Prescription onlyLower-cost generic availableClass: Women's health

Menest 

(esterified estrogen)

Prescription onlyLower-cost generic availableClass: Women's health
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Treats low estrogen and relieves menopause symptoms.

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Our bottom line

Menest (Esterified Estrogen) relieves menopausal symptoms. It's an oral hormone replacement, so it can have a lot of side effects, and it's important to think through the benefits and potential hassles of this drug before using it.

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Upsides

  • Available as a generic, unlike some oral estrogen alternatives.
  • Menest (Esterified Estrogen) replenishes estrogen to your whole body and relieves multiple symptoms due to low estrogen (hot flashes, night sweats, vaginal dryness).
  • Lowers your risk of fractures by keeping your bones healthy. Make sure you also take enough calcium and Vitamin D.
  • Improves mood, energy, and mental alertness for some people.
  • Does not expose your partner to estrogen during sexual acitivities like vaginal estrogen creams.
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Downsides

  • More potential side effects than estrogen creams since it exposes your whole body to estrogen.
  • Increases your risk of uterine and breast cancer.
  • If you have your uterus, you have to take Menest (Esterified Estrogen) with another hormone called progestin to lower your risk of uterine cancer.
  • Increases your risk of developing blood clots and stroke.
  • Can't be used in people with liver problems.
How it works

Menest (Esterified Estrogen) is an oral medication that replaces estrogen hormones during and after menopause. Higher levels of estrogen lower menopause-related hot flashes, flushing, night sweats, vaginal problems, and bone loss.

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Side effect rates for Menest (esterified estrogen)

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These are side effects of Menest (esterified estrogen) reported to the FDA by people taking it, and by doctors and pharmacists.
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Risks and Warnings for Menest (esterified estrogen)

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    • Higher risk if:
    • Using estrogen for more than one year

    Vaginal bleeding after menopause can be a warning sign of uterus (endometrial) cancer, so let your doctor know if you notice any unusual bleeding. When estrogen is prescribed to women after menopause who still have a uterus, progestin should be used with it to lower the risk of cancer. Low-dose vaginal estrogen products are often a better choice than oral pills for women 65 years or older who have vaginal symptoms.

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Common concerns from people taking Menest (esterified estrogen)

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  • Can cause nausea, dizziness, bloating, and breast tenderness.