Otrexup

(methotrexate)

Skip to: what to expect sectionSkip to: side effects sectionSkip to: risks and warnings sectionSkip to: common concerns from users and pharmacists

Reduces inflammation and cell replication.

Skip Upsides & Downsides section. Skip to side effects section.

Our bottom line

Otrexup (methotrexate) is the first-choice treatment for many types of cancer and arthritis, but it has many side effects.

Quick facts about methotrexate
  • Drug class: Autoimmune
  • Rx status: Prescription only
  • Generic status: Lower-cost generic available (methotrexate)
Prices and discounts
Lowest price for 24 2.5mg tablets
Determining your location...
$31.32
  • Price before coupon
    $48.01
  • Lowest price with coupon
    $31.32
  • Savings
    35%

Upsides

  • Otrexup (methotrexate) is available as an affordable generic form.
  • Otrexup (methotrexate) comes as a tablet, an injection that you give yourself, or an infusion that you get in the doctor's office or infusion center.

Get the newsletter!

Sign up and get Pill Talk, the latest in health & medicine news from Iodine

Get our free fact sheet

What to expect from methotrexate, on one page

Download Fact Sheet
Tried methotrexate? Write a review!

Downsides

  • You may need frequent blood tests for monitoring when taking Otrexup (methotrexate).
  • Otrexup (methotrexate) can cause serious birth defects so women should avoid getting pregnant for at least 6 month and men 3 months after taking it.
  • While on Otrexup (methotrexate), you should avoid alcohol and staying out in the sun for too long.

Get the newsletter!

Sign up and get Pill Talk, the latest in health & medicine news from Iodine

Get our free fact sheet

What to expect from methotrexate, on one page

Download Fact Sheet
Prices and discounts
Lowest price for 24 2.5mg tablets
Determining your location...
$31.32
  • Price before coupon
    $48.01
  • Lowest price with coupon
    $31.32
  • Savings
    35%
How it works

Otrexup (methotrexate) blocks the growth of new cancer cells and reduces inflammation.

Quick facts about methotrexate
  • Drug class: Autoimmune
  • Rx status: Prescription only
  • Generic status: Lower-cost generic available (methotrexate)

Used for

Dosage forms

  • Pill
  • Injection
  • Liquid
Tried methotrexate? Write a review!

What to expect when you take Otrexup (methotrexate) for Psoriasis

Skip what to expect section. Skip to side effects section.
Skip side effects section. Skip to risks and warnings section.

Side effect rates for Otrexup (methotrexate)

Risks and Warnings for Otrexup (methotrexate)

Skip risks section. Skip to common concerns section.
  • Otrexup (methotrexate) affects your bone marrow and causes irregularities in the production of new blood cells. If you're taking Otrexup (methotrexate), you’ll need to have your blood drawn regularly to monitor for any side effects.

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Common concerns from people taking Otrexup (methotrexate)

Final section. Do you want to return to drug navigation?
Interactions
  • Can interfere with how other medicines work. Make sure you tell your doctor all of the medicines you take, including over-the-counter medicines and supplements.
Alcohol
  • While on Otrexup (methotrexate), you should avoid alcohol and staying out in the sun for too long.
Kidneys and liver
  • If you have kidney disease, fluid in the abdomen or other conditions that affect how your body clears Otrexup (methotrexate) from your system, you may be at higher risk for having harmful side effects. Your doctor will monitor your symptoms and blood tests very closely while on Otrexup (methotrexate).
Pain
  • Call your doctor immediately if you develop diarrhea or mouth sores. This could be a toxic reaction to Otrexup (methotrexate) and your doctor will need to stop the medication or prescribe an antidote.
Sleep
  • Reviewed methotrexateon 4/8/2017Take before bed to sleep through most side effects. Took for 6 months with not much relief and lots of hair loss. Even with adding folic acid daily.
    33
    Woman
    A few months
    Rheumatoid arthritis (severe)