Prescription onlyLower-cost generic availableClass: Autoimmune



Prescription onlyLower-cost generic availableClass: Autoimmune
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Calms down your immune system.

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Our bottom line

Medrol (methylprednisolone) is very effective for controlling allergic reactions and many types of inflammatory conditions, but it is associated with serious and potentially life-threatening side effects if you have to take it for a long time.


  • Medrol (methylprednisolone) is effective for treating a variety of conditions involving the immune system.
  • Can help improve energy and stimulate your appetite.
  • Works quickly to provide relief for swelling, rash, asthma attacks, and pain.
  • Medrol (methylprednisolone) is available in a generic form.
  • Available as blister packs that organize tablets into specific days and times for easier administration.
People’s experience with Medrol

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  • Medrol (methylprednisolone) can cause unwanted side effects such as mood changes, trouble sleeping, and increase in blood pressure as well as blood sugar at higher doses.
  • Long-term use can cause problems to your skin, bones, eyes, and place you at a higher risk for infections.
  • If Medrol (methylprednisolone) is used for more than 2 weeks, you will need to work with a doctor to get off of the medicine by gradually decreasing the dose.
  • Medrol (methylprednisolone) can cause harm to an unborn baby, so it might not be a good option for pregnant women.
  • Might cause abnormal growth and development when used in children.
How it works

Medrol (methylprednisolone) is a corticosteroid that is similar to a hormone your body naturally makes in response to stress. It helps reduce swelling and blocks the actions of your immune system that normally would cause pain, discomfort, or harm.

People’s experience with Medrol

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Used for
  • Allergies
  • Skin conditions
  • Endocrine conditions
Dosage forms
  • Pill
  • Injection

What to expect when you take Medrol (methylprednisolone) for Inflammatory or autoimmune conditions

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Side effect rates for Medrol (methylprednisolone)

Risks and Warnings for Medrol (methylprednisolone)

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    • Higher risk if:
    • Taking high doses of Medrol (methylprednisolone) for a long period of time
    • Young children
    • Stress such as trauma, injury, or infection

    If you've been taking Medrol (methylprednisolone) for a long time, it is dangerous to stop taking it suddenly since your body may have become dependent on it for responding to stress. Changes in your dose need to be done gradually over time. Talk to your doctor about how you should decrease the dose.

Common concerns from people taking Medrol (methylprednisolone)

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  • Take Medrol (methylprednisolone) in the morning with food to lower your chances of getting stomach upset and having trouble sleeping. For an evening dose, it is best to take the medicine at least 2 to 3 hours before bedtime.
Kidneys and liver
  • Medrol (methylprednisolone) can cause high blood pressure, unexplained weight gain, and other changes in the way your kidneys work. If you have a history of heart failure, high blood pressure, or kidney problems, talk to your doctor first before using this medicine.