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Lamictal Alternatives

(Lamotrigine)

  • Pill
  • Extended release
  • Chewable tablet
  • Dissolving tablet
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Compare Lamictal (Lamotrigine) to alternatives

These medications are comparable to Lamictal (Lamotrigine) or used for similar purposes.

Lamictal
(Lamotrigine)

Depacon
(Valproate, Valproic Acid, Or Divalproex)

Tegretol
(Carbamazepine)

Qudexy Xr
(Topiramate)

Prevents seizures and stabilizes mood. Lamictal (Lamotrigine) is most useful for treating severe seizure disorders, and for bipolar disorder with more depression symptoms than manic symptoms. Just be careful to increase your dose slowly to avoid skin rash.Prevents seizures and stabilizes mood. Depacon (Valproate, Valproic Acid, Or Divalproex) is good long-term prevention for epilepsy, bipolar disorder, and migraines, but can cause weight gain.Prevents seizures, stabilizes mood, and relieves nerve pain. Tegretol (Carbamazepine) is useful for preventing seizures and relieving certain types of nerve pain, but interacts with many drugs.Prevents seizures and migraine headaches. Qudexy Xr (Topiramate) is useful for preventing seizures and migraines, and doesn't require blood tests while you're on it.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
5.178571428571429Lamictal
Reviews for Lamictal (Lamotrigine)
67%
of people say Lamictal (Lamotrigine) is worth it
58%
say it works well
19%
say it's a big hassle
Reviews for Depacon (Valproate, Valproic Acid, Or Divalproex)
46%
21% vs. Lamictal (Lamotrigine)
39%
19% vs. Lamictal (Lamotrigine)
27%
8% vs. Lamictal (Lamotrigine)
Reviews for Tegretol (Carbamazepine)
58%
9% vs. Lamictal (Lamotrigine)
42%
16% vs. Lamictal (Lamotrigine)
21%
2% vs. Lamictal (Lamotrigine)
Reviews for Qudexy Xr (Topiramate)
54%
13% vs. Lamictal (Lamotrigine)
52%
6% vs. Lamictal (Lamotrigine)
33%
14% vs. Lamictal (Lamotrigine)
Side effects
LamictalDepakoteTegretolTopamax
  • Double vision 41%
  • Dizziness 27%
  • Lack of muscle coordination 18%
  • Blurred vision 15%
  • Nausea 14%
  • Vomiting 14%
  • Headache 10%
  • Inflammation inside the nose 5%
  • Sleep difficulty 4%
  • Incoordination 4%
More Lamictal side effects »
  • Nausea 34%
  • Muscle weakness 20%
  • Vomiting 20%
  • Abdominal pain 17%
  • Dizziness 12%
  • Headache 10%
  • Double vision 7%
  • Involuntary eye movement 7%
  • Lack of muscle coordination 7%
  • Accidental injury 6%
More Depakote side effects »
  • Dizziness 32%
  • Drowsiness 19%
  • Nausea 19%
  • Vomiting 15%
  • Itching 6%
  • Constipation 5%
  • Dry mouth 5%
  • Muscle weakness 4%
  • Blurred vision 4%
  • Rash 3%
More Tegretol side effects »
  • Tingling sensation 45%
  • Slowed-down thinking and movements 19%
  • Dizziness 17%
  • Drowsiness 17%
  • Fatigue 17%
  • Change in taste 14%
  • Difficulty with concentration/attention 13%
  • Nervousness 12%
  • Difficulty with memory 11%
  • Vision abnormal 11%
More Topamax side effects »
How it works
LamictalDepakoteTegretolTopamax
Lamictal (Lamotrigine) is an antiepileptic. Researchers don't know exactly how it works, but it seems to calm nerve activity in the brain.Depacon (Valproate, Valproic Acid, Or Divalproex) is an antiepileptic. Researchers don't know exactly how it works. It seems to increase the amount of GABA, a chemical that calms nerves in the brain.Tegretol (Carbamazepine) is an antiepileptic. Researchers don't know exactly how it works, but it seems to block certain kinds of nerve activity to reduce seizures and pain.Qudexy Xr (Topiramate) is an antiepileptic. Researchers don't know exactly how it works, but it seems to affect multiple parts of the brain to control seizures and migraines.
Type of medication
LamictalDepakoteTegretolTopamax
AnticonvulsantPrescription only
AnticonvulsantPrescription only
AnticonvulsantPrescription only
AnticonvulsantPrescription only
Available as
LamictalDepakoteTegretolTopamax
  • Pill
  • Extended release
  • Chewable tablet
  • Dissolving tablet
  • Pill
  • Extended release
  • Extended release capsule
  • Sprinkle
  • Liquid
  • Pill
  • Extended release
  • Chewable tablet
  • Oral suspension
  • Pill
  • Extended release capsule
Used for (click to learn more)
LamictalDepakoteTegretolTopamax
How well it works for depression
The free Iodine Start program helps people track how well they are improving, and find the right antidepressant faster.
The free Iodine Start program (personal reports and coaching) is currently only for antidepressants. For now, you can read our pharmacist info about this medication.Learn more about Lamictal (Lamotrigine)The free Iodine Start program (personal reports and coaching) is currently only for antidepressants. For now, you can read our pharmacist info about this medication.Learn more about Depacon (Valproate, Valproic Acid, Or Divalproex)The free Iodine Start program (personal reports and coaching) is currently only for antidepressants. For now, you can read our pharmacist info about this medication.Learn more about Tegretol (Carbamazepine)The free Iodine Start program (personal reports and coaching) is currently only for antidepressants. For now, you can read our pharmacist info about this medication.Learn more about Qudexy Xr (Topiramate)
Risk factors for serious side effects
LamictalDepakoteTegretolTopamax
  • History of depression
  • People also taking Depakote
  • Taking more than the prescribed dose
  • Increasing the dose too quickly
        • Taking birth control pills
        • Stopping Lamictal (Lamotrigine) suddenly
        Detailed Lamictal (Lamotrigine) risks & warnings »
        Coming soon.Coming soon.Coming soon.
        Pregnancy category
        LamictalDepakoteTegretolTopamax
        CFDA pregnancy category (Weigh risks vs. benefits)

        Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

        See the FDA package insert
        DFDA pregnancy category (Weigh risks vs. benefits)

        Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

        See the FDA package insert
        DFDA pregnancy category (Weigh risks vs. benefits)

        Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

        See the FDA package insert
        DFDA pregnancy category (Weigh risks vs. benefits)

        Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

        See the FDA package insert
        Alcohol
        No specific alcohol-related info.No specific alcohol-related info.No specific alcohol-related info.No specific alcohol-related info.
        Food
        • Take with food to avoid upset stomach.
        • Take with food to avoid upset stomach.
        No specific food-related info.No specific food-related info.
        Kidneys and liver
        No specific kidneys and liver-related info.No specific kidneys and liver-related info.No specific kidneys and liver-related info.
        • A few people will get kidney stones.
        Sex
        No specific sex-related info.No specific sex-related info.No specific sex-related info.No specific sex-related info.
        Sleep
        No specific sleep-related info.No specific sleep-related info.No specific sleep-related info.No specific sleep-related info.
        Weight
        No specific weight-related info.
        • Can cause upset stomach, hair loss, weight gain, sleepiness, and tremor.
        • May cause hair loss and weight gain.
        No specific weight-related info.
        • Can cause sleepiness, speech problems, tingling sensations, and weight loss.
        Upsides and benefits
        LamictalDepakoteTegretolTopamax
        • Effective at lowering the frequency of seizures in people with epilepsy or Lennox-Gestaut syndrome. Typically used together with other medications for severe seizure disorders.
        • Works best for partial, tonic-clonic, and absence seizures.
        • A first-line treatment for bipolar disorder. Effective long-term treatment for stabilizing mood. Prevents both depressive and manic episodes, but the effect is greater for preventing depression.
        • Doesn't require routine blood tests.
        • Lowers the frequency of seizures, especially for people with absence, tonic-clonic, and complex partial seizures.
        • One of the first-line options to stabilize mood for people with bipolar disorder.
        • Helpful in preventing frequent migraine headaches.
        • Lowers the frequency of seizures, especially for people with tonic-clonic and partial seizures.
        • First-line option for trigeminal neuralgia (nerve pain involving the face, head, and neck), and can relieve other types of nerve pain.
        • May be helpful in stabilizing mood for people with bipolar disorder.
        • Used on its own or with other antiepileptic medicines to lower the frequency of seizures, especially for people with tonic-clonic or partial seizures, or Lennox-Gestaut syndrome.
        • Doesn't need routine blood tests.
        • Helpful in preventing frequent migraine headaches.
        Downsides and risks
        LamictalDepakoteTegretolTopamax
        • Can cause double vision, dizziness, sleepiness, and headache.
        • Has the risk of a rare but life-threatening rash.
        • Can make hormonal birth control less effective.
        • Might be less effective than other medicines for treating manic episodes (acute mania) in people with bipolar disorder.
        • Can cause upset stomach, hair loss, weight gain, sleepiness, and tremor.
        • Can cause liver damage, so it's probably not safe if you already have liver problems.
        • Not safe to use if you're pregnant.
        • Requires routine blood tests to see how the medicine is affecting your body.
        • Interacts with many other medicines and supplements.
        • Higher risk of skin reactions compared to other antiepileptic medicines, ranging from mild to life-threatening rash.
        • Can cause blurry vision, dizziness, and upset stomach.
        • Not safe to use if you're pregnant.
        • Requires routine blood tests to see how the medicine is affecting your body.
        • Can cause sleepiness, speech problems, tingling sensations, and weight loss.
        • A few people will get kidney stones.
        • Not safe to use if you're pregnant.
        Tips from our pharmacists for people taking the medication
        LamictalDepakoteTegretolTopamax
        • Follow dose adjustments set by your doctor to minimize skin rash.
        • Report rash, blurry vision, fever, persistent headache, or neck stiffness to your doctor.
        • Makes hormonal birth control less effective.
        • Take with food to avoid upset stomach.
        • Takes 4 to 6 weeks to feel full effects on mood.
        • May cause hair loss and weight gain.
        • Different versions of Depakote have different dosing. Be careful.
        • For the first week, avoid activities that require you to be alert.
        • Don't use if pregnant.
        • Requires routine blood tests.
        • Take with food to avoid upset stomach.
        • Report confusion, persistent abdominal pain, yellowing of eyes/skin, or easy bruising to your doctor.
        • Takes 3 to 4 weeks to feel full effects on mood.
        • Report skin rashes or blistering immediately.
        • Takes up to 5 weeks to feel full effects on mood.
        • For the first week, avoid activities that require you to be alert.
        • Don't use if pregnant.
        • Requires routine blood tests.
        • Report confusion, persistent abdominal pain, yellowing of eyes/skin, or easy bruising to your doctor.
        • Can cause tingling skin sensations and reduced appetite.
        • Report any confusion, decreased sweating, fever, or changes in behavior or vision.
        • For the first week, avoid activities that require you to be alert.
        • Don't use if pregnant.
        • Takes 3 to 4 weeks to feel full effects on mood.
        Learn more
        More about LamictalSide effectsReviews & ratingsAlternativesFDA package insert
        More about DepakoteSide effectsReviews & ratingsFDA package insert
        More about TegretolSide effectsReviews & ratingsFDA package insert
        More about TopamaxSide effectsReviews & ratingsFDA package insert