Prescription onlyLower-cost generic availableClass: Autoimmune

Otrexup

(methotrexate)

Prescription onlyLower-cost generic availableClass: Autoimmune
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Treats cancer and changes how your immune system works.

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Our bottom line

Otrexup (Methotrexate) is a first line treatment for many autoimmune diseases and types of cancer. If you're taking it for a long time, you'll have to get routine blood tests.

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$31.32

Upsides

  • Recommended as first line treatment for rheumatoid arthritis.
  • Available as a generic medication. Comes as a tablet, an injection that you give yourself weekly, and as an infusion that you get in your doctor's office or at an infusion center.
  • If you accidentally take too much, there's an antidote to help your body recover.
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Downsides

  • You have to be on birth control for at least 2 to 3 months after you finish Otrexup (Methotrexate) since it can cause birth defects.
  • You have to avoid alcohol and being in the sun too long.
  • You'll have to get blood tests done if you're taking this long-term because it can cause harmful side effects.
Prices and discounts
Lowest price for 24 2.5mg tablets
Determining your location...
$31.32
How it works

Otrexup (Methotrexate) is an anti-cancer and immunosuppressive medication that treats forms of cancer, arthritis, and psoriasis. For cancer, it helps your body destroy cancer cells by blocking building blocks that cancer cells need to grow. For rheumatoid arthritis and psoriasis, it lowers the body's normal immune response and prevents the body from attacking itself.

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Used for
Dosage forms
  • Pill
  • Injection

What to expect when you take Otrexup (methotrexate) for Cancer

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Side effect rates for Otrexup (methotrexate)

  • Elevated liver function tests
  • Gastrointestinal reactions (e.g., nausea, vomiting, diarrhea)
  • Mouth and lip swelling
  • Low white blood cells

Risks and Warnings for Otrexup (methotrexate)

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    • Higher risk if:
    • Women of childbearing age
    • Men of childbearing potential

    Talk to your doctor if you are planning to have a baby or are pregnant. Otrexup (Methotrexate) can cause birth defects, including death. You or your partner will need to be on birth control for at least 2 to 3 months after you finish Otrexup (Methotrexate) to lower this risk.

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Common concerns from people taking Otrexup (methotrexate)

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Pregnancy
Alcohol
  • Don't use alcohol, NSAIDs (anti-inflammatory medications), or stay in the sun too long.
  • You have to avoid alcohol and being in the sun too long.
Sleep
  • Take before bed to sleep through most side effects. Took for 6 months with not much relief and lots of hair loss. Even with adding folic acid daily.