Prescription onlyClass: Women's health


(estradiol patch)

Prescription onlyClass: Women's health
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Relieves hot flashes due to menopause and lowers your risk of osteoporosis.

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Our bottom line

The Minivelle (Estradiol Patch) is the mini-me of estrogen patches. It's used twice a week, available in five strengths, and has the least amount of skin irritation.

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Prices and coupons for 8 (8 patches of 0.1mg) packages of minivelle
What is GoodRx?


  • The [name_comon] is the smallest estrogen patch available. It's the size a dime and comes in 5 different strengths.
  • You’ll need to replace it twice a week, every 3 to 4 days.
  • Causes little or no skin irritation and doesn't leave adhesive on your skin.
  • The Minivelle (Estradiol Patch) replenishes estrogen to your whole body and relieves multiple symptoms due to low estrogen, like hot flashes and vaginal dryness.
  • By using a patch instead of a pill, there's a lower risk of side effects such as blood clots and stroke since lower amounts of estrogen are used in patches.
  • Lowers your risk of fractures by keeping your bones healthy. Make sure you also get enough calcium and Vitamin D.
  • Improves mood, energy, and mental alertness for some people.
People say this drug is:
17 reviews


  • You need to replace the Minivelle (Estradiol Patch) twice a week, compared to other patches that are once a week.
  • Patch can fall off.
  • Increases your risk of uterine and breast cancer.
  • If you have your uterus, you have to use the Minivelle (Estradiol Patch) with another hormone called progestin to lower your risk of uterine cancer.
  • Increases your risk of developing blood clots and stroke.
  • Can worsen other health conditions, like high cholesterol, asthma, diabetes, fluid retention, and migraines.
  • Can't be used in people with liver problems.
How it works

The Minivelle (Estradiol Patch) replaces an estrogen hormone, estradiol, that your body loses during and after menopause. Higher levels of estradiol relieve symptoms of low estrogen and menopause and prevent bone loss.

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Side effect rates for Minivelle (estradiol patch)

289 From clinical trials of Minivelle / Estrogen replacement (0.1 mg/day)
  • Headache
  • Breast tenderness
  • Vaginal bleeding between periods
  • Back pain
  • Flu
  • Common cold
  • Neck pain
  • Ear, nose, or throat infection
  • Sinus congestion
  • Pain

Risks and Warnings for Minivelle (estradiol patch)

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    • Higher risk if:
    • Using estrogen for more than one year

    Vaginal bleeding after menopause can be a warning sign of uterus (endometrial) cancer, so let your doctor know if you notice any unusual bleeding. When estrogen is prescribed to women after menopause who still have a uterus, progestin should be used with it to lower the risk of cancer. Low-dose vaginal estrogen products are often a better choice than oral pills for women 65 years or older who have vaginal symptoms.

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Common concerns from people taking Minivelle (estradiol patch)

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  • Clean skin and then swab it with alcohol. Some patches are stickier than others; simetimes a whole box is drier than usual. Medical tape or a bandaid will keep it in place. Dry skin in winter is less sticky also. I put mine on firm not fatty areas. Get yout thyroid checked. Estrogen is a thyroid antagonist, so if you are on thyroid replacement, you will probably need to up your dose!
  • Can cause nausea, dizziness, bloating, and breast tenderness.