Prescription onlyLower-cost generic availableClass: Neurology

Keppra Alternatives

(levetiracetam)

Prescription onlyLower-cost generic availableClass: Neurology
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Compare Keppra (levetiracetam) to alternatives

These medications are comparable to Keppra (levetiracetam) or used for similar purposes.

Keppra
(levetiracetam)

Lamictal
(lamotrigine)

Dilantin
(phenytoin)

Tegretol
(carbamazepine)

Qudexy Xr
(topiramate)

Depacon
(valproate, valproic acid, or divalproex)

Prevents seizures. Keppra (Levetiracetam) is effective for preventing seizures in people with epilepsy. Compared to other anti-seizure medications, it has few drug interactions and you don’t need to get your levels checked.Prevents seizures and stabilizes mood. Lamictal (Lamotrigine) is most useful for treating severe seizure disorders, and for bipolar disorder with more depression symptoms than manic symptoms. Just be careful to increase your dose slowly to avoid skin rash.Prevents seizures. Dilantin (Phenytoin) is effective at preventing seizures, but has many drug interactions and side effects. If your blood tests show that you have the right amount of Dilantin (Phenytoin) levels, you’ll have a lower chance of getting side effects.Prevents seizures, stabilizes mood, and relieves nerve pain. Tegretol (Carbamazepine) is useful for preventing seizures and relieving certain types of nerve pain, but interacts with many drugs.Prevents seizures and migraine headaches. Qudexy Xr (Topiramate) is useful for preventing seizures and migraines, and doesn't require blood tests while you're on it.Prevents seizures and stabilizes mood. Depacon (Valproate, Valproic Acid, Or Divalproex) is good long-term prevention for epilepsy, bipolar disorder, and migraines, but can cause weight gain.
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Reviews & ratings
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6.24Keppra
Reviews for Keppra (levetiracetam)
33%
of people (All ages) say Keppra (levetiracetam) is worth it
81%
say it works well
33%
say it's a big hassle
Have you used Keppra (levetiracetam)?
Worth itNot sureNot worth it
Reviews for Lamictal (lamotrigine)
66%
+33% better vs. Keppra (levetiracetam)
58%
-23% worse vs. Keppra (levetiracetam)
18%
+15% better vs. Keppra (levetiracetam)
184 reviews
Have you used Lamictal (lamotrigine)?
Worth itNot sureNot worth it
Reviews for Dilantin (phenytoin)
Not enough review data. Review it!
+50% better vs. Keppra (levetiracetam)
Not enough review data. Review it!
-14% worse vs. Keppra (levetiracetam)
Not enough review data. Review it!
+33% better vs. Keppra (levetiracetam)
Have you used Dilantin (phenytoin)?
Worth itNot sureNot worth it
Reviews for Tegretol (carbamazepine)
56%
+23% better vs. Keppra (levetiracetam)
43%
-38% worse vs. Keppra (levetiracetam)
23%
+10% better vs. Keppra (levetiracetam)
Have you used Tegretol (carbamazepine)?
Worth itNot sureNot worth it
Reviews for Qudexy Xr (topiramate)
52%
+19% better vs. Keppra (levetiracetam)
50%
-31% worse vs. Keppra (levetiracetam)
36%
-3% worse vs. Keppra (levetiracetam)
Have you used Qudexy Xr (topiramate)?
Worth itNot sureNot worth it
Reviews for Depacon (valproate, valproic acid, or divalproex)
46%
+13% better vs. Keppra (levetiracetam)
40%
-41% worse vs. Keppra (levetiracetam)
27%
+6% better vs. Keppra (levetiracetam)
Have you used Depacon (valproate, valproic acid, or divalproex)?
Worth itNot sureNot worth it
Side effects
KeppraLamictalDilantinTegretolTopamaxDepakote
  • Headache 4%
  • Muscle weakness 6%
  • Vomiting 3%
  • Any side effect 3%
  • Common cold 3%
  • Drowsiness 7%
  • Infection 5%
  • Irritability 12%
  • Neck pain 6%
  • Sore throat 7%
More Keppra side effects »
  • Dizziness 25%
  • Headache 9%
  • Double vision 21%
  • Lack of muscle coordination 16%
  • Nausea 9%
  • Blurred vision 11%
  • Inflammation inside the nose 5%
  • Drowsiness 7%
  • Sore throat 1%
  • Rash 5%
More Lamictal side effects »

We haven’t found good data for Dilantin side effects.

FDA side effect reports for Dilantin »
  • Dizziness 32%
  • Drowsiness 19%
  • Nausea 18%
  • Vomiting 15%
  • Lack of muscle coordination 15%
  • Constipation 5%
  • Itching 6%
  • Dry mouth 5%
  • Muscle weakness 4%
  • Rash 3%
More Tegretol side effects »
  • Ear, nose, or throat infection 16%
  • Diarrhea 8%
  • Weight decrease 7%
  • Difficulty with concentration/attention 7%
  • Inflammation inside the nose 5%
  • Tingling sensation 3%
  • Infection 3%
  • Infection viral 3%
  • Rash 3%
  • Fatigue 17%
More Topamax side effects »
  • Nausea 7%
  • Drowsiness 7%
  • Dizziness 8%
  • Vomiting 9%
  • Accidental injury 6%
  • Muscle weakness 3%
  • Abdominal pain 1%
  • Indigestion 1%
  • Any side effect 4%
  • Rash 3%
More Depakote side effects »
How it works
KeppraLamictalDilantinTegretolTopamaxDepakote
Keppra (Levetiracetam) is an antiepileptic medication. It prevents seizures by helping regulate neurotransmitters in the brain.Lamictal (Lamotrigine) is an antiepileptic. Researchers don't know exactly how it works, but it seems to calm nerve activity in the brain.Dilantin (Phenytoin) is an antiepileptic medication. It prevents seizures by stabilizing brain cells and lowering abnormal communication within the brain.Tegretol (Carbamazepine) is an antiepileptic. Researchers don't know exactly how it works, but it seems to block certain kinds of nerve activity to reduce seizures and pain.Qudexy Xr (Topiramate) is an antiepileptic. Researchers don't know exactly how it works, but it seems to affect multiple parts of the brain to control seizures and migraines.Depacon (Valproate, Valproic Acid, Or Divalproex) is an antiepileptic. Researchers don't know exactly how it works. It seems to increase the amount of GABA, a chemical that calms nerves in the brain.
Type of medication
KeppraLamictalDilantinTegretolTopamaxDepakote
Prescription only
Prescription only
Prescription only
Prescription only
Prescription only
Prescription only
Available as
KeppraLamictalDilantinTegretolTopamaxDepakote
  • Pill
  • Extended release
  • Liquid
  • Pill
  • Extended release
  • Chewable tablet
  • Dissolving tablet
  • Extended release
  • Chewable tablet
  • Liquid
  • Pill
  • Extended release
  • Chewable tablet
  • Oral suspension
  • Pill
  • Extended release capsule
  • Pill
  • Extended release
  • Extended release capsule
  • Sprinkle
  • Liquid
Used for
KeppraLamictalDilantinTegretolTopamaxDepakote
Risk factors for serious side effects
KeppraLamictalDilantinTegretolTopamaxDepakote
  • History of depression
  • Starting the first month of therapy
  • Taking with alcohol
  • Taking other medicines that make you less alert
  • Stopping Keppra (Levetiracetam) suddenly
Detailed Keppra (levetiracetam) risks & warnings »
  • History of depression
  • People also taking Depakote
  • Taking more than the prescribed dose
  • Increasing the dose too quickly
  • Taking birth control pills
Detailed Lamictal (lamotrigine) risks & warnings »
  • People of Asian ancestry
  • Starting Dilantin (Phenytoin) within the first two months
  • Infusing Dilantin (Phenytoin) too fast
  • History of depression
  • History of osteoporosis
Detailed Dilantin (phenytoin) risks & warnings »
  • People also taking Depakote
  • Asian ancestry
  • History of depression
  • European, Chinese, or Japanese ancestry
  • Age 65 years or older
Detailed Tegretol (carbamazepine) risks & warnings »
  • History of depression
  • Children
  • History of metabolic disorders
  • People also taking Depakote
  • Low-carb diet
Detailed Qudexy Xr (topiramate) risks & warnings »
  • Children under age 2
  • History of metabolic disorders
  • History of depression
  • People also taking Topamax
Detailed Depacon (valproate, valproic acid, or divalproex) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Interactions
KeppraLamictalDilantinTegretolTopamaxDepakote
No interactions related info.No interactions related info.No interactions related info.
  • Interacts with many other medicines and supplements.
No interactions related info.No interactions related info.
Food
KeppraLamictalDilantinTegretolTopamaxDepakote
No food related info.
  • Take with food to avoid upset stomach.
No food related info.No food related info.No food related info.
  • Take with food to avoid upset stomach.
Kidneys and liver
KeppraLamictalDilantinTegretolTopamaxDepakote
  • If you have kidney problems, your dose may need to be adjusted. Your doctor will check your kidney function regularly.
No kidneys and liver related info.
  • If you have kidney problems, your dose and kidney function will have to be checked regularly to make sure Dilantin (Phenytoin) levels don’t get too high.
No kidneys and liver related info.
  • A few people will get kidney stones.
  • Qudexy Xr (Topiramate) may increase your risk for kidney stones. Stay well-hydrated to lower your risk.
  • Can cause liver damage, so it's probably not safe if you already have liver problems.
Sleep
KeppraLamictalDilantinTegretolTopamaxDepakote
  • You can experience drowsiness, weakness, dizziness, or respiratory infections while on this.
  • Taking Keppra (Levetiracetam) can make you feel sleepy, dizzy, and affect your coordination. Avoid activities that require you to be alert, such as driving a car or operating machinery, until you know how Keppra (Levetiracetam) affects you.
No sleep related info.No sleep related info.No sleep related info.No sleep related info.No sleep related info.
Weight
KeppraLamictalDilantinTegretolTopamaxDepakote
No weight related info.No weight related info.No weight related info.No weight related info.
  • Can cause sleepiness, speech problems, tingling sensations, and weight loss.
  • Can cause upset stomach, hair loss, weight gain, sleepiness, and tremor.
  • May cause hair loss and weight gain.
Upsides and benefits
KeppraLamictalDilantinTegretolTopamaxDepakote
  • Lowers the frequency of seizures, including partial-onset, generalized tonic-clonic, and myoclonic seizures.
  • Unlike many other medications for epilepsy, this has very few drug interactions, so your other medicines shouldn't be affected.
  • If you have trouble swallowing tablets, Keppra (Levetiracetam) is also available as an oral solution.
  • You won’t need to get regular blood tests to check the drug levels in your body.
  • Effective at lowering the frequency of seizures in people with epilepsy or Lennox-Gestaut syndrome. Typically used together with other medications for severe seizure disorders.
  • Works best for partial, tonic-clonic, and absence seizures.
  • A first-line treatment for bipolar disorder. Effective long-term treatment for stabilizing mood. Prevents both depressive and manic episodes, but the effect is greater for preventing depression.
  • Doesn't require routine blood tests.
  • Dilantin (Phenytoin) is effective at preventing seizures, and treating seizures in an emergency.
  • Available in an oral suspension and chewable tablets if you have trouble swallowing capsules.
  • Available as a generic.
  • Lowers the frequency of seizures, especially for people with tonic-clonic and partial seizures.
  • First-line option for trigeminal neuralgia (nerve pain involving the face, head, and neck), and can relieve other types of nerve pain.
  • May be helpful in stabilizing mood for people with bipolar disorder.
  • Used on its own or with other antiepileptic medicines to lower the frequency of seizures, especially for people with tonic-clonic or partial seizures, or Lennox-Gestaut syndrome.
  • Helpful in preventing frequent migraine headaches.
  • Doesn't need routine blood tests.
  • Lowers the frequency of seizures, especially for people with absence, tonic-clonic, and complex partial seizures.
  • One of the first-line options to stabilize mood for people with bipolar disorder.
  • Helpful in preventing frequent migraine headaches.
Downsides and risks
KeppraLamictalDilantinTegretolTopamaxDepakote
  • It’s important to take your dose on time so that Keppra (Levetiracetam) has consistent levels in your body.
  • May not be the best drug to take if you have a history of psychiatric issues, such as depression or bipolar disorder.
  • If you have kidney problems, your dose may need to be adjusted. Your doctor will check your kidney function regularly.
  • Keppra (Levetiracetam) is only FDA-approved to be taken with other medicines to treat epilepsy.
  • Can cause double vision, dizziness, sleepiness, and headache.
  • Has the risk of a rare but life-threatening rash.
  • Can make hormonal birth control less effective.
  • Might be less effective than other medicines for treating manic episodes (acute mania) in people with bipolar disorder.
  • Need to get blood tests regularly to make sure Dilantin (Phenytoin) has safe and effective levels in your body.
  • Can cause changes in your appearance, such as unwanted hair growth, enlargement of the gums, and coarsening of your facial features.
  • If you have kidney problems, your dose and kidney function will have to be checked regularly to make sure Dilantin (Phenytoin) levels don’t get too high.
  • Can make many other medicines less effective, including birth control.
  • Interacts with many other medicines and supplements.
  • Higher risk of skin reactions compared to other antiepileptic medicines, ranging from mild to life-threatening rash.
  • Can cause blurry vision, dizziness, and upset stomach.
  • Not safe to use if you're pregnant.
  • Requires routine blood tests to see how the medicine is affecting your body.
  • Can cause sleepiness, speech problems, tingling sensations, and weight loss.
  • A few people will get kidney stones.
  • Not safe to use if you're pregnant.
  • Can cause upset stomach, hair loss, weight gain, sleepiness, and tremor.
  • Can cause liver damage, so it's probably not safe if you already have liver problems.
  • Not safe to use if you're pregnant.
  • Requires routine blood tests to see how the medicine is affecting your body.
Tips from our pharmacists for people taking the medication
KeppraLamictalDilantinTegretolTopamaxDepakote
  • You can experience drowsiness, weakness, dizziness, or respiratory infections while on this.
  • If you start having skin rashes or changes in your mood, tell your doctor immediately.
  • If you need to stop taking Keppra (Levetiracetam), do so over at least one week to prevent withdrawal seizures.
  • If you are taking the oral solution, use the measuring device given with the medicine. Don’t use your household tablespoons to measure.
  • Don’t crush or cut this medicine before taking it, or else you’ll have dangerously high levels of this drug in your body.
  • Follow dose adjustments set by your doctor to minimize skin rash.
  • Take with food to avoid upset stomach.
  • Report rash, blurry vision, fever, persistent headache, or neck stiffness to your doctor.
  • Makes hormonal birth control less effective.
  • Takes 4 to 6 weeks to feel full effects on mood.
  • Can cause loss of coordination, confusion, uncontrollable eye movements, and unwanted hair growth while on this.
  • If you’re taking supplements, let your doctor know. You’ll likely have to space out the supplements and Dilantin (Phenytoin) so they don’t interact.
  • If you start having skin rashes or thoughts of suicide, tell your doctor immediately.
  • Makes many drugs less effective, so make sure your doctor has a complete list of what you’re taking.
  • If you need to stop taking Dilantin (Phenytoin), do so over at least one week to prevent withdrawal seizures.
  • For the first week, avoid activities that require you to be alert.
  • Report skin rashes or blistering immediately.
  • Don't use if pregnant.
  • Requires routine blood tests.
  • Report confusion, persistent abdominal pain, yellowing of eyes/skin, or easy bruising to your doctor.
  • Takes up to 5 weeks to feel full effects on mood.
  • For the first week, avoid activities that require you to be alert.
  • Don't use if pregnant.
  • Can cause tingling skin sensations and reduced appetite.
  • Report any confusion, decreased sweating, fever, or changes in behavior or vision.
  • Takes 3 to 4 weeks to feel full effects on mood.
  • For the first week, avoid activities that require you to be alert.
  • Don't use if pregnant.
  • Requires routine blood tests.
  • Take with food to avoid upset stomach.
  • May cause hair loss and weight gain.
  • Different versions of Depakote have different dosing. Be careful.
  • Report confusion, persistent abdominal pain, yellowing of eyes/skin, or easy bruising to your doctor.
  • Takes 3 to 4 weeks to feel full effects on mood.
Learn more
More about KeppraSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Keppra (levetiracetam)?
Worth itNot sureNot worth it
More about LamictalSide effectsReviews & ratingsFDA package insert
Have you used Lamictal (lamotrigine)?
Worth itNot sureNot worth it
More about DilantinSide effectsReviews & ratingsFDA package insert
Have you used Dilantin (phenytoin)?
Worth itNot sureNot worth it
More about TegretolSide effectsReviews & ratingsFDA package insert
Have you used Tegretol (carbamazepine)?
Worth itNot sureNot worth it
More about TopamaxSide effectsReviews & ratingsFDA package insert
Have you used Qudexy Xr (topiramate)?
Worth itNot sureNot worth it
More about DepakoteSide effectsReviews & ratingsFDA package insert
Have you used Depacon (valproate, valproic acid, or divalproex)?
Worth itNot sureNot worth it