Prescription onlyNo lower cost generic available


(Estradiol Patch)

  • Patch
  • Hot flashes and night sweats
  • Prevention of postmenopausal osteoporosis
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Relieves hot flashes due to menopause and lowers your risk of osteoporosis.

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Prescription onlyNo lower cost generic available

Our pharmacists’ bottom line

The Minivelle (Estradiol Patch) is the mini-me of estrogen patches. It's used twice a week, available in five strengths, and has the least amount of skin irritation.

  • The [name_comon] is the smallest estrogen patch available. It's the size a dime and comes in 5 different strengths.
  • You’ll need to replace it twice a week, every 3 to 4 days.
  • Causes little or no skin irritation and doesn't leave adhesive on your skin.
  • The Minivelle (Estradiol Patch) replenishes estrogen to your whole body and relieves multiple symptoms due to low estrogen, like hot flashes and vaginal dryness.
  • By using a patch instead of a pill, there's a lower risk of side effects such as blood clots and stroke since lower amounts of estrogen are used in patches.
  • Lowers your risk of fractures by keeping your bones healthy. Make sure you also get enough calcium and Vitamin D.
  • Improves mood, energy, and mental alertness for some people.
  • You need to replace the Minivelle (Estradiol Patch) twice a week, compared to other patches that are once a week.
  • Patch can fall off.
  • Increases your risk of uterine and breast cancer.
  • If you have your uterus, you have to use the Minivelle (Estradiol Patch) with another hormone called progestin to lower your risk of uterine cancer.
  • Increases your risk of developing blood clots and stroke.
  • Can worsen other health conditions, like high cholesterol, asthma, diabetes, fluid retention, and migraines.
  • Can't be used in people with liver problems.
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Side effects for Minivelle (Estradiol Patch)

From clinical trials of Minivelle / Estrogen replacement (0.1 mg/day) ( 289)

  • HeadacheHeadache26% for Minivelle patch vs.24% for placebo
  • Breast tendernessBreast tenderness13% for Minivelle patch vs.0% for placebo
  • Vaginal bleeding between periodsVaginal bleeding between periods11% for Minivelle patch vs.5% for placebo
  • Back painBack pain11% for Minivelle patch vs.6% for placebo
  • FluFlu8% for Minivelle patch vs.9% for placebo
  • Common coldCommon cold8% for Minivelle patch vs.15% for placebo
  • Neck painNeck pain5% for Minivelle patch vs.1% for placebo
  • Ear, nose, or throat infectionEar, nose, or throat infection5% for Minivelle patch vs.6% for placebo
  • Sinus congestionSinus congestion5% for Minivelle patch vs.5% for placebo
  • PainPain5% for Minivelle patch vs.5% for placebo

Manufacturers don’t say how common these side effects are

  • High blood pressure
  • Hot flashes
  • Indigestion
  • Weight increased

What to expect when you start Minivelle (Estradiol Patch)

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Tips from our pharmacists
  • Remove the patch by tearing the package by hand and not with scissors. Never cut the patch.
  • Apply the sticky side of the patch to clean, dry, hairless skin below your waistline on areas as instructed by the manufacturer (never on your breast).
  • Replace the patch twice a week (every 3-4 days) on a different area of your skin to lower your risk of skin irritation.
  • Fold together the sticky sides of used patches before throwing them away to avoid exposing others to the medicine. Don't flush them down the toilet.
  • Shouldn't be used forever. Talk to your doctor regularly to see if you still need treatment.
  • Can cause nausea, dizziness, bloating, and breast tenderness.
  • Tell your doctor about any unusual vaginal bleeding.
  • Get emergency care if you notice unexplained swelling and pain in your limbs, shortness of breath, chest pain, severe headache, or changes in vision.

Risks and Warnings for Minivelle (Estradiol Patch)

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    • Higher risk if:
    • Using estrogen for more than one year

    Vaginal bleeding after menopause can be a warning sign of uterus (endometrial) cancer, so let your doctor know if you notice any unusual bleeding. When estrogen is prescribed to women after menopause who still have a uterus, progestin should be used with it to lower the risk of cancer. Low-dose vaginal estrogen products are often a better choice than oral pills for women 65 years or older who have vaginal symptoms.

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Tips from pharmacists and people taking Minivelle (Estradiol Patch)

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The FDA category for this medication is X. It is advised that you: Unsafe