Prescription onlyLower-cost generic availableDrug class: Cardiovascular

Zestril

(Lisinopril)

Prescription onlyLower-cost generic availableDrug class: Cardiovascular
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Lowers blood pressure.

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Our bottom line

Zestril (Lisinopril) is a good blood pressure-lowering medicine that protects kidney function.

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Upsides

  • A first-choice blood pressure treatment for many people.
  • Lowers the risk of heart attack and stroke.
  • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
  • Recommended for anyone with heart failure since it lowers the risk of death and further damage to your heart.
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Downsides

  • Up to 1 in 10 people can get a dry cough with this medicine. It ranges from a mild tickle in the throat to a persistent hacking cough.
  • Requires a yearly blood test to see how the medicine is affecting your body.
  • Not safe to use if you're pregnant.
How it works

Zestril (Lisinopril) is an angiotensin converting enzyme (ACE) inhibitor. It blocks a chemical that tightens blood vessels. This makes blood vessels relax, which lowers blood pressure and allows more blood and oxygen to get to your heart and other organs.

What to expect when you take Zestril (Lisinopril) for Lowers blood pressure

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Side effect rates for Zestril (Lisinopril)

0From clinical trials of Lisinopril / After heart attack
  • Low blood pressure
  • Renal dysfunction

Risks and Warnings for Zestril (Lisinopril)

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    • Higher risk if:
    • Women of childbearing age

    Zestril (Lisinopril) can cause birth defects or death to a fetus. If you are pregnant or considering having a baby, talk to your doctor about alternative medicines.

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Common concerns from people taking Zestril (Lisinopril)

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Pregnancy
Kidneys and liver
  • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
  • Requires routine blood tests to check kidney function.
Pain
  • Had severe muscle pain (enough to make walking/biking almost impossible) at the 20mg dose, had to go down to 10mg dose.
Sleep
  • It will make you sleepy!I took a very low dose, 2.5 mg., to protect my kidney function from lupus. I had to get off it due to a life-threatening, but comical, allergic reaction: angio-edema causing facial swelling.