Prescription onlyLower-cost generic available

Otrexup Alternatives

(Methotrexate)

Back to: Full Site Navigation

Compare Otrexup (Methotrexate) to alternatives

These medications are comparable to Otrexup (Methotrexate) or used for similar purposes.

Otrexup
(Methotrexate)

Enbrel
(Etanercept)

Neoral
(Cyclosporine)

Humira
(Adalimumab)

Remicade
(Infliximab)

Stelara
(Ustekinumab)

Treats cancer and changes how your immune system works. Otrexup (Methotrexate) is a first line treatment for many autoimmune diseases and types of cancer. If you're taking it for a long time, you'll have to get routine blood tests.Calms down your immune system. Enbrel (Etanercept) is very effective at calming down your immune system, but it's expensive, you have to take into account the hassle of injections and traveling with the medication.Coming soon.Calms down your immune system. Humira (Adalimumab) is very effective at calming down your immune system, but it's expensive, you have to take into account the hassle of injections and traveling with the medication.Calms down your immune system. Remicade (Infliximab) is very effective at calming down your immune system, but you have to get each dose at your doctor's office and watch out for serious side effects.Treats moderate to severe psoriasis. Stelara (Ustekinumab) works for two psoriatic conditions. It may be somewhat of a hassle because of the injection, but after the first two doses, you only need to take it every 12 weeks.
Find lowest prices
Powered by GoodRxSave on your next prescription. Be sure you’re getting the lowest price for your medication, even if you have insurance.
Loading pricing data...
Loading pricing data...
Loading pricing data...
Loading pricing data...
Loading pricing data...
Reviews & ratings
Button Group. All currently active
Button Group. All currently active

Not enough reviews for this drug. Help someone out, leave a review!

Reviews for Enbrel (Etanercept)
58%
+8% vs. Otrexup (Methotrexate)
52%
+10% vs. Otrexup (Methotrexate)
19%
2% vs. Otrexup (Methotrexate)

Not enough reviews for this drug. Help someone out, leave a review!

Reviews for Humira (Adalimumab)
59%
+9% vs. Otrexup (Methotrexate)
49%
+7% vs. Otrexup (Methotrexate)
26%
9% vs. Otrexup (Methotrexate)
Reviews for Remicade (Infliximab)
77%
+27% vs. Otrexup (Methotrexate)
65%
+23% vs. Otrexup (Methotrexate)
13%
+4% vs. Otrexup (Methotrexate)
Reviews for Stelara (Ustekinumab)
43%
7% vs. Otrexup (Methotrexate)
39%
3% vs. Otrexup (Methotrexate)
22%
5% vs. Otrexup (Methotrexate)
Side effects
MethotrexateEnbrelCyclosporineHumiraRemicadeStelara

The Methotrexate FDA package insert doesn’t have numbers about how common side effects are.

More about Methotrexate side effects »
  • Injection site reactions 26%
  • Any infection 11%
  • Positive anti-double-stranded dna antibodies 11%
  • Upper respiratory infections 8%
  • Non-upper respiratory infections 6%
  • Positive ana 6%
  • Itching 1%
  • Rash 1%
More Enbrel side effects »

We haven’t found good data for Cyclosporine side effects.

FDA side effect reports for Cyclosporine »
  • Injection site reactions 6%
  • Rash 6%
  • Positive titers 5%
  • Upper respiratory infection 4%
  • Headache 4%
  • Abdominal pain 3%
  • Urinary tract infection 3%
  • High blood pressure 2%
  • Alkaline phosphatase increased 2%
  • High blood lipid levels 2%
More Humira side effects »
  • Infusion reaction 13%
  • Infections 11%
More Remicade side effects »
  • Headache 2%
  • Nausea 2%
  • Joint pain 2%
  • Dizziness 1%
  • Itching 1%
  • Back pain 1%
  • Throat pain 1%
  • Fatigue 1%
More Stelara side effects »
How it works
MethotrexateEnbrelCyclosporineHumiraRemicadeStelara
Otrexup (Methotrexate) is an anti-cancer and immunosuppressive medication that treats forms of cancer, arthritis, and psoriasis. For cancer, it helps your body destroy cancer cells by blocking building blocks that cancer cells need to grow. For rheumatoid arthritis and psoriasis, it lowers the body's normal immune response and prevents the body from attacking itself.Enbrel (Etanercept) is a biologic response modifier. It works in the immune system to block a protein called TNF (tumor necrosis factor). Blocking TNF relieves symptoms and prevents disease progression.Coming soon.Humira (Adalimumab) is a biologic response modifier. It works in the immune system to block a protein called TNF (tumor necrosis factor). Blocking TNF relieves symptoms and prevents disease progression.Remicade (Infliximab) is a biologic response modifier. It works in the immune system to block a protein called TNF (tumor necrosis factor). Blocking TNF relieves symptoms and prevents disease progression.Stelara (Ustekinumab) is a biologic response modifier, or biologic. It blocks two immune system proteins called IL-12 and IL-23. This slows down new skin cell formation, and lowers inflammation for people with psoriasis or psoriatic arthritis.
Type of medication
MethotrexateEnbrelCyclosporineHumiraRemicadeStelara
Immunosuppressant
Immunomodulator
Antirheumatic
Biological response modifier
Anticancer
Antimetabolite
Prescription only
Immunosuppressant
Immunomodulator
Antirheumatic
Biological response modifier
Prescription only
Coming soon.
Immunosuppressant
Immunomodulator
Antirheumatic
Biological response modifier
Prescription only
Immunosuppressant
Immunomodulator
Antirheumatic
Biological response modifier
Prescription only
Immunosuppressant
Immunomodulator
Antipsoriatic
Biological response modifier
Prescription only
Available as
MethotrexateEnbrelCyclosporineHumiraRemicadeStelara
  • Pill
  • Injection
  • Injection
  • Pill
  • Liquid
  • Injection
  • Injection
  • Injection
Used for (click to learn more)
MethotrexateEnbrelCyclosporineHumiraRemicadeStelara
  • Cardiac transplant rejection; Prophylaxis Liver transplant rejection; Prophylaxis Plaque psoriasis (Severe)
Risk factors for serious side effects
MethotrexateEnbrelCyclosporineHumiraRemicadeStelara
  • Women of childbearing age
  • Men of childbearing potential
    • Reduced kidney function
    • fluid in the abdomen (ascites)
    • fluid in the lungs (pleural effusion)
    • Long-term use
    • Psoriasis
      • Taking Otrexup (Methotrexate) with high-dose NSAIDs
        • Taking Otrexup (Methotrexate) to treat cancer
        • Rapidly growing tumors
        Detailed Otrexup (Methotrexate) risks & warnings »
        Coming soon.Coming soon.Coming soon.Coming soon.Coming soon.
        Pregnancy category
        MethotrexateEnbrelCyclosporineHumiraRemicadeStelara
        XFDA pregnancy category (Unsafe)

        Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

        See the FDA package insert
        BFDA pregnancy category (Probably safe)

        Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

        See the FDA package insert
        CFDA pregnancy category (Weigh risks vs. benefits)

        Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

        See the FDA package insert
        BFDA pregnancy category (Probably safe)

        Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

        See the FDA package insert
        BFDA pregnancy category (Probably safe)

        Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

        See the FDA package insert
        BFDA pregnancy category (Probably safe)

        Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

        See the FDA package insert
        Alcohol
        • You have to avoid alcohol and being in the sun too long.
        • Don't use alcohol, NSAIDs (anti-inflammatory medications), or stay in the sun too long.
        No specific alcohol-related info.No specific alcohol-related info.No specific alcohol-related info.No specific alcohol-related info.No specific alcohol-related info.
        Food
        No specific food-related info.No specific food-related info.No specific food-related info.No specific food-related info.No specific food-related info.No specific food-related info.
        Kidneys and liver
        • If you're taking Otrexup (Methotrexate), you’ll need to have your blood checked to avoid toxic effects (blood cells, platelets, liver enzymes, kidney function) and chest X-rays when you start and every 1 to 2 months during treatment. Otrexup (Methotrexate) can also cause malignant lymphoma (cancer of the white blood cells). It can happen when you take low-doses of Otrexup (Methotrexate).
        • You are at higher risk of having toxic symptoms because of too much Otrexup (Methotrexate) in your blood if you have kidney disease, or if you have fluid in the abdomen (ascites) or in the lungs (pleural effusion). Your doctor will monitor your body's reaction to Otrexup (Methotrexate) very closely if they decide you need to be on Otrexup (Methotrexate).
        • Tumor lysis syndrome happens when cancer cells are broken down very quickly and damage the kidneys. The damage can be so bad that people need dialysis. If you're taking Otrexup (Methotrexate) to treat cancer, your doctor can give you medicines and take measures to prevent this reaction.
        No specific kidneys and liver-related info.No specific kidneys and liver-related info.No specific kidneys and liver-related info.No specific kidneys and liver-related info.No specific kidneys and liver-related info.
        Sex
        No specific sex-related info.No specific sex-related info.No specific sex-related info.No specific sex-related info.No specific sex-related info.No specific sex-related info.
        Sleep
        No specific sleep-related info.No specific sleep-related info.No specific sleep-related info.No specific sleep-related info.No specific sleep-related info.No specific sleep-related info.
        Weight
        No specific weight-related info.No specific weight-related info.No specific weight-related info.No specific weight-related info.No specific weight-related info.No specific weight-related info.
        Upsides and benefits
        MethotrexateEnbrelCyclosporineHumiraRemicadeStelara
        • Recommended as first line treatment for rheumatoid arthritis.
        • Available as a generic medication. Comes as a tablet, an injection that you give yourself weekly, and as an infusion that you get in your doctor's office or at an infusion center.
        • If you accidentally take too much, there's an antidote to help your body recover.
        • Treats certain types of arthritis conditions caused by an overactive immune system.
        • Enbrel is the first biologic approved for moderate to severe rheumatoid arthritis.
        • It has an established safety profile for treatment of rheumatoid arthritis (RA).
        • Available as a single-use syringe and SureClick auto-injector pen which may be more convenient and easier for some people to use.
        • People taking Enbrel for rheumatoid arthritis showed significant improvement and were able to reduce the dose or stop immunosuppressant medicines.
        Coming soon.
        • Most people feel it's worth the hassle.
        • Once you've learned the correct way to use Humira, you can inject the medicine yourself without going to your doctor's office.
        • It's available in a single-use pen (Humira Pen) that may be more convenient and easier for some people to use.
        • It's an alternative for people with Crohn's disease who stopped getting better on other TNF-blockers or had side effects that made them switch.
        • Treats certain types of arthritis and gastrointestinal conditions caused by an overactive immune system.
        • Remicade has almost two decades of clinical trial data and real-life experience with millions of people who have used it.
        • Initial dosing to introduce Remicade to your body might be a hassle, but then you only need to take it every 6-8 weeks depending on your condition.
        • Treats certain types of arthritis and gastrointestinal conditions caused by an overactive immune system.
        • Stelara (Ustekinumab) works throughout your whole body (systemic therapy) and may be better than just applying medicine to your skin (local therapy) for moderate or severe plaque psoriasis that covers large areas or many areas of your body.
        • It's used alone or together with another medicine called methotrexate for better results to treat active psoriatic arthritis.
        • Initial dosing might be a hassle, but then you only have to take it every 12 weeks.
        • People treated with Stelara (Ustekinumab) for psoriatic arthritis felt better and had more physical improvement compared to not using the medicine (placebo).
        Downsides and risks
        MethotrexateEnbrelCyclosporineHumiraRemicadeStelara
        • You have to be on birth control for at least 2 to 3 months after you finish Otrexup (Methotrexate) since it can cause birth defects.
        • You have to avoid alcohol and being in the sun too long.
        • You'll have to get blood tests done if you're taking this long-term because it can cause harmful side effects.
        • Enbrel lowers your ability to fight infection and can cause serious life-threatening illness. The risk is greater if you take other drugs that lower your immune system, have an active infection, diabetes, or had tuberculosis (TB) in the past.
        • You're first dose of Enbrel will need to be given at your doctor's office. If you decide not to self-inject and don't have someone to do it for you, you'll need to continue to see your doctor for each dose.
        • You'll need to properly dispose of the needle, syringes, or Pen in a special (FDA-approved) sharps container.
        • It's an injection.
        • It's expensive because there's no generic available yet.
        • Because it needs to be refrigerated until you use it, if you're traveling, you'll need to carry it in a cooler with an ice pack.
        Coming soon.
        • Humira lowers your ability to fight infection and can cause serious life-threatening illness. The risk is greater if you take other drugs that lower your immune system, have an active infection, diabetes, or had tuberculosis (TB) in the past.
        • You're first dose of Humira will need to be given at your doctor's office. If you decide not to self-inject and don't have someone to do it for you, you'll need to continue to see your doctor for each dose.
        • You'll need to properly dispose of the needle, syringes, or Pen in a special (FDA-approved) sharps container.
        • It's an injection.
        • It's expensive because there's no generic available yet.
        • Because it needs to be refrigerated until you use it, if you're traveling, you'll need to carry it in a cooler with an ice pack.
        • You have to get every dose through an IV infusion at your doctor's office.
        • Remicade has a higher risk of serious infusion-related side effects during or after it's given since it's injected right into your veins. Your doctor can prescribe medication before your dose that may lower this risk.
        • Remicade lowers your ability to fight infection and can cause serious life-threatening illness. The risk is greater if you take other drugs that lower your immune system, have an active infection, diabetes, or had tuberculosis (TB) in the past.
        • Not the best choice if you have heart failure.
        • Talk to your baby's doctor if you're pregnant or breast-feeding. When women in a study took Remicade (Infliximab), the medicine was found in their breast milk 2 to 3 days after each dose, and in the baby's blood 6 months after they were born.
        • It's expensive because there's no generic available yet.
        • Stelara (Ustekinumab) lowers your ability to fight infection and can cause serious life-threatening illness. The risk is greater if you take other drugs that lower your immune system, have an active infection, diabetes, or had tuberculosis (TB) in the past.
        • You have to get your first dose of Stelara (Ustekinumab) at your doctor's office. If you decide not to self-inject and don't have someone to do it for you, you'll need to continue to see your doctor for each dose.
        • You'll need to properly dispose of the needle and syringes in a special (FDA-approved) sharps container.
        • Because Stelara (Ustekinumab) needs to be refrigerated until you use it, if you're traveling, you'll need to carry it in a cooler with an ice pack.
        • It's an injection.
        Tips from our pharmacists for people taking the medication
        MethotrexateEnbrelCyclosporineHumiraRemicadeStelara
        • Don't use alcohol, NSAIDs (anti-inflammatory medications), or stay in the sun too long.
        • Use birth control and avoid pregnancy for at least 2 months (for women) and 3 months (for men) after you finish Otrexup (Methotrexate).
        • Drink plenty of liquids to stay hydrated while taking this.
        • Take the medication exactly as your doctor or pharmacist tells you. Call your doctor or pharmacist if you're confused.
        • Enbrel (Etanercept) is available as a single-use prefilled syringe, single-use prefilled SureClick Autoinjector, and multiple-use vial. You and your doctor can discuss which is best for you.
        • The autoinjector can be stored at room temperature for up to 14 days and can't be refrigerated again.
        • Enbrel (Etanercept) is a medication that's injected under the skin (subcutaneous). Your doctor can give you your first dose, then let you self-inject it once so you learn how to do it correctly.
        • Enbrel (Etanercept) lowers the your immune system's ability to fight infections, so it's important to let your doctor know if you come down with a fever, cough, or notice flu-like symptoms.
        • You'll need to have a TB test before you start using Enbrel (Etanercept).
        • Don't inject Enbrel (Etanercept) into skin that's red, bruised, or irritated. Rotate your injection areas to avoid skin reactions.
        • Tell your doctor if you have an allergy to latex since the syringe needle cover has latex in it.
        • As with all injection medicines, store away from children and throw used syringes away in a protective container, and not in the trash.
        Coming soon.
        • Humira (Adalimumab) is a medication that's injected under the skin (subcutaneous). Your doctor can give you your first dose, then let you self-inject it once so you learn how to do it correctly.
        • Humira (Adalimumab) lowers the your immune system's ability to fight infections, so it's important to let your doctor know if you come down with a fever, cough, or notice flu-like symptoms.
        • You'll need to have a TB test before you start using Humira (Adalimumab).
        • Don't inject Humira (Adalimumab) into skin that's red, bruised, or irritated. Rotate your injection areas to avoid skin reactions.
        • Tell your doctor if you have an allergy to latex since the syringe needle cover has latex in it.
        • As with all injection medicines, store away from children and throw used syringes away in a protective container, and not in the trash.
        • Remicade (Infliximab) is a medication that's given as an infusion at your doctor's office or clinic.
        • It's very important to read the patient Medication Guide when you first start using Remicade (Infliximab).
        • It's possible to get an allergic reaction to Remicade (Infliximab) either immediately during the treatment or a several days after stopping it. Your doctor can give you medicines that'll lower this risk.
        • You'll need to have a TB test before you start taking Remicade (Infliximab) and periodically during treatment.
        • Remicade (Infliximab) lowers your immune system's ability to fight infections, so it's important to let your doctor know if you notice a fever, cough, or flu-like symptoms. Children seem to get more infections than adults, so keep a close eye on them.
        • If you have a young child, let their doctor know if you were on Remicade (Infliximab) while pregnant or nursing. It can increase their risk of infections for several months after your last dose and can delay their vaccine schedule.
        • Stelara (Ustekinumab) is an immunosuppressant medication that's injected under the skin (subcutaneous).
        • Your doctor will give your first dose then let you self-inject once you learn how to do it correctly.
        • It's very important you read the Medication Guide especially if you're giving yourself injections.
        • Usual dosing to build up the medicine in your body is a starting dose, then 4 weeks, then 12 weeks. Maintenance dosing is every 12 weeks.
        • You'll need to have a TB test before you start injecting Stelara (Ustekinumab).
        • Tell your doctor if you have an allergy to latex. The prefilled syringe needle cover contains a latex product.
        • Don't use/inject if the medicine contains any particles or is discolored.
        • Rotate your injection areas using front of the thigh, outer area of upper arms or lower part of your belly (not around belly button). Don't inject into skin that's red, bruised or irritated.
        • Stelara (Ustekinumab) can increase your risk of common infections, reactivate infections hidden in your body, and in some people, cause rare infections.
        • Serious and life-threatening nervous system and allergic reactions can happen immediately, days or months after starting Stelara (Ustekinumab). Stelara (Ustekinumab) can increase your risk of certain skin cancer.
        • Dispose of used syringes in a protective (Sharps) container. DON'T throw in the trash.
        • Don't get any live vaccines while you're taking Stelara (Ustekinumab). If you need to get a vaccine, ask your doctor first.
        Learn more
        More about MethotrexateSide effectsReviews & ratingsAlternativesFDA package insert
        More about EnbrelSide effectsReviews & ratingsFDA package insert
        More about CyclosporineSide effectsFDA package insert
        More about HumiraSide effectsReviews & ratingsFDA package insert
        More about RemicadeSide effectsReviews & ratingsFDA package insert
        More about StelaraSide effectsReviews & ratingsFDA package insert