Prescription onlyLower-cost generic availableClass: Autoimmune

OtrexupAlternatives

(methotrexate)

Prescription onlyLower-cost generic availableClass: Autoimmune
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Compare Otrexup (methotrexate) to alternatives

These medications are comparable to Otrexup (methotrexate) or used for similar purposes.

Otrexup
(methotrexate)

Enbrel
(etanercept)

Neoral
(cyclosporine)

Humira
(adalimumab)

Remicade
(infliximab)

Stelara
(ustekinumab)

Treats cancer and changes how your immune system works. Otrexup (Methotrexate) is a first line treatment for many autoimmune diseases and types of cancer. If you're taking it for a long time, you'll have to get routine blood tests.Calms down your immune system. Enbrel (Etanercept) is very effective at calming down your immune system, but it's expensive, you have to take into account the hassle of injections and traveling with the medication.Coming soon.Calms down the immune system. Humira (adalimumab) is good for treating many autoimmune conditions, but it can also cause serious side effects.Calms down your immune system. Remicade (Infliximab) is very effective at calming down your immune system, but you have to get each dose at your doctor's office and watch out for serious side effects.Treats moderate to severe psoriasis. Stelara (Ustekinumab) works for two psoriatic conditions. It may be somewhat of a hassle because of the injection, but after the first two doses, you only need to take it every 12 weeks.
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Reviews & ratings
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Not enough reviews for this drug. Help someone out, leave a review!

Have you used Otrexup (methotrexate)?
Worth itNot sureNot worth it
Reviews for Enbrel (etanercept)
62%
-13% worse vs. Otrexup (methotrexate)
53%
+3% better vs. Otrexup (methotrexate)
17%
-17% worse vs. Otrexup (methotrexate)
Have you used Enbrel (etanercept)?
Worth itNot sureNot worth it

Not enough reviews for this drug. Help someone out, leave a review!

Have you used Neoral (cyclosporine)?
Worth itNot sureNot worth it
Reviews for Humira (adalimumab)
60%
-15% worse vs. Otrexup (methotrexate)
51%
+1% better vs. Otrexup (methotrexate)
26%
-26% worse vs. Otrexup (methotrexate)
182 reviews
Have you used Humira (adalimumab)?
Worth itNot sureNot worth it
Reviews for Remicade (infliximab)
76%
+1% better vs. Otrexup (methotrexate)
62%
+12% better vs. Otrexup (methotrexate)
15%
-15% worse vs. Otrexup (methotrexate)
Have you used Remicade (infliximab)?
Worth itNot sureNot worth it
Reviews for Stelara (ustekinumab)
48%
-27% worse vs. Otrexup (methotrexate)
42%
-8% worse vs. Otrexup (methotrexate)
20%
-20% worse vs. Otrexup (methotrexate)
Have you used Stelara (ustekinumab)?
Worth itNot sureNot worth it
Side effects
MethotrexateEnbrelCyclosporineHumiraRemicadeStelara
  • Elevated liver function tests 15%
  • Nausea/vomiting 10%
  • Mouth and lip swelling 10%
  • Thrombocytopenia 10%
  • Rash/pruritus/dermatitis 3%
  • Diarrhea 3%
  • Hair loss or baldness 3%
  • Low white blood cells 3%
  • Low blood cell count 3%
  • Dizziness 3%
More Methotrexate side effects »
  • Positive anti-double-stranded dna antibodies 11%
  • Antibodies to etanercept 6%
  • Crithidia luciliae 3%
  • Anticardiolipin 3%
  • Mild or moderate skin reactions 15%
  • Any infection 11%
  • Upper respiratory infections 8%
  • Injection site reactions 26%
  • Non-upper respiratory infections 6%
  • Positive ana 6%
More Enbrel side effects »

We haven’t found good data for Cyclosporine side effects.

FDA side effect reports for Cyclosporine »
  • Upper airway infection 4%
  • Rash 6%
  • Headache 4%
  • Sinus infection 2%
  • Nausea 1%
  • Injection site reactions 7%
  • Urinary tract infection 3%
  • Flu syndrome 1%
  • Stomach pain 3%
  • High cholesterol 2%
More Humira side effects »
  • Infections 11%
  • Infusion reaction 13%
More Remicade side effects »
  • Headache 2%
  • Fatigue 1%
  • Itching 1%
  • Back pain 1%
  • Dizziness 1%
  • Throat pain 1%
  • Injection site erythema 2%
More Stelara side effects »
How it works
MethotrexateEnbrelCyclosporineHumiraRemicadeStelara
Otrexup (Methotrexate) is an anti-cancer and immunosuppressive medication that treats forms of cancer, arthritis, and psoriasis. For cancer, it helps your body destroy cancer cells by blocking building blocks that cancer cells need to grow. For rheumatoid arthritis and psoriasis, it lowers the body's normal immune response and prevents the body from attacking itself.Enbrel (Etanercept) is a biologic response modifier. It works in the immune system to block a protein called TNF (tumor necrosis factor). Blocking TNF relieves symptoms and prevents disease progression.Coming soon.Humira (adalimumab) is a TNF blocker which stops inflammation.Remicade (Infliximab) is a biologic response modifier. It works in the immune system to block a protein called TNF (tumor necrosis factor). Blocking TNF relieves symptoms and prevents disease progression.Stelara (Ustekinumab) is a biologic response modifier, or biologic. It blocks two immune system proteins called IL-12 and IL-23. This slows down new skin cell formation, and lowers inflammation for people with psoriasis or psoriatic arthritis.
Type of medication
MethotrexateEnbrelCyclosporineHumiraRemicadeStelara
Prescription only
Prescription only
Prescription only
Prescription only
Prescription only
Available as
MethotrexateEnbrelCyclosporineHumiraRemicadeStelara
  • Pill
  • Injection
  • Injection
  • Pill
  • Liquid
  • Injection
  • Injection
  • Injection
Used for
MethotrexateEnbrelCyclosporineHumiraRemicadeStelara
  • Cardiac Transplant Rejection Prophylaxis Liver Transplant Rejection Prophylaxis Plaque Psoriasis Severe
Risk factors for serious side effects
MethotrexateEnbrelCyclosporineHumiraRemicadeStelara
  • Women of childbearing age
  • Men of childbearing potential
    • Reduced kidney function
    • fluid in the abdomen (ascites)
    • fluid in the lungs (pleural effusion)
    • Long-term use
    • Psoriasis
      • Taking Otrexup (Methotrexate) with high-dose NSAIDs
        • Taking Otrexup (Methotrexate) to treat cancer
        • Rapidly growing tumors
        Detailed Otrexup (methotrexate) risks & warnings »
          • History of heart failure
          • Taking other immunosuppressant drugs
          • Age 60 or older
          • Taking other immunosuppressant drugs
          • History of malignancy
          • History of neurologic condition
            Detailed Enbrel (etanercept) risks & warnings »
            Coming soon.
            • Taking other immunosuppressant medications such as Kineret or Orencia
            • Age 65 or older
            • Active, chronic, or recurrent infection
            • Comorbidities
            • Taking other immunosuppressant medications, such as azathiprine or 6-mercaptopurine, at the same time as Humira (adalimumab)
            • History of malignancy
            • Adolescent age
            • COPD with significant smoking history
              • History of heart failure
              • Preexisting or recently acquired neurologic condition
                Detailed Humira (adalimumab) risks & warnings »
                  • History of heart failure
                  • Taking other immunosuppressant drugs
                  • Age 60 or older
                  • Taking other immunosuppressant drugs
                  • History of malignancy
                  • History of neurologic condition
                      Detailed Remicade (infliximab) risks & warnings »
                      • Taking other immunosuppressant drugs
                      • Age 60 or older
                      • Weak immune system
                          • Age 60 or older
                          • Long-term use of drugs that suppress the immune system
                          • History of PUVA (photochemotherapy)
                          • Preeclampsia/eclampsia
                          • Acute hypertension
                          • Taking other drugs that suppress the immune system
                          • Taking cytotoxic chemotherapy
                              Detailed Stelara (ustekinumab) risks & warnings »
                              Pregnancy

                              Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

                              Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

                              Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

                              Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

                              Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

                              Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

                              Interactions
                              MethotrexateEnbrelCyclosporineHumiraRemicadeStelara
                              No interactions related info.No interactions related info.No interactions related info.No interactions related info.No interactions related info.
                              • There are certain medicines that interact with Stelara (Ustekinumab) or will need the dose adjusted, especially if they are "narrow" therapy medicines like warfarin,
                              Alcohol
                              MethotrexateEnbrelCyclosporineHumiraRemicadeStelara
                              • You have to avoid alcohol and being in the sun too long.
                              • Don't use alcohol, NSAIDs (anti-inflammatory medications), or stay in the sun too long.
                              No alcohol related info.No alcohol related info.No alcohol related info.No alcohol related info.No alcohol related info.
                              Weight
                              MethotrexateEnbrelCyclosporineHumiraRemicadeStelara
                              No weight related info.No weight related info.No weight related info.No weight related info.
                              • Although rare, Remicade (Infliximab) can cause serious liver injury. You'll need to have your liver enzymes tested regularly. If liver enzymes are significantly elevated and you have appetite/weight loss, stomach discomfort, vomiting, and notice dark urine, yellowing of skin/eyes, change in stool color, and skin rash you should stop treatment with Remicade (Infliximab) until you can be completely assessed,
                              No weight related info.
                              Upsides and benefits
                              MethotrexateEnbrelCyclosporineHumiraRemicadeStelara
                              • Recommended as first line treatment for rheumatoid arthritis.
                              • Available as a generic medication. Comes as a tablet, an injection that you give yourself weekly, and as an infusion that you get in your doctor's office or at an infusion center.
                              • If you accidentally take too much, there's an antidote to help your body recover.
                              • Treats certain types of arthritis conditions caused by an overactive immune system.
                              • Enbrel is the first biologic approved for moderate to severe rheumatoid arthritis.
                              • It has an established safety profile for treatment of rheumatoid arthritis (RA).
                              • Available as a single-use syringe and SureClick auto-injector pen which may be more convenient and easier for some people to use.
                              • People taking Enbrel for rheumatoid arthritis showed significant improvement and were able to reduce the dose or stop immunosuppressant medicines.
                              Coming soon
                              • Humira (adalimumab) is effective in reducing symptoms in all of its approved indications.
                              • You can give yourself Humira (adalimumab) on your own at home rather than visiting a clinic or hospital.
                              • Humira (adalimumab) treats many different autoimmune conditions.
                              • Available in a single-use pen (Humira Pen) that may be more convenient and easier for some people to use.
                              • Treats certain types of arthritis and gastrointestinal conditions caused by an overactive immune system.
                              • Remicade has almost two decades of clinical trial data and real-life experience with millions of people who have used it.
                              • Initial dosing to introduce Remicade to your body might be a hassle, but then you only need to take it every 6-8 weeks depending on your condition.
                              • Stelara (Ustekinumab) works throughout your whole body (systemic therapy) and may be better than just applying medicine to your skin (local therapy) for moderate or severe plaque psoriasis that covers large areas or many areas of your body.
                              • It's used alone or together with another medicine called methotrexate for better results to treat active psoriatic arthritis.
                              • Initial dosing might be a hassle, but then you only have to take it every 12 weeks.
                              • People treated with Stelara (Ustekinumab) for psoriatic arthritis felt better and had more physical improvement compared to not using the medicine (placebo).
                              Downsides and risks
                              MethotrexateEnbrelCyclosporineHumiraRemicadeStelara
                              • You have to be on birth control for at least 2 to 3 months after you finish Otrexup (Methotrexate) since it can cause birth defects.
                              • You have to avoid alcohol and being in the sun too long.
                              • You'll have to get blood tests done if you're taking this long-term because it can cause harmful side effects.
                              • It's an injection.
                              • It's expensive because there's no generic available yet.
                              • Enbrel lowers your ability to fight infection and can cause serious life-threatening illness. The risk is greater if you take other drugs that lower your immune system, have an active infection, diabetes, or had tuberculosis (TB) in the past.
                              • You're first dose of Enbrel will need to be given at your doctor's office. If you decide not to self-inject and don't have someone to do it for you, you'll need to continue to see your doctor for each dose.
                              • You'll need to properly dispose of the needle, syringes, or Pen in a special (FDA-approved) sharps container.
                              • Because it needs to be refrigerated until you use it, if you're traveling, you'll need to carry it in a cooler with an ice pack.
                              Coming soon
                              • Not first-choice treatment for rheumatoid arthritis.
                              • Humira (adalimumab) is an injection and not an oral medication.
                              • Humira (adalimumab) is expensive because there's no generic available yet.
                              • Humira (adalimumab) lowers your ability to fight infection and in some cases can cause serious life-threatening illness. The risk is greater if you take other drugs that lower your immune system, have an active infection, diabetes, or had tuberculosis (TB) in the past.
                              • You'll need to properly dispose of the needle, syringes, or Pen in a sharps container.
                              • Humira (adalimumab) needs to be refrigerated until you use it, so if you're traveling, you'll need to carry it in a cooler with an ice pack.
                              • You have to get every dose through an IV infusion at your doctor's office.
                              • It's expensive because there's no generic available yet.
                              • Remicade has a higher risk of serious infusion-related side effects during or after it's given since it's injected right into your veins. Your doctor can prescribe medication before your dose that may lower this risk.
                              • Remicade lowers your ability to fight infection and can cause serious life-threatening illness. The risk is greater if you take other drugs that lower your immune system, have an active infection, diabetes, or had tuberculosis (TB) in the past.
                              • Not the best choice if you have heart failure.
                              • Talk to your baby's doctor if you're pregnant or breast-feeding. When women in a study took Remicade (Infliximab), the medicine was found in their breast milk 2 to 3 days after each dose, and in the baby's blood 6 months after they were born.
                              • It's an injection.
                              • Stelara (Ustekinumab) lowers your ability to fight infection and can cause serious life-threatening illness. The risk is greater if you take other drugs that lower your immune system, have an active infection, diabetes, or had tuberculosis (TB) in the past.
                              • You have to get your first dose of Stelara (Ustekinumab) at your doctor's office. If you decide not to self-inject and don't have someone to do it for you, you'll need to continue to see your doctor for each dose.
                              • You'll need to properly dispose of the needle and syringes in a special (FDA-approved) sharps container.
                              • Because Stelara (Ustekinumab) needs to be refrigerated until you use it, if you're traveling, you'll need to carry it in a cooler with an ice pack.
                              Tips from our pharmacists for people taking the medication
                              MethotrexateEnbrelCyclosporineHumiraRemicadeStelara
                              • Don't use alcohol, NSAIDs (anti-inflammatory medications), or stay in the sun too long.
                              • Use birth control and avoid pregnancy for at least 2 months (for women) and 3 months (for men) after you finish Otrexup (Methotrexate).
                              • Drink plenty of liquids to stay hydrated while taking this.
                              • Take the medication exactly as your doctor or pharmacist tells you. Call your doctor or pharmacist if you're confused.
                              • Enbrel (Etanercept) is available as a single-use prefilled syringe, single-use prefilled SureClick Autoinjector, and multiple-use vial. You and your doctor can discuss which is best for you.
                              • The autoinjector can be stored at room temperature for up to 14 days and can't be refrigerated again.
                              • Enbrel (Etanercept) is a medication that's injected under the skin (subcutaneous). Your doctor can give you your first dose, then let you self-inject it once so you learn how to do it correctly.
                              • Enbrel (Etanercept) lowers the your immune system's ability to fight infections, so it's important to let your doctor know if you come down with a fever, cough, or notice flu-like symptoms.
                              • You'll need to have a TB test before you start using Enbrel (Etanercept).
                              • Tell your doctor if you have an allergy to latex since the syringe needle cover has latex in it.
                              • Don't inject Enbrel (Etanercept) into skin that's red, bruised, or irritated. Rotate your injection areas to avoid skin reactions.
                              • As with all injection medicines, store away from children and throw used syringes away in a protective container, and not in the trash.
                              Coming soon
                              • Humira (adalimumab) is a medication that's injected under the skin. Your doctor can give you your first dose, then you can inject yourself at home once you feel comfortable doing so on your own.
                              • Humira (adalimumab) lowers your ability to fight infections, so it's important to let your doctor know if you have a fever, cough, or flu-like symptoms.
                              • Tell your doctor if you have an allergy to latex since the syringe needle cover has latex in it.
                              • Each time you use Humira (adalimumab), it's important to rotate the sites you chose to inject it in. Don't inject Humira (adalimumab) into skin that's red, bruised, or irritated.
                              • As with all injection medicines, store securely away from children and throw away used syringes in an FDA-approved sharps disposal container, and not in the trash.
                              • Remicade (Infliximab) is a medication that's given as an infusion at your doctor's office or clinic.
                              • It's very important to read the patient Medication Guide when you first start using Remicade (Infliximab).
                              • It's possible to get an allergic reaction to Remicade (Infliximab) either immediately during the treatment or a several days after stopping it. Your doctor can give you medicines that'll lower this risk.
                              • You'll need to have a TB test before you start taking Remicade (Infliximab) and periodically during treatment.
                              • Remicade (Infliximab) lowers your immune system's ability to fight infections, so it's important to let your doctor know if you notice a fever, cough, or flu-like symptoms. Children seem to get more infections than adults, so keep a close eye on them.
                              • If you have a young child, let their doctor know if you were on Remicade (Infliximab) while pregnant or nursing. It can increase their risk of infections for several months after your last dose and can delay their vaccine schedule.
                              • Stelara (Ustekinumab) is an immunosuppressant medication that's injected under the skin (subcutaneous).
                              • Your doctor will give your first dose then let you self-inject once you learn how to do it correctly.
                              • It's very important you read the Medication Guide especially if you're giving yourself injections.
                              • Usual dosing to build up the medicine in your body is a starting dose, then 4 weeks, then 12 weeks. Maintenance dosing is every 12 weeks.
                              • You'll need to have a TB test before you start injecting Stelara (Ustekinumab).
                              • Tell your doctor if you have an allergy to latex. The prefilled syringe needle cover contains a latex product.
                              • Don't use/inject if the medicine contains any particles or is discolored.
                              • Rotate your injection areas using front of the thigh, outer area of upper arms or lower part of your belly (not around belly button). Don't inject into skin that's red, bruised or irritated.
                              • Stelara (Ustekinumab) can increase your risk of common infections, reactivate infections hidden in your body, and in some people, cause rare infections.
                              • Serious and life-threatening nervous system and allergic reactions can happen immediately, days or months after starting Stelara (Ustekinumab). Stelara (Ustekinumab) can increase your risk of certain skin cancer.
                              • Dispose of used syringes in a protective (Sharps) container. DON'T throw in the trash.
                              • Don't get any live vaccines while you're taking Stelara (Ustekinumab). If you need to get a vaccine, ask your doctor first.
                              Learn more
                              More about MethotrexateSide effectsReviews & ratingsAlternativesFDA package insert
                              Have you used Otrexup (methotrexate)?
                              Worth itNot sureNot worth it
                              More about EnbrelSide effectsReviews & ratingsFDA package insert
                              Have you used Enbrel (etanercept)?
                              Worth itNot sureNot worth it
                              More about CyclosporineSide effectsReviews & ratingsFDA package insert
                              Have you used Neoral (cyclosporine)?
                              Worth itNot sureNot worth it
                              More about HumiraSide effectsReviews & ratingsFDA package insert
                              Have you used Humira (adalimumab)?
                              Worth itNot sureNot worth it
                              More about RemicadeSide effectsReviews & ratingsFDA package insert
                              Have you used Remicade (infliximab)?
                              Worth itNot sureNot worth it
                              More about StelaraSide effectsReviews & ratingsFDA package insert
                              Have you used Stelara (ustekinumab)?
                              Worth itNot sureNot worth it