Prescription onlyLower-cost generic availableClass: Cardiovascular



Prescription onlyLower-cost generic availableClass: Cardiovascular
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Treats ADHD and lowers blood pressure.

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Our bottom line

Clonidine is a non-stimulant option to manage ADHD symptoms and behaviors, but it can lower your blood pressure.

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  • Can be used alone or together with a stimulant-type medicine to treat ADHD.
  • In studies, it improved attention span and lowered hyperactivity and impulsivity in children and adolescents ages 6 to 17.
  • Also treats blood pressure and some nervous system and psychiatric conditions.


  • Can lower blood pressure.
  • The pill form can make some people sleepy, dizzy, and have dry mouth.
  • You can't miss doses. Stopping Clonidine suddenly can cause your blood pressure to go up suddenly, which raises the risk of heart attack and stroke.
How it works

Clonidine is an alpha-2 agonist. Researchers don't know exactly how it works for ADHD. It works in the brain and lowers the activity of certain stress hormones, but it's not a stimulant like many ADHD medicines.

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Side effect rates for Kapvay (clonidine)

152 From clinical trials of Kapvay / ADHD (0.2 mg/day)
  • Drowsiness
  • Headache
  • Fatigue
  • Upper abdominal pain
  • Irritability
  • Any side effect
  • Dizziness
  • Sleep difficulty
  • Nausea
  • Emotional disorder

Risks and Warnings for Kapvay (clonidine)

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    • Higher risk if:
    • Sudden discontinuation of medicine

    Stopping Kapvay (Clonidine) suddenly can cause agitation, headache, tremors, and a sudden rise of blood pressure that can produce complications. Kapvay (Clonidine) should be stopped over 2-4 days with the supervision of a doctor. If using with a beta blocker medicine, slowly stop the beta blocker first before stopping Kapvay (Clonidine).

Common concerns from people taking Kapvay (clonidine)

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  • Can cause drowsiness, headache, dizziness, and dry mouth.
  • Best to take at night due to drowsiness side effect.