Makena

(Hydroxyprogesterone)

3.2/ 5 average rating with 30 reviewsforMakena
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Helps you stay pregnant.

Skip Upsides & Downsides section. Skip to side effects section.

Our bottom line

Makena (Hydroxyprogesterone) lowers your chance of having your baby too early, but you should weigh its risks and benefits carefully with your prenatal care provider.

Quick facts about Makena
  • Drug class: Women's health
  • Rx status: Prescription only
  • Generic status: No lower cost generic available

Upsides

  • Makena (Hydroxyprogesterone) helps pregnant women avoid delivering too early if they've already delivered a baby too early in the past.
  • In studies, Makena (Hydroxyprogesterone) increased the amount of time women with a single baby can stay pregnant.
  • If there's concern that you will have an early delivery (preterm birth), your doctor can start giving you the injection every week in their office. You can start between 16 and 20 weeks and continue through week 37, or until you deliver.
  • Your doctor can give you this shot every week, or you can get a helper to give it to you at home. There are also programs where pharmacies work with registered nurses to give you this shot in your home. Ask your doctor or pharmacist.
People’s experience with Makena

30reviews so far. What do you think?

Downsides

  • Makena (Hydroxyprogesterone) injections can cause pain, soreness, swelling, or bruising near the injection site.
  • Makena (Hydroxyprogesterone) isn't right for you if you're pregnant with multiple babies or haven't had a preterm delivery in the past.
  • In a study, women using Makena (Hydroxyprogesterone) had a higher chance of miscarriage, gestational diabetes (diabetes caused by pregnancy), and preeclampsia (high blood pressure and too much protein in your urine).
How it works

Makena (Hydroxyprogesterone) is an injection that contains hydroxyprogesterone, a progesterone hormone that lowers the risk of having your baby too early (a preterm birth). The exact way Makena (Hydroxyprogesterone) works isn't known, but progesterone helps create a healthy environment for your baby in your uterus during the last half of your pregnancy.

Quick facts about Makena
  • Drug class: Women's health
  • Rx status: Prescription only
  • Generic status: No lower cost generic available

Used for

Dosage forms

  • Injection
People’s experience with Makena

30reviews so far. What do you think?

Skip side effects section. Skip to risks and warnings section.

Side effect rates for Makena (Hydroxyprogesterone)

From 316 clinical trials of Makena when taken for reduce risk of preterm birth
  • Miscarriage

Risks and Warnings for Makena (Hydroxyprogesterone)

Skip risks section. Skip to common concerns section.
    • Higher risk if:
    • Personal or family history of blood clots
    • Smoking
    • Obesity
    • Hypertension
    • Diabetes
    • High cholesterol
    • Systemic lupus erythematosus (SLE)

    Using progestin with or without estrogen can increase your risk of blood clots. Blood clots can cause pain and discomfort from a deep vein thrombosis (a clot in the arm or leg), or serious disability due to a stroke or pulmonary embolism (a clot in the brain or lung). Get medical care right away if you have pain in your legs or arms, bad headaches, trouble breathing, or sudden changes in your speech or vision.

Common concerns from people taking Makena (Hydroxyprogesterone)

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Pregnancy

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Disclaimer: We don't provide medical advice. If you think you might have a medical emergency, call your doctor or 911 immediately.