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Calms down your immune system.

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Prescription onlyLower-cost generic available

Our bottom line

Medrol (Methylprednisolone) is corticosteroid available in many forms (oral, injectable) that's great for controlling the unwanted symptoms from your immune responses and will make you feel better. There are lots of side effects but most of are tolerable or can be managed.


  • Steroid magic, can help you feel better, have more energy and get more appetite.
  • Useful in controlling immune responses that are causing you discomfort, and works quickly to relieve symptoms like swelling, rash, asthma attacks, gout attacks.
  • Useful in suppressing the immune system from causing your body harm, like many autoimmune related conditions.
  • Available in many different forms, including injection, that will expose the rest of your body less of the medicine.
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  • Lots of side effects, especially with long term use.
  • Short-term use can cause mood changes, trouble sleeping and increase in blood pressure, blood sugar, and possible water retention.
  • Long-term use can cause problems with skin, bone, eye health and put you at a higher risk for infections.
  • People with certain conditions will have to pay extra attention to their symptoms or may have to adjust the dose of other medicines when taking Medrol.
  • When using corticosteroids for more than 1 week, you will need to work with a doctor to get off the medicine slowly.

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What to expect when you take Medrol (Methylprednisolone)

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Tips from our pharmacists
  • The dose and duration on how long you need the medicine depends on your condition and response.
  • Take it exactly as your doctor prescribed.
  • Take with food to decrease stomach upset.
  • Can cause trouble sleeping. Take in the morning or 2-3 hours before bed if more than one dose is needed.
  • Can cause changes in mood, blood pressure, blood sugar, and water retention.
  • You should check your blood pressure and blood sugar when taking this medicine if you already have high blood pressure or diabetes.
  • A taper is often needed to stop the medicine, especially if you've been on it for more than 1 week.
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Side effects for Medrol (Methylprednisolone)

Manufacturers don’t say how common these side effects are

  • Aseptic necrosis of femoral and humeral heads
  • Body shaking
  • Bulging eyes
  • Congestive heart failure in susceptible patients
  • Decreased carbohydrate tolerance
  • Development of cushingoid state
  • Facial erythema
  • Glaucoma
  • Headache
  • High blood pressure
  • Holding water
  • Hypokalemic alkalosis
  • Impaired wound healing
  • Increased intracranial pressure with papilledema
  • Increased intraocular pressure
  • Increased requirements of insulin or oral hypoglycemic agents in diabetics
  • Increased sweating
  • Increases alt, sgpt, ast, sgot, and alkaline phosphatase
  • Loss of muscle mass
  • Manifestations of latent diabetes mellitus
  • May suppress reactions to skin tests
  • Menstrual irregularities
  • Muscle weakness
  • Negative nitrogen balance
  • Pancreatitis
  • Pathologic fracture of long bones
  • Peptic ulcer with possible perforation and hemorrhage
  • Petechiae and ecchymoses
  • Posterior subcapsular cataracts
  • Potassium loss
  • Secondary adrenocortical and pituitary unresponsiveness
  • Sodium retention
  • Steroid myopathy
  • Suppression of growth in children
  • Swollen belly
  • Tendon rupture
  • Thin fragile skin
  • Ulcerative esophagitis
  • Vertebral compression fractures
  • Vertigo
  • Very low bone mineral density

Risks and Warnings for Medrol (Methylprednisolone)

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    • Higher risk if:
    • Lowering dose or stopping too quickly especially after long-term treatment
    • Stress such as trauma, surgery or infection

    Adrenal suppression leading to adrenal crisis can occur if you lower your dose or stop taking Medrol (Methylprednisolone) too quickly. Symptoms include joint or muscle pain, extreme low energy and depression. Changes in your Medrol (Methylprednisolone) dose need to be done slowly over time. Talk to your doctor before you make any changes or stop the medication.

Means that some groups have a high risk of experiencing this side effect

Tips from pharmacists and people taking Medrol (Methylprednisolone)

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The FDA category for this medication is C. It is advised that you: Weigh risks vs. benefits
  • Risks from our pharmacists
  • Taking Medrol (Methylprednisolone) increases the risk of injury to the lining of your stomach and intestine including irritation, tears/holes and ulcers. You should avoid alcohol/alcoholic beverages because it can worsen stomach irritation. Tell your doctor or get medical care right away if you have stomach pain, notice blood or dark colored stools when you go to the bathroom.
  • Tips from our pharmacists
  • Take with food to decrease stomach upset.
  • just take them (however many you are supposed to take that day) all with the same meal every day so you dont forget.
  • Upsides and downsides from our pharmacists
  • Short-term use can cause mood changes, trouble sleeping and increase in blood pressure, blood sugar, and possible water retention.
  • Tips from our pharmacists
  • Can cause trouble sleeping. Take in the morning or 2-3 hours before bed if more than one dose is needed.
  • Risks from our pharmacists
  • Like most corticosteroid medicines, Medrol (Methylprednisolone) may cause changes in your mood or behavior. Tell your doctor right away if you become depressed, have mood swings, trouble sleeping, irritability or anxiety, hyperactivity, delusions or hallucinations while taking this medicine. If you need to make any changes or slowly taper your dose, talk to your doctor first.