Prescription onlyNo lower cost generic available


(Estradiol Patch)

  • Patch
  • Hot flashes and night sweats
  • Prevention of postmenopausal osteoporosis
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Relieves hot flashes due to menopause and lowers your risk of osteoporosis.

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Prescription onlyNo lower cost generic available

Our bottom line

The Minivelle (Estradiol Patch) is the mini-me of estrogen patches. It's used twice a week, available in five strengths, and has the least amount of skin irritation.


  • The [name_comon] is the smallest estrogen patch available. It's the size a dime and comes in 5 different strengths.
  • You’ll need to replace it twice a week, every 3 to 4 days.
  • Causes little or no skin irritation and doesn't leave adhesive on your skin.
  • The Minivelle (Estradiol Patch) replenishes estrogen to your whole body and relieves multiple symptoms due to low estrogen, like hot flashes and vaginal dryness.
  • By using a patch instead of a pill, there's a lower risk of side effects such as blood clots and stroke since lower amounts of estrogen are used in patches.
  • Lowers your risk of fractures by keeping your bones healthy. Make sure you also get enough calcium and Vitamin D.
  • Improves mood, energy, and mental alertness for some people.


  • You need to replace the Minivelle (Estradiol Patch) twice a week, compared to other patches that are once a week.
  • Patch can fall off.
  • Increases your risk of uterine and breast cancer.
  • If you have your uterus, you have to use the Minivelle (Estradiol Patch) with another hormone called progestin to lower your risk of uterine cancer.
  • Increases your risk of developing blood clots and stroke.
  • Can worsen other health conditions, like high cholesterol, asthma, diabetes, fluid retention, and migraines.
  • Can't be used in people with liver problems.
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What to expect when you take Minivelle (Estradiol Patch)

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Tips from our pharmacists
  • Remove the patch by tearing the package by hand and not with scissors. Never cut the patch.
  • Apply the sticky side of the patch to clean, dry, hairless skin below your waistline on areas as instructed by the manufacturer (never on your breast).
  • Replace the patch twice a week (every 3-4 days) on a different area of your skin to lower your risk of skin irritation.
  • Fold together the sticky sides of used patches before throwing them away to avoid exposing others to the medicine. Don't flush them down the toilet.
  • Shouldn't be used forever. Talk to your doctor regularly to see if you still need treatment.
  • Can cause nausea, dizziness, bloating, and breast tenderness.
  • Tell your doctor about any unusual vaginal bleeding.
  • Get emergency care if you notice unexplained swelling and pain in your limbs, shortness of breath, chest pain, severe headache, or changes in vision.
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Side effects for Minivelle (Estradiol Patch)

From clinical trials of Minivelle / Estrogen replacement (0.1 mg/day)  ( 289)

  • HeadacheHeadache26% for Minivelle patch vs.24% for placebo
  • Breast tendernessBreast tenderness13% for Minivelle patch vs.0% for placebo
  • Vaginal bleeding between periodsVaginal bleeding between periods11% for Minivelle patch vs.5% for placebo
  • Back painBack pain11% for Minivelle patch vs.6% for placebo
  • FluFlu8% for Minivelle patch vs.9% for placebo
  • Common coldCommon cold8% for Minivelle patch vs.15% for placebo
  • Neck painNeck pain5% for Minivelle patch vs.1% for placebo
  • Ear, nose, or throat infectionEar, nose, or throat infection5% for Minivelle patch vs.6% for placebo
  • Sinus congestionSinus congestion5% for Minivelle patch vs.5% for placebo
  • PainPain5% for Minivelle patch vs.5% for placebo

Manufacturers don’t say how common these side effects are

  • High blood pressure
  • Hot flashes
  • Indigestion
  • Weight increased

Risks and Warnings for Minivelle (Estradiol Patch)

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    • Higher risk if:
    • Using estrogen for more than one year

    Vaginal bleeding after menopause can be a warning sign of uterus (endometrial) cancer, so let your doctor know if you notice any unusual bleeding. When estrogen is prescribed to women after menopause who still have a uterus, progestin should be used with it to lower the risk of cancer. Low-dose vaginal estrogen products are often a better choice than oral pills for women 65 years or older who have vaginal symptoms.

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Tips from pharmacists and people taking Minivelle (Estradiol Patch)

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The FDA category for this medication is X. It is advised that you: Unsafe