Prescription onlyClass: Endocrine

Januvia Alternatives

(sitagliptin)

Prescription onlyClass: Endocrine
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Compare Januvia (sitagliptin) to alternatives

These medications are comparable to Januvia (sitagliptin) or used for similar purposes.

Januvia
(sitagliptin)

Onglyza
(saxagliptin)

Nesina
(alogliptin)

Byetta
(exenatide)

Glucophage
(metformin)

Actos
(pioglitazone)

Diabeta
(glyburide)

Humalog
(insulin lispro)

Lowers your blood sugar. Januvia (sitagliptin) is a good add-on treatment if your blood sugars are not controlled and you don't want to use an injectable medicine.Lowers blood sugar. Onglyza (saxagliptin) can cause heart failure unlike other medicines that work just like it.Lowers your blood sugar. alogliptin is a good add-on treatment if your blood sugar is still too high, but you don't want to use an injectable medicine.Lowers blood sugar. Byetta (Exenatide) can lower your blood sugars in addition to metformin. It does not increase your appetite unlike some other anti-diabetics, but must be given by injection and usually causes upset stomach.Lowers blood sugar. Glucophage (metformin) is the first choice medicine to control your blood sugar and lower the risk of death from diabetes, although a few people may not tolerate the stomach side effects.Lowers blood sugar. Actos (Pioglitazone) is a last-choice blood sugar-lowering medicine since it's only moderately effective but has a lot of undesirable side effects.Lowers blood sugar. Diabeta (glyburide) is a good oral anti-diabetic medicine, but can cause hypoglycemia or low blood sugar.Lowers blood sugar. Humalog is a fast-acting insulin that provides meal-time sugar control. It can cause low blood sugar, so make sure you know what the symptoms are and always have a source of sugar nearby.
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Best available price for 30 (100mg) tablets of januvia
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.34Januvia
Reviews for Januvia
44%
of people (All ages) say Januvia is worth it
34%
say it works well
17%
say it's a big hassle
143 reviews
Have you used Januvia (sitagliptin)?
Worth itNot sureNot worth it

Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Onglyza (saxagliptin)?
Worth itNot sureNot worth it

Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Nesina (alogliptin)?
Worth itNot sureNot worth it

Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Byetta (exenatide)?
Worth itNot sureNot worth it
Reviews for metformin
65%
-21% worse vs. Januvia
46%
-12% worse vs. Januvia
16%
-1% worse vs. Januvia
938 reviews
Have you used Glucophage (metformin)?
Worth itNot sureNot worth it
Reviews for Actos
42%
+2% better vs. Januvia
30%
+4% better vs. Januvia
21%
+4% better vs. Januvia
175 reviews
Have you used Actos (pioglitazone)?
Worth itNot sureNot worth it
Reviews for glyburide
45%
-1% worse vs. Januvia
34%
Same vs. Januvia
21%
+4% better vs. Januvia
110 reviews
Have you used Diabeta (glyburide)?
Worth itNot sureNot worth it
Reviews for Humalog
64%
-20% worse vs. Januvia
50%
-16% worse vs. Januvia
16%
-1% worse vs. Januvia
280 reviews
Have you used Humalog (insulin lispro)?
Worth itNot sureNot worth it
Side effects
JanuviaOnglyzaNesinaByettametforminActosglyburideHumalog
  • Common cold 2%
  • Diarrhea 1%
  • Upper respiratory infection 3%
  • Headache 1%
More Januvia side effects »
  • Urinary tract infection 1%
  • Headache 1%
  • Swelling in arms and legs 4%
  • Low blood sugar (hypoglycemia) 2%
  • Allergic reactions 2%
More Onglyza side effects »

We haven’t found good data for Nesina side effects.

FDA side effect reports for Nesina »
  • Low blood sugar 11%
  • Nausea 33%
  • Diarrhea 10%
  • Vomiting 14%
  • Headache 10%
  • Constipation 8%
  • Indigestion 5%
  • Weakness 4%
  • Abdominal swelling 3%
  • Loss of appetite 3%
More Byetta side effects »
  • Diarrhea 41%
  • Nausea/vomiting 18%
  • Gas 6%
  • Weakness 3%
  • Indigestion 3%
  • Stomach pain 1%
  • Headache 1%
More metformin side effects »
  • Swelling due to excess fluid 11%
  • Low blood sugar 8%
  • Ear, nose, or throat infection 4%
  • Headache 2%
  • Cardiac failure 2%
  • Back pain 1%
  • Sinus inflammation 1%
  • Muscle pain 2%
More Actos side effects »
  • Nausea and heartburn 2%
  • Skin allergies 2%
More glyburide side effects »
  • Flu syndrome 35%
  • Sore throat 33%
  • Headache 30%
  • Inflammation inside the nose 25%
  • Pain 20%
  • Cough increased 17%
  • Infection 14%
  • Accidental injury 9%
  • Diarrhea 9%
  • Muscle weakness 7%
More Humalog side effects »
How it works
JanuviaOnglyzaNesinaByettametforminActosglyburideHumalog
Januvia (sitagliptin) is an anti-diabetic drug that enhances your body's release of insulin.Onglyza (saxagliptin) is an anti-diabetic drug. It lowers your blood sugar by enhancing your body's release of insulin.alogliptin is an anti-diabetic drug. It improves your body's ability to use insulin to lower your blood sugar.Byetta (Exenatide) enhances the release of insulin in your gut and pancreas to lower your blood sugar.Glucophage (metformin) is an anti-diabetic drug. It lowers the amount of sugar your body makes or absorbs, and allows your body use the existing insulin better.Actos (Pioglitazone) is an anti-diabetic drug. It improves your body's ability to use insulin to lower your blood sugar.Diabeta (glyburide) stimulates your body to release insulin and lower blood sugar.Humalog is a short-acting insulin medicine for diabetes. It acts like the insulin that your body normally makes to process sugars and fats, and it keeps your blood sugar stable after meals.
Type of medication
JanuviaOnglyzaNesinaByettametforminActosglyburideHumalog
Prescription onlyPrescription onlyPrescription onlyPrescription onlyPrescription onlyPrescription onlyPrescription only
Available as
JanuviaOnglyzaNesinaByettametforminActosglyburideHumalog
  • Pill
  • Pill
  • Pill
  • Injection
  • Pill
  • Extended release pill
  • Liquid
  • Pill
  • Pill
  • Injection
Used for
JanuviaOnglyzaNesinaByettametforminActosglyburideHumalog
  • Diabetes Mellitus Type 2
Risk factors for serious side effects
JanuviaOnglyzaNesinaByettametforminActosglyburideHumalog
  • History of pancreatitis
  • High blood triglyceride levels
  • Gallstones (stones in gallbladder)
  • History of alchoholism
  • Kidney problems
Detailed Januvia (sitagliptin) risks & warnings »
  • Alcoholism
  • Elevated triglycerides
  • History of pancreatitis
  • Gallstones
  • History of heart failure
Detailed Onglyza (saxagliptin) risks & warnings »
    Detailed Nesina (alogliptin) risks & warnings »
    • Severe renal impairment
    • End-stage renal disease
    • Severe gastrointestinal disease
    • Gastroparesis
    Detailed Byetta (exenatide) risks & warnings »
    • Kidney problems
    • Liver problems
    • Congestive heart failure
    • Using contrast dye for procedures
    • Surgery
    Detailed Glucophage (metformin) risks & warnings »
    • Heart failure diagnosis
    • Current liver problems
    • Female
    Detailed Actos (pioglitazone) risks & warnings »
    • Over age 65
    • Kidney problems
    • Use of other blood sugar lowering medicines
    • Alcohol
    • Intense physical activity
    Detailed Diabeta (glyburide) risks & warnings »
    • Insulin dose too high
    • Use of other blood sugar lowering medicines
    • Poor injection techniques
    • Unstable kidney functions
    • Unstable liver functions
    Detailed Humalog (insulin lispro) risks & warnings »
    Pregnancy

    Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

    Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

    Interactions
    JanuviaOnglyzaNesinaByettametforminActosglyburideHumalog
    No interactions related info.
    • Certain drugs may interact with Onglyza (saxagliptin), let your doctor know all the medications you are currently taking and before starting Onglyza (saxagliptin).
    No interactions related info.No interactions related info.No interactions related info.No interactions related info.No interactions related info.No interactions related info.
    Alcohol
    JanuviaOnglyzaNesinaByettametforminActosglyburideHumalog
    No alcohol related info.No alcohol related info.No alcohol related info.No alcohol related info.
    • Limit or avoid alcohol when taking this medicine.
    • Excessive or chronic alcohol use can increase the risk of a dangerous side effect.
    No alcohol related info.
    • Try to avoid drinking alcohol while on Diabeta (glyburide).
    No alcohol related info.
    Food
    JanuviaOnglyzaNesinaByettametforminActosglyburideHumalog
    • Take once a day in the morning with or without food.
    No food related info.No food related info.No food related info.
    • Always take it with food to lessen stomach upset.
    No food related info.
    • Eat well-balanced meals to avoid low blood sugar.
    • Short-acting insulin good for blood sugar control around meal times.
    Kidneys and liver
    JanuviaOnglyzaNesinaByettametforminActosglyburideHumalog
    • Januvia (sitagliptin) can worsen kidney problems. Your doctor may check your kidney function before and during treatment. Your doctor may have to adjust the dose or stop this medicine based on changes in kidney function.
    • May be a good option for those with bad liver function.
    No kidneys and liver related info.
    • If you have severe kidney or liver problems, you should not take Byetta (Exenatide). Talk to your doctor about testing your kidneys before starting Byetta (Exenatide). People taking medications that are damaging to kidneys such as ACE inhibitors, NSAIDs or diuretics in addition to Byetta (Exenatide) may notice nausea, vomiting, or diarrhea.
    • Glucophage (metformin) can cause this rare life-threatening condition. Your doctor will check your kidneys and liver before you start. Symptoms include deep and rapid breathing, nausea, vomiting, and stomach pain. This is a medical emergency and you should get help right away. You're more likely to get this if you already have kidney problems. Glucophage (metformin) should be stopped 48 hours before and after surgery or any imaging procedure needing contrast dye.
    • Usually not a good choice for people with kidney problems. Your doctor will tell you if Glucophage (metformin) is right for you to take.
    No kidneys and liver related info.
    • Not ideal for elderly or those with poor kidney function.
    • Okay to use even if you have liver or kidney problems, unlike most other blood sugar-lowering medicines.
    Pain
    JanuviaOnglyzaNesinaByettametforminActosglyburideHumalog
    • Tell your doctor right away if you have severe stomach pain, nausea, and/or vomiting. These are symptoms of pancreatitis.
    No pain related info.No pain related info.
    • Using Byetta (Exenatide) has been associated with stomach pain, nausea, vomiting and diarrhea. If you have severe gastrointestinal disease such as Crohn’s Disease or Ulcerative Colitis, you should talk to your doctor about using a different medicine for diabetes. You should not use Byetta (Exenatide) if you have gastroparesis, a condition that causes slow or irregular digestion. Gastroparesis can be common for people that have had uncontrolled diabetes for a while.
    No pain related info.No pain related info.No pain related info.No pain related info.
    Weight
    JanuviaOnglyzaNesinaByettametforminActosglyburideHumalog
    • It is less likely to cause weight gain and low blood sugar compared to other diabetes medicines.
    • Does not cause weight gain.
    No weight related info.No weight related info.
    • Doesn't cause weight gain.
    • Can cause weight gain, headache, and fluid retention.
    • More likely to cause weight gain (2 to 6 pounds or more) compared to other blood sugar-lowering medicines.
    • Can cause weight gain, dizziness, or stomach upset.
    • Can cause weight gain (about 2 to 3 pounds).
    • Can cause weight gain and low blood sugar.
    • Likely to cause moderate weight gain (around 4 to 6 pounds).
    Upsides and benefits
    JanuviaOnglyzaNesinaByettametforminActosglyburideHumalog
    • Oral blood sugar-lowering medicine.
    • Januvia (sitagliptin) is not linked to worsening heart failure like other medicines in its class.
    • Uses the hormones naturally produced by your body to affect how sugar is processed.
    • It is less likely to cause weight gain and low blood sugar compared to other diabetes medicines.
    • DRUG-NAME is an oral blood sugar lowering medicine. It's a good option if you don't like injections.
    • Does not cause weight gain.
    • May be a good option for those with bad liver function.
    • Does not cause hypoglycemia (low blood sugar) when taken by itself.
    • Oral blood sugar-lowering medicine.
    • Lowers A1c levels by around 1%. (Hemoglobin A1c measures your average blood sugar over time.)
    • Prevents the harmful effects of high sugar levels on your organs and blood vessels.
    • Rarely causes low blood sugar.
    • Patients taking alogliptin had less cold symptoms than patients taking Januvia.
    • Can lower your A1c (average blood sugar over time) by 1%.
    • Not as likely to cause very low blood sugar as glyburine or insulin.
    • Does not increase your appetite like other anti-diabetic medicines.
    • Pen is dialed to a single dose for easy injections.
    • Improves sugar control and lowers A1c levels as much as 2%.
    • One of the few diabetes medicines that lowers the risk of death from diabetes-related complications.
    • Doesn't cause weight gain.
    • Rarely causes low blood sugar.
    • Oral blood sugar-lowering medicine.
    • Lowers A1c levels by around 1%. (Hemoglobin A1c measures your average blood sugar over time.)
    • Prevents the harmful effects of high sugar levels on your organs and blood vessels.
    • Rarely causes low blood sugar.
    • Available as an oral tablet.
    • Lowers your A1c (average blood sugar over time) up to 2%.
    • Available in generic version.
    • Available in single pill combination with other anti-diabetic medicines.
    • Insulin is the most effective blood sugar-lowering medicine. When used correctly, it'll lower blood sugar every time you use it and prevent the harmful effects of high sugar levels on your organs and blood vessels.
    • Humalog is a fast-acting insulin that provides sugar control after meals.
    • Dose can be easily adjusted to make a customized regimen that's tailored to your body.
    • Starting insulin early in the treatment of Type 2 diabetes can maintain your body's insulin-producing cells and slow down disease progression.
    • Okay to use even if you have liver or kidney problems, unlike most other blood sugar-lowering medicines.
    Downsides and risks
    JanuviaOnglyzaNesinaByettametforminActosglyburideHumalog
    • Lowers A1c (average blood sugar over time) by less than 1%.
    • Available as brand version only.
    • Some people might get frequent cold-like symptoms.
    • Rare but serious side effects include pancreatitis and severe joint pain.
    • Typically not first-choice treatment for diabetes.
    • Only lowers A1C (average blood sugar over time) by ~0.5%.
    • Risk for heart failure has not been seen in other medicines that work just like it.
    • May be more expensive than other anti-diabetic medicines.
    • Not as strong as other diabetes medicines. Your doctor might add it to your blood sugar-lowering regimen if your sugar levels are still too high.
    • Likely expensive since there's no generic version available.
    • Some people might get frequent throat infections or nasal congestion.
    • Byetta (Exenatide) must be injected twice a day. Other medicines like it can be injected once daily or even weekly.
    • It commonly causes nausea, vomiting, diarrhea, constipation, or indigestion.
    • Can affect how well your antibiotics and birth control pills work. Take them no sooner than one hour after your injections.
    • Often causes stomach upset, like diarrhea, nausea, gas, or stomach cramping.
    • Usually not a good choice for people with kidney problems. Your doctor will tell you if Glucophage (metformin) is right for you to take.
    • Excessive or chronic alcohol use can increase the risk of a dangerous side effect.
    • May take several weeks to lower blood sugar.
    • You have to check your blood sugar regularly with this medicine.
    • Has more side effects than similar medicines, so it's usually not the first choice for new Type 2 diabetes patients.
    • More likely to cause weight gain (2 to 6 pounds or more) compared to other blood sugar-lowering medicines.
    • Up to 1 in 10 people might get fluid retention (edema), ranging from mild ankle swelling to severe swelling in the lungs that makes it hard to breathe. People with severe congestive heart failure shouldn't use Actos.
    • Raises the risk of bone fractures, especially for people who already have a risk for fractures.
    • Slightly raises the risk of bladder cancer.
    • More likely to cause hypoglycemia or low blood sugar than other types of oral anti-diabetics.
    • You will have to check your blood sugar often when you first start taking it.
    • Can cause weight gain (about 2 to 3 pounds).
    • Not ideal for elderly or those with poor kidney function.
    • May not work as well for those with severe diabetes and when pancreas cannot produce insulin.
    • You have to take insulin by injection.
    • You have to check your blood sugar multiple times every day, usually before each meal.
    • Likely to cause moderate weight gain (around 4 to 6 pounds).
    • Higher risk of low blood sugar episodes than other kinds of diabetes medicines.
    Tips from our pharmacists for people taking the medication
    JanuviaOnglyzaNesinaByettametforminActosglyburideHumalog
    • Take once a day in the morning with or without food.
    • Can cause headache and cold-like symptoms.
    • Tell your doctor right away if you have severe stomach pain, nausea, and/or vomiting. These are symptoms of pancreatitis.
    • Tell your doctor right away if you are experiencing severe joint pain.
    • Check your blood sugar regularly to check for low blood sugar.
    • Is taken once daily.
    • Certain drugs may interact with Onglyza (saxagliptin), let your doctor know all the medications you are currently taking and before starting Onglyza (saxagliptin).
    • Stop taking Onglyza (saxagliptin) and see your doctor immediately if you experience severe stomach pain that does not go away, as this may indicate dangerous inflammation of the pancreas.
    • Maintain a consistent diet and exercise regimen to prevent low blood sugar or high blood sugar.
    • Can cause headache and cold-like symptoms.
    • Tell your doctor about any mental confusion, persistent abdominal pain, dark urine, yellowing of eyes/skin, or easy bruising.
    • Can be expensive depending on insurance coverage.
    • Check your blood sugar regularly.
    • Inject into your belly, thighs, or upper arms within an hour of your main meals.
    • Store unused pens in the refrigerator.
    • After first use, pens can be kept at room temperature for 30 days.
    • Change the needle and prime the pen every time you inject.
    • If you're also on insulin, don't inject into the same site.
    • Best to check your blood sugar once a day to make sure your medicine is working properly.
    • Can cause upset stomach with nausea and especially diarrhea in the first couple of weeks.
    • Always take it with food to lessen stomach upset.
    • Stay hydrated.
    • Limit or avoid alcohol when taking this medicine.
    • Tell your doctor about any deep or rapid breathing, or persistent nausea, vomiting, and stomach pain.
    • Check your blood sugar regularly.
    • Takes several weeks to see full effect on blood sugar control.
    • Can cause weight gain, headache, and fluid retention.
    • Tell your doctor about any mental confusion, persistent abdominal pain, dark urine, yellowing of eyes/skin, or easy bruising.
    • Not recommended for patients with certain heart problems.
    • Check your blood sugar regularly.
    • Check your blood sugar regularly.
    • Eat well-balanced meals to avoid low blood sugar.
    • Works best if you take it 30 minutes before first main meal of the day.
    • Can cause weight gain, dizziness, or stomach upset.
    • Try to avoid drinking alcohol while on Diabeta (glyburide).
    • Short-acting insulin good for blood sugar control around meal times.
    • Take 5 to 10 minutes before a meal. Effects last for 2-4 hours.
    • Can cause weight gain and low blood sugar.
    • Make sure you and your family know the symptoms of low blood sugar: sweating, shakiness, weakness, fast heartbeat, nervousness, headache, blurry vision, trouble thinking clearly, or passing out.
    • Always have a good source of sugar nearby for low blood sugar episodes.
    • Make sure you understand how to give yourself the injections.
    • When mixing with another insulin (such as insulin NPH), draw this insulin into the syringe first.
    • Don't shake the vial. Store unopened vials in the refrigerator. Opened vials are good at room temperature for 28 days.
    • Check your blood sugar levels every day.
    Learn more
    More about JanuviaSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Januvia (sitagliptin)?
    Worth itNot sureNot worth it
    More about OnglyzaSide effectsFDA package insert
    Have you used Onglyza (saxagliptin)?
    Worth itNot sureNot worth it
    More about NesinaSide effectsReviews & ratingsFDA package insert
    Have you used Nesina (alogliptin)?
    Worth itNot sureNot worth it
    More about ByettaSide effectsReviews & ratingsFDA package insert
    Have you used Byetta (exenatide)?
    Worth itNot sureNot worth it
    More about metforminSide effectsReviews & ratingsFDA package insert
    Have you used Glucophage (metformin)?
    Worth itNot sureNot worth it
    More about ActosSide effectsReviews & ratingsFDA package insert
    Have you used Actos (pioglitazone)?
    Worth itNot sureNot worth it
    More about glyburideSide effectsReviews & ratingsFDA package insert
    Have you used Diabeta (glyburide)?
    Worth itNot sureNot worth it
    More about HumalogSide effectsReviews & ratingsFDA package insert
    Have you used Humalog (insulin lispro)?
    Worth itNot sureNot worth it