Prescription onlyLower-cost generic available

Menest

(Esterified Estrogen)

  • Pill
  • Hot flashes and night sweats
  • Vaginal dryness and inflammation
  • Low estrogen
  • Primary ovarian failure
  • Metastatic breast cancer
  • Advanced prostate cancer
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Treats low estrogen and relieves menopause symptoms.

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Prescription onlyLower-cost generic available

Our pharmacists’ bottom line

Menest (Esterified Estrogen) relieves menopausal symptoms. It's an oral hormone replacement, so it can have a lot of side effects, and it's important to think through the benefits and potential hassles of this drug before using it.

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  • Available as a generic, unlike some oral estrogen alternatives.
  • Menest (Esterified Estrogen) replenishes estrogen to your whole body and relieves multiple symptoms due to low estrogen (hot flashes, night sweats, vaginal dryness).
  • Lowers your risk of fractures by keeping your bones healthy. Make sure you also take enough calcium and Vitamin D.
  • Improves mood, energy, and mental alertness for some people.
  • Does not expose your partner to estrogen during sexual acitivities like vaginal estrogen creams.
  • More potential side effects than estrogen creams since it exposes your whole body to estrogen.
  • Increases your risk of uterine and breast cancer.
  • If you have your uterus, you have to take Menest (Esterified Estrogen) with another hormone called progestin to lower your risk of uterine cancer.
  • Increases your risk of developing blood clots and stroke.
  • Can't be used in people with liver problems.

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Side effects for Menest (Esterified Estrogen)

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These are side effects of Menest (Esterified Estrogen) reported to the FDA by people taking it, and by doctors and pharmacists.

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What to expect when you take Menest (Esterified Estrogen)

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Tips from our pharmacists
  • Take Menest (Esterified Estrogen) with food at the same time each day, following the dosing schedule your doctor gave you.
  • Shouldn't be used forever. Talk to your doctor regularly to see if you still need treatment.
  • Can cause nausea, dizziness, bloating, and breast tenderness.
  • Tell your doctor about any unusual vaginal bleeding.
  • Get emergency care if you notice unexplained swelling and pain in your limbs, shortness of breath, chest pain, severe headache, or changes in vision.

Risks and Warnings for Menest (Esterified Estrogen)

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    • Higher risk if:
    • Using estrogen for more than one year

    Vaginal bleeding after menopause can be a warning sign of uterus (endometrial) cancer, so let your doctor know if you notice any unusual bleeding. When estrogen is prescribed to women after menopause who still have a uterus, progestin should be used with it to lower the risk of cancer. Low-dose vaginal estrogen products are often a better choice than oral pills for women 65 years or older who have vaginal symptoms.

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Tips from pharmacists and people taking Menest (Esterified Estrogen)

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The FDA category for this medication is X. It is advised that you: Unsafe
Pregnancy
Food
  • Tips from our pharmacists
  • Take Menest (Esterified Estrogen) with food at the same time each day, following the dosing schedule your doctor gave you.
Sex
  • Upsides and downsides from our pharmacists
  • Does not expose your partner to estrogen during sexual acitivities like vaginal estrogen creams.