Prescription onlyClass: Endocrine

Janumet Alternatives

(sitagliptin / metformin)

Prescription onlyClass: Endocrine
Back to: Full Site Navigation

Compare Janumet (sitagliptin / metformin) to alternatives

These medications are comparable to Janumet (sitagliptin / metformin) or used for similar purposes.

Janumet
(sitagliptin / metformin)

Precose
(acarbose)

Humalog
(insulin lispro)

Glucophage
(metformin)

Glucovance
(metformin / glyburide)

Novolog
(insulin aspart)

Levemir
(insulin detemir)

Januvia
(sitagliptin)

Metaglip
(metformin / glipizide)

Byetta
(exenatide)

Actos
(pioglitazone)

Humulin
(human insulin)

Glucotrol
(glipizide)

Lantus
(insulin glargine)

Diabeta
(glyburide)

Lowers your blood sugar. Janumet is a combination of two anti-diabetic medicines that work better together, but is available as brand only.Coming soon.Lowers blood sugar. Humalog is a fast-acting insulin that provides meal-time sugar control. It can cause low blood sugar, so make sure you know what the symptoms are and always have a source of sugar nearby.Lowers blood sugar. Glucophage (metformin) is the first choice medicine to control your blood sugar and lower the risk of death from diabetes, although a few people may not tolerate the stomach side effects.Lowers blood sugar. Glucovance (Metformin / Glyburide) is a very effective combo medication to lower blood sugar when taking one medication alone isn't enough. It's likely to cause diarrhea for the first few weeks, and you can’t drink much alcohol.Lowers blood sugar. Novolog is a fast-acting insulin that provides meal-time sugar control. It can cause low blood sugar, so make sure you know what the symptoms are and always have a source of sugar nearby.Lowers blood sugar. Levemir is a long-acting insulin that provides all-day sugar control. It can cause low blood sugar, so make sure you know what the symptoms are and always have a source of sugar nearby.Lowers your blood sugar. Januvia (sitagliptin) is a good add-on treatment if your blood sugars are not controlled and you don't want to use an injectable medicine.Coming soon.Lowers blood sugar. Byetta (Exenatide) can lower your blood sugars in addition to metformin. It does not increase your appetite unlike some other anti-diabetics, but must be given by injection and usually causes upset stomach.Lowers blood sugar. Actos (Pioglitazone) is a last-choice blood sugar-lowering medicine since it's only moderately effective but has a lot of undesirable side effects.Lowers blood sugar. This form of insulin is one of the few medications in its class that you can get without a prescription, but it's expensive.Lowers blood sugar. Glucotrol (Glipizide) is a very effective oral blood sugar-lowering medicine. It can cause low blood sugar, so make sure you know what the symptoms are and always have a source of sugar nearby.Lowers blood sugar. Lantus (Insulin Glargine) is a long-acting insulin that provides all-day sugar control. It can cause low blood sugar, so make sure you know what the symptoms are and always have a source of sugar nearby.Lowers blood sugar. Diabeta (glyburide) is a good oral anti-diabetic medicine, but can cause hypoglycemia or low blood sugar.
Find lowest prices
Powered by GoodRxSave on your next prescription. Be sure you’re getting the lowest price for your medication, even if you have insurance.
No pricing data for this drug at this filter setting. Try searching onGoodRx
No pricing data for this drug at this filter setting. Try searching onGoodRx
No pricing data for this drug at this filter setting. Try searching onGoodRx
No pricing data for this drug at this filter setting. Try searching onGoodRx
No pricing data for this drug at this filter setting. Try searching onGoodRx
No pricing data for this drug at this filter setting. Try searching onGoodRx
No pricing data for this drug at this filter setting. Try searching onGoodRx
No pricing data for this drug at this filter setting. Try searching onGoodRx
No pricing data for this drug at this filter setting. Try searching onGoodRx
No pricing data for this drug at this filter setting. Try searching onGoodRx
No pricing data for this drug at this filter setting. Try searching onGoodRx
No pricing data for this drug at this filter setting. Try searching onGoodRx
No pricing data for this drug at this filter setting. Try searching onGoodRx
No pricing data for this drug at this filter setting. Try searching onGoodRx
No pricing data for this drug at this filter setting. Try searching onGoodRx
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.53Janumet
Reviews for Janumet (sitagliptin / metformin)
46%
of people (All ages) say Janumet (sitagliptin / metformin) is worth it
38%
say it works well
15%
say it's a big hassle
Have you used Janumet (sitagliptin / metformin)?
Worth itNot sureNot worth it
Reviews for Precose (acarbose)
Not enough review data. Review it!
+54% better vs. Janumet (sitagliptin / metformin)
Not enough review data. Review it!
+62% better vs. Janumet (sitagliptin / metformin)
Not enough review data. Review it!
+15% better vs. Janumet (sitagliptin / metformin)
Have you used Precose (acarbose)?
Worth itNot sureNot worth it
Reviews for Humalog (insulin lispro)
64%
+18% better vs. Janumet (sitagliptin / metformin)
50%
+12% better vs. Janumet (sitagliptin / metformin)
16%
-1% worse vs. Janumet (sitagliptin / metformin)
280 reviews
Have you used Humalog (insulin lispro)?
Worth itNot sureNot worth it
Reviews for Glucophage (metformin)
65%
+19% better vs. Janumet (sitagliptin / metformin)
46%
+8% better vs. Janumet (sitagliptin / metformin)
16%
-1% worse vs. Janumet (sitagliptin / metformin)
938 reviews
Have you used Glucophage (metformin)?
Worth itNot sureNot worth it
Reviews for Glucovance (metformin / glyburide)
Not enough review data. Review it!
-46% worse vs. Janumet (sitagliptin / metformin)
Not enough review data. Review it!
-38% worse vs. Janumet (sitagliptin / metformin)
Not enough review data. Review it!
+15% better vs. Janumet (sitagliptin / metformin)
Have you used Glucovance (metformin / glyburide)?
Worth itNot sureNot worth it
Reviews for Novolog (insulin aspart)
58%
+12% better vs. Janumet (sitagliptin / metformin)
46%
+8% better vs. Janumet (sitagliptin / metformin)
19%
-4% worse vs. Janumet (sitagliptin / metformin)
177 reviews
Have you used Novolog (insulin aspart)?
Worth itNot sureNot worth it
Reviews for Levemir (insulin detemir)
45%
-1% worse vs. Janumet (sitagliptin / metformin)
35%
-3% worse vs. Janumet (sitagliptin / metformin)
22%
-7% worse vs. Janumet (sitagliptin / metformin)
130 reviews
Have you used Levemir (insulin detemir)?
Worth itNot sureNot worth it
Reviews for Januvia (sitagliptin)
44%
-2% worse vs. Janumet (sitagliptin / metformin)
34%
-4% worse vs. Janumet (sitagliptin / metformin)
17%
-2% worse vs. Janumet (sitagliptin / metformin)
143 reviews
Have you used Januvia (sitagliptin)?
Worth itNot sureNot worth it
Reviews for Metaglip (metformin / glipizide)
Not enough review data. Review it!
-46% worse vs. Janumet (sitagliptin / metformin)
Not enough review data. Review it!
-38% worse vs. Janumet (sitagliptin / metformin)
Not enough review data. Review it!
+15% better vs. Janumet (sitagliptin / metformin)
Have you used Metaglip (metformin / glipizide)?
Worth itNot sureNot worth it
Reviews for Byetta (exenatide)
Not enough review data. Review it!
+4% better vs. Janumet (sitagliptin / metformin)
Not enough review data. Review it!
+12% better vs. Janumet (sitagliptin / metformin)
Not enough review data. Review it!
+15% better vs. Janumet (sitagliptin / metformin)
Have you used Byetta (exenatide)?
Worth itNot sureNot worth it
Reviews for Actos (pioglitazone)
42%
-4% worse vs. Janumet (sitagliptin / metformin)
30%
-8% worse vs. Janumet (sitagliptin / metformin)
21%
-6% worse vs. Janumet (sitagliptin / metformin)
175 reviews
Have you used Actos (pioglitazone)?
Worth itNot sureNot worth it
Reviews for Humulin (human insulin)
67%
+21% better vs. Janumet (sitagliptin / metformin)
46%
+8% better vs. Janumet (sitagliptin / metformin)
11%
+4% better vs. Janumet (sitagliptin / metformin)
Have you used Humulin (human insulin)?
Worth itNot sureNot worth it
Reviews for Glucotrol (glipizide)
50%
+4% better vs. Janumet (sitagliptin / metformin)
32%
-6% worse vs. Janumet (sitagliptin / metformin)
19%
-4% worse vs. Janumet (sitagliptin / metformin)
332 reviews
Have you used Glucotrol (glipizide)?
Worth itNot sureNot worth it
Reviews for Lantus (insulin glargine)
67%
+21% better vs. Janumet (sitagliptin / metformin)
51%
+13% better vs. Janumet (sitagliptin / metformin)
14%
+1% better vs. Janumet (sitagliptin / metformin)
584 reviews
Have you used Lantus (insulin glargine)?
Worth itNot sureNot worth it
Reviews for Diabeta (glyburide)
45%
-1% worse vs. Janumet (sitagliptin / metformin)
34%
-4% worse vs. Janumet (sitagliptin / metformin)
21%
-6% worse vs. Janumet (sitagliptin / metformin)
110 reviews
Have you used Diabeta (glyburide)?
Worth itNot sureNot worth it
Side effects
JanumetPrecoseHumalogmetforminGlucovanceNovologLevemirJanuviaMetaglipByettaActosHuman InsulinGlucotrolLantusglyburide
  • Low blood sugar 15%
  • Diarrhea 4%
  • Ear, nose, or throat infection 1%
  • Headache 3%
More Janumet side effects »

We haven’t found good data for Precose side effects.

FDA side effect reports for Precose »
  • Flu syndrome 35%
  • Sore throat 33%
  • Headache 30%
  • Inflammation inside the nose 25%
  • Pain 20%
  • Cough increased 17%
  • Infection 14%
  • Accidental injury 9%
  • Diarrhea 9%
  • Muscle weakness 7%
More Humalog side effects »
  • Diarrhea 41%
  • Nausea/vomiting 18%
  • Gas 6%
  • Weakness 3%
  • Indigestion 3%
  • Stomach pain 1%
  • Headache 1%
More metformin side effects »
  • Upper respiratory infection 3%
  • Diarrhea 11%
  • Nausea/vomiting 2%
  • Abdominal pain 3%
  • Dizziness 2%
  • Gi side effects 8%
  • Low blood sugar 8%
More Glucovance side effects »
  • Decreased muscle reflexes 11%
  • Nail fungal infection 10%
  • Abnormal sense of touch 9%
  • Urinary tract infection 8%
  • Chest pain 5%
  • Headache 5%
  • Skin disorder 5%
  • Abdominal pain 5%
  • Sinus inflammation 5%
  • Injury accidental 11%
More Novolog side effects »
  • Ear, nose, or throat infection 26%
  • Headache 23%
  • Sore throat 10%
  • Influenza-like illness 8%
  • Abdominal pain 6%
  • "stomach flu" 17%
  • Fever 10%
  • Cough 8%
  • Viral infection 7%
  • Nausea 7%
More Levemir side effects »
  • Common cold 2%
  • Diarrhea 1%
  • Upper respiratory infection 3%
  • Headache 1%
More Januvia side effects »

We haven’t found good data for Metaglip side effects.

FDA side effect reports for Metaglip »
  • Low blood sugar 11%
  • Nausea 33%
  • Diarrhea 10%
  • Vomiting 14%
  • Headache 10%
  • Constipation 8%
  • Indigestion 5%
  • Weakness 4%
  • Abdominal swelling 3%
  • Loss of appetite 3%
More Byetta side effects »
  • Swelling due to excess fluid 11%
  • Low blood sugar 8%
  • Ear, nose, or throat infection 4%
  • Headache 2%
  • Cardiac failure 2%
  • Back pain 1%
  • Sinus inflammation 1%
  • Muscle pain 2%
More Actos side effects »

The Human Insulin FDA package insert doesn’t have numbers about how common side effects are.

More about Human Insulin side effects »
  • Dizziness 1%
  • Diarrhea 5%
  • Nervousness 1%
  • Tremor 4%
  • Passing gas 2%
  • Drowsiness 2%
More Glucotrol side effects »
  • Ear, nose, or throat infection 22%
  • Infection 9%
  • Accidental injury 6%
  • Headache 6%
  • Ankle and leg swelling 20%
  • High blood pressure 20%
  • Sinus inflammation 19%
  • Flu 19%
  • Clouded eye lens 18%
  • Bronchitis 15%
More Lantus side effects »
  • Nausea and heartburn 2%
  • Skin allergies 2%
More glyburide side effects »
How it works
JanumetPrecoseHumalogmetforminGlucovanceNovologLevemirJanuviaMetaglipByettaActosHuman InsulinGlucotrolLantusglyburide
Janumet (sitagliptin / metformin) is a combination of two anti-diabetic medicines. Metformin lowers the amount of sugar your body produces, and sitagliptin enhances the release of insulin.Coming soon.Humalog is a short-acting insulin medicine for diabetes. It acts like the insulin that your body normally makes to process sugars and fats, and it keeps your blood sugar stable after meals.Glucophage (metformin) is an anti-diabetic drug. It lowers the amount of sugar your body makes or absorbs, and allows your body use the existing insulin better.Glucovance (Metformin / Glyburide) is a combination medication for diabetes. Metformin lowers sugar (glucose) production in your body, decreases the amount of glucose getting into your blood, and makes your body more sensitive to insulin. Glyburide helps your body make more insulin to lower blood sugar.Novolog is a short-acting insulin medicine for diabetes. It acts like the insulin that your body normally makes to process sugars and fats, and it keeps your blood sugar stable after meals.Levemir is a long-acting insulin medicine for diabetes. It acts like the insulin that your body normally makes to process sugars and fats, and it keeps your blood sugar stable throughout the day.Januvia (sitagliptin) is an anti-diabetic drug that enhances your body's release of insulin.Coming soon.Byetta (Exenatide) enhances the release of insulin in your gut and pancreas to lower your blood sugar.Actos (Pioglitazone) is an anti-diabetic drug. It improves your body's ability to use insulin to lower your blood sugar.Insulin is a hormone normally produced by your pancreas. It helps your body absorb and store sugar and fat from your bloodstream.Glucotrol (Glipizide) is an anti-diabetic drug. It stimulates your body to make more insulin to lower blood sugar.Lantus (Insulin Glargine) is a long-acting insulin medicine for diabetes. It acts like the insulin that your body normally makes to process sugars and fats, and it keeps your blood sugar stable throughout the day.Diabeta (glyburide) stimulates your body to release insulin and lower blood sugar.
Type of medication
JanumetPrecoseHumalogmetforminGlucovanceNovologLevemirJanuviaMetaglipByettaActosHuman InsulinGlucotrolLantusglyburide
Prescription only
Prescription only
Prescription only
Prescription only
Prescription only
Prescription only
Prescription only
Prescription only
Prescription only
Prescription only
Prescription only
Prescription only
Prescription only
Available as
JanumetPrecoseHumalogmetforminGlucovanceNovologLevemirJanuviaMetaglipByettaActosHuman InsulinGlucotrolLantusglyburide
  • Pill
  • Extended release
  • Pill
  • Injection
  • Pill
  • Extended release pill
  • Liquid
  • Pill
  • Injection
  • Injection
  • Pill
  • Pill
  • Injection
  • Pill
  • Injection
  • Inhaler
  • Pill
  • Extended release
  • Injection
  • Pill
Used for
JanumetPrecoseHumalogmetforminGlucovanceNovologLevemirJanuviaMetaglipByettaActosHuman InsulinGlucotrolLantusglyburide
  • Diabetes Mellitus Type 2
  • Diabetes Mellitus Type 2
Risk factors for serious side effects
JanumetPrecoseHumalogmetforminGlucovanceNovologLevemirJanuviaMetaglipByettaActosHuman InsulinGlucotrolLantusglyburide
  • Kidney problems
  • Liver problems
  • Congestive heart failure
  • Using contrast dye for procedures
  • Surgery
Detailed Janumet (sitagliptin / metformin) risks & warnings »
    Coming soon.
    • Insulin dose too high
    • Use of other blood sugar lowering medicines
    • Poor injection techniques
    • Unstable kidney functions
    • Unstable liver functions
    Detailed Humalog (insulin lispro) risks & warnings »
    • Kidney problems
    • Liver problems
    • Congestive heart failure
    • Using contrast dye for procedures
    • Surgery
    Detailed Glucophage (metformin) risks & warnings »
    • Kidney problems
    • Liver problems
    • Congestive heart failure
    • Using contrast dye for procedures
    • Surgery
    Detailed Glucovance (metformin / glyburide) risks & warnings »
    • Insulin dose too high
    • Use of other blood sugar lowering medicines
    • Poor injection techniques
    • Unstable kidney functions
    • Unstable liver functions
    Detailed Novolog (insulin aspart) risks & warnings »
    • Insulin dose too high
    • Use of other blood sugar lowering medicines
    • Poor injection techniques
    • Unstable kidney functions
    • Unstable liver functions
    Detailed Levemir (insulin detemir) risks & warnings »
    • History of pancreatitis
    • High blood triglyceride levels
    • Gallstones (stones in gallbladder)
    • History of alchoholism
    • Kidney problems
    Detailed Januvia (sitagliptin) risks & warnings »
      Coming soon.
      • Severe renal impairment
      • End-stage renal disease
      • Severe gastrointestinal disease
      • Gastroparesis
      Detailed Byetta (exenatide) risks & warnings »
      • Heart failure diagnosis
      • Current liver problems
      • Female
      Detailed Actos (pioglitazone) risks & warnings »
        Detailed Humulin (human insulin) risks & warnings »
        • Use of other blood sugar lowering medicines
        • Alcohol
        • Intense physical activity
        • History of sulfa allergies
        Detailed Glucotrol (glipizide) risks & warnings »
        • Insulin dose too high
        • Use of other blood sugar lowering medicines
        • Poor injection techniques
        • Unstable kidney functions
        • Unstable liver functions
        Detailed Lantus (insulin glargine) risks & warnings »
        • Over age 65
        • Kidney problems
        • Use of other blood sugar lowering medicines
        • Alcohol
        • Intense physical activity
        Detailed Diabeta (glyburide) risks & warnings »
        Pregnancy

        Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

        Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

        Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

        Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

        Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

        Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

        Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

        Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

        Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

        Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

        Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

        Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

        Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

        Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

        Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

        Alcohol
        JanumetPrecoseHumalogmetforminGlucovanceNovologLevemirJanuviaMetaglipByettaActosHuman InsulinGlucotrolLantusglyburide
        No alcohol related info.No alcohol related info.No alcohol related info.
        • Excessive or chronic alcohol use can increase the risk of a dangerous side effect.
        • Limit or avoid alcohol when taking this medicine.
        • Can't drink excessive amounts of alcohol or “binge drink” while taking this.
        • Try limiting the amount of alcohol you drink while taking this medication.
        No alcohol related info.No alcohol related info.No alcohol related info.No alcohol related info.No alcohol related info.No alcohol related info.No alcohol related info.
        • Avoid drinking alcohol.
        No alcohol related info.
        • Try to avoid drinking alcohol while on Diabeta (glyburide).
        Food
        JanumetPrecoseHumalogmetforminGlucovanceNovologLevemirJanuviaMetaglipByettaActosHuman InsulinGlucotrolLantusglyburide
        • Take with food to avoid upset stomach with diarrhea, nausea, and vomiting.
        No food related info.
        • Short-acting insulin good for blood sugar control around meal times.
        • Always take it with food to lessen stomach upset.
        No food related info.
        • Novolog is a fast-acting insulin that provides sugar control after meals.
        • Short-acting insulin good for blood sugar control around meal times.
        No food related info.
        • Take once a day in the morning with or without food.
        No food related info.No food related info.No food related info.No food related info.
        • Food can cause unpredictable effects of the immediate-release version of Glipizide, so you have to take it at least 30 minutes before a meal.
        • Eat regular, balanced meals to avoid low blood sugar.
        No food related info.
        • Eat well-balanced meals to avoid low blood sugar.
        Kidneys and liver
        JanumetPrecoseHumalogmetforminGlucovanceNovologLevemirJanuviaMetaglipByettaActosHuman InsulinGlucotrolLantusglyburide
        • Not appropriate for those with poor kidney function.
        No kidneys and liver related info.
        • Okay to use even if you have liver or kidney problems, unlike most other blood sugar-lowering medicines.
        • Usually not a good choice for people with kidney problems. Your doctor will tell you if Glucophage (metformin) is right for you to take.
        • Glucophage (metformin) can cause this rare life-threatening condition. Your doctor will check your kidneys and liver before you start. Symptoms include deep and rapid breathing, nausea, vomiting, and stomach pain. This is a medical emergency and you should get help right away. You're more likely to get this if you already have kidney problems. Glucophage (metformin) should be stopped 48 hours before and after surgery or any imaging procedure needing contrast dye.
        • People with poor kidney function can't use Glucovance (Metformin / Glyburide).
        • Glucovance (Metformin / Glyburide) can cause lactic acidosis, a rare but life-threatening condition. Symptoms include deep and rapid breathing, nausea, vomiting, and stomach pain. This is a medical emergency and you should get help right away. Baseline blood work for kidney and liver function are helpful to see if you can use Glucovance (Metformin / Glyburide). It may not be a good choice for people with kidney problems. Glucovance (Metformin / Glyburide) should be stopped 48 hours before and/or after surgery or procedure that'll use contrast dye.
        • Okay to use even if you have liver or kidney problems, unlike most other blood sugar-lowering medicines.
        • Okay to use even if you have liver or kidney problems, unlike most other blood sugar-lowering medicines.
        • Januvia (sitagliptin) can worsen kidney problems. Your doctor may check your kidney function before and during treatment. Your doctor may have to adjust the dose or stop this medicine based on changes in kidney function.
        No kidneys and liver related info.
        • If you have severe kidney or liver problems, you should not take Byetta (Exenatide). Talk to your doctor about testing your kidneys before starting Byetta (Exenatide). People taking medications that are damaging to kidneys such as ACE inhibitors, NSAIDs or diuretics in addition to Byetta (Exenatide) may notice nausea, vomiting, or diarrhea.
        No kidneys and liver related info.No kidneys and liver related info.
        • Might be a better choice for people with kidney problems compared to similar drugs because Glipizide isn't processed by the kidneys.
        • Okay to use even if you have liver or kidney problems, unlike most other blood sugar-lowering medicines.
        • Not ideal for elderly or those with poor kidney function.
        Pain
        JanumetPrecoseHumalogmetforminGlucovanceNovologLevemirJanuviaMetaglipByettaActosHuman InsulinGlucotrolLantusglyburide
        No pain related info.No pain related info.No pain related info.No pain related info.No pain related info.No pain related info.No pain related info.
        • Tell your doctor right away if you have severe stomach pain, nausea, and/or vomiting. These are symptoms of pancreatitis.
        No pain related info.
        • Using Byetta (Exenatide) has been associated with stomach pain, nausea, vomiting and diarrhea. If you have severe gastrointestinal disease such as Crohn’s Disease or Ulcerative Colitis, you should talk to your doctor about using a different medicine for diabetes. You should not use Byetta (Exenatide) if you have gastroparesis, a condition that causes slow or irregular digestion. Gastroparesis can be common for people that have had uncontrolled diabetes for a while.
        No pain related info.No pain related info.No pain related info.No pain related info.No pain related info.
        Weight
        JanumetPrecoseHumalogmetforminGlucovanceNovologLevemirJanuviaMetaglipByettaActosHuman InsulinGlucotrolLantusglyburide
        No weight related info.No weight related info.
        • Likely to cause moderate weight gain (around 4 to 6 pounds).
        • Can cause weight gain and low blood sugar.
        • Doesn't cause weight gain.
        • Can cause some weight gain.
        • Likely to cause moderate weight gain (around 4 to 6 pounds).
        • Can cause weight gain and low blood sugar.
        • Likely to cause moderate weight gain (around 4 to 6 pounds).
        • Can cause weight gain and low blood sugar.
        • It is less likely to cause weight gain and low blood sugar compared to other diabetes medicines.
        No weight related info.No weight related info.
        • More likely to cause weight gain (2 to 6 pounds or more) compared to other blood sugar-lowering medicines.
        • Can cause weight gain, headache, and fluid retention.
        • People on Humulin (Human Insulin) can experience weight gain. Talk to your doctor or dietitian about changing your diet if this bothers you.
        • Can cause mild weight gain (2 to 3 pounds).
        • Can cause weight gain, dizziness, or stomach upset.
        • Likely to cause moderate weight gain (around 4 to 6 pounds).
        • Can cause weight gain and low blood sugar.
        • Can cause weight gain (about 2 to 3 pounds).
        • Can cause weight gain, dizziness, or stomach upset.
        Upsides and benefits
        JanumetPrecoseHumalogmetforminGlucovanceNovologLevemirJanuviaMetaglipByettaActosHuman InsulinGlucotrolLantusglyburide
        • This 2-in-1 combination can lower the number of pills you have to take daily.
        • Lowers A1c (average blood sugar over time) up to 2.5%.
        • Available in extended and immediate release forms to allow better control of your blood sugar.
        • Doesn't increase your appetite unlike other anti-diabetic medicines.
        • Does not cause hypoglycemia or very low blood sugar.
        Coming soon
        • Insulin is the most effective blood sugar-lowering medicine. When used correctly, it'll lower blood sugar every time you use it and prevent the harmful effects of high sugar levels on your organs and blood vessels.
        • Humalog is a fast-acting insulin that provides sugar control after meals.
        • Dose can be easily adjusted to make a customized regimen that's tailored to your body.
        • Starting insulin early in the treatment of Type 2 diabetes can maintain your body's insulin-producing cells and slow down disease progression.
        • Okay to use even if you have liver or kidney problems, unlike most other blood sugar-lowering medicines.
        • Improves sugar control and lowers A1c levels as much as 2%.
        • One of the few diabetes medicines that lowers the risk of death from diabetes-related complications.
        • Doesn't cause weight gain.
        • Rarely causes low blood sugar.
        • A combination medication that lowers your blood sugar in multiple ways. It's used by people who need tighter control of their blood sugar.
        • Can greatly lower A1c levels. The Hemoglobin A1c test measures your average blood sugar levels over the last few months.
        • Prevents harmful effects of high blood sugar levels on your organs and blood vessels.
        • Also lowers certain lipid (fat and cholesterol) levels.
        • Insulin is the most effective blood sugar-lowering medicine. When used correctly, it'll lower blood sugar every time you use it and prevent the harmful effects of high sugar levels on your organs and blood vessels.
        • Novolog is a fast-acting insulin that provides sugar control after meals.
        • Dose can be easily adjusted to make a customized regimen that's tailored to your body.
        • Starting insulin early in the treatment of Type 2 diabetes can maintain your body's insulin-producing cells and slow down disease progression.
        • Okay to use even if you have liver or kidney problems, unlike most other blood sugar-lowering medicines.
        • Insulin is the most effective blood sugar-lowering medicine. When used correctly, it'll lower blood sugar every time you use it and prevent the harmful effects of high sugar levels on your organs and blood vessels.
        • Levemir is a long-lasting insulin that provides consistent, all-day sugar control with less risk of low blood sugar.
        • Dose can be easily adjusted to make a customized regimen that's tailored to your body.
        • Starting insulin early in the treatment of Type 2 diabetes can maintain your body's insulin-producing cells and slow down disease progression.
        • Okay to use even if you have liver or kidney problems, unlike most other blood sugar-lowering medicines.
        • Oral blood sugar-lowering medicine.
        • Januvia (sitagliptin) is not linked to worsening heart failure like other medicines in its class.
        • Uses the hormones naturally produced by your body to affect how sugar is processed.
        • It is less likely to cause weight gain and low blood sugar compared to other diabetes medicines.
        Coming soon
        • Can lower your A1c (average blood sugar over time) by 1%.
        • Not as likely to cause very low blood sugar as glyburine or insulin.
        • Does not increase your appetite like other anti-diabetic medicines.
        • Pen is dialed to a single dose for easy injections.
        • Oral blood sugar-lowering medicine.
        • Lowers A1c levels by around 1%. (Hemoglobin A1c measures your average blood sugar over time.)
        • Prevents the harmful effects of high sugar levels on your organs and blood vessels.
        • Rarely causes low blood sugar.
        • Some types of this medication are available without a prescription.
        • Available as a shot to be injected into the fatty part of the skin, and as a powder to be inhaled through your nose.
        • Available in different combinations so that you can do one shot or multiple shots a day.
        • Oral blood sugar-lowering medicine.
        • Lowers A1c levels by 1-2%. (Hemoglobin A1c measures your average blood sugar over time.)
        • Prevents the harmful effects of high sugar levels on your organs and blood vessels.
        • Might be a better choice for people with kidney problems compared to similar drugs because Glipizide isn't processed by the kidneys.
        • One of the least expensive diabetes medicines.
        • Insulin is the most effective blood sugar-lowering medicine. When used correctly, it'll lower blood sugar every time you use it and prevent the harmful effects of high sugar levels on your organs and blood vessels.
        • Lantus is a long-lasting insulin that provides consistent, all-day sugar control with less risk of low blood sugar.
        • Dose can be easily adjusted to make a customized regimen that's tailored to your body.
        • Starting insulin early in the treatment of Type 2 diabetes can maintain your body's insulin-producing cells and slow down disease progression.
        • Okay to use even if you have liver or kidney problems, unlike most other blood sugar-lowering medicines.
        • Available as an oral tablet.
        • Lowers your A1c (average blood sugar over time) up to 2%.
        • Available in generic version.
        • Available in single pill combination with other anti-diabetic medicines.
        Downsides and risks
        JanumetPrecoseHumalogmetforminGlucovanceNovologLevemirJanuviaMetaglipByettaActosHuman InsulinGlucotrolLantusglyburide
        • Available as brand name only and may be expensive.
        • Metformin component usually causes upset stomach.
        • Sitagliptin component may increase your risk for throat infections and inflammation of pancreas.
        • Not appropriate for those with poor kidney function.
        Coming soon
        • You have to take insulin by injection.
        • You have to check your blood sugar multiple times every day, usually before each meal.
        • Likely to cause moderate weight gain (around 4 to 6 pounds).
        • Higher risk of low blood sugar episodes than other kinds of diabetes medicines.
        • Often causes stomach upset, like diarrhea, nausea, gas, or stomach cramping.
        • Usually not a good choice for people with kidney problems. Your doctor will tell you if Glucophage (metformin) is right for you to take.
        • Excessive or chronic alcohol use can increase the risk of a dangerous side effect.
        • There's a higher risk of low blood sugar episodes than with other kinds of oral diabetes medications.
        • Most people will have nausea, stomach upset, or diarrhea in the first few weeks. You can lower these symptoms if you take it on a full stomach.
        • People with poor kidney function can't use Glucovance (Metformin / Glyburide).
        • Can't drink excessive amounts of alcohol or “binge drink” while taking this.
        • Can cause some weight gain.
        • You have to take insulin by injection.
        • You have to check your blood sugar multiple times every day, usually before each meal.
        • Likely to cause moderate weight gain (around 4 to 6 pounds).
        • Higher risk of low blood sugar episodes than other kinds of diabetes medicines.
        • You have to take insulin by injection.
        • You have to check your blood sugar every day.
        • Likely to cause moderate weight gain (around 4 to 6 pounds).
        • Higher risk of low blood sugar episodes than other kinds of diabetes medicines.
        • Lowers A1c (average blood sugar over time) by less than 1%.
        • Available as brand version only.
        • Some people might get frequent cold-like symptoms.
        • Rare but serious side effects include pancreatitis and severe joint pain.
        Coming soon
        • Byetta (Exenatide) must be injected twice a day. Other medicines like it can be injected once daily or even weekly.
        • It commonly causes nausea, vomiting, diarrhea, constipation, or indigestion.
        • Can affect how well your antibiotics and birth control pills work. Take them no sooner than one hour after your injections.
        • May take several weeks to lower blood sugar.
        • You have to check your blood sugar regularly with this medicine.
        • Has more side effects than similar medicines, so it's usually not the first choice for new Type 2 diabetes patients.
        • More likely to cause weight gain (2 to 6 pounds or more) compared to other blood sugar-lowering medicines.
        • Up to 1 in 10 people might get fluid retention (edema), ranging from mild ankle swelling to severe swelling in the lungs that makes it hard to breathe. People with severe congestive heart failure shouldn't use Actos.
        • Raises the risk of bone fractures, especially for people who already have a risk for fractures.
        • Slightly raises the risk of bladder cancer.
        • Has to be taken exactly as directed or it can cause high or low blood sugar.
        • As with all insulins, you have to work with your doctor closely to make sure you're giving yourself the correct dose, or you can have low or high blood sugar.
        • Higher risk of low blood sugar episodes than other kinds of oral diabetes medicines.
        • You have to check your blood sugar 2 to 5 times a week (less often once you are on a stable dose).
        • Can cause mild weight gain (2 to 3 pounds).
        • Loses effectiveness over time or as your body stops making insulin.
        • Food can cause unpredictable effects of the immediate-release version of Glipizide, so you have to take it at least 30 minutes before a meal.
        • You have to take insulin by injection.
        • You have to check your blood sugar every day.
        • Likely to cause moderate weight gain (around 4 to 6 pounds).
        • Higher risk of low blood sugar episodes than other kinds of diabetes medicines.
        • More likely to cause hypoglycemia or low blood sugar than other types of oral anti-diabetics.
        • You will have to check your blood sugar often when you first start taking it.
        • Can cause weight gain (about 2 to 3 pounds).
        • Not ideal for elderly or those with poor kidney function.
        • May not work as well for those with severe diabetes and when pancreas cannot produce insulin.
        Tips from our pharmacists for people taking the medication
        JanumetPrecoseHumalogmetforminGlucovanceNovologLevemirJanuviaMetaglipByettaActosHuman InsulinGlucotrolLantusglyburide
        • Take with food to avoid upset stomach with diarrhea, nausea, and vomiting.
        • May cause headaches and cold-like symptoms.
        • Tell your doctor about any deep or rapid breathing, or persistent nausea, vomiting, and stomach pain.
        • Can be expensive depending on insurance coverage.
        • Check your blood sugar regularly.
        Coming soon
        • Short-acting insulin good for blood sugar control around meal times.
        • Take 5 to 10 minutes before a meal. Effects last for 2-4 hours.
        • Can cause weight gain and low blood sugar.
        • Make sure you and your family know the symptoms of low blood sugar: sweating, shakiness, weakness, fast heartbeat, nervousness, headache, blurry vision, trouble thinking clearly, or passing out.
        • Always have a good source of sugar nearby for low blood sugar episodes.
        • Make sure you understand how to give yourself the injections.
        • When mixing with another insulin (such as insulin NPH), draw this insulin into the syringe first.
        • Don't shake the vial. Store unopened vials in the refrigerator. Opened vials are good at room temperature for 28 days.
        • Check your blood sugar levels every day.
        • Can cause upset stomach with nausea and especially diarrhea in the first couple of weeks.
        • Always take it with food to lessen stomach upset.
        • Stay hydrated.
        • Limit or avoid alcohol when taking this medicine.
        • Tell your doctor about any deep or rapid breathing, or persistent nausea, vomiting, and stomach pain.
        • Check your blood sugar regularly.
        • Can cause upset stomach, nausea, and diarrhea in the first couple of weeks.
        • Works best if you take it 30 minutes before a meal, usually your first big meal of the day.
        • Tell your doctor about any deep or rapid breathing, persistent nausea, vomiting, or stomach pain.
        • Try limiting the amount of alcohol you drink while taking this medication.
        • Check your blood sugar regularly.
        • Short-acting insulin good for blood sugar control around meal times.
        • Take 5 to 10 minutes before a meal. Effects last for 2-4 hours.
        • Can cause weight gain and low blood sugar.
        • Make sure you and your family know the symptoms of low blood sugar: sweating, shakiness, weakness, fast heartbeat, nervousness, headache, blurry vision, trouble thinking clearly, or passing out.
        • Always have a good source of sugar nearby for low blood sugar episodes.
        • Make sure you understand how to give yourself the injections.
        • When mixing with another insulin (such as insulin NPH), draw this insulin into the syringe first.
        • Don't shake the vial. Store unopened vials in the refrigerator. Opened vials are good at room temperature for 28 days.
        • Check your blood sugar levels every day.
        • Long-acting insulin good for baseline blood sugar control.
        • Works in 1 hour and lasts about 24 hours.
        • Can cause weight gain and low blood sugar.
        • Make sure you and your family know the symptoms of low blood sugar: sweating, shakiness, weakness, fast heartbeat, nervousness, headache, blurry vision, trouble thinking clearly, or passing out.
        • Always have a good source of sugar nearby for low blood sugar episodes.
        • Take it at the same time every day.
        • Make sure you understand how to give yourself the injections.
        • Don't shake the vial or mix with another insulin. Store unopened vials in the refrigerator. Opened vials are good at room temperature for 28 days.
        • Check your blood sugar levels every day.
        • Take once a day in the morning with or without food.
        • Can cause headache and cold-like symptoms.
        • Tell your doctor right away if you have severe stomach pain, nausea, and/or vomiting. These are symptoms of pancreatitis.
        • Tell your doctor right away if you are experiencing severe joint pain.
        • Check your blood sugar regularly to check for low blood sugar.
        Coming soon
        • Inject into your belly, thighs, or upper arms within an hour of your main meals.
        • Store unused pens in the refrigerator.
        • After first use, pens can be kept at room temperature for 30 days.
        • Change the needle and prime the pen every time you inject.
        • If you're also on insulin, don't inject into the same site.
        • Best to check your blood sugar once a day to make sure your medicine is working properly.
        • Takes several weeks to see full effect on blood sugar control.
        • Can cause weight gain, headache, and fluid retention.
        • Tell your doctor about any mental confusion, persistent abdominal pain, dark urine, yellowing of eyes/skin, or easy bruising.
        • Not recommended for patients with certain heart problems.
        • Check your blood sugar regularly.
        • Change the location where you give yourself the shot every time.
        • Don't use if the liquid in the vial looks different than normal.
        • Store the unopened vials in the refrigerator. The used vials can be kept at room temperature for up to 28 days.
        • Take the medication exactly how your doctor tells you to.
        • Know the symptoms of low blood sugar.
        • Works best if you take it 30 minutes before a meal, usually your first big meal of the day.
        • Can cause weight gain, dizziness, or stomach upset.
        • Avoid drinking alcohol.
        • Eat regular, balanced meals to avoid low blood sugar.
        • Check your blood sugar regularly.
        • Long-acting insulin good for baseline blood sugar control.
        • Works in 1 hour and lasts about 24 hours.
        • Can cause weight gain and low blood sugar.
        • Make sure you and your family know the symptoms of low blood sugar: sweating, shakiness, weakness, fast heartbeat, nervousness, headache, blurry vision, trouble thinking clearly, or passing out.
        • Always have a good source of sugar nearby for low blood sugar episodes.
        • Take it at the same time every day.
        • Make sure you understand how to give yourself the injections.
        • Don't shake the vial or mix with another insulin. Store unopened vials in the refrigerator. Opened vials are good at room temperature for 28 days.
        • Check your blood sugar levels every day.
        • Check your blood sugar regularly.
        • Eat well-balanced meals to avoid low blood sugar.
        • Works best if you take it 30 minutes before first main meal of the day.
        • Can cause weight gain, dizziness, or stomach upset.
        • Try to avoid drinking alcohol while on Diabeta (glyburide).
        Learn more
        More about JanumetSide effectsReviews & ratingsAlternativesFDA package insert
        Have you used Janumet (sitagliptin / metformin)?
        Worth itNot sureNot worth it
        More about PrecoseSide effectsReviews & ratingsFDA package insert
        Have you used Precose (acarbose)?
        Worth itNot sureNot worth it
        More about HumalogSide effectsReviews & ratingsFDA package insert
        Have you used Humalog (insulin lispro)?
        Worth itNot sureNot worth it
        More about metforminSide effectsReviews & ratingsFDA package insert
        Have you used Glucophage (metformin)?
        Worth itNot sureNot worth it
        More about GlucovanceSide effectsFDA package insert
        Have you used Glucovance (metformin / glyburide)?
        Worth itNot sureNot worth it
        More about NovologSide effectsReviews & ratingsFDA package insert
        Have you used Novolog (insulin aspart)?
        Worth itNot sureNot worth it
        More about LevemirSide effectsReviews & ratingsFDA package insert
        Have you used Levemir (insulin detemir)?
        Worth itNot sureNot worth it
        More about JanuviaSide effectsReviews & ratingsFDA package insert
        Have you used Januvia (sitagliptin)?
        Worth itNot sureNot worth it
        More about MetaglipSide effectsFDA package insert
        Have you used Metaglip (metformin / glipizide)?
        Worth itNot sureNot worth it
        More about ByettaSide effectsReviews & ratingsFDA package insert
        Have you used Byetta (exenatide)?
        Worth itNot sureNot worth it
        More about ActosSide effectsReviews & ratingsFDA package insert
        Have you used Actos (pioglitazone)?
        Worth itNot sureNot worth it
        More about Human InsulinSide effectsReviews & ratingsFDA package insert
        Have you used Humulin (human insulin)?
        Worth itNot sureNot worth it
        More about GlucotrolSide effectsReviews & ratingsFDA package insert
        Have you used Glucotrol (glipizide)?
        Worth itNot sureNot worth it
        More about LantusSide effectsReviews & ratingsFDA package insert
        Have you used Lantus (insulin glargine)?
        Worth itNot sureNot worth it
        More about glyburideSide effectsReviews & ratingsFDA package insert
        Have you used Diabeta (glyburide)?
        Worth itNot sureNot worth it