Prescription onlyLower-cost generic availableClass: Cardiovascular

ZestrilAlternatives

(lisinopril)

Prescription onlyLower-cost generic availableClass: Cardiovascular
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Compare Zestril (lisinopril) to alternatives

These medications are comparable to Zestril (lisinopril) or used for similar purposes.

Zestril
(lisinopril)

Lotensin
(benazepril)

Capoten
(captopril)

Vasotec
(enalapril)

Cozaar
(losartan)

Benicar
(olmesartan)

Lowers blood pressure. Zestril (lisinopril) is a good blood pressure-lowering medicine that protects kidney function.Lowers blood pressure. Lotensin (benazepril) is a good blood pressure-lowering medicine that also protects kidney function.Lowers blood pressure. Captopril is a good blood pressure-lowering medicine that protects kidney function, but you have to take it on an empty stomach.Lowers blood pressure. Enalapril is a good blood pressure-lowering medicine that protects kidney function.Lowers blood pressure. Cozaar (Losartan) is a good blood pressure-lowering medicine that protects kidney function like an ACE inhibitor, but with fewer side effects.Lowers blood pressure. Benicar (Olmesartan) is a good blood pressure-lowering medicine that protects kidney function like an ACE inhibitor, but with fewer side effects.
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Reviews & ratings
Filter group. All currently selected
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5.17Lisinopril
Reviews for Zestril (lisinopril)
61%
of people (All ages) say Zestril (lisinopril) is worth it
51%
say it works well
14%
say it's a big hassle
687 reviews
Have you used Zestril (lisinopril)?
Worth itNot sureNot worth it
Reviews for Lotensin (benazepril)
61%
Same vs. Zestril (lisinopril)
64%
+13% better vs. Zestril (lisinopril)
23%
-9% worse vs. Zestril (lisinopril)
Have you used Lotensin (benazepril)?
Worth itNot sureNot worth it
Reviews for Capoten (captopril)
34%
-27% worse vs. Zestril (lisinopril)
25%
-26% worse vs. Zestril (lisinopril)
25%
-11% worse vs. Zestril (lisinopril)
106 reviews
Have you used Capoten (captopril)?
Worth itNot sureNot worth it
Reviews for Vasotec (enalapril)
44%
-17% worse vs. Zestril (lisinopril)
40%
-11% worse vs. Zestril (lisinopril)
21%
-7% worse vs. Zestril (lisinopril)
Have you used Vasotec (enalapril)?
Worth itNot sureNot worth it
Reviews for Cozaar (losartan)
57%
-4% worse vs. Zestril (lisinopril)
48%
-3% worse vs. Zestril (lisinopril)
16%
-2% worse vs. Zestril (lisinopril)
535 reviews
Have you used Cozaar (losartan)?
Worth itNot sureNot worth it
Reviews for Benicar (olmesartan)
65%
+4% better vs. Zestril (lisinopril)
63%
+12% better vs. Zestril (lisinopril)
12%
+2% better vs. Zestril (lisinopril)
118 reviews
Have you used Benicar (olmesartan)?
Worth itNot sureNot worth it
Side effects
LisinoprilbenazeprilCaptoprilEnalaprilLosartanBenicar
  • Headache 4%
  • Dizziness 4%
  • Cough 3%
  • Low blood pressure 4%
  • Chest pain 2%
  • Kidney damage 10%
  • Fainting 7%
  • High potassium 6%
More Lisinopril side effects »
  • Headache 2%
  • Dizziness 2%
  • Drowsiness 2%
  • Dizziness when standing up 2%
More benazepril side effects »
  • Rash 7%
  • Flushing 5%
  • Abnormal sense of taste 4%
  • Itching 2%
  • Cough 2%
More Captopril side effects »
  • Low blood pressure 7%
  • Positional low blood pressure 2%
  • Muscle weakness 2%
  • Orthostatic effects 2%
  • Fainting 2%
More Enalapril side effects »
  • Upper respiratory infection 1%
  • Dizziness 1%
  • Back pain 1%
  • Nasal congestion 1%
  • Urinary tract infection 6%
  • Diarrhea 5%
  • Muscle weakness/fatiguea/fatigue 4%
  • Low red blood cells 3%
  • Low blood sugar 4%
  • Back pain 2%
More Losartan side effects »
  • Dizziness 2%
More Benicar side effects »
How it works
LisinoprilbenazeprilCaptoprilEnalaprilLosartanBenicar
Zestril (lisinopril) is an angiotensin converting enzyme (ACE) inhibitor. It blocks a chemical that tightens blood vessels. This makes blood vessels relax, which lowers blood pressure and allows more blood and oxygen to get to your heart and other organs.Lotensin (benazepril) is an angiotensin converting enzyme (ACE) inhibitor. It blocks a chemical that tightens blood vessels. This makes blood vessels relax, which lowers blood pressure and allows more blood and oxygen to get to your heart and other organs.Captopril is an angiotensin converting enzyme (ACE) inhibitor. It blocks a chemical that tightens blood vessels. This makes blood vessels relax, which lowers blood pressure and allows more blood and oxygen to get to your heart and other organs.Enalapril is an angiotensin converting enzyme (ACE) inhibitor. It blocks a chemical that tightens blood vessels. This makes blood vessels relax, which lowers blood pressure and allows more blood and oxygen to get to your heart and other organs.Cozaar (Losartan) is an angiotensin receptor blocker (ARB). It blocks a chemical that tightens blood vessels. This makes blood vessels relax, which lowers blood pressure and allows more blood and oxygen to get to your heart and other organs.Benicar (Olmesartan) is an angiotensin receptor blocker (ARB). It blocks a chemical that tightens blood vessels. This makes blood vessels relax, which lowers blood pressure and allows more blood and oxygen to get to your heart and other organs.
Type of medication
LisinoprilbenazeprilCaptoprilEnalaprilLosartanBenicar
Prescription only
Prescription only
Prescription only
Prescription only
Prescription only
Prescription only
Available as
LisinoprilbenazeprilCaptoprilEnalaprilLosartanBenicar
  • Pill
  • Liquid
  • Pill
  • Pill
  • Pill
  • Liquid
  • Pill
  • Pill
Used for
LisinoprilbenazeprilCaptoprilEnalaprilLosartanBenicar
Risk factors for serious side effects
LisinoprilbenazeprilCaptoprilEnalaprilLosartanBenicar
  • Women of childbearing age
    • African descent
    • Current kidney problems
    • Medicines that increase potassium
    • Use of salt substitutes
    • History of kidney problems
    • Taking with alcohol
    • Taking other medicines that lower your blood pressure
    Detailed Zestril (lisinopril) risks & warnings »
    • Women of childbearing age
    • Infants less than one year old
    • African descent
    • Taking with alcohol
    • Taking other medicines that lower your blood pressure
      • Current kidney problems
      • Taking other medicines that increase potassium
      • Using salt substitutes
      • Kidney disease
      Detailed Lotensin (benazepril) risks & warnings »
      • Women of childbearing age
        • African descent
        • Current kidney problems
        • Medicine that increase potassium
        • Use of salt substitute
        Detailed Capoten (captopril) risks & warnings »
        • Women of childbearing age
          • African descent
          • Current kidney problems
          • Medicine that increase potassium
          • Use of salt substitute
          Detailed Vasotec (enalapril) risks & warnings »
          • Women of childbearing age
          • Concurrent liver disease
          • Current kidney problems
          • Medicine that increase potassium
          • Use of salt substitute
          Detailed Cozaar (losartan) risks & warnings »
            • African descent
            • Current kidney problems
            • Medicine that increase potassium
            • Use of salt substitute
              Detailed Benicar (olmesartan) risks & warnings »
              Pregnancy

              Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

              Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

              Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

              Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

              Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

              Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

              Interactions
              LisinoprilbenazeprilCaptoprilEnalaprilLosartanBenicar
              No interactions related info.
              • This drug interacts with other medications that affect potassium, so it needs to be dosed carefully.
              No interactions related info.No interactions related info.No interactions related info.No interactions related info.
              Kidneys and liver
              LisinoprilbenazeprilCaptoprilEnalaprilLosartanBenicar
              • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
              • You'll need to have blood tests done to check your kidney function.
              • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
              • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
              • Requires routine blood tests to check kidney function.
              • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
              • Requires routine blood tests to check kidney function.
              • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
              • Requires routine blood tests to check kidney function.
              • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
              • Requires routine blood tests to check kidney function.
              Weight
              LisinoprilbenazeprilCaptoprilEnalaprilLosartanBenicar
              No weight related info.No weight related info.No weight related info.No weight related info.No weight related info.
              • Benicar (Olmesartan) has been reported to cause severe diarrhea and weight loss unexplained by other causes. Stay hydrated and notify your doctor if you continue to have more than 3-4 loose stools a day.
              Upsides and benefits
              LisinoprilbenazeprilCaptoprilEnalaprilLosartanBenicar
              • A first-choice blood pressure treatment for many people.
              • Lowers the risk of heart attack and stroke.
              • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
              • Recommended for anyone with heart failure since it lowers the risk of death and further damage to your heart.
              • Very cheap drug, and comes available as a liquid for children over 6 years of age.
              • A first-choice blood pressure treatment for many people.
              • Lowers the risk of heart attack and stroke.
              • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
              • A first-choice blood pressure treatment for many people.
              • Lowers the risk of heart attack and stroke.
              • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
              • Recommended for anyone with heart failure since it lowers the risk of death and further damage to your heart.
              • A first-choice blood pressure treatment for many people.
              • Lowers the risk of heart attack and stroke.
              • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
              • Recommended for anyone with heart failure since it lowers the risk of death and further damage to your heart.
              • The only ACE inhibitor that doctors can give through an IV if that's needed.
              • A first-choice blood pressure treatment for many people.
              • Lowers the risk of heart attack and stroke.
              • Similar to ACE inhibitors (like Lisinopril), with fewer side effects like cough and swelling.
              • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
              • Recommended for anyone with heart failure since it lowers the risk of death and further damage to your heart.
              • A first-choice blood pressure treatment for many people.
              • Lowers the risk of heart attack and stroke.
              • Similar to ACE inhibitors (like Lisinopril), with fewer side effects like cough and swelling.
              • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
              • Recommended for anyone with heart failure since it lowers the risk of death and further damage to your heart.
              Downsides and risks
              LisinoprilbenazeprilCaptoprilEnalaprilLosartanBenicar
              • Up to 10% of people can get a dry cough while using this medicine. It ranges from a mild tickle in the throat to a persistent hacking cough.
              • Requires a yearly blood test to see how the medicine is affecting your body.
              • Zestril (lisinopril) isn't safe to use if you're pregnant.
              • Doesn't work as well in people of African descent, and can cause a greater chance of face, tongue, or lip swelling.
              • Up to 1 in 10 people can get a dry cough with this medicine. It ranges from a mild tickle in the throat to a persistent hacking cough.
              • Requires a regular blood test to see how the medicine is affecting your body.
              • Not safe to use if you're pregnant.
              • This drug interacts with other medications that affect potassium, so it needs to be dosed carefully.
              • Up to 1 in 10 people can get a dry cough with this medicine. It ranges from a mild tickle in the throat to a persistent hacking cough.
              • Compared to other ACE inhibitors, less flexible on when and how you take it. Captopril needs to be taken multiple times a day on an empty stomach.
              • Requires a yearly blood test to see how the medicine is affecting your body.
              • Not safe to use if you're pregnant.
              • Up to 1 in 10 people can get a dry cough with this medicine. It ranges from a mild tickle in the throat to a persistent hacking cough.
              • Compared to other ACE inhibitors, less flexible on when you take it. Enalapril needs to be taken multiple times a day on an empty stomach.
              • Requires a yearly blood test to see how the medicine is affecting your body.
              • Not safe to use if you're pregnant.
              • Requires a yearly blood test to see how the medicine is affecting your body.
              • Not safe to use if you're pregnant.
              • Requires a yearly blood test to see how the medicine is affecting your body.
              • Not safe to use if you're pregnant.
              • Not available in less expensive generic form.
              Tips from our pharmacists for people taking the medication
              LisinoprilbenazeprilCaptoprilEnalaprilLosartanBenicar
              • Can cause dizziness the first few days you're taking it.
              • Check your blood pressure about 1 week after starting Zestril (lisinopril), and tell your doctor if it hasn't improved.
              • Let your doctor know about any dizziness, tiredness, cough, or throat irritation that doesn't go away.
              • You'll need to have blood tests done to check your kidney function.
              • Don't take Zestril (lisinopril) if you're pregnant.
              • Can cause dizziness in the first few days.
              • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it doesn't get better.
              • Tell your doctor about any tiredness, cough, mouth swelling, or throat irritation that doesn't go away.
              • Requires blood tests to check potassium levels and kidney function.
              • Don't take it if you're pregnant.
              • Take 1 hour before or 2 hours after eating.
              • Can cause dizziness in the first few days.
              • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
              • Tell your doctor about any dizziness, fatigue, cough, or change in taste sensation that doesn't go away.
              • Requires routine blood tests to check kidney function.
              • Don't take it if you're pregnant.
              • Can cause dizziness in the first few days.
              • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
              • Tell your doctor about any dizziness, fatigue, cough, or throat irritation that doesn't go away.
              • Requires routine blood tests to check kidney function.
              • Don't take it if you're pregnant.
              • Can cause dizziness in the first few days.
              • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
              • Tell your doctor about any dizziness, fatigue, cough, or throat irritation that doesn't go away.
              • Requires routine blood tests to check kidney function.
              • Don't take it if you're pregnant.
              • Can cause dizziness in the first few days.
              • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
              • Tell your doctor about any dizziness, fatigue, cough, or throat irritation that doesn't go away.
              • Requires routine blood tests to check kidney function.
              • Don't take it if you're pregnant.
              Learn more
              More about LisinoprilSide effectsReviews & ratingsAlternativesFDA package insert
              Have you used Zestril (lisinopril)?
              Worth itNot sureNot worth it
              More about benazeprilSide effectsReviews & ratingsFDA package insert
              Have you used Lotensin (benazepril)?
              Worth itNot sureNot worth it
              More about CaptoprilSide effectsReviews & ratingsFDA package insert
              Have you used Capoten (captopril)?
              Worth itNot sureNot worth it
              More about EnalaprilSide effectsReviews & ratingsFDA package insert
              Have you used Vasotec (enalapril)?
              Worth itNot sureNot worth it
              More about LosartanSide effectsReviews & ratingsFDA package insert
              Have you used Cozaar (losartan)?
              Worth itNot sureNot worth it
              More about BenicarSide effectsReviews & ratingsFDA package insert
              Have you used Benicar (olmesartan)?
              Worth itNot sureNot worth it