Over-the-counterLower-cost generic availableClass: Respiratory

Mucinex D

(guaifenesin / pseudoephedrine)

Over-the-counterLower-cost generic availableClass: Respiratory
Back to: Full Site NavigationSkip to: side effects sectionSkip to: What to expect sectionSkip to: Risks and warnings sectionSkip to: Common concerns from users and pharmacists
5.16Mucinex D

Breaks up mucus and relieves congestion.

Skip Upsides & Downsides section. Skip to side effects section.

Our bottom line

Mucinex D (Guaifenesin / Pseudoephedrine) is good if you have a stuffy nose and a cough with mucus, but it could keep you up at night.


  • Mucinex D (Guaifenesin / Pseudoephedrine) is a combination medicine that relieves multiple cold symptoms. It's good to use if you have sinus and chest congestion.
  • Helps loosen the mucus in your airways so that you can cough it up more easily.
  • Works well to clear nasal congestion and help you breathe better.
People’s experience with Mucinex D

1249reviews so far. What do you think?

Worth itNot sureNot worth it


  • Pseudoephedrine, the decongestant in Mucinex D (Guaifenesin / Pseudoephedrine), can make your heart race or make you feel anxious and restless.
  • Doesn't work as well if you use it for more than 4 days at a time.
  • Although you don't need a prescription to get Mucinex D (Guaifenesin / Pseudoephedrine), you need to show a photo ID to buy it in the drugstore.
  • Mucinex D (Guaifenesin / Pseudoephedrine) isn’t useful if you have a dry cough.
How it works

Mucinex D (Guaifenesin / Pseudoephedrine) is a combination medicine. Guaifenesin (an expectorant) breaks up and thins out mucus. Pseudoephedrine (a decongestant) clears your sinuses.

People’s experience with Mucinex D

1249reviews so far. What do you think?

Worth itNot sureNot worth it
Dosage forms
  • Extended release
Skip side effects section. Skip to What to Expect and Pharmacists Tips section.

Side effect rates for Mucinex D (guaifenesin / pseudoephedrine)

0 reports
These are side effects of Mucinex D (guaifenesin / pseudoephedrine) reported to the FDA by people taking it, and by doctors and pharmacists.
Filter group. All currently selected
Filter group. All currently selected

Risks and Warnings for Mucinex D (guaifenesin / pseudoephedrine)

Skip risks section. Skip to common concerns section.
    • Higher risk if:
    • History of high blood pressure

    People taking Mucinex D (Guaifenesin / Pseudoephedrine) and MAO inhibitors together, or up to 14 days apart from each other, can experience very high blood pressure that can cause headaches and strokes. MAOI drugs are used to treat Parkinson's disease, depression, and other emotional conditions. Talk to your doctor or pharmacist if you're taking MAO inhibitors and still want to use a cough medicine.

Common concerns from people taking Mucinex D (guaifenesin / pseudoephedrine)

Final section. Do you want to return to drug navigation?