Medrol Alternatives

(methylprednisolone)

Alternatives

Compare Medrol (methylprednisolone) to alternatives

These medications are comparable to Medrol (methylprednisolone) or used for similar purposes.

Medrol
(methylprednisolone)

dexamethasone

Cortef
(Hydrocortisone)

Remicade
(infliximab)

prednisone

Calms down your immune system. Medrol (methylprednisolone) is very effective for controlling allergic reactions and many types of inflammatory conditions, but it is associated with serious and potentially life-threatening side effects if you have to take it for a long time.Calms down your immune system. Decadron (dexamethasone) is a long-acting oral corticosteroid that is very effective in treating allergic reactions and immune conditions, however, if you're taking Decadron (dexamethasone) for a long time, there can be serious side effects.Cortef (Hydrocortisone) lowers inflammation, suppresses the immune system, and replaces low cortisol. Cortef (Hydrocortisone) is identical to an essential hormone that humans produce and has been proven to work safely.Calms down your immune system. Remicade (infliximab) is an effective treatment for many autoimmune diseases, but you can have serious side effects.Calms down your immune system. Deltasone (prednisone) is effective for controlling allergic reactions and conditions involving the immune system. It can quickly make you feel better, but Deltasone (prednisone) can cause serious complications and side effects if taken for a long time.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.12Medrol
Reviews for Medrol
59%
of people (All ages) say Medrol is worth it
53%
say it works well
23%
say it's a big hassle
Have you used Medrol (methylprednisolone)?
Worth itNot sureNot worth it

Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Decadron (dexamethasone)?
Worth itNot sureNot worth it

Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Cortef (Hydrocortisone)?
Worth itNot sureNot worth it
Reviews for Remicade
76%
-17% worse vs. Medrol
62%
-9% worse vs. Medrol
15%
-8% worse vs. Medrol
Have you used Remicade (infliximab)?
Worth itNot sureNot worth it
Reviews for prednisone
59%
Same vs. Medrol
45%
+8% better vs. Medrol
20%
-3% worse vs. Medrol
540 reviews
Have you used Deltasone (prednisone)?
Worth itNot sureNot worth it
Side effects
MedroldexamethasoneCortefRemicadeprednisone

The Medrol FDA package insert doesn’t have numbers about how common side effects are.

More about Medrol side effects »

The dexamethasone FDA package insert doesn’t have numbers about how common side effects are.

More about dexamethasone side effects »

We haven’t found good data for Cortef side effects.

FDA side effect reports for Cortef »
  • Yeast infectionn 2%
  • Itchiness 5%
  • Fever 3%
  • High blood pressure 2%
  • Pain 1%
  • Joint pain 1%
  • Urinary tract infection 2%
  • Fatigue 2%
  • Indigestion 3%
  • Bronchitis 1%
More Remicade side effects »

The prednisone FDA package insert doesn’t have numbers about how common side effects are.

More about prednisone side effects »
How it works
MedroldexamethasoneCortefRemicadeprednisone
Medrol (methylprednisolone) is a corticosteroid that is similar to a hormone your body naturally makes in response to stress. It helps reduce swelling and blocks the actions of your immune system that normally would cause pain, discomfort, or harm.Decadron (dexamethasone) is a corticosteroid that is similar to what your body naturally makes. It reduces swelling and other immune responses that can cause you pain, discomfort, or harm.Cortef (Hydrocortisone) is a short-acting corticosteroid. It lowers inflammation by preventing your capillaries (small blood vessels) from leaking out excess fluid and chemicals that cause swelling.Remicade (infliximab) blocks a protein in your immune system called TNF (tumor necrosis factor) that causes inflammation.Deltasone (prednisone) is a corticosteroid similar to a hormone your body naturally makes in response to stress. It helps reduce swelling and blocks the actions of your immune system that normally would cause pain, discomfort, or harm.
Type of medication
MedroldexamethasoneCortefRemicadeprednisone
Prescription onlyLower-cost generic availablePrescription onlyLower-cost generic availablePrescription onlyLower-cost generic availablePrescription onlyNo lower cost generic availablePrescription onlyLower-cost generic available
Available as
MedroldexamethasoneCortefRemicadeprednisone
  • Pill
  • Injection
  • Pill
  • Liquid
  • Pill
  • Liquid
  • Suppository
  • Injection
  • Pill
  • Delayed release pill
  • Liquid
Used for
MedroldexamethasoneCortefRemicadeprednisone
  • Allergies
Risk factors for serious side effects
MedroldexamethasoneCortefRemicadeprednisone
  • Taking high doses of Medrol (methylprednisolone) for a long period of time
  • Young children
  • Stress such as trauma, injury, or infection
  • Taking other medicines that weaken the immune system
  • Taking Medrol (methylprednisolone) for a long time
Detailed Medrol (methylprednisolone) risks & warnings »
  • Lowering dose or stopping too quickly especially after long-term treatment
  • Stress such as trauma, surgery or infection
  • Taking other immunosuppressants
  • Long-term treatment
  • Not vaccinated against viral diseases
Detailed Decadron (dexamethasone) risks & warnings »
  • Lowering dose or stopping too quickly especially after long-term treatment
  • Stress such as trauma, surgery or infection
  • Long-term treatment
  • Not vaccinated against viral diseases
  • Contact with people who have viral illness
Detailed Cortef (Hydrocortisone) risks & warnings »
  • Taking other immunosuppressant drugs
  • Age 65 or older
  • Comorbidities
  • History of malignancy
Detailed Remicade (infliximab) risks & warnings »
  • Taking high doses of Deltasone (prednisone) for a long period of time
  • Young children
  • Stress such as trauma, injury, or infection
  • Taking other medicines that weaken the immune system
  • Taking Deltasone (prednisone) for a long time
Detailed Deltasone (prednisone) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Price
MedroldexamethasoneCortefRemicadeprednisone
No price related info.
  • Can control immune responses that are causing you discomfort and works quickly to relieve symptoms like swelling, rash, asthma attacks, and pain.
No price related info.No price related info.No price related info.
Food
MedroldexamethasoneCortefRemicadeprednisone
  • Take Medrol (methylprednisolone) in the morning with food to lower your chances of getting stomach upset and having trouble sleeping. For an evening dose, it is best to take the medicine at least 2 to 3 hours before bedtime.
  • Take Decadron (dexamethasone) in the morning with food to minimize stomach upset. If taking an evening dose, take 2-3 hours before bedtime to help you sleep better at night.
No food related info.No food related info.
  • Take Deltasone (prednisone) in the morning with food to lower your chances of getting stomach upset and having trouble sleeping. For an evening dose, it is best to take the medicine at least 2 to 3 hours before bedtime.
Kidneys and liver
MedroldexamethasoneCortefRemicadeprednisone
  • Medrol (methylprednisolone) can cause high blood pressure, unexplained weight gain, and other changes in the way your kidneys work. If you have a history of heart failure, high blood pressure, or kidney problems, talk to your doctor first before using this medicine.
  • Decadron (dexamethasone) can cause high blood pressure, increased salt retention and increased processing of electrolytes by your kidneys. If you have heart failure, high blood pressure, or kidney damage, talk to your doctor.
  • Adrenal suppression leading to adrenal crisis can occur if you lower your dose or stop taking Cortef (Hydrocortisone) too quickly. Symptoms include joint or muscle pain, extreme low energy and depression. Changes in your Cortef (Hydrocortisone) dose need to be done slowly over time. Talk to your doctor before you make any changes or stop the medication.
No kidneys and liver related info.
  • Deltasone (prednisone) can cause high blood pressure, unexplained weight gain, and other changes in the way your kidneys work. If you have a history of heart failure, high blood pressure, or kidney problems, talk to your doctor first before using this medicine.
Pain
MedroldexamethasoneCortefRemicadeprednisone
No pain related info.
  • Taking Decadron (dexamethasone) increases the risk of injury to the lining of your stomach and intestine including irritation and tears. You should avoid alcohol/alcoholic beverages because it can worsen stomach irritation. Tell your doctor and get medical care right away if you have stomach pain or bloody/dark stools when you go to the bathroom.
  • Decadron (dexamethasone) can increase your chance of infection. Call your doctor right away if you have a fever, chills, flu-like signs, cough, pain with passing urine, or a wound that will not heal.
  • Taking Cortef (Hydrocortisone) increases the risk of injury to the lining of your stomach and intestine including irritation, tears/holes and ulcers. You should avoid alcohol/alcoholic beverages because it can worsen stomach irritation. Tell your doctor or get medical care right away if you have stomach pain, notice blood or dark colored stools when you go to the bathroom.
No pain related info.No pain related info.
Weight
MedroldexamethasoneCortefRemicadeprednisone
No weight related info.No weight related info.
  • Some people gain weight while taking Cortef (Hydrocortisone). Using a weight loss program, eating smaller portions, and drinking a glass of water before meals tend to help.
  • Although rare, Remicade (infliximab) can hurt your liver. If you have appetite/weight loss, stomach discomfort, vomiting, or dark urine, talk to your doctor. If you have yellowing of skin/eyes, talk to your doctor right away.
No weight related info.
Upsides and benefits
MedroldexamethasoneCortefRemicadeprednisone
  • Medrol (methylprednisolone) is effective for treating a variety of conditions involving the immune system.
  • Can help improve energy and stimulate your appetite.
  • Works quickly to provide relief for swelling, rash, asthma attacks, and pain.
  • Medrol (methylprednisolone) is available in a generic form.
  • Available as blister packs that organize tablets into specific days and times for easier administration.
  • Effective in treating many conditions.
  • Can improve energy and appetite.
  • Can control immune responses that are causing you discomfort and works quickly to relieve symptoms like swelling, rash, asthma attacks, and pain.
  • Has long-term benefit in calming down the immune system and keeping it from causing your body harm, such as in autoimmune conditions.
  • Available in generic form.
  • Normal doses of hydrocortisone have been safely and successfully used for over 60 years. It's especially good for people using it as a long-term cortisol supplement.
  • Cortef (Hydrocortisone) converts into cortisol, a natural hormone, which will not interfere with other medications you may be taking.
  • Taking a dose of Cortef (Hydrocortisone) in the evening doesn't affect your ability to sleep.
  • At safe doses, Cortef (Hydrocortisone) can actually increase your body's ability to fight infection.
  • People taking Remicade (infliximab) for ulcerative colitis, Crohn's disease, rheumatoid arthritis and other autoimmune conditions had more clinical response, clinical remission and symptom improvement compared to people who did not take Remicade (infliximab).
  • People who were also taking steroids for treatment were able to discontinue steroid use while taking Remicade (infliximab).
  • Remicade (infliximab) has almost two decades of clinical trial data and real-life experience with many people who have used it.
  • After the initial dosing, you only need to take Remicade (infliximab) every 6-8 weeks, depending on your condition.
  • Compared to other medications used to treat autoimmune conditions, Remicade (infliximab) has not been associated with as many harmful effects during pregnancy and breastfeeding.
  • Deltasone (prednisone) effectively treats a variety of conditions involving the immune system.
  • Can help improve energy and stimulate your appetite.
  • Works quickly to provide relief for swelling, rash, asthma attacks, and pain.
  • Good long-term treatment option for autoimmune disorders.
  • Deltasone (prednisone) is available in a generic form.
Downsides and risks
MedroldexamethasoneCortefRemicadeprednisone
  • Medrol (methylprednisolone) can cause unwanted side effects such as mood changes, trouble sleeping, and increase in blood pressure as well as blood sugar at higher doses.
  • Long-term use can cause problems to your skin, bones, eyes, and place you at a higher risk for infections.
  • If Medrol (methylprednisolone) is used for more than 2 weeks, you will need to work with a doctor to get off of the medicine by gradually decreasing the dose.
  • Medrol (methylprednisolone) can cause harm to an unborn baby, so it might not be a good option for pregnant women.
  • Might cause abnormal growth and development when used in children.
  • Many side effects, particularly with long term use.
  • Side effects include mood changes, trouble sleeping and increase in blood pressure and blood sugar at higher doses.
  • Long-term use can cause problems with skin, bone, eye health and put you at a higher risk for infections.
  • If you've been using corticosteroids for more than 2 weeks, you will need to work with a doctor to get off the medicine slowly.
  • Limited studies conducted with use of steroids during pregnancy or breastfeeding - potential harm to unborn baby.
  • In the first few weeks, your doctor might adjust the dose of Cortef (Hydrocortisone) multiple times.
  • You may be at an increased risk of infection if you take high doses of Cortef (Hydrocortisone), or if you take it in combination with other immunosuppressive medications.
  • Your body could stop making its own cortisol once it gets used to Cortef (Hydrocortisone). If so, you'll likely have to keep taking Cortef (Hydrocortisone) for a really long time.
  • Depending on why your doctor prescribed Cortef (Hydrocortisone) to you, corticosteroids can have different effects on your body.
  • You have to receive this medication at your doctor's office or clinic. You might need to be tested regularly for tuberculosis.
  • Remicade (infliximab) lowers your ability to fight infection and can cause serious illness. The risk is greater if you take other drugs that lower your immune system, or have a history of diabetes or tuberculosis.
  • Remicade (infliximab) can in some cases worsen symptoms of heart failure or neurologic conditions. People 65 years and older may have more side effects from this medication.
  • In rare cases, Remicade (infliximab) has been associated with cancers in children and adolescents.
  • No generic available, so it can be costly.
  • Deltasone (prednisone) can cause unwanted side effects such as mood changes, trouble sleeping, and increase in blood pressure as well as blood sugar at higher doses.
  • Long-term use can cause problems to your skin, bones, eyes, and place you at a higher risk for infections.
  • If Deltasone (prednisone) is used for more than 2 weeks, you will need to work with a doctor to taper off the medicine by gradually decreasing the dose.
  • Deltasone (prednisone) can harm an unborn baby, so it's not a good option for pregnant women.
Tips from our pharmacists for people taking the medication
MedroldexamethasoneCortefRemicadeprednisone
  • Take Medrol (methylprednisolone) in the morning with food to lower your chances of getting stomach upset and having trouble sleeping. For an evening dose, it is best to take the medicine at least 2 to 3 hours before bedtime.
  • Medrol (methylprednisolone) can increase your appetite, make your body retain more water, and cause changes to your mood.
  • Medrol (methylprednisolone) can increase your blood pressure and blood sugar at higher doses. If you have high blood pressure or diabetes, it is important that you check your blood pressure and blood sugar regularly while taking this medicine.
  • If you need to take Medrol (methylprednisolone) for longer than 2 weeks, you may need to gradually stop taking this medicine. Take it exactly as your doctor told you and do not stop suddenly.
  • While you are on this medicine, don't get any live vaccines, unless approved by your doctor.
  • Medrol (methylprednisolone) can increase your chances of getting an infection. Call your doctor right away if you have a fever, chills, flu-like symptoms, cough, pain with passing urine, or a wound that will not heal.
  • The dose and how long you need to take the medicine for depends on your specific condition and response.
  • Take Decadron (dexamethasone) in the morning with food to minimize stomach upset. If taking an evening dose, take 2-3 hours before bedtime to help you sleep better at night.
  • Decadron (dexamethasone) can cause an increase in appetite and water retention, as well as changes in mood.
  • Decadron (dexamethasone) can increase blood pressure and blood sugar with higher doses. If you have high blood pressure or diabetes, it is important that you check your blood pressure and blood sugar regularly while taking this medicine.
  • If you need to take Decadron (dexamethasone) for longer than 2 weeks, you may need to gradually stop taking this medication. Take it exactly as your doctor prescribed and do not stop suddenly.
  • Decadron (dexamethasone) can increase your chance of infection. Call your doctor right away if you have a fever, chills, flu-like signs, cough, pain with passing urine, or a wound that will not heal.
  • You can crush the tablets and take Cortef (Hydrocortisone) with your food or drink. Do not open up a capsule, since they need to be swallowed whole.
  • Be sure not to stop taking Cortef (Hydrocortisone) suddenly, as it can lead to loss of appetite, nausea, weakness, low blood pressure, and low blood sugar.
  • Some people gain weight while taking Cortef (Hydrocortisone). Using a weight loss program, eating smaller portions, and drinking a glass of water before meals tend to help.
  • Remicade (infliximab) can in some cases cause a serious allergic reaction either immediately or several days after the treatment. Your doctor can give you medicines that will lower this risk.
  • Your doctor will test you for tuberculosis before taking Remicade (infliximab) and regularly during treatment.
  • Remicade (infliximab) lowers your immune system's ability to fight infections, so it's important to let your doctor know if you notice a fever, cough, or flu-like symptoms.
  • You should not receive any live vaccines while taking Remicade (infliximab). Tell your doctor that you are taking Remicade (infliximab) before receiving any vaccines.
  • If you have any signs or new or worsening symptoms such as heart, neurological, or autoimmune conditions, talk to your doctor. Tell your doctor about symptoms such as bruising or bleeding.
  • Take Deltasone (prednisone) in the morning with food to lower your chances of getting stomach upset and having trouble sleeping. For an evening dose, it is best to take the medicine at least 2 to 3 hours before bedtime.
  • Deltasone (prednisone) can increase your appetite, make your body retain more water, and cause changes to your mood.
  • Deltasone (prednisone) can increase your blood pressure and blood sugar at higher doses. If you have high blood pressure or diabetes, it is important that you check your blood pressure and blood sugar regularly while taking this medicine.
  • If you need to take Deltasone (prednisone) for longer than 2 weeks, you may need to gradually stop taking this medicine. Take it exactly as your doctor told you and do not stop suddenly.
  • Deltasone (prednisone) can increase your chances of getting an infection. Call your doctor right away if you have a fever, chills, flu-like symptoms, cough, pain with passing urine, or a wound that will not heal.
Learn more
More about MedrolSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Medrol (methylprednisolone)?
Worth itNot sureNot worth it
More about dexamethasoneSide effectsReviews & ratingsFDA package insert
Have you used Decadron (dexamethasone)?
Worth itNot sureNot worth it
More about CortefSide effectsReviews & ratingsFDA package insert
Have you used Cortef (Hydrocortisone)?
Worth itNot sureNot worth it
More about RemicadeSide effectsReviews & ratingsFDA package insert
Have you used Remicade (infliximab)?
Worth itNot sureNot worth it
More about prednisoneSide effectsReviews & ratingsFDA package insert
Have you used Deltasone (prednisone)?
Worth itNot sureNot worth it