Class: Endocrine

Nesina Alternatives

(alogliptin)

Class: Endocrine
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Compare Nesina (alogliptin) to alternatives

These medications are comparable to Nesina (alogliptin) or used for similar purposes.

Nesina
(alogliptin)

Januvia
(sitagliptin)

Byetta
(exenatide)

Glucophage
(metformin)

Precose
(acarbose)

Glucotrol
(glipizide)

Actos
(pioglitazone)

Lowers your blood sugar. alogliptin is a good add-on treatment if your blood sugar is still too high, but you don't want to use an injectable medicine.Lowers your blood sugar. Januvia (sitagliptin) is a good add-on treatment if your blood sugars are not controlled and you don't want to use an injectable medicine.Lowers blood sugar. Byetta (Exenatide) can lower your blood sugars in addition to metformin. It does not increase your appetite unlike some other anti-diabetics, but must be given by injection and usually causes upset stomach.Lowers blood sugar. Glucophage (metformin) is the first choice medicine to control your blood sugar and lower the risk of death from diabetes, although a few people may not tolerate the stomach side effects.Coming soon.Lowers blood sugar. Glucotrol (Glipizide) is a very effective oral blood sugar-lowering medicine. It can cause low blood sugar, so make sure you know what the symptoms are and always have a source of sugar nearby.Lowers blood sugar. Actos (Pioglitazone) is a last-choice blood sugar-lowering medicine since it's only moderately effective but has a lot of undesirable side effects.
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Prices and coupon for 30 (25mg) tablets of alogliptin
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Reviews & ratings
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Filter group. All currently selected
Reviews for Nesina (alogliptin)
Not enough review data. Review it!
of people (All ages) say Nesina (alogliptin) is worth it
Not enough review data. Review it!
say it works well
Not enough review data. Review it!
say it's a big hassle
Have you used Nesina (alogliptin)?
Worth itNot sureNot worth it
Reviews for Januvia (sitagliptin)
44%
-56% worse vs. Nesina (alogliptin)
34%
-66% worse vs. Nesina (alogliptin)
17%
-17% worse vs. Nesina (alogliptin)
143 reviews
Have you used Januvia (sitagliptin)?
Worth itNot sureNot worth it
Reviews for Byetta (exenatide)
Not enough review data. Review it!
-50% worse vs. Nesina (alogliptin)
Not enough review data. Review it!
-50% worse vs. Nesina (alogliptin)
Not enough review data. Review it!
Same vs. Nesina (alogliptin)
Have you used Byetta (exenatide)?
Worth itNot sureNot worth it
Reviews for Glucophage (metformin)
65%
-35% worse vs. Nesina (alogliptin)
46%
-54% worse vs. Nesina (alogliptin)
16%
-16% worse vs. Nesina (alogliptin)
938 reviews
Have you used Glucophage (metformin)?
Worth itNot sureNot worth it
Reviews for Precose (acarbose)
Not enough review data. Review it!
Same vs. Nesina (alogliptin)
Not enough review data. Review it!
Same vs. Nesina (alogliptin)
Not enough review data. Review it!
Same vs. Nesina (alogliptin)
Have you used Precose (acarbose)?
Worth itNot sureNot worth it
Reviews for Glucotrol (glipizide)
50%
-50% worse vs. Nesina (alogliptin)
32%
-68% worse vs. Nesina (alogliptin)
19%
-19% worse vs. Nesina (alogliptin)
332 reviews
Have you used Glucotrol (glipizide)?
Worth itNot sureNot worth it
Reviews for Actos (pioglitazone)
42%
-58% worse vs. Nesina (alogliptin)
30%
-70% worse vs. Nesina (alogliptin)
21%
-21% worse vs. Nesina (alogliptin)
175 reviews
Have you used Actos (pioglitazone)?
Worth itNot sureNot worth it
Side effects
NesinaJanuviaByettametforminPrecoseGlucotrolActos

We haven’t found good data for Nesina side effects.

FDA side effect reports for Nesina »
  • Common cold 2%
  • Diarrhea 1%
  • Upper respiratory infection 3%
  • Headache 1%
More Januvia side effects »
  • Low blood sugar 11%
  • Nausea 33%
  • Diarrhea 10%
  • Vomiting 14%
  • Headache 10%
  • Constipation 8%
  • Indigestion 5%
  • Weakness 4%
  • Abdominal swelling 3%
  • Loss of appetite 3%
More Byetta side effects »
  • Diarrhea 41%
  • Nausea/vomiting 18%
  • Gas 6%
  • Weakness 3%
  • Indigestion 3%
  • Stomach pain 1%
  • Headache 1%
More metformin side effects »

We haven’t found good data for Precose side effects.

FDA side effect reports for Precose »
  • Dizziness 1%
  • Diarrhea 5%
  • Nervousness 1%
  • Tremor 4%
  • Passing gas 2%
  • Drowsiness 2%
More Glucotrol side effects »
  • Swelling due to excess fluid 11%
  • Low blood sugar 8%
  • Ear, nose, or throat infection 4%
  • Headache 2%
  • Cardiac failure 2%
  • Back pain 1%
  • Sinus inflammation 1%
  • Muscle pain 2%
More Actos side effects »
How it works
NesinaJanuviaByettametforminPrecoseGlucotrolActos
alogliptin is an anti-diabetic drug. It improves your body's ability to use insulin to lower your blood sugar.Januvia (sitagliptin) is an anti-diabetic drug that enhances your body's release of insulin.Byetta (Exenatide) enhances the release of insulin in your gut and pancreas to lower your blood sugar.Glucophage (metformin) is an anti-diabetic drug. It lowers the amount of sugar your body makes or absorbs, and allows your body use the existing insulin better.Coming soon.Glucotrol (Glipizide) is an anti-diabetic drug. It stimulates your body to make more insulin to lower blood sugar.Actos (Pioglitazone) is an anti-diabetic drug. It improves your body's ability to use insulin to lower your blood sugar.
Type of medication
NesinaJanuviaByettametforminPrecoseGlucotrolActos
Prescription only
Prescription only
Prescription only
Prescription only
Prescription only
Available as
NesinaJanuviaByettametforminPrecoseGlucotrolActos
  • Pill
  • Pill
  • Injection
  • Pill
  • Extended release pill
  • Liquid
  • Pill
  • Pill
  • Extended release
  • Pill
Used for
NesinaJanuviaByettametforminPrecoseGlucotrolActos
  • Diabetes Mellitus Type 2
  • Diabetes Mellitus Type 2
Risk factors for serious side effects
NesinaJanuviaByettametforminPrecoseGlucotrolActos
    Detailed Nesina (alogliptin) risks & warnings »
    • History of pancreatitis
    • High blood triglyceride levels
    • Gallstones (stones in gallbladder)
    • History of alchoholism
    • Kidney problems
    Detailed Januvia (sitagliptin) risks & warnings »
    • Severe renal impairment
    • End-stage renal disease
    • Severe gastrointestinal disease
    • Gastroparesis
    Detailed Byetta (exenatide) risks & warnings »
    • Kidney problems
    • Liver problems
    • Congestive heart failure
    • Using contrast dye for procedures
    • Surgery
    Detailed Glucophage (metformin) risks & warnings »
      Coming soon.
      • Use of other blood sugar lowering medicines
      • Alcohol
      • Intense physical activity
      • History of sulfa allergies
      Detailed Glucotrol (glipizide) risks & warnings »
      • Heart failure diagnosis
      • Current liver problems
      • Female
      Detailed Actos (pioglitazone) risks & warnings »
      Pregnancy

      Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

      Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

      Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      Alcohol
      NesinaJanuviaByettametforminPrecoseGlucotrolActos
      No alcohol related info.No alcohol related info.No alcohol related info.
      • Excessive or chronic alcohol use can increase the risk of a dangerous side effect.
      • Limit or avoid alcohol when taking this medicine.
      No alcohol related info.
      • Avoid drinking alcohol.
      No alcohol related info.
      Food
      NesinaJanuviaByettametforminPrecoseGlucotrolActos
      No food related info.
      • Take once a day in the morning with or without food.
      No food related info.
      • Always take it with food to lessen stomach upset.
      No food related info.
      • Food can cause unpredictable effects of the immediate-release version of Glipizide, so you have to take it at least 30 minutes before a meal.
      • Eat regular, balanced meals to avoid low blood sugar.
      No food related info.
      Kidneys and liver
      NesinaJanuviaByettametforminPrecoseGlucotrolActos
      No kidneys and liver related info.
      • Januvia (sitagliptin) can worsen kidney problems. Your doctor may check your kidney function before and during treatment. Your doctor may have to adjust the dose or stop this medicine based on changes in kidney function.
      • If you have severe kidney or liver problems, you should not take Byetta (Exenatide). Talk to your doctor about testing your kidneys before starting Byetta (Exenatide). People taking medications that are damaging to kidneys such as ACE inhibitors, NSAIDs or diuretics in addition to Byetta (Exenatide) may notice nausea, vomiting, or diarrhea.
      • Usually not a good choice for people with kidney problems. Your doctor will tell you if Glucophage (metformin) is right for you to take.
      • Glucophage (metformin) can cause this rare life-threatening condition. Your doctor will check your kidneys and liver before you start. Symptoms include deep and rapid breathing, nausea, vomiting, and stomach pain. This is a medical emergency and you should get help right away. You're more likely to get this if you already have kidney problems. Glucophage (metformin) should be stopped 48 hours before and after surgery or any imaging procedure needing contrast dye.
      No kidneys and liver related info.
      • Might be a better choice for people with kidney problems compared to similar drugs because Glipizide isn't processed by the kidneys.
      No kidneys and liver related info.
      Pain
      NesinaJanuviaByettametforminPrecoseGlucotrolActos
      No pain related info.
      • Tell your doctor right away if you have severe stomach pain, nausea, and/or vomiting. These are symptoms of pancreatitis.
      • Using Byetta (Exenatide) has been associated with stomach pain, nausea, vomiting and diarrhea. If you have severe gastrointestinal disease such as Crohn’s Disease or Ulcerative Colitis, you should talk to your doctor about using a different medicine for diabetes. You should not use Byetta (Exenatide) if you have gastroparesis, a condition that causes slow or irregular digestion. Gastroparesis can be common for people that have had uncontrolled diabetes for a while.
      No pain related info.No pain related info.No pain related info.No pain related info.
      Weight
      NesinaJanuviaByettametforminPrecoseGlucotrolActos
      No weight related info.
      • It is less likely to cause weight gain and low blood sugar compared to other diabetes medicines.
      No weight related info.
      • Doesn't cause weight gain.
      No weight related info.
      • Can cause mild weight gain (2 to 3 pounds).
      • Can cause weight gain, dizziness, or stomach upset.
      • More likely to cause weight gain (2 to 6 pounds or more) compared to other blood sugar-lowering medicines.
      • Can cause weight gain, headache, and fluid retention.
      Upsides and benefits
      NesinaJanuviaByettametforminPrecoseGlucotrolActos
      • Oral blood sugar-lowering medicine.
      • Lowers A1c levels by around 1%. (Hemoglobin A1c measures your average blood sugar over time.)
      • Prevents the harmful effects of high sugar levels on your organs and blood vessels.
      • Rarely causes low blood sugar.
      • Patients taking alogliptin had less cold symptoms than patients taking Januvia.
      • Oral blood sugar-lowering medicine.
      • Januvia (sitagliptin) is not linked to worsening heart failure like other medicines in its class.
      • Uses the hormones naturally produced by your body to affect how sugar is processed.
      • It is less likely to cause weight gain and low blood sugar compared to other diabetes medicines.
      • Can lower your A1c (average blood sugar over time) by 1%.
      • Not as likely to cause very low blood sugar as glyburine or insulin.
      • Does not increase your appetite like other anti-diabetic medicines.
      • Pen is dialed to a single dose for easy injections.
      • Improves sugar control and lowers A1c levels as much as 2%.
      • One of the few diabetes medicines that lowers the risk of death from diabetes-related complications.
      • Doesn't cause weight gain.
      • Rarely causes low blood sugar.
      Coming soon
      • Oral blood sugar-lowering medicine.
      • Lowers A1c levels by 1-2%. (Hemoglobin A1c measures your average blood sugar over time.)
      • Prevents the harmful effects of high sugar levels on your organs and blood vessels.
      • Might be a better choice for people with kidney problems compared to similar drugs because Glipizide isn't processed by the kidneys.
      • One of the least expensive diabetes medicines.
      • Oral blood sugar-lowering medicine.
      • Lowers A1c levels by around 1%. (Hemoglobin A1c measures your average blood sugar over time.)
      • Prevents the harmful effects of high sugar levels on your organs and blood vessels.
      • Rarely causes low blood sugar.
      Downsides and risks
      NesinaJanuviaByettametforminPrecoseGlucotrolActos
      • Not as strong as other diabetes medicines. Your doctor might add it to your blood sugar-lowering regimen if your sugar levels are still too high.
      • Likely expensive since there's no generic version available.
      • Some people might get frequent throat infections or nasal congestion.
      • Lowers A1c (average blood sugar over time) by less than 1%.
      • Available as brand version only.
      • Some people might get frequent cold-like symptoms.
      • Rare but serious side effects include pancreatitis and severe joint pain.
      • Byetta (Exenatide) must be injected twice a day. Other medicines like it can be injected once daily or even weekly.
      • It commonly causes nausea, vomiting, diarrhea, constipation, or indigestion.
      • Can affect how well your antibiotics and birth control pills work. Take them no sooner than one hour after your injections.
      • Often causes stomach upset, like diarrhea, nausea, gas, or stomach cramping.
      • Usually not a good choice for people with kidney problems. Your doctor will tell you if Glucophage (metformin) is right for you to take.
      • Excessive or chronic alcohol use can increase the risk of a dangerous side effect.
      Coming soon
      • Higher risk of low blood sugar episodes than other kinds of oral diabetes medicines.
      • You have to check your blood sugar 2 to 5 times a week (less often once you are on a stable dose).
      • Can cause mild weight gain (2 to 3 pounds).
      • Loses effectiveness over time or as your body stops making insulin.
      • Food can cause unpredictable effects of the immediate-release version of Glipizide, so you have to take it at least 30 minutes before a meal.
      • May take several weeks to lower blood sugar.
      • You have to check your blood sugar regularly with this medicine.
      • Has more side effects than similar medicines, so it's usually not the first choice for new Type 2 diabetes patients.
      • More likely to cause weight gain (2 to 6 pounds or more) compared to other blood sugar-lowering medicines.
      • Up to 1 in 10 people might get fluid retention (edema), ranging from mild ankle swelling to severe swelling in the lungs that makes it hard to breathe. People with severe congestive heart failure shouldn't use Actos.
      • Raises the risk of bone fractures, especially for people who already have a risk for fractures.
      • Slightly raises the risk of bladder cancer.
      Tips from our pharmacists for people taking the medication
      NesinaJanuviaByettametforminPrecoseGlucotrolActos
      • Can cause headache and cold-like symptoms.
      • Tell your doctor about any mental confusion, persistent abdominal pain, dark urine, yellowing of eyes/skin, or easy bruising.
      • Can be expensive depending on insurance coverage.
      • Check your blood sugar regularly.
      • Take once a day in the morning with or without food.
      • Can cause headache and cold-like symptoms.
      • Tell your doctor right away if you have severe stomach pain, nausea, and/or vomiting. These are symptoms of pancreatitis.
      • Tell your doctor right away if you are experiencing severe joint pain.
      • Check your blood sugar regularly to check for low blood sugar.
      • Inject into your belly, thighs, or upper arms within an hour of your main meals.
      • Store unused pens in the refrigerator.
      • After first use, pens can be kept at room temperature for 30 days.
      • Change the needle and prime the pen every time you inject.
      • If you're also on insulin, don't inject into the same site.
      • Best to check your blood sugar once a day to make sure your medicine is working properly.
      • Can cause upset stomach with nausea and especially diarrhea in the first couple of weeks.
      • Always take it with food to lessen stomach upset.
      • Stay hydrated.
      • Limit or avoid alcohol when taking this medicine.
      • Tell your doctor about any deep or rapid breathing, or persistent nausea, vomiting, and stomach pain.
      • Check your blood sugar regularly.
      Coming soon
      • Works best if you take it 30 minutes before a meal, usually your first big meal of the day.
      • Can cause weight gain, dizziness, or stomach upset.
      • Avoid drinking alcohol.
      • Eat regular, balanced meals to avoid low blood sugar.
      • Check your blood sugar regularly.
      • Takes several weeks to see full effect on blood sugar control.
      • Can cause weight gain, headache, and fluid retention.
      • Tell your doctor about any mental confusion, persistent abdominal pain, dark urine, yellowing of eyes/skin, or easy bruising.
      • Not recommended for patients with certain heart problems.
      • Check your blood sugar regularly.
      Learn more
      More about NesinaSide effectsReviews & ratingsAlternativesFDA package insert
      Have you used Nesina (alogliptin)?
      Worth itNot sureNot worth it
      More about JanuviaSide effectsReviews & ratingsFDA package insert
      Have you used Januvia (sitagliptin)?
      Worth itNot sureNot worth it
      More about ByettaSide effectsReviews & ratingsFDA package insert
      Have you used Byetta (exenatide)?
      Worth itNot sureNot worth it
      More about metforminSide effectsReviews & ratingsFDA package insert
      Have you used Glucophage (metformin)?
      Worth itNot sureNot worth it
      More about PrecoseSide effectsReviews & ratingsFDA package insert
      Have you used Precose (acarbose)?
      Worth itNot sureNot worth it
      More about GlucotrolSide effectsReviews & ratingsFDA package insert
      Have you used Glucotrol (glipizide)?
      Worth itNot sureNot worth it
      More about ActosSide effectsReviews & ratingsFDA package insert
      Have you used Actos (pioglitazone)?
      Worth itNot sureNot worth it