Prescription onlyLower-cost generic availableDrug class: Autoimmune

Medrol Alternatives

(Methylprednisolone)

Prescription onlyLower-cost generic availableDrug class: Autoimmune
Back to: Full Site Navigation

Compare Medrol (Methylprednisolone) to alternatives

These medications are comparable to Medrol (Methylprednisolone) or used for similar purposes.

Medrol
(Methylprednisolone)

Deltasone
(Prednisone)

Decadron
(Dexamethasone)

Anusol Hc
(Hydrocortisone)

Calms down your immune system. Medrol (Methylprednisolone) is corticosteroid available in many forms (oral, injectable) that's great for controlling the unwanted symptoms from your immune responses and will make you feel better. There are lots of side effects but most of are tolerable or can be managed.Calms down your immune system. Deltasone (Prednisone) is a common oral corticosteroid that's great for controlling the unwanted symptoms from your immune responses and will make you feel better. There are lots of side effects but most of are tolerable or can be managed.Lowers inflammation and suppresses your immune system. Decadron (Dexamethasone) is identical to an essential hormone that humans produce and has been proven to work safely.Treats itchy or irritated skin. Anusol Hc (Hydrocortisone) is a good topical steroid to try for treating minor rashes or skin irritation.
Find lowest prices
Powered by GoodRxSave on your next prescription. Be sure you’re getting the lowest price for your medication, even if you have insurance.
No pricing data for this drug at this filter setting. Try searching onGoodRx
No pricing data for this drug at this filter setting. Try searching onGoodRx
No pricing data for this drug at this filter setting. Try searching onGoodRx
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.12Medrol
Reviews for Medrol (Methylprednisolone)
59%
of people (All ages) say Medrol (Methylprednisolone) is worth it
53%
say it works well
23%
say it's a big hassle
Have you used Medrol (Methylprednisolone)?
Worth itNot sureNot worth it
Reviews for Deltasone (Prednisone)
59%
Same vs. Medrol (Methylprednisolone)
45%
-8% worse vs. Medrol (Methylprednisolone)
20%
+3% better vs. Medrol (Methylprednisolone)
540 reviews
Have you used Deltasone (Prednisone)?
Worth itNot sureNot worth it

Not enough reviews for this drug. Help someone out, leave a review!

Have you used Decadron (Dexamethasone)?
Worth itNot sureNot worth it

Not enough reviews for this drug. Help someone out, leave a review!

Have you used Anusol Hc (Hydrocortisone)?
Worth itNot sureNot worth it
Side effects
MedrolPrednisoneDexamethasoneHydrocortisone

The Medrol FDA package insert doesn’t have numbers about how common side effects are.

More about Medrol side effects »

The Prednisone FDA package insert doesn’t have numbers about how common side effects are.

More about Prednisone side effects »

The Dexamethasone FDA package insert doesn’t have numbers about how common side effects are.

More about Dexamethasone side effects »

We haven’t found good data for Hydrocortisone side effects.

FDA side effect reports for Hydrocortisone »
How it works
MedrolPrednisoneDexamethasoneHydrocortisone
Medrol (Methylprednisolone) is a corticosteroid that's similar to what your body naturally makes. It reduces swelling and other immune responses that can cause you pain, discomfort, or harm.Deltasone (Prednisone) is a corticosteroid that's similar to what your body naturally makes. It reduces swelling and other immune responses that can cause you pain, discomfort, or harm.Decadron (Dexamethasone) is a short-acting corticosteroid. It lowers inflammation by preventing your capillaries (small blood vessels) from leaking out excess fluid and chemicals that cause swelling.Anusol Hc (Hydrocortisone) is a topical steroid that works by decreasing skin itching, swelling, and redness.
Type of medication
MedrolPrednisoneDexamethasoneHydrocortisone
Prescription only
Prescription only
Prescription only
Over-the-counter
Available as
MedrolPrednisoneDexamethasoneHydrocortisone
  • Pill
  • Pill
  • Extended release
  • Liquid
  • Pill
  • Liquid
  • Cream, gel, or ointment
  • Lotion
  • Topical solution
Used for
MedrolPrednisoneDexamethasoneHydrocortisone
  • Skin Inflammation
Risk factors for serious side effects
MedrolPrednisoneDexamethasoneHydrocortisone
  • Lowering dose or stopping too quickly especially after long-term treatment
  • Stress such as trauma, surgery or infection
  • Duration of treatment
    • History of psychiatric conditions
    • Dose of Medrol (Methylprednisolone)
    • Duration of treatment
    • Women of childbearing age
    • History of stomach bleeding
    • Active or history of stomach or duodenal ulcers
    • Ulcerative colitis
    • Taking Medrol (Methylprednisolone) with other medicine that can cause stomach problems
    • Long-term treatment
    • Not vaccinated against viral diseases
    • Contact with people who have viral illness
    • History of bacterial or viral conditions
    Detailed Medrol (Methylprednisolone) risks & warnings »
    • Lowering dose or stopping too quickly especially after long-term treatment
    • Stress such as trauma, surgery or infection
    • Long-term treatment
    • Not vaccinated against viral diseases
    • Contact with people who have viral illness
    • History of bacterial or viral conditions
    • Duration of treatment
      • History of psychiatric conditions
      • Dose of Deltasone (Prednisone)
      • Duration of treatment
      • Women of childbearing age
      • History of stomach bleeding
      • Active or history of stomach or duodenal ulcers
      • Ulcerative colitis
      • Taking Deltasone (Prednisone) with other medicine that can cause stomach problems
      Detailed Deltasone (Prednisone) risks & warnings »
      • Lowering dose or stopping too quickly especially after long-term treatment
      • Stress such as trauma, surgery or infection
      • Long-term treatment
      • Not vaccinated against viral diseases
      • Contact with people who have viral illness
      • History of bacterial or viral conditions
      • Duration of treatment
      • History of psychiatric conditions
      • Dose of Decadron (Dexamethasone)
      • Duration of treatment
      • Women of childbearing age
      Detailed Decadron (Dexamethasone) risks & warnings »
      • Long-term treatment
      • Not vaccinated against viral diseases
      • Contact with people who have viral illness
      • History of bacterial or viral conditions
      • Long-term treatment
      • Dose of Anusol Hc (Hydrocortisone)
      • Duration of treatment
      Detailed Anusol Hc (Hydrocortisone) risks & warnings »
      Pregnancy

      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      Food
      MedrolPrednisoneDexamethasoneHydrocortisone
      • Take with food to decrease stomach upset.
      • Take with food to decrease stomach upset.
      No food related info.No food related info.
      Kidneys and liver
      MedrolPrednisoneDexamethasoneHydrocortisone
      • Adrenal suppression leading to adrenal crisis can occur if you lower your dose or stop taking Medrol (Methylprednisolone) too quickly. Symptoms include joint or muscle pain, extreme low energy and depression. Changes in your Medrol (Methylprednisolone) dose need to be done slowly over time. Talk to your doctor before you make any changes or stop the medication.
      • Adrenal suppression leading to adrenal crisis can occur if you lower your dose or stop taking Deltasone (Prednisone) too quickly. Symptoms include joint or muscle pain, extreme low energy and depression. Changes in your Deltasone (Prednisone) dose need to be done slowly over time. Talk to your doctor before you make any changes or stop the medication.
      • Adrenal suppression leading to adrenal crisis can occur if you lower your dose or stop taking Decadron (Dexamethasone) too quickly. Symptoms include joint or muscle pain, extreme low energy and depression. Changes in your Decadron (Dexamethasone) dose need to be done slowly over time. Talk to your doctor before you make any changes or stop the medication.
      No kidneys and liver related info.
      Weight
      MedrolPrednisoneDexamethasoneHydrocortisone
      No weight related info.No weight related info.
      • Some people gain weight while taking Decadron (Dexamethasone) or can experience other side effects like mood changes.
      No weight related info.
      Upsides and benefits
      MedrolPrednisoneDexamethasoneHydrocortisone
      • Steroid magic, can help you feel better, have more energy and get more appetite.
      • Useful in controlling immune responses that are causing you discomfort, and works quickly to relieve symptoms like swelling, rash, asthma attacks, gout attacks.
      • Useful in suppressing the immune system from causing your body harm, like many autoimmune related conditions.
      • Available in many different forms, including injection, that will expose the rest of your body less of the medicine.
      • Steroid magic, can help you feel better, have more energy and get more appetite.
      • Useful for many conditions.
      • Short-term use in controlling immune responses that are causing you discomfort, and works quickly to relieve symptoms like swelling, rash, asthma attacks, gout attacks.
      • Long-term use in suppressing the immune system from causing your body harm, like many autoimmune related conditions.
      • Treats a large variety of inflammatory disorders including asthma, dermatitis, drug reactions, rashes, and endocrine disorders.
      • Can help prevent nausea, especially when it's caused by chemotherapy.
      • You can get it orally or as an injection.
      • Relieves itchy and irritated skin.
      • Doesn't cause the same types of side effects that oral forms of steroids do.
      • It's available over the counter in the drugstore.
      • Most people have very few side effects.
      Downsides and risks
      MedrolPrednisoneDexamethasoneHydrocortisone
      • Lots of side effects, especially with long term use.
      • Short-term use can cause mood changes, trouble sleeping and increase in blood pressure, blood sugar, and possible water retention.
      • Long-term use can cause problems with skin, bone, eye health and put you at a higher risk for infections.
      • People with certain conditions will have to pay extra attention to their symptoms or may have to adjust the dose of other medicines when taking Medrol.
      • When using corticosteroids for more than 1 week, you will need to work with a doctor to get off the medicine slowly.
      • Lots of side effects, especially with long term use.
      • Short-term use can cause mood changes, trouble sleeping and increase in blood pressure, blood sugar, and possible water retention.
      • Long-term use can cause problems with skin, bone, eye health and put you at a higher risk for infections.
      • People with certain conditions will have to pay extra attention to their symptoms or may have to adjust the dose of other medicines when taking Prednisone.
      • When using corticosteroids for more than 1 week, you will need to work with a doctor to get off the medicine slowly.
      • Only available as an oral medicine so the rest of your body will be exposed to the medicine.
      • Can't be used on its own to treat low cortisol levels.
      • Since it suppresses your immune system, you're more likely to get infections.
      • You can't take Decadron (Dexamethasone) if you have a systemic fungal infection.
      • Shouldn't be used if you have a stomach ulcer.
      • Can decrease bone formation and lead to an increased risk of osteoporosis.
      • It's not a strong steroid, so it doesn't work for everyone.
      • When used longer than a week, it can cause skin-thinning and make it harder for broken skin to heal.
      Tips from our pharmacists for people taking the medication
      MedrolPrednisoneDexamethasoneHydrocortisone
      • The dose and duration on how long you need the medicine depends on your condition and response.
      • Take it exactly as your doctor prescribed.
      • Take with food to decrease stomach upset.
      • Can cause trouble sleeping. Take in the morning or 2-3 hours before bed if more than one dose is needed.
      • Can cause changes in mood, blood pressure, blood sugar, and water retention.
      • You should check your blood pressure and blood sugar when taking this medicine if you already have high blood pressure or diabetes.
      • A taper is often needed to stop the medicine, especially if you've been on it for more than 1 week.
      • The dose and duration on how long you need the medicine depends on your condition and response.
      • Take it exactly as your doctor prescribed.
      • Take with food to decrease stomach upset.
      • Can cause trouble sleeping. Take in the morning or 2-3 hours before bed if more than one dose is needed.
      • Can cause changes in mood, blood pressure, blood sugar, and water retention.
      • You should check your blood pressure and blood sugar when taking this medicine if you already have high blood pressure or diabetes.
      • A taper is is often needed to stop the medicine, especially if you've been on it for more than 1 week.
      • The lowest possible dose of corticosteroids should be used to control your symptoms.
      • When reducing or stopping the dose, do it very slowly and follow your doctor's instructions exactly to prevent major health emergencies.
      • If you used Decadron (Dexamethasone) for a long time, you could get withdrawal symptoms like muscle pain, joint pain, and malaise.
      • Some people gain weight while taking Decadron (Dexamethasone) or can experience other side effects like mood changes.
      • Don't get live or live/attenuated vaccines while on this. Killed or inactivated vaccines are fine.
      • Rub a thin layer of Anusol Hc (Hydrocortisone) into the area of skin that is affected.
      • Don't rub it into broken areas of skin and leave the area uncovered.
      • Wash your hands after applying it each time.
      • Don't use Anusol Hc (Hydrocortisone) more often than your doctor or the package label recommends.
      • Wait at least 30 minutes between applying moisturizing lotions and this medication.
      • Talk to your doctor if your skin gets worse or hasn't improved in seven days.
      Learn more
      More about MedrolSide effectsReviews & ratingsAlternativesFDA package insert
      Have you used Medrol (Methylprednisolone)?
      Worth itNot sureNot worth it
      More about PrednisoneSide effectsReviews & ratingsFDA package insert
      Have you used Deltasone (Prednisone)?
      Worth itNot sureNot worth it
      More about DexamethasoneSide effectsReviews & ratingsFDA package insert
      Have you used Decadron (Dexamethasone)?
      Worth itNot sureNot worth it
      More about HydrocortisoneSide effectsReviews & ratingsFDA package insert
      Have you used Anusol Hc (Hydrocortisone)?
      Worth itNot sureNot worth it