescription onlyPrescription onlyPrescription onlyPrescription onlyPrescription onlyPrescription onlyPrescription onlyPrescription onlyPrescription onlyPrescription onlyPrescription onlyPrescription onlyPrescription only
Available as
JanumetPrecoseHumalogmetforminGlucovanceNovologLevemirJanuviaMetaglipByettaActosHuman InsulinGlucotrolLantusglyburide
  • Pill
  • Extended release
  • Pill
  • Injection
  • Pill
  • Extended release pill
  • Liquid
  • Pill
  • Injection
  • Injection
  • Pill
  • Pill
  • Injection
  • Pill
  • Injection
  • Inhaler
  • Pill
  • Extended release pill
  • Injection
  • Pill
Used for
JanumetPrecoseHumalogmetforminGlucovanceNovologLevemirJanuviaMetaglipByettaActosHuman InsulinGlucotrolLantusglyburide
  • Diabetes Mellitus Type 2
Risk factors for serious side effects
JanumetPrecoseHumalogmetforminGlucovanceNovologLevemirJanuviaMetaglipByettaActosHuman InsulinGlucotrolLantusglyburide
  • Kidney problems
  • Liver problems
  • Congestive heart failure
  • Using contrast dye for procedures
  • Surgery
Detailed Janumet (sitagliptin / metformin) risks & warnings »
  • Using insulin or other medicines that stimulate insulin release
  • Those with kidney problems
  • Taking multiple medicines together
Detailed Precose (acarbose) risks & warnings »
  • Insulin dose too high
  • Use of other blood sugar lowering medicines
  • Poor injection techniques
  • Unstable kidney functions
  • Unstable liver functions
Detailed Humalog (insulin lispro) risks & warnings »
  • Kidney problems
  • Liver problems
  • Congestive heart failure
  • Using contrast dye for procedures
  • Surgery
Detailed Glucophage (metformin) risks & warnings »
  • History of kidney problems
  • History of liver problems
  • Those with congestive heart failure
  • Using contrast dye for procedures
  • Undergoing surgery
Detailed Glyburide / Metformin risks & warnings »
  • Insulin dose too high
  • Use of other blood sugar lowering medicines
  • Poor injection techniques
  • Unstable kidney functions
  • Unstable liver functions
Detailed Novolog (insulin aspart) risks & warnings »
  • Insulin dose too high
  • Use of other blood sugar lowering medicines
  • Poor injection techniques
  • Unstable kidney functions
  • Unstable liver functions
Detailed Levemir (insulin detemir) risks & warnings »
  • History of pancreatitis
  • High blood triglyceride levels
  • Gallstones (stones in gallbladder)
  • History of alchoholism
  • Kidney problems
Detailed Januvia (sitagliptin) risks & warnings »
    Coming soon.
    • Severe renal impairment
    • End-stage renal disease
    • Severe gastrointestinal disease
    • Gastroparesis
    Detailed Byetta (exenatide) risks & warnings »
    • Heart failure
    • Current liver problems
    • History of bladder cancer
    • Women
    Detailed Actos (pioglitazone) risks & warnings »
      Detailed Humulin (human insulin) risks & warnings »
      • Skipping meals or having inconsistent meal times
      • Drinking alcohol
      • Using other blood sugar-lowering medicine
      • People age 60 or older
      • Those with kidney and/or liver problems
      Detailed Glucotrol (glipizide) risks & warnings »
      • Insulin dose too high
      • Use of other blood sugar lowering medicines
      • Poor injection techniques
      • Unstable kidney functions
      • Unstable liver functions
      Detailed Lantus (insulin glargine) risks & warnings »
      • Over age 65
      • Kidney problems
      • Use of other blood sugar lowering medicines
      • Alcohol
      • Intense physical activity
      Detailed Diabeta (glyburide) risks & warnings »
      Pregnancy

      Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

      Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

      Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

      Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

      Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

      Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      Interactions
      JanumetPrecoseHumalogmetforminGlucovanceNovologLevemirJanuviaMetaglipByettaActosHuman InsulinGlucotrolLantusglyburide
      No interactions related info.
      • Has relatively few interactions with other medicines.
      No interactions related info.No interactions related info.No interactions related info.No interactions related info.No interactions related info.No interactions related info.No interactions related info.No interactions related info.No interactions related info.No interactions related info.No interactions related info.No interactions related info.No interactions related info.
      Alcohol
      JanumetPrecoseHumalogmetforminGlucovanceNovologLevemirJanuviaMetaglipByettaActosHuman InsulinGlucotrolLantusglyburide
      No alcohol related info.No alcohol related info.No alcohol related info.
      • Limit or avoid alcohol when taking this medicine.
      • Excessive or chronic alcohol use can increase the risk of a dangerous side effect.
      • Limit the amount of alcohol you drink while taking Glyburide / Metformin.
      • Drinking large amounts of or frequently using alcohol while taking Glyburide / Metformin can cause harm to your body.
      No alcohol related info.No alcohol related info.No alcohol related info.No alcohol related info.No alcohol related info.No alcohol related info.No alcohol related info.
      • Avoid drinking alcohol while taking Glucotrol (glipizide).
      No alcohol related info.
      • Try to avoid drinking alcohol while on Diabeta (glyburide).
      Food
      JanumetPrecoseHumalogmetforminGlucovanceNovologLevemirJanuviaMetaglipByettaActosHuman InsulinGlucotrolLantusglyburide
      • Take with food to avoid upset stomach with diarrhea, nausea, and vomiting.
      No food related info.
      • Short-acting insulin good for blood sugar control around meal times.
      • Always take it with food to lessen stomach upset.
      No food related info.
      • Short-acting insulin good for blood sugar control around meal times.
      • Novolog is a fast-acting insulin that provides sugar control after meals.
      No food related info.
      • Take once a day in the morning with or without food.
      No food related info.No food related info.
      • Take once a day with or without food.
      No food related info.
      • Eat regular and well-balanced meals to keep your blood sugar levels normal.
      No food related info.
      • Eat well-balanced meals to avoid low blood sugar.
      Kidneys and liver
      JanumetPrecoseHumalogmetforminGlucovanceNovologLevemirJanuviaMetaglipByettaActosHuman InsulinGlucotrolLantusglyburide
      • Not appropriate for those with poor kidney function.
      • Precose (acarbose) is not a recommended treatment option if you have bad kidney function or kidney problems. Your doctor will have you do a blood test to decide if this is the right medicine for you.
      • Okay to use even if you have liver or kidney problems, unlike most other blood sugar-lowering medicines.
      • Glucophage (metformin) can cause this rare life-threatening condition. Your doctor will check your kidneys and liver before you start. Symptoms include deep and rapid breathing, nausea, vomiting, and stomach pain. This is a medical emergency and you should get help right away. You're more likely to get this if you already have kidney problems. Glucophage (metformin) should be stopped 48 hours before and after surgery or any imaging procedure needing contrast dye.
      • Usually not a good choice for people with kidney problems. Your doctor will tell you if Glucophage (metformin) is right for you to take.
      • Not a good treatment option for those with kidney and/or liver problems.
      • Okay to use even if you have liver or kidney problems, unlike most other blood sugar-lowering medicines.
      • Okay to use even if you have liver or kidney problems, unlike most other blood sugar-lowering medicines.
      • Januvia (sitagliptin) can worsen kidney problems. Your doctor may check your kidney function before and during treatment. Your doctor may have to adjust the dose or stop this medicine based on changes in kidney function.
      No kidneys and liver related info.
      • If you have severe kidney or liver problems, you should not take Byetta (Exenatide). Talk to your doctor about testing your kidneys before starting Byetta (Exenatide). People taking medications that are damaging to kidneys such as ACE inhibitors, NSAIDs or diuretics in addition to Byetta (Exenatide) may notice nausea, vomiting, or diarrhea.
      • If you've had liver problems or damage in the past, talk to your doctor before starting Actos (pioglitazone), since there's a small chance that it can hurt your liver. Tell your doctor about any stomach pain that don't go away, dark urine, or yellowing of eyes/skin. Your doctor will check your liver regularly.
      No kidneys and liver related info.No kidneys and liver related info.
      • Okay to use even if you have liver or kidney problems, unlike most other blood sugar-lowering medicines.
      • Not ideal for elderly or those with poor kidney function.
      Pain
      JanumetPrecoseHumalogmetforminGlucovanceNovologLevemirJanuviaMetaglipByettaActosHuman InsulinGlucotrolLantusglyburide
      No pain related info.
      • Causes side effects usually during the first few weeks of treatment including stomach pain, excessive gas, and diarrhea that will become less bothersome with time.
      No pain related info.No pain related info.No pain related info.No pain related info.No pain related info.
      • Tell your doctor right away if you have severe stomach pain, nausea, and/or vomiting. These are symptoms of pancreatitis.
      No pain related info.
      • Using Byetta (Exenatide) has been associated with stomach pain, nausea, vomiting and diarrhea. If you have severe gastrointestinal disease such as Crohn’s Disease or Ulcerative Colitis, you should talk to your doctor about using a different medicine for diabetes. You should not use Byetta (Exenatide) if you have gastroparesis, a condition that causes slow or irregular digestion. Gastroparesis can be common for people that have had uncontrolled diabetes for a while.
      No pain related info.No pain related info.No pain related info.No pain related info.No pain related info.
      Weight
      JanumetPrecoseHumalogmetforminGlucovanceNovologLevemirJanuviaMetaglipByettaActosHuman InsulinGlucotrolLantusglyburide
      No weight related info.
      • Precose (acarbose) helps control meal-time blood sugar levels without causing weight gain.
      • Can cause weight gain and low blood sugar.
      • Likely to cause moderate weight gain (around 4 to 6 pounds).
      • Doesn't cause weight gain.
      • Can cause some weight gain.
      • Can cause weight gain and low blood sugar.
      • Likely to cause moderate weight gain (around 4 to 6 pounds).
      • Can cause weight gain and low blood sugar.
      • Likely to cause moderate weight gain (around 4 to 6 pounds).
      • It is less likely to cause weight gain and low blood sugar compared to other diabetes medicines.
      No weight related info.No weight related info.
      • Can cause weight gain, headache, and swelling from fluid build-up.
      • Can cause weight gain.
      • People on Humulin (Human Insulin) can experience weight gain. Talk to your doctor or dietitian about changing your diet if this bothers you.
      • Can cause mild weight gain of 2-3lb.
      • Can cause weight gain and low blood sugar.
      • Likely to cause moderate weight gain (around 4 to 6 pounds).
      • Can cause weight gain, dizziness, or stomach upset.
      • Can cause weight gain (about 2 to 3 pounds).
      Upsides and benefits
      JanumetPrecoseHumalogmetforminGlucovanceNovologLevemirJanuviaMetaglipByettaActosHuman InsulinGlucotrolLantusglyburide
      • This 2-in-1 combination can lower the number of pills you have to take daily.
      • Lowers A1c (average blood sugar over time) up to 2.5%.
      • Available in extended and immediate release forms to allow better control of your blood sugar.
      • Doesn't increase your appetite unlike other anti-diabetic medicines.
      • Does not cause hypoglycemia or very low blood sugar.
      • Precose (acarbose) helps control meal-time blood sugar levels without causing weight gain.
      • When used alone it doesn't normally cause blood sugar levels to be too low unlike other anti-diabetes medicines.
      • Safe to be used in people age 65 or older.
      • Has relatively few interactions with other medicines.
      • Insulin is the most effective blood sugar-lowering medicine. When used correctly, it'll lower blood sugar every time you use it and prevent the harmful effects of high sugar levels on your organs and blood vessels.
      • Humalog is a fast-acting insulin that provides sugar control after meals.
      • Dose can be easily adjusted to make a customized regimen that's tailored to your body.
      • Starting insulin early in the treatment of Type 2 diabetes can maintain your body's insulin-producing cells and slow down disease progression.
      • Okay to use even if you have liver or kidney problems, unlike most other blood sugar-lowering medicines.
      • Improves sugar control and lowers A1c levels as much as 2%.
      • One of the few diabetes medicines that lowers the risk of death from diabetes-related complications.
      • Doesn't cause weight gain.
      • Rarely causes low blood sugar.
      • Glyburide / Metformin effectively lowers blood sugar levels more so than if each of the individual medicines it contains are taken alone.
      • Protects your organs and blood vessels from the harmful effects of high blood sugar levels.
      • Can potentially lower your "bad cholesterol" levels.
      • Glyburide / Metformin is available in a generic form and is cheaper than many other combination diabetes medicines.
      • Insulin is the most effective blood sugar-lowering medicine. When used correctly, it'll lower blood sugar every time you use it and prevent the harmful effects of high sugar levels on your organs and blood vessels.
      • Novolog is a fast-acting insulin that provides sugar control after meals.
      • Dose can be easily adjusted to make a customized regimen that's tailored to your body.
      • Starting insulin early in the treatment of Type 2 diabetes can maintain your body's insulin-producing cells and slow down disease progression.
      • Okay to use even if you have liver or kidney problems, unlike most other blood sugar-lowering medicines.
      • Insulin is the most effective blood sugar-lowering medicine. When used correctly, it'll lower blood sugar every time you use it and prevent the harmful effects of high sugar levels on your organs and blood vessels.
      • Levemir is a long-lasting insulin that provides consistent, all-day sugar control with less risk of low blood sugar.
      • Dose can be easily adjusted to make a customized regimen that's tailored to your body.
      • Starting insulin early in the treatment of Type 2 diabetes can maintain your body's insulin-producing cells and slow down disease progression.
      • Okay to use even if you have liver or kidney problems, unlike most other blood sugar-lowering medicines.
      • Oral blood sugar-lowering medicine.
      • Januvia (sitagliptin) is not linked to worsening heart failure like other medicines in its class.
      • Uses the hormones naturally produced by your body to affect how sugar is processed.
      • It is less likely to cause weight gain and low blood sugar compared to other diabetes medicines.
      Coming soon
      • Can lower your A1c (average blood sugar over time) by 1%.
      • Not as likely to cause very low blood sugar as glyburine or insulin.
      • Does not increase your appetite like other anti-diabetic medicines.
      • Pen is dialed to a single dose for easy injections.
      • Improves sugar control and lowers A1c levels by around 1%.
      • Easily taken by mouth as a once a day pill.
      • Prevents the harmful effects of high sugar levels on your organs.
      • Rarely causes low blood sugar.
      • Lower the risk of heart attack or stroke.
      • Some types of this medication are available without a prescription.
      • Available as a shot to be injected into the fatty part of the skin, and as a powder to be inhaled through your nose.
      • Available in different combinations so that you can do one shot or multiple shots a day.
      • Lowers A1c levels by 1-2%.
      • Glucotrol (glipizide) is an oral medicine so it might be a good alternative for those who don't like injections.
      • Protects your organs and blood vessels by preventing the harmful effects of high blood sugar levels.
      • Okay to use by people with kidney problems.
      • Available as a generic form and is relatively cheap.
      • Insulin is the most effective blood sugar-lowering medicine. When used correctly, it'll lower blood sugar every time you use it and prevent the harmful effects of high sugar levels on your organs and blood vessels.
      • Lantus is a long-lasting insulin that provides consistent, all-day sugar control with less risk of low blood sugar.
      • Dose can be easily adjusted to make a customized regimen that's tailored to your body.
      • Starting insulin early in the treatment of Type 2 diabetes can maintain your body's insulin-producing cells and slow down disease progression.
      • Okay to use even if you have liver or kidney problems, unlike most other blood sugar-lowering medicines.
      • Available as an oral tablet.
      • Lowers your A1c (average blood sugar over time) up to 2%.
      • Available in generic version.
      • Available in single pill combination with other anti-diabetic medicines.
      Downsides and risks
      JanumetPrecoseHumalogmetforminGlucovanceNovologLevemirJanuviaMetaglipByettaActosHuman InsulinGlucotrolLantusglyburide
      • Available as brand name only and may be expensive.
      • Metformin component usually causes upset stomach.
      • Sitagliptin component may increase your risk for throat infections and inflammation of pancreas.
      • Not appropriate for those with poor kidney function.
      • Not a first choice medicine because it isn't as effective at lowering blood sugar compared to other treatment options.
      • Associated with bothersome side effects like excessive gas and diarrhea.
      • Relatively more expensive than other diabetes medicines.
      • Has to be taken three times a day with each meal.
      • Might cause episodes of low blood sugar when taken together with insulin or medicines that stimulate insulin release.
      • You have to take insulin by injection.
      • You have to check your blood sugar multiple times every day, usually before each meal.
      • Likely to cause moderate weight gain (around 4 to 6 pounds).
      • Higher risk of low blood sugar episodes than other kinds of diabetes medicines.
      • Often causes stomach upset, like diarrhea, nausea, gas, or stomach cramping.
      • Usually not a good choice for people with kidney problems. Your doctor will tell you if Glucophage (metformin) is right for you to take.
      • Excessive or chronic alcohol use can increase the risk of a dangerous side effect.
      • Has a higher risk than other diabetes medicine for causing blood sugar levels to be too low.
      • Glyburide / Metformin is likely to cause nausea, stomach upset, or diarrhea in the first few weeks.
      • Not a good treatment option for those with kidney and/or liver problems.
      • Drinking large amounts of or frequently using alcohol while taking Glyburide / Metformin can cause harm to your body.
      • Can cause some weight gain.
      • You have to take insulin by injection.
      • You have to check your blood sugar multiple times every day, usually before each meal.
      • Likely to cause moderate weight gain (around 4 to 6 pounds).
      • Higher risk of low blood sugar episodes than other kinds of diabetes medicines.
      • You have to take insulin by injection.
      • You have to check your blood sugar every day.
      • Likely to cause moderate weight gain (around 4 to 6 pounds).
      • Higher risk of low blood sugar episodes than other kinds of diabetes medicines.
      • Lowers A1c (average blood sugar over time) by less than 1%.
      • Available as brand version only.
      • Some people might get frequent cold-like symptoms.
      • Rare but serious side effects include pancreatitis and severe joint pain.
      Coming soon
      • Byetta (Exenatide) must be injected twice a day. Other medicines like it can be injected once daily or even weekly.
      • It commonly causes nausea, vomiting, diarrhea, constipation, or indigestion.
      • Can affect how well your antibiotics and birth control pills work. Take them no sooner than one hour after your injections.
      • May take several weeks to lower blood sugar.
      • Can cause weight gain.
      • People with heart failure or history of bladder cancer shouldn't use this medicine.
      • Some people might get fluid accumulation (edema), from minor ankle swelling to fluid in lungs that makes it hard to breathe.
      • Raises the risk of bone fractures, especially for people who already have a risk for fractures.
      • Has to be taken exactly as directed or it can cause high or low blood sugar.
      • As with all insulins, you have to work with your doctor closely to make sure you're giving yourself the correct dose, or you can have low or high blood sugar.
      • Has a higher risk than other diabetes medicine for causing blood sugar levels to be too low.
      • While taking Glucotrol (glipizide), your blood sugars should be checked 2 to 5 times a week, but less often once you are on a stable dose.
      • Can cause mild weight gain of 2-3lb.
      • Might lose its effectiveness over time.
      • Needs to be taken 30 minutes before a meal for it to be most effective.
      • You have to take insulin by injection.
      • You have to check your blood sugar every day.
      • Likely to cause moderate weight gain (around 4 to 6 pounds).
      • Higher risk of low blood sugar episodes than other kinds of diabetes medicines.
      • More likely to cause hypoglycemia or low blood sugar than other types of oral anti-diabetics.
      • You will have to check your blood sugar often when you first start taking it.
      • Can cause weight gain (about 2 to 3 pounds).
      • Not ideal for elderly or those with poor kidney function.
      • May not work as well for those with severe diabetes and when pancreas cannot produce insulin.
      Tips from our pharmacists for people taking the medication
      JanumetPrecoseHumalogmetforminGlucovanceNovologLevemirJanuviaMetaglipByettaActosHuman InsulinGlucotrolLantusglyburide
      • Take with food to avoid upset stomach with diarrhea, nausea, and vomiting.
      • May cause headaches and cold-like symptoms.
      • Tell your doctor about any deep or rapid breathing, or persistent nausea, vomiting, and stomach pain.
      • Can be expensive depending on insurance coverage.
      • Check your blood sugar regularly.
      • Take Precose (acarbose) with the first bite of each main meal.
      • Don't take the medicine for the times you have skipped a meal.
      • Causes side effects usually during the first few weeks of treatment including stomach pain, excessive gas, and diarrhea that will become less bothersome with time.
      • You should continue to maintain a healthy diet, exercise regularly, and monitor your blood sugar levels while taking Precose (acarbose).
      • Your doctor will work with you to increase your dose gradually.
      • Carry glucose tablets with you at all times so that you can take them when your blood sugar drops to dangerously low levels. This is more likely to happen if you are also using insulin or a medicine that stimulates insulin release.
      • Short-acting insulin good for blood sugar control around meal times.
      • Take 5 to 10 minutes before a meal. Effects last for 2-4 hours.
      • Can cause weight gain and low blood sugar.
      • Make sure you and your family know the symptoms of low blood sugar: sweating, shakiness, weakness, fast heartbeat, nervousness, headache, blurry vision, trouble thinking clearly, or passing out.
      • Always have a good source of sugar nearby for low blood sugar episodes.
      • Make sure you understand how to give yourself the injections.
      • When mixing with another insulin (such as insulin NPH), draw this insulin into the syringe first.
      • Don't shake the vial. Store unopened vials in the refrigerator. Opened vials are good at room temperature for 28 days.
      • Check your blood sugar levels every day.
      • Can cause upset stomach with nausea and especially diarrhea in the first couple of weeks.
      • Always take it with food to lessen stomach upset.
      • Stay hydrated.
      • Limit or avoid alcohol when taking this medicine.
      • Tell your doctor about any deep or rapid breathing, or persistent nausea, vomiting, and stomach pain.
      • Check your blood sugar regularly.
      • Check your blood sugar regularly.
      • Wear sunscreen and appropriate clothing to protect yourself from the sun.
      • Take the medicine with meals to prevent an upset stomach.
      • Tell your doctor right away if you experience rapid breathing, ongoing nausea, vomiting, or stomach pain.
      • Limit the amount of alcohol you drink while taking Glyburide / Metformin.
      • Short-acting insulin good for blood sugar control around meal times.
      • Take 5 to 10 minutes before a meal. Effects last for 2-4 hours.
      • Can cause weight gain and low blood sugar.
      • Make sure you and your family know the symptoms of low blood sugar: sweating, shakiness, weakness, fast heartbeat, nervousness, headache, blurry vision, trouble thinking clearly, or passing out.
      • Always have a good source of sugar nearby for low blood sugar episodes.
      • Make sure you understand how to give yourself the injections.
      • When mixing with another insulin (such as insulin NPH), draw this insulin into the syringe first.
      • Don't shake the vial. Store unopened vials in the refrigerator. Opened vials are good at room temperature for 28 days.
      • Check your blood sugar levels every day.
      • Long-acting insulin good for baseline blood sugar control.
      • Works in 1 hour and lasts about 24 hours.
      • Can cause weight gain and low blood sugar.
      • Make sure you and your family know the symptoms of low blood sugar: sweating, shakiness, weakness, fast heartbeat, nervousness, headache, blurry vision, trouble thinking clearly, or passing out.
      • Always have a good source of sugar nearby for low blood sugar episodes.
      • Take it at the same time every day.
      • Make sure you understand how to give yourself the injections.
      • Don't shake the vial or mix with another insulin. Store unopened vials in the refrigerator. Opened vials are good at room temperature for 28 days.
      • Check your blood sugar levels every day.
      • Take once a day in the morning with or without food.
      • Can cause headache and cold-like symptoms.
      • Tell your doctor right away if you have severe stomach pain, nausea, and/or vomiting. These are symptoms of pancreatitis.
      • Tell your doctor right away if you are experiencing severe joint pain.
      • Check your blood sugar regularly to check for low blood sugar.
      Coming soon
      • Inject into your belly, thighs, or upper arms within an hour of your main meals.
      • Store unused pens in the refrigerator.
      • After first use, pens can be kept at room temperature for 30 days.
      • Change the needle and prime the pen every time you inject.
      • If you're also on insulin, don't inject into the same site.
      • Best to check your blood sugar once a day to make sure your medicine is working properly.
      • Take once a day with or without food.
      • May need several weeks to see full effect on blood sugar control.
      • Can cause weight gain, headache, and swelling from fluid build-up.
      • Tell your doctor about any shortness of breath, heart troubles, or unusual swelling.
      • Not recommended for patients with a history of heart failure or bladder cancer.
      • Check your blood sugar regularly.
      • Change the location where you give yourself the shot every time.
      • Don't use if the liquid in the vial looks different than normal.
      • Store the unopened vials in the refrigerator. The used vials can be kept at room temperature for up to 28 days.
      • Take the medication exactly how your doctor tells you to.
      • Know the symptoms of low blood sugar.
      • Take the medicine 30 minutes before eating, usually before your first big meal of the day.
      • Avoid drinking alcohol while taking Glucotrol (glipizide).
      • Eat regular and well-balanced meals to keep your blood sugar levels normal.
      • Check your blood sugar regularly.
      • Glucotrol (glipizide) can cause dizziness so avoid activities that require coordination until you know how your body can handle the medicine.
      • Long-acting insulin good for baseline blood sugar control.
      • Works in 1 hour and lasts about 24 hours.
      • Can cause weight gain and low blood sugar.
      • Make sure you and your family know the symptoms of low blood sugar: sweating, shakiness, weakness, fast heartbeat, nervousness, headache, blurry vision, trouble thinking clearly, or passing out.
      • Always have a good source of sugar nearby for low blood sugar episodes.
      • Take it at the same time every day.
      • Make sure you understand how to give yourself the injections.
      • Don't shake the vial or mix with another insulin. Store unopened vials in the refrigerator. Opened vials are good at room temperature for 28 days.
      • Check your blood sugar levels every day.
      • Check your blood sugar regularly.
      • Eat well-balanced meals to avoid low blood sugar.
      • Works best if you take it 30 minutes before first main meal of the day.
      • Can cause weight gain, dizziness, or stomach upset.
      • Try to avoid drinking alcohol while on Diabeta (glyburide).
      Learn more
      More about JanumetSide effectsReviews & ratingsAlternativesFDA package insert
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