Prescription onlyClass: Endocrine



Prescription onlyClass: Endocrine
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Lowers your blood sugar.

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Our bottom line

Januvia (sitagliptin) is a good add-on treatment if your blood sugars are not controlled and you don't want to use an injectable medicine.

Price and discounts
Best available price for 30 (100mg) tablets of sitagliptin


  • Oral blood sugar-lowering medicine.
  • Januvia (sitagliptin) is not linked to worsening heart failure like other medicines in its class.
  • Uses the hormones naturally produced by your body to affect how sugar is processed.
  • It is less likely to cause weight gain and low blood sugar compared to other diabetes medicines.
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  • Lowers A1c (average blood sugar over time) by less than 1%.
  • Available as brand version only.
  • Some people might get frequent cold-like symptoms.
  • Rare but serious side effects include pancreatitis and severe joint pain.
How it works

Januvia (sitagliptin) is an anti-diabetic drug that enhances your body's release of insulin.

What to expect when you take Januvia (sitagliptin) for Type 2 diabetes

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Side effect rates for Januvia (sitagliptin)

806 From clinical trials of Januvia / Type 2 diabetes (100mg)
  • Common cold
  • Diarrhea
  • Abdominal pain

Risks and Warnings for Januvia (sitagliptin)

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    • Higher risk if:
    • History of pancreatitis
    • High blood triglyceride levels
    • Gallstones (stones in gallbladder)
    • History of alchoholism
    • Kidney problems

    Januvia (sitagliptin) can cause a sudden inflammation of the pancreas. This can be life-threatening if not treated. Let your doctor know about any stomach pain, nausea, vomiting, or loss of appetite that doesn't go away.

Common concerns from people taking Januvia (sitagliptin)

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  • Take once a day in the morning with or without food.
Kidneys and liver
  • Januvia (sitagliptin) can worsen kidney problems. Your doctor may check your kidney function before and during treatment. Your doctor may have to adjust the dose or stop this medicine based on changes in kidney function.
  • Tell your doctor right away if you have severe stomach pain, nausea, and/or vomiting. These are symptoms of pancreatitis.
  • It is less likely to cause weight gain and low blood sugar compared to other diabetes medicines.