Prescription onlyNo lower cost generic available



  • Injection
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Helps you stay pregnant.

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Prescription onlyNo lower cost generic available

Our pharmacists’ bottom line

Makena (Hydroxyprogesterone) lowers your chance of having your baby too early, but you should weigh its risks and benefits carefully with your prenatal care provider.

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  • Makena (Hydroxyprogesterone) helps pregnant women avoid delivering too early if they've already delivered a baby too early in the past.
  • In studies, Makena (Hydroxyprogesterone) increased the amount of time women with a single baby can stay pregnant.
  • If there's concern that you will have an early delivery (preterm birth), your doctor can start giving you the injection every week in their office. You can start between 16 and 20 weeks and continue through week 37, or until you deliver.
  • Your doctor can give you this shot every week, or you can get a helper to give it to you at home. There are also programs where pharmacies work with registered nurses to give you this shot in your home. Ask your doctor or pharmacist.
  • Makena (Hydroxyprogesterone) injections can cause pain, soreness, swelling, or bruising near the injection site.
  • Makena (Hydroxyprogesterone) isn't right for you if you're pregnant with multiple babies or haven't had a preterm delivery in the past.
  • In a study, women using Makena (Hydroxyprogesterone) had a higher chance of miscarriage, gestational diabetes (diabetes caused by pregnancy), and preeclampsia (high blood pressure and too much protein in your urine).

Save on your next Makena (Hydroxyprogesterone) prescription

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  • (4) 1ml of 250mg/ml dose
  • Cost for (4) 1ml of 250mg/ml doses of Makena (Hydroxyprogesterone) at pharmacies
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Side effects for Makena (Hydroxyprogesterone)

From clinical trials of Makena / Reduce risk of preterm birth  ( 316)

  • MiscarriageMiscarriage2% for Makena vs.0% for placebo

What to expect when you take Makena (Hydroxyprogesterone)

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Tips from our pharmacists
  • The Makena (Hydroxyprogesterone) injection is given by your doctor or a helper at home every 7 days in your buttocks.
  • It’s important that you don’t miss any doses.
  • Let your doctor know if you notice any unexplained pain while you are on Makena (Hydroxyprogesterone), or if you have a reaction (redness or oozing fluid) at the injection site.

Risks and Warnings for Makena (Hydroxyprogesterone)

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    • Higher risk if:
    • Personal or family history of blood clots
    • Smoking
    • Obesity
    • Hypertension
    • Diabetes
    • High cholesterol
    • Systemic lupus erythematosus (SLE)

    Using progestin with or without estrogen can increase your risk of blood clots. Blood clots can cause pain and discomfort from a deep vein thrombosis (a clot in the arm or leg), or serious disability due to a stroke or pulmonary embolism (a clot in the brain or lung). Get medical care right away if you have pain in your legs or arms, bad headaches, trouble breathing, or sudden changes in your speech or vision.

Means that some groups have a high risk of experiencing this side effect

Tips from pharmacists and people taking Makena (Hydroxyprogesterone)

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The FDA category for this medication is B. It is advised that you: Probably safe