Prescription onlyNo lower cost generic available

Lyrica

(Pregabalin)

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Treats nerve pain and prevents seizures.

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Prescription onlyNo lower cost generic available

Our pharmacists’ bottom line

Lyrica (Pregabalin) works well as an add-on medicine for seizures and fibromyalgia, but it's especially effective for nerve-related pain after shingles. Not available as a generic, so it might be expensive.

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  • Relieves nerve-related (neuropathic) pain caused by different conditions including diabetes, shingles (herpes zoster), fibromyalgia, and spinal cord damage.
  • Studies show that lower doses of Lyrica (Pregabalin) cause fewer side effects and still relieve pain just as well as higher doses.
  • Also used in combination with other medications to treat epilepsy (partial seizures).
  • Not available as a generic, so it can be pricey.
  • You can't skip or miss doses since suddenly stopping Lyrica (Pregabalin) can cause seizures.
  • Lyrica (Pregabalin) is likely to cause some side effects, including memory problems, drowsiness, dizziness, and confusion.
  • Has a higher risk than other pain medicines of affecting your heart rate or rhythm, so it might not be the best choice if you have cardiovascular disease (previous heart attack, stroke, fast/uncontrolled heart rate, or irregular heartbeat).

Save on your next Lyrica (Pregabalin) prescription

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Side effects for Lyrica (Pregabalin)

From clinical trials of Lyrica / Nerve pain from diabetes (75 mg daily) ( 536)

  • Nerve damageNerve damage9% for Lyrica vs.3% for placebo
  • DizzinessDizziness8% for Lyrica vs.5% for placebo
  • Lack of muscle coordinationLack of muscle coordination6% for Lyrica vs.1% for placebo
  • Accidental injuryAccidental injury5% for Lyrica vs.3% for placebo
  • Chest painChest pain4% for Lyrica vs.1% for placebo
  • Leg or ankle swellingLeg or ankle swelling4% for Lyrica vs.2% for placebo
  • DrowsinessDrowsiness4% for Lyrica vs.3% for placebo
  • Muscle weaknessMuscle weakness4% for Lyrica vs.2% for placebo
  • Dry mouthDry mouth3% for Lyrica vs.1% for placebo
  • Passing gasPassing gas3% for Lyrica vs.1% for placebo

Manufacturers don’t say how common these side effects are

  • Back pain
  • Confusion
  • Constipation
  • Euphoria
  • Face swelling
  • Nervousness
  • Swelling due to excess fluid
  • Weight gain

What to expect when you take Lyrica (Pregabalin) for Diabetic nerve pain

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Tips from our pharmacists
  • Some people feel relief from pain in a week.
  • Can make you drowsy or dizzy.
  • Don't stop taking it suddenly without talking to your doctor. You'll need to slowly lower your dose over at least a week to avoid withdrawal symptoms.
  • Tell your doctor if you have unexplained confusion or changes in your thoughts or behavior.
  • It's not safe to take this medication with alcohol or other drugs that make you drowsy.

Risks and Warnings for Lyrica (Pregabalin)

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  • Lyrica (Pregabalin) is only approved for use in adults. It can increase the risk of suicidal thoughts or behavior. Report new or worsening depression or unusual changes in mood or behavior to your doctor right away, especially during the first few months of treatment or when the dose changes.

Means that some groups have a high risk of experiencing this side effect

Tips from pharmacists and people taking Lyrica (Pregabalin)

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The FDA category for this medication is C. It is advised that you: Weigh risks vs. benefits
Pregnancy
Alcohol
  • Tips from our pharmacists
  • It's not safe to take this medication with alcohol or other drugs that make you drowsy.
  • It enhances the effects of other drugs, so avoid alcohol at all costs. Causes sleepiness so take it at night. Taking it for Generalised Anxiety Disorder, and I can't say it has helped greatly.
    Age: 41
    Gender: Woman
    Taken for: Anxiety
    Duration taken: A year or so
Food
  • Start slowly and work your way up. Even experiment taking it with or without food to get rid of the initial side effects.
    Age: 45
    Gender: Woman
    Taken for: Nerve pain from diabetes
Kidneys & liver
  • Risks from our pharmacists
  • Some people taking Lyrica (Pregabalin) develop muscle damage leading to kidney failure (rhabdomyolysis), however, this is very rare. Tell your doctor if you develop sudden muscle pain, weakness or fever and there is no other related cause.
Sleep
  • Upsides and downsides from our pharmacists
  • Lyrica (Pregabalin) is likely to cause some side effects, including memory problems, drowsiness, dizziness, and confusion.
  • Tips from our pharmacists
  • Can make you drowsy or dizzy.
  • It's not safe to take this medication with alcohol or other drugs that make you drowsy.
  • Take it at night, it will help you sleep better without the pain
    Anonymous
    Taken for: Nerve pain from spinal cord injury
    Duration taken: A year or so
Weight gain or loss
  • This stuff is notorious for making people gain weight!! I was on it for about 4 months and it made me gain more than 30lbs....
    Age: 44
    Gender: Man
    Taken for: Nerve pain from spinal cord injury
  • Great if you're thin, but if on the heavy side ask for something different as this medication will put weight on you, don't stop it suddenly as the withdrawals are horrendous, go to your gp or neurologist to set out a plan to be weaned off
    Age: 45
    Gender: Woman
    Taken for: Nerve pain from spinal cord injury
  • Urinary retention and major weight gain!
    Age: 32
    Gender: Woman
    Taken for: Fibromyalgia
    Duration taken: A couple weeks