Prescription onlyLower-cost generic availableClass: Pain

Lidoderm Alternatives

(lidocaine)

Prescription onlyLower-cost generic availableClass: Pain
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Compare Lidoderm (lidocaine) to alternatives

These medications are comparable to Lidoderm (lidocaine) or used for similar purposes.

Lidoderm
(lidocaine)

Elavil
(amitriptyline)

Neurontin
(gabapentin)

Horizant
(gabapentin enacarbil)

Lyrica
(pregabalin)

Neurontin
(gabapentin)

Pamelor
(nortriptyline)

Treats nerve pain. Lidoderm (Lidocaine) patches work well by releasing a local anesthetic into the skin and relieving pain by targeting damaged nerves.Improves mood and relieves certain kinds of pain. Elavil (Amitriptyline) is an older antidepressant that's sometimes used to treat pain and sleep problems, but it can have more side effects than similar medications.Treats tingling and burning nerve pain. Neurontin (Gabapentin) is an old seizure disorder medicine that's now used to treat nerve-related pain caused by different conditions.Calms leg movements and nerve pain. Horizant (Gabapentin Enacarbil) is a good way to treat pain since it can be used with other pain medications and it's not addictive. You'll need to stop drinking alcohol and it can be somewhat expensive.Treats nerve pain and prevents seizures. Lyrica (Pregabalin) works well as an add-on medicine for seizures and fibromyalgia, but it's especially effective for nerve-related pain after shingles. Not available as a generic, so it might be expensive.Treats tingling and burning nerve pain. Neurontin (Gabapentin) is an old seizure disorder medicine that's now used to treat nerve-related pain caused by different conditions.Improves your mood. Pamelor (Nortriptyline) is a good option for treating depression, especially for people who also have problems with persistent nerve pain.
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Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.78Lidocaine
Reviews for Lidocaine
67%
of people (All ages) say Lidocaine is worth it
72%
say it works well
22%
say it's a big hassle
Have you used Lidoderm (lidocaine)?
Worth itNot sureNot worth it
Reviews for Elavil
53%
+14% better vs. Lidocaine
36%
+36% better vs. Lidocaine
25%
+3% better vs. Lidocaine
134 reviews
Have you used Elavil (amitriptyline)?
Worth itNot sureNot worth it
Reviews for Neurontin
57%
+10% better vs. Lidocaine
40%
+32% better vs. Lidocaine
19%
-3% worse vs. Lidocaine
620 reviews
Have you used Neurontin (gabapentin)?
Worth itNot sureNot worth it

Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Horizant (gabapentin enacarbil)?
Worth itNot sureNot worth it
Reviews for Lyrica
47%
+20% better vs. Lidocaine
42%
+30% better vs. Lidocaine
32%
+10% better vs. Lidocaine
Have you used Lyrica (pregabalin)?
Worth itNot sureNot worth it
Reviews for Pamelor
79%
-12% worse vs. Lidocaine
79%
-7% worse vs. Lidocaine
21%
-1% worse vs. Lidocaine
Have you used Pamelor (nortriptyline)?
Worth itNot sureNot worth it
Side effects
LidocaineElavilNeurontinHorizantLyricaNeurontinPamelor

The Lidocaine FDA package insert doesn’t have numbers about how common side effects are.

More about Lidocaine side effects »

The Elavil FDA package insert doesn’t have numbers about how common side effects are.

More about Elavil side effects »
  • Dizziness 21%
  • Drowsiness 16%
  • Leg or ankle swelling 6%
  • Muscle weakness 1%
  • Diarrhea 2%
  • Infection 2%
  • Dry mouth 3%
  • Constipation 2%
  • Accidental injury 2%
  • Vomiting 2%
More Neurontin side effects »
  • Somnolence/sedation 14%
  • Dizziness 9%
  • Headache 1%
  • Nausea 1%
  • Fatigue 2%
  • Irritability 3%
  • Dry mouth 1%
  • Passing gas 3%
  • Increased appetite 2%
More Horizant side effects »
  • Nerve damage 6%
  • Dizziness 3%
  • Lack of muscle coordination 5%
  • Accidental injury 2%
  • Chest pain 3%
  • Leg or ankle swelling 2%
  • Muscle weakness 2%
  • Drowsiness 1%
  • Passing gas 2%
  • Dry mouth 2%
More Lyrica side effects »
  • Dizziness 21%
  • Drowsiness 16%
  • Leg or ankle swelling 6%
  • Muscle weakness 1%
  • Diarrhea 2%
  • Infection 2%
  • Dry mouth 3%
  • Constipation 2%
  • Accidental injury 2%
  • Vomiting 2%
More Neurontin side effects »

We haven’t found good data for Pamelor side effects.

FDA side effect reports for Pamelor »
How it works
LidocaineElavilNeurontinHorizantLyricaNeurontinPamelor
Lidoderm (Lidocaine) is a local anesthetic. It absorbs into your skin where it targets damaged nerves and relieves burning pain.Elavil (Amitriptyline) is a tricyclic antidepressant (TCA). Researchers don't know exactly how it works. It may change serotonin and norepinephrine activity in the brain, which regulates mood and pain perception. It also has sedative effects.Neurontin (Gabapentin) is an antiepileptic and nerve pain reliever. Researchers don't know exactly how it works, but it has a similar structure to GABA, a neurotransmitter that calms nerves in the brain and spinal cord.Horizant (Gabapentin Enacarbil) treats restless leg syndrome and pain caused by shingles by lowering your body's response to pain. It's used for long-lasting (chronic) pain and doesn't work for sudden (acute) pain.Lyrica (Pregabalin) is a nerve pain reliever. Researchers don't know exactly how it works, but it has a similar structure to GABA, a neurotransmitter that calms nerves in the brain and spinal cord.Neurontin (Gabapentin) is an antiepileptic and nerve pain reliever. Researchers don't know exactly how it works, but it has a similar structure to GABA, a neurotransmitter that calms nerves in the brain and spinal cord.Pamelor (Nortriptyline) is a tricyclic antidepressant (TCA). It helps improve your mood by altering the levels of serotonin, norepinephrine, and other similar chemicals in your brain.
Type of medication
LidocaineElavilNeurontinHorizantLyricaNeurontinPamelor
Prescription onlyPrescription onlyPrescription onlyPrescription onlyPrescription onlyPrescription onlyPrescription only
Available as
LidocaineElavilNeurontinHorizantLyricaNeurontinPamelor
  • Cream, gel, or ointment
  • Jelly
  • Spray
  • Topical solution
  • Patch
  • Pill
  • Pill
  • Oral solution
  • Pill
  • Pill
  • Liquid
  • Pill
  • Oral solution
  • Pill
  • Liquid
Used for
LidocaineElavilNeurontinHorizantLyricaNeurontinPamelor
Risk factors for serious side effects
LidocaineElavilNeurontinHorizantLyricaNeurontinPamelor
  • Use of heating pad on skin
  • Applying patch to red, irritated or broken skin
  • Leaving patch on for more than 12 hours
  • Using patch on a very large area
  • Older age and lower body weight
Detailed Lidoderm (lidocaine) risks & warnings »
  • Age 24 years or younger
  • History of bipolar disorder
  • At risk for bipolar disorder
  • History of cardiovascular disease
  • Age 65 years or older
Detailed Elavil (amitriptyline) risks & warnings »
  • Children ages 3 to 12
  • Taking with alcohol or drugs
  • Stopping Neurontin (Gabapentin) suddenly
Detailed Neurontin (gabapentin) risks & warnings »
  • Stopping Horizant (Gabapentin Enacarbil) suddenly
Detailed Horizant (gabapentin enacarbil) risks & warnings »
  • Taking with alcohol
  • Taking other medicines that make you less alert
  • History of unusual swelling (angioedema)
  • Taking other medications that can angioedema
  • History of cardiovascular disease
Detailed Lyrica (pregabalin) risks & warnings »
  • Children ages 3 to 12
  • Taking with alcohol or drugs
  • Stopping Neurontin (Gabapentin) suddenly
Detailed Neurontin (gabapentin) risks & warnings »
  • Age 24 years or younger
  • Age 65 years or older
  • Stopping Pamelor (Nortriptyline) suddenly
  • Using other medications that affect serotonin
  • History of heart disease
Detailed Pamelor (nortriptyline) risks & warnings »
Pregnancy

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

Price
LidocaineElavilNeurontinHorizantLyricaNeurontinPamelor
No price related info.No price related info.No price related info.No price related info.
  • Not available as a generic, so it can be pricey.
No price related info.No price related info.
Alcohol
LidocaineElavilNeurontinHorizantLyricaNeurontinPamelor
No alcohol related info.No alcohol related info.No alcohol related info.
  • Need to avoid alcohol while on Horizant (Gabapentin Enacarbil).
  • It's not safe to take this medication with alcohol or other drugs that make you drowsy.
No alcohol related info.No alcohol related info.
Food
LidocaineElavilNeurontinHorizantLyricaNeurontinPamelor
No food related info.No food related info.
  • Take the extended-release tablet with food.
  • Swallow the pills whole and take with food.
  • Has to be taken with food.
No food related info.
  • Take the extended-release tablet with food.
  • Take it with food and/or at bedtime to decrease the potential side effects.
Pain
LidocaineElavilNeurontinHorizantLyricaNeurontinPamelor
  • Lidoderm (Lidocaine) can treat pain better for people who can't take oral pain medications due to allergies or bad side effects.
  • Has been shown to relieve nerve pain due to shingles for up to 12 hours at a time.
  • Low doses work well to treat certain kinds of chronic pain. It can take 2 weeks to feel the full effects of the medication.
  • Studies show it's most effective for nerve pain from diabetes, shingles, and fibromyalgia (a painful muscle condition).
  • Can be used with other pain medications.
  • Has a higher risk than other pain medicines of affecting your heart rate or rhythm, so it might not be the best choice if you have cardiovascular disease (previous heart attack, stroke, fast/uncontrolled heart rate, or irregular heartbeat).
  • Studies show it's most effective for nerve pain from diabetes, shingles, and fibromyalgia (a painful muscle condition).
No pain related info.
Sleep
LidocaineElavilNeurontinHorizantLyricaNeurontinPamelor
No sleep related info.
  • Can cause dizziness, drowsiness, constipation, and weight gain.
  • Neurontin (Gabapentin) is likely to cause some side effects, including memory problems, drowsiness, dizziness, or confusion.
  • Horizant (Gabapentin Enacarbil) can make you feel dizzy or sleepy for the first few days or weeks that you take it. Until your body has adjusted to the medication, be very careful getting up from sitting or lying down, and don't drive or use machinery.
  • Can make you drowsy or dizzy.
  • Lyrica (Pregabalin) is likely to cause some side effects, including memory problems, drowsiness, dizziness, and confusion.
  • Neurontin (Gabapentin) is likely to cause some side effects, including memory problems, drowsiness, dizziness, or confusion.
No sleep related info.
Weight
LidocaineElavilNeurontinHorizantLyricaNeurontinPamelor
No weight related info.
  • It's more likely to cause sleepiness, nausea, constipation, diarrhea, and weight gain (1 to 5 pounds) than other antidepressants.
No weight related info.No weight related info.No weight related info.No weight related info.No weight related info.
Upsides and benefits
LidocaineElavilNeurontinHorizantLyricaNeurontinPamelor
  • Lidoderm (Lidocaine) can treat pain better for people who can't take oral pain medications due to allergies or bad side effects.
  • Has been shown to relieve nerve pain due to shingles for up to 12 hours at a time.
  • Patches can be cut into smaller pieces to best fit the areas of skin they need to be used on.
  • Low doses work well to treat certain kinds of chronic pain. It can take 2 weeks to feel the full effects of the medication.
  • Low doses of Elavil (Amitriptyline) start working in 45 minutes to help you sleep better.
  • Six out of every ten people who use an antidepressant for the first time find that it works for them.
  • Originally used to treat epilepsy (partial seizures), but now it primarily treats neuropathic pain that's caused by nerve stimulation or damage.
  • Studies show it's most effective for nerve pain from diabetes, shingles, and fibromyalgia (a painful muscle condition).
  • It's available as a generic, so it's less expensive than similar medications.
  • Not habit-forming or addictive.
  • Can be used with other pain medications.
  • Only has to be taken once or twice a day.
  • Relieves nerve-related (neuropathic) pain caused by different conditions including diabetes, shingles (herpes zoster), fibromyalgia, and spinal cord damage.
  • Studies show that lower doses of Lyrica (Pregabalin) cause fewer side effects and still relieve pain just as well as higher doses.
  • Also used in combination with other medications to treat epilepsy (partial seizures).
  • Originally used to treat epilepsy (partial seizures), but now it primarily treats neuropathic pain that's caused by nerve stimulation or damage.
  • Studies show it's most effective for nerve pain from diabetes, shingles, and fibromyalgia (a painful muscle condition).
  • It's available as a generic, so it's less expensive than similar medications.
  • Helpful with treating certain types of pain, like migraines or nerve-related pain.
  • Generally well tolerated and has fewer side effects than other medicines in the same class of drugs.
Downsides and risks
LidocaineElavilNeurontinHorizantLyricaNeurontinPamelor
  • Can cause skin irritation after using it the first time, but for most people it's mild and goes away in a few minutes or hours.
  • Used patches contain enough medicine to be dangerous to children and pets, so store and dispose of the patches in a safe place out of their reach.
  • Might not be the best choice if you've had allergic reactions to numbing medications (local anesthetics) in the past.
  • Even though only small amounts of Lidoderm (Lidocaine) are absorbed into the body through the skin, if you're taking medications that treat arrhythmias, Lidoderm (Lidocaine) can affect how they work.
  • Patches shouldn't be left on for more than 12 hours, used on very large areas of skin, or covered with a heating pad.
  • When used for depression, Elavil (Amitriptyline) causes more side effects and has a higher risk of overdose than other antidepressants. It's usually used when other medications haven't worked.
  • It's more likely to cause sleepiness, nausea, constipation, diarrhea, and weight gain (1 to 5 pounds) than other antidepressants.
  • People age 65 and older have a higher risk for this medication's side effects.
  • Like most antidepressants, it can cause a higher risk of suicidal thoughts and behavior for people age 24 and younger.
  • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
  • Neurontin (Gabapentin) is likely to cause some side effects, including memory problems, drowsiness, dizziness, or confusion.
  • You can't skip or miss doses since suddenly stopping Neurontin (Gabapentin) can cause seizures. This is even more likely if you drink alcohol, so it might not be the best medication for heavy drinkers.
  • Need to avoid alcohol while on Horizant (Gabapentin Enacarbil).
  • Has to be taken with food.
  • If you want to stop taking this medication, you need to talk to your doctor first since stopping it cold turkey can cause seizures.
  • Not available as a generic.
  • Not available as a generic, so it can be pricey.
  • You can't skip or miss doses since suddenly stopping Lyrica (Pregabalin) can cause seizures.
  • Lyrica (Pregabalin) is likely to cause some side effects, including memory problems, drowsiness, dizziness, and confusion.
  • Has a higher risk than other pain medicines of affecting your heart rate or rhythm, so it might not be the best choice if you have cardiovascular disease (previous heart attack, stroke, fast/uncontrolled heart rate, or irregular heartbeat).
  • Neurontin (Gabapentin) is likely to cause some side effects, including memory problems, drowsiness, dizziness, or confusion.
  • You can't skip or miss doses since suddenly stopping Neurontin (Gabapentin) can cause seizures. This is even more likely if you drink alcohol, so it might not be the best medication for heavy drinkers.
  • Side effects are usually manageable, but can be annoying.
  • Increases the risk of falls, especially when used in the elderly.
  • There's an increased chance of it causing heart problems, especially in people with a history of heart problems.
Tips from our pharmacists for people taking the medication
LidocaineElavilNeurontinHorizantLyricaNeurontinPamelor
  • Starts working with the first dose, but full effects can take longer.
  • Remove the protective lining on the patch before applying the patch to unbroken skin.
  • Leave the patch on for up to 12 hours during a 24 hour period.
  • You can cut the patches to create a custom fit for the area of skin you need to apply it to.
  • Don't place any tight wraps or heating pads over the patch while it's on.
  • Make sure not to touch your eyes after touching the patch. Always wash your hands after putting it on or taking it off.
  • Take at bedtime to avoid some of its side effects.
  • Can cause dizziness, drowsiness, constipation, and weight gain.
  • Stop taking it slowly to avoid getting withdrawal symptoms.
  • Tell your doctor if you notice sudden mood changes or unusual thoughts.
  • Side effects are common, but usually manageable.
  • Don't drive while taking Neurontin (Gabapentin) until you know how the medication affects you.
  • Neurontin and generic forms of Gabapentin have the same ingredients as Gralise and Horizant, but are dosed differently. Make sure you know which form you're taking since they are used for different purposes.
  • Take the extended-release tablet with food.
  • Stop taking Neurontin (Gabapentin) slowly over at least one week to avoid getting withdrawal symptoms.
  • Don't stop taking Horizant (Gabapentin Enacarbil) suddenly without telling your doctor.
  • Can make you feel dizzy or drowsy the first few days or weeks that you're taking it.
  • Swallow the pills whole and take with food.
  • Horizant (Gabapentin Enacarbil) is different from other forms of gabapentin (like Neurontin), so these two medications can't be switched or substituted for each other.
  • Some people feel relief from pain in a week.
  • Can make you drowsy or dizzy.
  • Don't stop taking it suddenly without talking to your doctor. You'll need to slowly lower your dose over at least a week to avoid withdrawal symptoms.
  • Tell your doctor if you have unexplained confusion or changes in your thoughts or behavior.
  • It's not safe to take this medication with alcohol or other drugs that make you drowsy.
  • Side effects are common, but usually manageable.
  • Don't drive while taking Neurontin (Gabapentin) until you know how the medication affects you.
  • Neurontin and generic forms of Gabapentin have the same ingredients as Gralise and Horizant, but are dosed differently. Make sure you know which form you're taking since they are used for different purposes.
  • Take the extended-release tablet with food.
  • Stop taking Neurontin (Gabapentin) slowly over at least one week to avoid getting withdrawal symptoms.
  • Needs to be taken every day for 1 to 2 weeks to start feeling better, and for 6 to 8 weeks to see the full effect of the medication.
  • It's important to keep taking Pamelor (Nortriptyline) even when you feel your symptoms are getting better.
  • Take it with food and/or at bedtime to decrease the potential side effects.
  • Tell your doctor if you notice sudden mood changes or unusual thoughts.
  • If you decide to stop taking Pamelor (Nortriptyline), work with your doctor to slowly get off this medicine to avoid getting withdrawal symptoms.
Learn more
More about LidocaineSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Lidoderm (lidocaine)?
Worth itNot sureNot worth it
More about ElavilSide effectsReviews & ratingsFDA package insert
Have you used Elavil (amitriptyline)?
Worth itNot sureNot worth it
More about NeurontinSide effectsReviews & ratingsFDA package insert
Have you used Neurontin (gabapentin)?
Worth itNot sureNot worth it
More about HorizantSide effectsReviews & ratingsFDA package insert
Have you used Horizant (gabapentin enacarbil)?
Worth itNot sureNot worth it
More about LyricaSide effectsReviews & ratingsFDA package insert
Have you used Lyrica (pregabalin)?
Worth itNot sureNot worth it
More about NeurontinSide effectsReviews & ratingsFDA package insert
Have you used Neurontin (gabapentin)?
Worth itNot sureNot worth it
More about PamelorSide effectsReviews & ratingsFDA package insert
Have you used Pamelor (nortriptyline)?
Worth itNot sureNot worth it