Prescription onlyLower-cost generic availableClass: Pain

Methadose 

(methadone)

Prescription onlyLower-cost generic availableClass: Pain
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Treats severe pain and drug dependence.

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Prescription opioids are used to treat several kinds of pain - but they carry significant risks, including addiction. Learn more about these drugs and be sure to discuss the risks with your doctor.

Our bottom line

Methadose (Methadone) works well for moderate to severe pain especially nerve-related and complex pain and is effective for maintenance opioid addiction treatment. You need to be careful with dosing.

Price and discounts
Prices and coupons for 120 (10mg) tablets of methadone

Upsides

  • Relieves pain and treats opioid addiction.
  • Good option for people who don't get pain relief with more-common opioids, have side effects or allergies with other options, or have nerve pain (neuropathic pain).
  • Even low doses are more effective than placebo at treating shooting, burning pain.
  • Less constipating than other opioid medicines to treat pain.
  • Available as a generic medicine.

Downsides

  • Need to use it “around-the-clock for pain control not “as needed”.
  • Even one dose is too much for child or pet and is a medical emergency so store out of their reach.
  • Can cause slowed breathing, coma and death from overdose, especially if you mix with other nervous system depressants.
  • Has a higher risk of affecting heart rate control especially if you have cardiovascular disease (previous heart attack, stroke, fast/uncontrolled heart rate, or irregular heart beat).
  • Can reduce your ability to focus, think, and react so avoid activities that require you to be alert, such as driving a car or operating machinery, until you know how this medicine affects you.
  • Not safe to take if you're pregnant or breast-feeding and can increase the risk of neonatal withdrawal syndrome in women with a history of long-term opioid use.
  • May cause you to become tolerant (more medicine is needed to treat the same pain) and physically dependent if you’ve used it for a while so don’t stop talking it suddenly or you may feel withdrawal symptoms.
  • Can cause your blood pressure drop suddenly if you change positions quickly.
  • Certain prescription and over-the-counter medicines can change the amount of medicine in your body and cause either overdose or withdrawal.
How it works

Methadose (Methadone) is an opioid medicine (similar to morphine) that works in the brain to lower pain perception. Because withdrawal from Methadose (Methadone) is slower, takes longer, and is less severe than other opioids, it's used under the care of a doctor to treat opioid addiction.

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Side effect rates for Methadose (methadone)

Risks and Warnings for Methadose (methadone)

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    • Higher risk if:
    • Start of treatment
    • Age 65 or greater
    • Dose changes and higher doses
    • People with not enough thyroid hormones
    • History of lung problems

    Taking too much Methadose (Methadone) can cause irregular or slow breathing that can put you in a coma and can cause death. Serious breathing effects can happen after pain relief but may last longer. If your lips and fingers start turning blue from low oxygen, see a doctor immediately. In the hospital, doctors can give you a medicine that reverses the effects of Methadose (Methadone). Don't take more than your doctor prescribes.

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Common concerns from people taking Methadose (methadone)

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Pregnancy
Alcohol
  • Don't mix with alcohol or other sedating drugs.
Food
  • Some medicines can affect enzymes that break down Methadose (Methadone). Certain drugs to treat infections, HIV, and seizures can change the amount of Methadose (Methadone) in the body and cause either overdose or withdrawal. Tell your doctor about any prescription or over-the-counter medications you are taking.
Pain
  • Relieves pain and treats opioid addiction.
  • Need to use it “around-the-clock for pain control not “as needed”.
  • May cause you to become tolerant (more medicine is needed to treat the same pain) and physically dependent if you’ve used it for a while so don’t stop talking it suddenly or you may feel withdrawal symptoms.