Prescription onlyLower-cost generic availableClass: Neurology

Lamictal Alternatives

(lamotrigine)

Prescription onlyLower-cost generic availableClass: Neurology
Back to: Full Site Navigation

Compare Lamictal (lamotrigine) to alternatives

These medications are comparable to Lamictal (lamotrigine) or used for similar purposes.

Lamictal
(lamotrigine)

Depacon
(valproate, valproic acid, or divalproex)

Tegretol
(carbamazepine)

Qudexy Xr
(topiramate)

Prevents seizures and stabilizes mood. Lamictal (Lamotrigine) is most useful for treating severe seizure disorders, and for bipolar disorder with more depression symptoms than manic symptoms. Just be careful to increase your dose slowly to avoid skin rash.Prevents seizures and stabilizes mood. Depacon (Valproate, Valproic Acid, Or Divalproex) is good long-term prevention for epilepsy, bipolar disorder, and migraines, but can cause weight gain.Prevents seizures, stabilizes mood, and relieves nerve pain. Tegretol (Carbamazepine) is useful for preventing seizures and relieving certain types of nerve pain, but interacts with many drugs.Prevents seizures and migraine headaches. Qudexy Xr (Topiramate) is useful for preventing seizures and migraines, and doesn't require blood tests while you're on it.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.11Lamictal
Reviews for Lamictal
66%
of people (All ages) say Lamictal is worth it
58%
say it works well
18%
say it's a big hassle
184 reviews
Have you used Lamictal (lamotrigine)?
Worth itNot sureNot worth it
Reviews for Depakote
46%
+20% better vs. Lamictal
40%
+18% better vs. Lamictal
27%
+9% better vs. Lamictal
Have you used Depacon (valproate, valproic acid, or divalproex)?
Worth itNot sureNot worth it
Reviews for Tegretol
56%
+10% better vs. Lamictal
43%
+15% better vs. Lamictal
23%
+5% better vs. Lamictal
Have you used Tegretol (carbamazepine)?
Worth itNot sureNot worth it
Reviews for Topamax
52%
+14% better vs. Lamictal
50%
+8% better vs. Lamictal
36%
+18% better vs. Lamictal
Have you used Qudexy Xr (topiramate)?
Worth itNot sureNot worth it
Side effects
LamictalDepakoteTegretolTopamax
  • Dizziness 25%
  • Headache 9%
  • Diplopia 21%
  • Ataxia 16%
  • Nausea 9%
  • Blurred vision 11%
  • Rhinitis 5%
  • Somnolence 7%
  • Pharyngitis 1%
  • Rash 5%
More Lamictal side effects »
  • Nausea 7%
  • Somnolence 7%
  • Dizziness 8%
  • Vomiting 9%
  • Accidental injury 6%
  • Asthenia 3%
  • Abdominal Pain 1%
  • Dyspepsia 1%
  • Any side effect 4%
  • Rash 3%
More Depakote side effects »
  • Dizziness 32%
  • Somnolence 19%
  • Nausea 18%
  • Vomiting 15%
  • Ataxia 15%
  • Constipation 5%
  • Pruritus 6%
  • Dry Mouth 5%
  • Asthenia 4%
  • Rash 3%
More Tegretol side effects »
  • Upper respiratory tract infection 16%
  • Diarrhea 8%
  • Weight decrease 7%
  • Difficulty with concentration/attention 7%
  • Rhinitis 5%
  • Paresthesia 3%
  • Infection 3%
  • Infection viral 3%
  • Rash 3%
  • Fatigue 17%
More Topamax side effects »
How it works
LamictalDepakoteTegretolTopamax
Lamictal (Lamotrigine) is an antiepileptic. Researchers don't know exactly how it works, but it seems to calm nerve activity in the brain.Depacon (Valproate, Valproic Acid, Or Divalproex) is an antiepileptic. Researchers don't know exactly how it works. It seems to increase the amount of GABA, a chemical that calms nerves in the brain.Tegretol (Carbamazepine) is an antiepileptic. Researchers don't know exactly how it works, but it seems to block certain kinds of nerve activity to reduce seizures and pain.Qudexy Xr (Topiramate) is an antiepileptic. Researchers don't know exactly how it works, but it seems to affect multiple parts of the brain to control seizures and migraines.
Type of medication
LamictalDepakoteTegretolTopamax
Prescription onlyPrescription onlyPrescription onlyPrescription only
Available as
LamictalDepakoteTegretolTopamax
  • Pill
  • Extended release
  • Chewable tablet
  • Dissolving tablet
  • Pill
  • Extended release
  • Extended release capsule
  • Sprinkle
  • Liquid
  • Pill
  • Extended release
  • Chewable tablet
  • Oral suspension
  • Pill
  • Extended release capsule
Used for
LamictalDepakoteTegretolTopamax
Risk factors for serious side effects
LamictalDepakoteTegretolTopamax
  • History of depression
  • People also taking Depakote
  • Taking more than the prescribed dose
  • Increasing the dose too quickly
  • Taking birth control pills
Detailed Lamictal (lamotrigine) risks & warnings »
  • Children under age 2
  • History of metabolic disorders
  • History of depression
  • People also taking Topamax
Detailed Depacon (valproate, valproic acid, or divalproex) risks & warnings »
  • People also taking Depakote
  • Asian ancestry
  • History of depression
  • European, Chinese, or Japanese ancestry
  • Age 65 years or older
Detailed Tegretol (carbamazepine) risks & warnings »
  • History of depression
  • Children
  • History of metabolic disorders
  • People also taking Depakote
  • Low-carb diet
Detailed Qudexy Xr (topiramate) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Interactions
LamictalDepakoteTegretolTopamax
No interactions related info.No interactions related info.
  • Interacts with many other medicines and supplements.
No interactions related info.
Food
LamictalDepakoteTegretolTopamax
  • Take with food to avoid upset stomach.
  • Take with food to avoid upset stomach.
No food related info.No food related info.
Kidneys and liver
LamictalDepakoteTegretolTopamax
No kidneys and liver related info.
  • Can cause liver damage, so it's probably not safe if you already have liver problems.
No kidneys and liver related info.
  • Qudexy Xr (Topiramate) may increase your risk for kidney stones. Stay well-hydrated to lower your risk.
  • A few people will get kidney stones.
Weight
LamictalDepakoteTegretolTopamax
No weight related info.
  • May cause hair loss and weight gain.
  • Can cause upset stomach, hair loss, weight gain, sleepiness, and tremor.
No weight related info.
  • Can cause sleepiness, speech problems, tingling sensations, and weight loss.
Upsides and benefits
LamictalDepakoteTegretolTopamax
  • Effective at lowering the frequency of seizures in people with epilepsy or Lennox-Gestaut syndrome. Typically used together with other medications for severe seizure disorders.
  • Works best for partial, tonic-clonic, and absence seizures.
  • A first-line treatment for bipolar disorder. Effective long-term treatment for stabilizing mood. Prevents both depressive and manic episodes, but the effect is greater for preventing depression.
  • Doesn't require routine blood tests.
  • Lowers the frequency of seizures, especially for people with absence, tonic-clonic, and complex partial seizures.
  • One of the first-line options to stabilize mood for people with bipolar disorder.
  • Helpful in preventing frequent migraine headaches.
  • Lowers the frequency of seizures, especially for people with tonic-clonic and partial seizures.
  • First-line option for trigeminal neuralgia (nerve pain involving the face, head, and neck), and can relieve other types of nerve pain.
  • May be helpful in stabilizing mood for people with bipolar disorder.
  • Used on its own or with other antiepileptic medicines to lower the frequency of seizures, especially for people with tonic-clonic or partial seizures, or Lennox-Gestaut syndrome.
  • Helpful in preventing frequent migraine headaches.
  • Doesn't need routine blood tests.
Downsides and risks
LamictalDepakoteTegretolTopamax
  • Can cause double vision, dizziness, sleepiness, and headache.
  • Has the risk of a rare but life-threatening rash.
  • Can make hormonal birth control less effective.
  • Might be less effective than other medicines for treating manic episodes (acute mania) in people with bipolar disorder.
  • Can cause upset stomach, hair loss, weight gain, sleepiness, and tremor.
  • Can cause liver damage, so it's probably not safe if you already have liver problems.
  • Not safe to use if you're pregnant.
  • Requires routine blood tests to see how the medicine is affecting your body.
  • Interacts with many other medicines and supplements.
  • Higher risk of skin reactions compared to other antiepileptic medicines, ranging from mild to life-threatening rash.
  • Can cause blurry vision, dizziness, and upset stomach.
  • Not safe to use if you're pregnant.
  • Requires routine blood tests to see how the medicine is affecting your body.
  • Can cause sleepiness, speech problems, tingling sensations, and weight loss.
  • A few people will get kidney stones.
  • Not safe to use if you're pregnant.
Tips from our pharmacists for people taking the medication
LamictalDepakoteTegretolTopamax
  • Follow dose adjustments set by your doctor to minimize skin rash.
  • Take with food to avoid upset stomach.
  • Report rash, blurry vision, fever, persistent headache, or neck stiffness to your doctor.
  • Makes hormonal birth control less effective.
  • Takes 4 to 6 weeks to feel full effects on mood.
  • For the first week, avoid activities that require you to be alert.
  • Don't use if pregnant.
  • Requires routine blood tests.
  • Take with food to avoid upset stomach.
  • May cause hair loss and weight gain.
  • Different versions of Depakote have different dosing. Be careful.
  • Report confusion, persistent abdominal pain, yellowing of eyes/skin, or easy bruising to your doctor.
  • Takes 3 to 4 weeks to feel full effects on mood.
  • For the first week, avoid activities that require you to be alert.
  • Report skin rashes or blistering immediately.
  • Don't use if pregnant.
  • Requires routine blood tests.
  • Report confusion, persistent abdominal pain, yellowing of eyes/skin, or easy bruising to your doctor.
  • Takes up to 5 weeks to feel full effects on mood.
  • For the first week, avoid activities that require you to be alert.
  • Don't use if pregnant.
  • Can cause tingling skin sensations and reduced appetite.
  • Report any confusion, decreased sweating, fever, or changes in behavior or vision.
  • Takes 3 to 4 weeks to feel full effects on mood.
Learn more
More about LamictalSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Lamictal (lamotrigine)?
Worth itNot sureNot worth it
More about DepakoteSide effectsReviews & ratingsFDA package insert
Have you used Depacon (valproate, valproic acid, or divalproex)?
Worth itNot sureNot worth it
More about TegretolSide effectsReviews & ratingsFDA package insert
Have you used Tegretol (carbamazepine)?
Worth itNot sureNot worth it
More about TopamaxSide effectsReviews & ratingsFDA package insert
Have you used Qudexy Xr (topiramate)?
Worth itNot sureNot worth it