Prescription onlyLower-cost generic available


(Amlodipine / Benazepril)

  • Pill
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Lowers blood pressure.

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Prescription onlyLower-cost generic available

Our bottom line

Lotrel (Amlodipine / Benazepril) is good because it combines two first-line medications to lower blood pressure, and it's available in generic. However, it can cause throat irritation or a dry cough, and you can't stop it suddenly since it can cause your blood pressure to rise.


  • Both medications in Lotrel (Amlodipine / Benazepril) are recommended as first line medications to help lower blood pressure.
  • The combination of these two medications work together to lower your blood pressure better than either by itself.
  • This combines two medications into one pill, so it reduces the amount of pills you have to take every day.
  • Available as a generic version, so it shouldn't be too expensive.


  • Can't be stopped suddenly because it can cause your blood pressure to bounce back very high.
  • Because it comes in fixed doses, it's hard to switch dosages if one medication isn't working as well as the other.
  • If you're pregnant or want to be pregnant, you'll have to be changed to another medication since Lotrel (Amlodipine / Benazepril) can cause birth defects.
  • In some people, benazepril, the ACE inhibitor, can cause throat irritation or a dry cough, and you can switch to another medication if it bothers you.
  • This is usually not given until you've tried at least one medication to lower your blood pressure and it hasn't worked.

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What to expect when you take Lotrel (Amlodipine / Benazepril)

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Tips from our pharmacists
  • Can make you feel dizzy the first days you take it, so be careful getting up from lying down or sitting, and be careful driving.
  • Drink plenty of fluids and stay hydrated to lower your risk of dizziness and falls.
  • Let your doctor know if you're using salt substitutes with potassium or medications with potassium.
  • Talk to your doctor if you want to stop taking Lotrel (Amlodipine / Benazepril), since stopping it suddenly can cause your blood pressure to rise very quickly.
  • If you're pregnant or wanting to get pregnant, let your doctor know, since they will have to change Lotrel (Amlodipine / Benazepril) to another medication.
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Side effects for Lotrel (Amlodipine / Benazepril)

From clinical trials of Lotrel / High blood pressure  ( 1170)

  • Any side effectAny side effect4% for Lotrel vs.3% for placebo
  • CoughCough3% for Lotrel vs.0% for placebo
  • HeadacheHeadache2% for Lotrel vs.6% for placebo
  • Swelling due to excess fluidSwelling due to excess fluid2% for Lotrel vs.2% for placebo
  • DizzinessDizziness1% for Lotrel vs.2% for placebo

Risks and Warnings for Lotrel (Amlodipine / Benazepril)

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    • Higher risk if:
    • Women of childbearing age

    Lotrel (Amlodipine / Benazepril) can cause birth defects. If you're pregnant or considering having a baby, talk to your doctor about alternative medicines.

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Tips from pharmacists and people taking Lotrel (Amlodipine / Benazepril)

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The FDA category for this medication is D. It is advised that you: Weigh risks vs. benefits
Kidneys and liver
  • Risks from our pharmacists
  • Lotrel (Amlodipine / Benazepril) has a risk of making your kidneys not work as well. It's important to get blood work done to check your kidney function before starting Lotrel (Amlodipine / Benazepril) and at least yearly after.