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Lunesta Alternatives

(Eszopiclone)

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Compare Lunesta (Eszopiclone) to alternatives

These medications are comparable to Lunesta (Eszopiclone) or used for similar purposes.

Lunesta
(Eszopiclone)

Ambien
(Zolpidem)

Sonata
(Zaleplon)

Valium
(Diazepam)

Klonopin
(Clonazepam)

Ativan
(Lorazepam)

Unisom Sleeptabs
(Doxylamine)

Helps you sleep. Lunesta (Eszopiclone) is good for falling asleep and staying asleep. Not as habit-forming as some sleep medicines, but more likely to cause withdrawal symptoms if you stop suddenly.Helps you sleep. Ambien (Zolpidem) is good for falling asleep and staying asleep, but it can be habit-forming and might be more likely than other sleep medicines to cause disturbing side effects.Helps you sleep. Sonata (Zaleplon) helps you fall asleep, but it's not as good for staying asleep. It also interacts with a lot of diseases and other drugs.Helps you relax. Valium (Diazepam) is okay for occasional or short-term use (up to 4 weeks) for anxiety and for pain and sleeplessness from muscle spasm. Less severe withdrawal symptoms compared to similar drugs.Controls seizures and helps you relax. Klonopin (Clonazepam) is okay for occasional or short-term use (up to 4 weeks) for anxiety, and to treat seizures. Less severe withdrawal symptoms compared to similar drugs.Helps you relax. Ativan (Lorazepam) is okay for occasional or short-term use (up to 4 weeks) for anxiety and sleep. Less likely to have drug interactions, but more likely to cause withdrawal symptoms compared to similar drugs.Treats allergy symptoms and helps you sleep. Unisom Sleeptabs (Doxylamine) can help you get a good night's sleep, but you can have a hard time waking up if you don't give yourself enough time to sleep.
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Reviews & ratings
Button Group. All currently active
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4.439862542955327Lunesta
Reviews for Lunesta (Eszopiclone)
54%
of people say Lunesta (Eszopiclone) is worth it
35%
say it works well
17%
say it's a big hassle
Reviews for Ambien (Zolpidem)
66%
+12% vs. Lunesta (Eszopiclone)
50%
+15% vs. Lunesta (Eszopiclone)
16%
+1% vs. Lunesta (Eszopiclone)
Reviews for Sonata (Zaleplon)
42%
12% vs. Lunesta (Eszopiclone)
24%
11% vs. Lunesta (Eszopiclone)
27%
10% vs. Lunesta (Eszopiclone)
Reviews for Valium (Diazepam)
69%
+15% vs. Lunesta (Eszopiclone)
52%
+17% vs. Lunesta (Eszopiclone)
16%
+1% vs. Lunesta (Eszopiclone)
Reviews for Klonopin (Clonazepam)
69%
+15% vs. Lunesta (Eszopiclone)
51%
+16% vs. Lunesta (Eszopiclone)
15%
+2% vs. Lunesta (Eszopiclone)
Reviews for Ativan (Lorazepam)
70%
+16% vs. Lunesta (Eszopiclone)
50%
+15% vs. Lunesta (Eszopiclone)
15%
+2% vs. Lunesta (Eszopiclone)
Reviews for Unisom Sleeptabs (Doxylamine)
58%
+4% vs. Lunesta (Eszopiclone)
32%
3% vs. Lunesta (Eszopiclone)
11%
+6% vs. Lunesta (Eszopiclone)
Side effects
LunestaAmbienSonataValiumKlonopinAtivanUnisom
  • Unpleasant taste 31%
  • Headache 8%
  • Drowsiness 7%
  • Infection 7%
  • Dry mouth 4%
  • Indigestion 4%
  • Dizziness 3%
  • Pain 3%
  • Rash 3%
  • Itching 3%
More Lunesta side effects »
  • Dizziness 4%
  • Drowsiness 3%
  • Allergy 3%
  • Sinus inflammation 2%
  • Dry mouth 2%
  • Sore throat 2%
  • Diarrhea 2%
  • Lack of energy 2%
  • Lightheadedness 1%
  • Low mood disorder 1%
More Ambien side effects »
  • Headache 7%
  • Abdominal pain 3%
  • Amnesia 3%
  • Muscle weakness 2%
  • Eye pain 2%
  • Menstrual cramps 2%
  • Drowsiness 2%
  • Tingling sensation 2%
  • Dizziness 2%
  • Tremor 1%
More Sonata side effects »

The Valium FDA package insert doesn’t have numbers about how common side effects are.

More about Valium side effects »
  • Dizziness 8%
  • Low mood disorder 7%
  • Ear, nose, or throat infection 6%
  • Sinus inflammation 5%
  • Fatigue 5%
  • Menstrual cramps 4%
  • Memory disturbance 3%
  • Constipation 3%
  • Allergic reaction 3%
  • Vaginal inflammation 3%
More Klonopin side effects »

The Ativan FDA package insert doesn’t have numbers about how common side effects are.

More about Ativan side effects »

We haven’t found good data for Unisom side effects.

FDA side effect reports for Unisom »
How it works
LunestaAmbienSonataValiumKlonopinAtivanUnisom
Lunesta (Eszopiclone) is in a class of drugs called sedative-hypnotics. Researchers don't know exactly how it works, but it interacts with your brain to make you relaxed and sleepy.Ambien (Zolpidem) is in a class of drugs called sedative-hypnotics. Researchers don't know exactly how it works, but it interacts with your brain to make you relaxed and sleepy.Sonata (Zaleplon) is in a class of drugs called sedative-hypnotics. Researchers don't know exactly how it works, but it interacts with your brain to make you relaxed and sleepy.Valium (Diazepam) is a fast-acting benzodiazepine. It affects neurotransmitters in the brain and calms the nervous system. This reduces anxiety and muscle spasms, and causes sleepiness.Klonopin (Clonazepam) is a fast-acting benzodiazepine. It affects neurotransmitters in the brain and calms the nervous system. This reduces anxiety and muscle spasms, and causes sleepiness.Ativan (Lorazepam) is a fast-acting benzodiazepine. It affects neurotransmitters in the brain and calms the nervous system. This reduces anxiety and can cause sleepiness.Unisom Sleeptabs (Doxylamine) is an antihistamine. It blocks histamine, a chemical that causes congestion, itching, and other allergic reactions. It also makes you sleepy.
Type of medication
LunestaAmbienSonataValiumKlonopinAtivanUnisom
SedativePrescription only
SedativePrescription only
SedativePrescription only
Anti-anxiety
Benzodiazepine
Prescription only
Anti-anxiety
Benzodiazepine
Prescription only
Anti-anxiety
Benzodiazepine
Prescription only
Antihistamine
Ethanolamine derivative
Prescription or OTC
Available as
LunestaAmbienSonataValiumKlonopinAtivanUnisom
  • Pill
  • Pill
  • Extended release
  • Pill
  • Pill
  • Liquid
  • Rectal gel
  • Pill
  • Dissolving tablet
  • Pill
  • Liquid
  • Pill
  • Chewable tablet
  • Liquid
Used for (click to learn more)
LunestaAmbienSonataValiumKlonopinAtivanUnisom
Risk factors for serious side effects
LunestaAmbienSonataValiumKlonopinAtivanUnisom
  • Continuous use for 2 weeks or more
  • Alcohol
  • Taking other medicines that make you less alert
  • Less than 7 hours of sleep.
  • Undiagnosed psychiatric conditions
  • Taking with alcohol or drugs that acts in the brain
    • Elderly
    • Higher dose
    • Liver problems
    • Taking Lunesta (Eszopiclone) with other nervous system depressants
    • Long-term use
    • Women of childbearing age
    • Breast-feeding
    Detailed Lunesta (Eszopiclone) risks & warnings »
    Coming soon.Coming soon.Coming soon.Coming soon.Coming soon.Coming soon.
    Pregnancy category
    LunestaAmbienSonataValiumKlonopinAtivanUnisom
    CFDA pregnancy category (Weigh risks vs. benefits)

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    See the FDA package insert
    CFDA pregnancy category (Weigh risks vs. benefits)

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    See the FDA package insert
    CFDA pregnancy category (Weigh risks vs. benefits)

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    See the FDA package insert
    DFDA pregnancy category (Weigh risks vs. benefits)

    Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    See the FDA package insert
    DFDA pregnancy category (Weigh risks vs. benefits)

    Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    See the FDA package insert
    DFDA pregnancy category (Weigh risks vs. benefits)

    Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    See the FDA package insert
    NFDA pregnancy category (Unknown)

    The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

    See the FDA package insert
    Alcohol
    • Might not be safe if you have a history of drug or alcohol abuse, depression, lung disease, or a condition that affects metabolism.
    • Avoid alcohol and drugs.
    • Lunesta (Eszopiclone) can be disinhibiting (like alcohol) or cause hallucinations. Tell your doctor if you notice any unusual changes in behavior.
    • Avoid alcohol and drugs.
    • It works best if taken without food and avoid taking it with alcohol or drugs.
    • Can be habit-forming, so it's not typically used for long-term treatment, or for people who've had problems with drug or alcohol abuse.
    • Not safe to use with alcohol.
    • Can be habit-forming, so it's not typically used for long-term treatment, or for people who've had problems with drug or alcohol abuse.
    • Not safe to use with alcohol.
    • Can be habit-forming, so it's not typically used for long-term treatment, or for people who've had problems with drug or alcohol abuse.
    • Not safe to use with alcohol.
    • Drinking alcohol while taking Unisom Sleeptabs (Doxylamine) isn't recommended.
    • Don't take it with alcohol or other drugs that make you sleepy.
    Food
    • Works best if taken without food.
    • Works best if taken without food.
    • It works best if taken without food and avoid taking it with alcohol or drugs.
    No specific food-related info.No specific food-related info.No specific food-related info.No specific food-related info.
    Kidneys and liver
    No specific kidneys and liver-related info.
    • Might not be safe if you have problems with your liver, kidneys, or lungs, or if you have a history of depression.
    • Might not be safe if you have problems with your liver, kidneys, lungs, or if you have a history of depression.
    No specific kidneys and liver-related info.No specific kidneys and liver-related info.No specific kidneys and liver-related info.No specific kidneys and liver-related info.
    Sex
    No specific sex-related info.No specific sex-related info.No specific sex-related info.No specific sex-related info.No specific sex-related info.No specific sex-related info.No specific sex-related info.
    Sleep
    • It's easy to become reliant on sleep medicines. In the long run, it's better to learn good sleeping habits and behavior so that you can sleep better naturally.
    • Effective at helping people fall asleep faster and sleep longer.
    • Not as habit-forming, so you can use it for longer than most other sleep medicines.
    • Only take it if you have time to sleep for at least 7 hours.
    • Can cause headache, drowsiness, and dizziness.
    • Can cause sleep-walking, sleep-driving, and sleep-eating.
    • All prescription sleep-aid medicines like Lunesta (Eszopiclone) have a risk of physical dependence. Dependence means that you'll feel withdrawal symptoms if you stop taking the medication all at once. Talk to your doctor about natural ways to improve sleep or treat underlying conditions that prevent sleep.
    • Lunesta (Eszopiclone) increases your risk of performing potentially dangerous activities while asleep, such as sleep-walking, sleep-driving, and sleep-eating. Talk to your doctor immediately about stopping Lunesta (Eszopiclone) if any sleep-related activities occur.
    • Lunesta (Eszopiclone) make you feel drowsy and sleepy, leading to falls and severe injuries. This is especially a risk if your older. Falls from sleep medicines like Lunesta (Eszopiclone) have caused severe injuries such as hip fractures and head injury. You may need a lower dose if you're taking other medicine that affects your nervous system or have issues with falls in the past. Check with your doctor first.
    • More likely to cause sleep-walking, sleep-driving, and sleep-eating.
    • It's easy to become reliant on sleep medicines. In the long run, it's better to learn good sleeping habits and behavior so that you can sleep better naturally.
    • Effective at helping people fall asleep faster and sleep longer.
    • Only take it if you have time to sleep for at least 7 hours.
    • Can cause headache, drowsiness, and dizziness.
    • Can cause sleep-walking, sleep-driving, and sleep-eating.
    • Doesn't last as long in the body as other sleep medicines, so it's not as good at helping you stay asleep.
    • People have sleep-walked, sleep-driven, and sleep-eaten while on Sonata (Zaleplon).
    • It's easy to become reliant on sleep medicines. In the long run, it's better to learn good sleeping habits and behaviors so you can sleep better naturally.
    • Doesn't last as long in the body as some other sleep medicines, so it's okay to take it in the middle of the night as long as you enough time to sleep. (But be sure to discuss it with your doctor first.)
    • Only take it if you have time to sleep for at least 7 hours.
    • Can cause headache, drowsiness, or dizziness.
    • Can cause memory problems, drowsiness, dizziness, and confusion.
    • Can cause temporary dizziness and drowsiness.
    • Can cause memory problems, drowsiness, dizziness, and confusion.
    • Can cause dizziness, drowsiness, and salivation.
    • Can cause memory problems, drowsiness, dizziness, and confusion.
    • Can cause temporary dizziness and drowsiness.
    • Shouldn't be used unless you have a full night to sleep.
    • Has fewer side effects than prescription sleep aid medications.
    • Not habit-forming like other sleep aids can be.
    • Unisom Sleeptabs (Doxylamine) makes you tired, so take it before you go to sleep.
    • Unisom comes in two different generic forms, doxylamine (Unisom SleepTabs) and diphenhydramine (other Unisom products). Both are antihistamines that help you sleep.
    Weight
    No specific weight-related info.No specific weight-related info.No specific weight-related info.No specific weight-related info.No specific weight-related info.No specific weight-related info.No specific weight-related info.
    Upsides and benefits
    LunestaAmbienSonataValiumKlonopinAtivanUnisom
    • Not as habit-forming, so you can use it for longer than most other sleep medicines.
    • Effective at helping people fall asleep faster and sleep longer.
    • Extended release form is particularly good for staying asleep, and you can use it for longer than the immediate release form.
    • Effective at helping people fall asleep faster and sleep longer.
    • Effective at helping people fall asleep faster.
    • Doesn't last as long in the body as some other sleep medicines, so it's okay to take it in the middle of the night as long as you enough time to sleep. (But be sure to discuss it with your doctor first.)
    • Effective at relieving muscle spasms caused by a variety of conditions.
    • Effective at relieving short-term anxiety and sleeplessness.
    • Can be used together with antidepressants to manage anxiety disorders. Especially helpful for anxiety symptoms while you wait for an antidepressant to kick in (it can take several weeks).
    • Less severe withdrawal symptoms compared to other benzodiazepines.
    • Can be used alone or with other medicines to treat seizures.
    • Effective at relieving short-term anxiety and sleeplessness.
    • Can be used together with antidepressants to manage anxiety disorders. Especially helpful for anxiety symptoms while you wait for an antidepressant to kick in (it can take several weeks).
    • Less severe withdrawal symptoms compared to other benzodiazepines.
    • Less likely to have drug interactions compared to other benzodiazepines, so it might be a better option if you're taking multiple medications.
    • Effective at relieving short-term anxiety and sleeplessness.
    • Can be used together with antidepressants to manage anxiety disorders. Especially helpful for anxiety symptoms while you wait for an antidepressant to kick in (it can take several weeks).
    • Works well to help you fall asleep and doesn't make you feel groggy the next morning.
    • Has fewer side effects than prescription sleep aid medications.
    • Available over the counter without a prescription.
    • Not habit-forming like other sleep aids can be.
    Downsides and risks
    LunestaAmbienSonataValiumKlonopinAtivanUnisom
    • More likely to cause withdrawal symptoms if you stop taking it suddenly.
    • Might not be safe if you have a history of drug or alcohol abuse, depression, lung disease, or a condition that affects metabolism.
    • It's easy to become reliant on sleep medicines. In the long run, it's better to learn good sleeping habits and behavior so that you can sleep better naturally.
    • Not typically used for long-term treatment because it can be habit-forming.
    • Some people find that it's less effective over time.
    • More likely to cause sleep-walking, sleep-driving, and sleep-eating.
    • Might not be safe if you have problems with your liver, kidneys, or lungs, or if you have a history of depression.
    • It's easy to become reliant on sleep medicines. In the long run, it's better to learn good sleeping habits and behavior so that you can sleep better naturally.
    • Not typically used for long-term treatment since it can be habit-forming.
    • Doesn't last as long in the body as other sleep medicines, so it's not as good at helping you stay asleep.
    • Interacts badly with many other medications.
    • Not a good option if you're pregnant or breast-feeding.
    • People have sleep-walked, sleep-driven, and sleep-eaten while on Sonata (Zaleplon).
    • Might not be safe if you have problems with your liver, kidneys, lungs, or if you have a history of depression.
    • It's easy to become reliant on sleep medicines. In the long run, it's better to learn good sleeping habits and behaviors so you can sleep better naturally.
    • Processed by the liver, so might not be the best choice if you have liver problems.
    • Can cause memory problems, drowsiness, dizziness, and confusion.
    • Can be habit-forming, so it's not typically used for long-term treatment, or for people who've had problems with drug or alcohol abuse.
    • Most people find that it gets less effective over time.
    • Can cause memory problems, drowsiness, dizziness, and confusion.
    • Can be habit-forming, so it's not typically used for long-term treatment, or for people who've had problems with drug or alcohol abuse.
    • Most people find that it gets less effective over time.
    • Compared to other benzodiazepines, more likely to cause withdrawal if you take it for a long time and then stop suddenly.
    • Can cause memory problems, drowsiness, dizziness, and confusion.
    • Can be habit-forming, so it's not typically used for long-term treatment, or for people who've had problems with drug or alcohol abuse.
    • Most people find that it gets less effective over time.
    • Shouldn't be used unless you have a full night to sleep.
    • You shouldn't drive after taking Unisom Sleeptabs (Doxylamine) until you know how it affects you.
    • Drinking alcohol while taking Unisom Sleeptabs (Doxylamine) isn't recommended.
    • It can increase the risk of falls, so elderly people shouldn't use Unisom Sleeptabs (Doxylamine).
    Tips from our pharmacists for people taking the medication
    LunestaAmbienSonataValiumKlonopinAtivanUnisom
    • Take 30 to 45 minutes before bedtime.
    • Only take it if you have time to sleep for at least 7 hours.
    • Very addictive. Meant for short-term treatment. Dependence can form after daily use for 2 weeks.
    • Can cause headache, drowsiness, and dizziness.
    • Can cause sleep-walking, sleep-driving, and sleep-eating.
    • Works best if taken without food.
    • Avoid alcohol and drugs.
    • Withdrawal symptoms usually resolve in 1 to 2 nights.
    • Report any confusion or changes in thoughts or behavior.
    • Take 30 to 45 minutes before bedtime.
    • Only take it if you have time to sleep for at least 7 hours.
    • Very addictive. Meant for short-term treatment. Dependence can form after daily use for 2 weeks.
    • Can cause headache, drowsiness, and dizziness.
    • Can cause sleep-walking, sleep-driving, and sleep-eating.
    • Works best if taken without food.
    • Avoid alcohol and drugs.
    • Withdrawal symptoms usually resolve in 1 to 2 nights.
    • Report any confusion or changes in thoughts or behavior.
    • It's very addictive and meant for short-term treatment. Dependence can start to form after using it daily for 2 weeks.
    • Can cause headache, drowsiness, or dizziness.
    • It works best if taken without food and avoid taking it with alcohol or drugs.
    • Withdrawal symptoms usually get better in 1 to 2 days.
    • Tell your doctor about any sudden confusion or changes in thoughts or behavior.
    • Take 30 to 45 minutes before bedtime.
    • Only take it if you have time to sleep for at least 7 hours.
    • Starts working in 30 minutes when swallowed.
    • Helpful with muscle spasms.
    • Good for short-term relief of anxiety symptoms.
    • Can cause temporary dizziness and drowsiness.
    • Addictive. Long-term use can cause dependence or abuse.
    • Not safe to use with alcohol.
    • For the first week, avoid activities that require you to be alert.
    • Can cause dizziness, drowsiness, and salivation.
    • Report any confusion or inability to control muscle movements to your doctor.
    • Not safe to use with alcohol.
    • Starts working in 45 minutes when swallowed.
    • Starts working in 10 to 20 minutes when dissolved under your tongue.
    • Good for short-term relief of anxiety symptoms.
    • Can cause temporary dizziness and drowsiness.
    • Addictive. Long-term use can cause dependence or abuse.
    • Not safe to use with alcohol.
    • Starts working in 30 minutes.
    • Unisom Sleeptabs (Doxylamine) makes you tired, so take it before you go to sleep.
    • Don't take it with alcohol or other drugs that make you sleepy.
    • If you need to use it for more than a few weeks, talk with your doctor. A different medication might work better for you long-term.
    • Unisom comes in two different generic forms, doxylamine (Unisom SleepTabs) and diphenhydramine (other Unisom products). Both are antihistamines that help you sleep.
    Learn more
    More about LunestaSide effectsReviews & ratingsAlternativesFDA package insert
    More about AmbienSide effectsReviews & ratingsFDA package insert
    More about SonataSide effectsReviews & ratingsFDA package insert
    More about ValiumSide effectsReviews & ratingsFDA package insert
    More about KlonopinSide effectsReviews & ratingsFDA package insert
    More about AtivanSide effectsReviews & ratingsFDA package insert
    More about UnisomSide effectsReviews & ratingsFDA package insert