Prescription onlyLower-cost generic availableClass: Neurology

MaxaltAlternatives

(rizatriptan)

Prescription onlyLower-cost generic availableClass: Neurology
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Compare Maxalt (rizatriptan) to alternatives

These medications are comparable to Maxalt (rizatriptan) or used for similar purposes.

Maxalt
(rizatriptan)

Amerge
(naratriptan)

Fioricet
(butalbital / acetaminophen / caffeine)

Fiorinal
(butalbital / aspirin / caffeine)

Relpax
(eletriptan)

Frova
(frovatriptan)

Axert
(almotriptan)

Imitrex
(sumatriptan)

Zomig
(zolmitriptan)

Treats migraine headaches. Maxalt (Rizatriptan) is great for relieving short migraines, but doesn't work as well for long-lasting headaches.Treats migraine headaches. Amerge (naratriptan) isn't as good as other similar medications for migraines, but can be good if other drugs haven't worked for you.Treats tension headaches. Fioricet (Butalbital / Acetaminophen / Caffeine) works well for tension headaches, but isn’t recommended due to the ability to overuse it and have withdrawal symptoms.Coming soon.Treats migraine headaches. Relpax (eletriptan) is a first choice medicine to treat migraines, but it can be expensive.Treats migraine headaches. Triptans are the first-choice to treat migraines. Frova (frovatriptan) works just as well as other triptans for migraines, but doesn't work for other types of headaches like cluster headaches.Coming soon.Treats migraine headaches. Imitrex (Sumatriptan) is an excellent choice for acute migraine relief, but you might need another medication to prevent headaches.Coming soon.
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Reviews & ratings
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Not enough reviews for this drug. Help someone out, leave a review!

Have you used Maxalt (rizatriptan)?
Worth itNot sureNot worth it

Not enough reviews for this drug. Help someone out, leave a review!

Have you used Amerge (naratriptan)?
Worth itNot sureNot worth it

Not enough reviews for this drug. Help someone out, leave a review!

Have you used Fioricet (butalbital / acetaminophen / caffeine)?
Worth itNot sureNot worth it

Not enough reviews for this drug. Help someone out, leave a review!

Have you used Fiorinal (butalbital / aspirin / caffeine)?
Worth itNot sureNot worth it

Not enough reviews for this drug. Help someone out, leave a review!

Have you used Relpax (eletriptan)?
Worth itNot sureNot worth it

Not enough reviews for this drug. Help someone out, leave a review!

Have you used Frova (frovatriptan)?
Worth itNot sureNot worth it

Not enough reviews for this drug. Help someone out, leave a review!

Have you used Axert (almotriptan)?
Worth itNot sureNot worth it
Reviews for Imitrex (sumatriptan)
74%
-7% worse vs. Maxalt (rizatriptan)
68%
+6% better vs. Maxalt (rizatriptan)
19%
Same vs. Maxalt (rizatriptan)
Have you used Imitrex (sumatriptan)?
Worth itNot sureNot worth it

Not enough reviews for this drug. Help someone out, leave a review!

Have you used Zomig (zolmitriptan)?
Worth itNot sureNot worth it
Side effects
MaxaltAmergeFioricetFiorinalRelpaxFrovaAxertImitrexZomig

We haven’t found good data for Maxalt side effects.

FDA side effect reports for Maxalt »
  • Stomach problems 1%
  • Nervous system issues 1%
  • Unusual sensation 1%
  • Fatigue or uneasiness 1%
  • Tingling or prickling sensation 2%
  • Dizziness 1%
  • Drowsiness 2%
  • Pain & pressure in throat or neck 1%
More Amerge side effects »

We haven’t found good data for Fioricet side effects.

FDA side effect reports for Fioricet »

We haven’t found good data for Fiorinal side effects.

FDA side effect reports for Fiorinal »
  • Headache 1%
  • Weakness 1%
  • Tingling or prickling sensation 1%
  • Indigestion 1%
  • Abdominal issues 1%
More Relpax side effects »
  • Dizziness 3%
  • Fatigue 3%
  • Headache 1%
  • Tingling or prickling sensation 2%
  • Flushing 2%
  • Dry mouth 2%
  • Hot or cold sensation 1%
  • Muscle pain 1%
  • Indigestion 1%
  • Chest pain 1%
More Frova side effects »

We haven’t found good data for Axert side effects.

FDA side effect reports for Axert »
  • Pain and other pressure sensations 2%
  • Atypical sensations 1%
  • Paresthesia (all types) 1%
  • Sensation warm/cold 1%
  • Pain - location specified 1%
  • Malaise/fatigue 2%
  • Chest - pain/tightness/pressure and/or heaviness 1%
  • Neck/throat/jaw - pain/ tightness/pressure 2%
  • Other - pressure/tightness/ heaviness 1%
  • Vertigo 2%
More Imitrex side effects »

We haven’t found good data for Zomig side effects.

FDA side effect reports for Zomig »
How it works
MaxaltAmergeFioricetFiorinalRelpaxFrovaAxertImitrexZomig
Maxalt (Rizatriptan) is a triptan medication that treats migraine headaches. It releases serotonin, which lowers the inflammation that causes headaches.Amerge (naratriptan) is a selective serotonin receptor agonist or triptan. Migraine headaches happen when blood vessels are too open and allow too much blood in the brain. Amerge (naratriptan) tightens the blood vessels which relieves the pain.Fioricet (Butalbital / Acetaminophen / Caffeine) is a combination of three medications. Butalbital is a barbiturate that relaxes you. Acetaminophen relieves pain, and caffeine narrows the blood vessels that otherwise cause headaches.Coming soon.Relpax (eletriptan) is a triptan. Migraine headaches happen when blood vessels are too open and allow too much blood to the brain. Relpax (eletriptan) tightens the blood vessels, which relieves the pain.Frova (frovatriptan) is a triptan. It prevents the opening of blood vessels in your brain, which causes migraines.Coming soon.Imitrex (Sumatriptan) is a triptan medication that treats migraine headaches. It releases serotonin, which lowers the inflammation that causes headaches.Coming soon.
Type of medication
MaxaltAmergeFioricetFiorinalRelpaxFrovaAxertImitrexZomig
Prescription only
Prescription only
Prescription only
Prescription only
Prescription only
Prescription only
Available as
MaxaltAmergeFioricetFiorinalRelpaxFrovaAxertImitrexZomig
  • Pill
  • Dissolving tablet
  • Pill
  • Pill
  • Oral solution
  • Pill
  • Pill
  • Pill
  • Pill
  • Pill
  • Injection
  • Nasal spray
  • Pill
  • Dissolving tablet
  • Nasal spray
Used for
MaxaltAmergeFioricetFiorinalRelpaxFrovaAxertImitrexZomig
  • Tension Type Headache
  • Migraine Acute
  • Migraine Acute
Risk factors for serious side effects
MaxaltAmergeFioricetFiorinalRelpaxFrovaAxertImitrexZomig
  • History of heart problems
  • High blood pressure
  • High cholesterol
  • Diabetes
  • Being overweight or obese
  • Smoking
  • History of heart problems
  • High blood pressure
  • High cholesterol
  • Diabetes
  • Being overweight or obese
  • Smoking
    • Patients taking SSRIs and SNRIs
    • History of high blood pressure
    • History of seizures
    • Phenylketonuria (PKU)
    Detailed Maxalt (rizatriptan) risks & warnings »
    • Heart disease
    • history of chest pain/angina
    • uncontrolled high blood pressure
    • History of a stroke
    • Using Amerge (naratriptan) for more than 10 days a month
    • Tricyclic antidepressants
    • Fentanyl
    • Tramadol
    • Buspirone
    • ADHD medicines
    • Triptans
    • Uncontrolled high blood pressure
    • High blood pressure
    • history of stroke
    • History of clots in the legs or arms (DVT)
    Detailed Amerge (naratriptan) risks & warnings »
    • Drinking more than 2 alcoholic beverages a day
    • Taking with other acetaminophen-containing medicines
    • History of liver disease
      Detailed Fioricet (butalbital / acetaminophen / caffeine) risks & warnings »
      Coming soon.
      • Heart rhythm problems
      • History of chest pain
      • Uncontrolled high blood pressure
      • History of a stroke
      • Using Relpax (eletriptan) for more than 10 days a month
      • Tricyclic antidepressants
      • Fentanyl
      • Tramadol
      • Buspirone
      • ADHD medicines
      • Triptans
      • Uncontrolled high blood pressure
      • High blood pressure
      • History of stroke
      • History of heart attack
      Detailed Relpax (eletriptan) risks & warnings »
      • Heart disease
      • history of chest pain/angina
      • uncontrolled high blood pressure
      • History of a stroke
      • Using Frova (frovatriptan) for more than 2 to 3 days a week or 10 days a month
      • Tricyclic antidepressants
      • Fentanyl
      • Tramadol
      • Buspirone
      • ADHD medicines
      • Triptans
      • Uncontrolled high blood pressure
      • High blood pressure
      • history of stroke or heart attack
      Detailed Frova (frovatriptan) risks & warnings »
      Coming soon.
      • History of heart problems
      • High blood pressure
      • High cholesterol
      • Diabetes
      • Being overweight or obese
      • Smoking
      • History of heart problems
      • High blood pressure
      • High cholesterol
      • Diabetes
      • Being overweight or obese
      • Smoking
        • Patients taking SSRIs and SNRIs
        • History of high blood pressure
        • History of seizures
        Detailed Imitrex (sumatriptan) risks & warnings »
        Coming soon.
        Pregnancy

        Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

        Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

        Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

        Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

        Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

        Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

        Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

        Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

        Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

        Sleep
        MaxaltAmergeFioricetFiorinalRelpaxFrovaAxertImitrexZomig
        No sleep related info.No sleep related info.No sleep related info.No sleep related info.No sleep related info.
        • Frova (frovatriptan) can make you dizzy or sleepy. Don't drive or do anything that requires concentration until you know how your body reacts to it.
        No sleep related info.
        • Imitrex (Sumatriptan) can make you drowsy, so avoid activities that need you to be fully alert until you know how it affects you.
        No sleep related info.
        Upsides and benefits
        MaxaltAmergeFioricetFiorinalRelpaxFrovaAxertImitrexZomig
        • Triptans like Maxalt (Rizatriptan) are considered the first-choice treatment to relieve moderate to severe migraine-type headaches.
        • It can also be used to treat tension-type headaches.
        • Not all triptans work the same way for people, so you can try multiple ones to find the right medication for you.
        • You don't need to drink water with the orally disintegrating tablet for it to work, so this could be a good medication for people who can't keep water down when they have a migraine.
        • Amerge (naratriptan) is a good alternative to other triptans since it's less likely to cause side effects and if other triptans haven't worked for you.
        • Available as a generic, which makes it cheaper than other medicines and is more likely to be covered by insurances.
        • Amerge (naratriptan) comes in two different strengths.
        • Fioricet (Butalbital / Acetaminophen / Caffeine) works better and faster in treating tension headaches than the combination of acetaminophen and codeine.
        • Fioricet (Butalbital / Acetaminophen / Caffeine) doesn’t cost much since it's available as a generic medication.
        • Fioricet (Butalbital / Acetaminophen / Caffeine) has very few side effects.
        • It has been widely used for a long time.
        Coming soon
        • Relpax (eletriptan) works as well as other first choice medicines for migraines.
        • Relpax (eletriptan) comes in 2 different strengths.
        • Frova (frovatriptan) is available in generic.
        • Unlike other similar medicines, you can take up to 3 tablets of Frova (frovatriptan) every 24 hours.
        • Frova (frovatriptan) is first choice of medicines for treatment of migraine headaches.
        Coming soon
        • Comes in several forms. Ask your doctor if you should use the pill, nasal spray, patch, or injection.
        • A combination of forms can be used if symptoms do not improve.
        • The nasal spray and injectable forms work very quickly.
        • It's generally safe to use if you are pregnant.
        • Comes in a generic form, so it can be pretty cheap.
        Coming soon
        Downsides and risks
        MaxaltAmergeFioricetFiorinalRelpaxFrovaAxertImitrexZomig
        • Maxalt (Rizatriptan) doesn’t prevent migraines or tension headaches, but only works once the headache starts.
        • It can cause rebound headaches if it’s used too often.
        • You need to wait at least 2 hours after your first dose to take a second dose.
        • May not be the best choice if you have long, drawn-out headaches. Ask your doctor about other triptans that can last longer than Maxalt (Rizatriptan).
        • Not a good choice if you have heart disease or if you’re pregnant or breast-feeding.
        • Amerge (naratriptan) is only available as a pill that must be swallowed, so it might not be good if you have trouble swallowing when you have a migraine.
        • Unlike other migraine medications, you have to wait for 4 hours before you can take the second dose of Amerge (naratriptan).
        • Amerge (naratriptan) is not as good as other medications for treating nausea that can happen with migraines.
        • Fioricet (Butalbital / Acetaminophen / Caffeine) isn't the first choice medication for treating tension headaches.
        • It's not a good medication for long-term use.
        • Overuse of Fioricet (Butalbital / Acetaminophen / Caffeine) can lead to chronic tension headaches.
        • Fioricet (Butalbital / Acetaminophen / Caffeine) can cause dangerous withdrawal symptoms, intoxication, and dependence.
        • Taking Fioricet (Butalbital / Acetaminophen / Caffeine) can decrease your ability to drive a car, or operate machinery.
        Coming soon
        • Relpax (eletriptan) is only available as a brand name.
        • Relpax (eletriptan) can cause dizziness and might make you more likely to fall.
        • If you have more than 3 migraines a month, Relpax (eletriptan) isn't a good choice because of its side effects.
        • Available as an oral tablet only, which may be difficult to swallow during bad migraine attack.
        • Doesn't prevent migraines.
        • Doesn't work for other types of headaches like cluster headaches.
        • Not recommended for children under 18 years old.
        Coming soon
        • The oral and nasal versions of Imitrex (Sumatriptan) have an unpleasant after-taste.
        • Does not prevent migraine headaches; it only treats them once they start.
        • Must wait 1 hour before using second injection.
        • Can cause rebound (more) headaches if Imitrex (Sumatriptan) is used too often.
        • Need to have your blood pressure checked often, especially if you're pregnant.
        Coming soon
        Tips from our pharmacists for people taking the medication
        MaxaltAmergeFioricetFiorinalRelpaxFrovaAxertImitrexZomig
        • Take Maxalt (Rizatriptan) as soon as you feel you’re getting a headache or experience warning signs like being sensitive to light or sound.
        • If you're taking other medicines to control your headaches (like propranolol), the dose of Maxalt (Rizatriptan) will be different.
        • Let your doctor know if your headaches don’t go away after taking [name-common] or if you have more than 4 migraines per month.
        • It’s available in two different dosage forms, a tablet you take by mouth and an orally disintegrating tablet (Maxalt-MLT) you place on your tongue to let it dissolve.
        • Lie down in a dark room after taking Maxalt (Rizatriptan) to help ease pain. Ask your doctor about other medicines that can help prevent your headaches.
        • Amerge (naratriptan) can only treat a migraine that's already happening. Amerge (naratriptan) doesn't prevent migraines.
        • Take Amerge (naratriptan) at the first sign of a migraine. You can take another dose if you don't feel better after 4 hours. Don't take more than two doses every 24 hours.
        • Amerge (naratriptan) can make you feel dizzy or tired when you first start taking it. Don't drive or do anything that requires concentration until you know how your body reacts to it.
        • If you finish the entire month's supply of Amerge (naratriptan) before it's time for your next refill, or if you have more than 4 migraines a month, talk to your doctor to see if you should try something else.
        • Amerge (naratriptan) can cause nausea or tightness in the chest or throat. Talk to your doctor if it bothers you.
        • Take Fioricet (Butalbital / Acetaminophen / Caffeine) as soon as your headache starts, then lie down in a dark room to help ease the pain.
        • Be sure to take each dose with a full glass of water.
        • Take your time getting up from sitting or lying down while taking Fioricet (Butalbital / Acetaminophen / Caffeine) to decrease your chances of feeling dizzy.
        • Be sure to limit how much caffeine and chocolate you take while on Fioricet (Butalbital / Acetaminophen / Caffeine) since it can cause nervousness, shakiness, and a fast heartbeat.
        • While taking Fioricet (Butalbital / Acetaminophen / Caffeine), don’t drink alcohol or take other drugs that slow your body down.
        • Don't take other forms of acetaminophen (Tylenol) while taking Fioricet (Butalbital / Acetaminophen / Caffeine), since taking too much can lead to liver problems.
        Coming soon
        • Relpax (eletriptan) can only treat a migraine that's already happening. Relpax (eletriptan) doesn't prevent migraines from starting.
        • Take Relpax (eletriptan) at the first sign of a migraine. You can take another dose if you don't feel better after 2 hours. Don't take more than 80 mg every 24 hours.
        • Relpax (eletriptan) can make you feel dizzy or tired when you first start taking it. Don't drive or do anything that requires concentration until you know how your body reacts to it.
        • If you find you're using the entire month's supply of Relpax (eletriptan) before your next refill, talk to your doctor to see if you should try something else.
        • Relpax (eletriptan) can cause nausea or tightness in the chest or throat. Talk to your doctor if it bothers you.
        • Doesn't prevent migraines.
        • Use as soon as you feel a migraine starting. You can take another dose 2 hours later, but don't take more than 3 tablets in 24 hours.
        • Don't use it excessively since it can cause you to have more headaches. Talk to your doctor if you are having more than 4 migraines in a month.
        • Frova (frovatriptan) can make you dizzy or sleepy. Don't drive or do anything that requires concentration until you know how your body reacts to it.
        • Frova (frovatriptan) can cause nausea or tightness in the chest or throat. Talk to your doctor if it bothers you.
        Coming soon
        • Take it as soon as your headache starts.
        • If you use the nasal spray, be sure to blow your nose before using it.
        • If you use the patch, put it on a dry area free of scars, tattoos, or other cuts and scrapes. Be sure to press the button to activate it.
        • If you use the injection, you can use a second injection if you still have a headache after an hour. If you have symptoms 2 hours after the injection, switch to the pill version.
        • Imitrex (Sumatriptan) can make you drowsy, so avoid activities that need you to be fully alert until you know how it affects you.
        • Lie down in a dark room after taking Imitrex (Sumatriptan) to help ease the pain.
        Coming soon
        Learn more
        More about MaxaltSide effectsReviews & ratingsAlternativesFDA package insert
        Have you used Maxalt (rizatriptan)?
        Worth itNot sureNot worth it
        More about AmergeSide effectsReviews & ratingsFDA package insert
        Have you used Amerge (naratriptan)?
        Worth itNot sureNot worth it
        More about FioricetSide effectsReviews & ratingsFDA package insert
        Have you used Fioricet (butalbital / acetaminophen / caffeine)?
        Worth itNot sureNot worth it
        More about FiorinalSide effectsReviews & ratingsFDA package insert
        Have you used Fiorinal (butalbital / aspirin / caffeine)?
        Worth itNot sureNot worth it
        More about RelpaxSide effectsReviews & ratingsFDA package insert
        Have you used Relpax (eletriptan)?
        Worth itNot sureNot worth it
        More about FrovaSide effectsFDA package insert
        Have you used Frova (frovatriptan)?
        Worth itNot sureNot worth it
        More about AxertSide effectsReviews & ratingsFDA package insert
        Have you used Axert (almotriptan)?
        Worth itNot sureNot worth it
        More about ImitrexSide effectsReviews & ratingsFDA package insert
        Have you used Imitrex (sumatriptan)?
        Worth itNot sureNot worth it
        More about ZomigSide effectsReviews & ratingsFDA package insert
        Have you used Zomig (zolmitriptan)?
        Worth itNot sureNot worth it